Autophagy articles from across Nature Portfolio

Autophagy is a process by which cellular material is degraded by lysosomes or vacuoles and recycled. Several autophagy pathways operate within a cell, including macroautophagy, microautophagy and chaperone-mediated autophagy.

Featured

News & Views | 16 March 2023

Structural basis for phosphorylation of TFEB by mTORC1
- Katarzyna Ciazynska
Nature Structural & Molecular Biology 30, 244
News & Views | 13 March 2023

STING is ESCRTed to degradation by microautophagy
- Sonia Assil
- & Søren R. Paludan
Nature Cell Biology 25, 379-380

Latest Research and Reviews

Research
25 March 2023 | Open Access

SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation
- Lilia Sanchez
- , Jessica Epps
- & Weston W. Porter
Cell Death & Differentiation, 1-16
Research
22 March 2023 | Open Access

Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease
- Rebeka Popovic
- , Amrita Mukherjee
- & L. Miguel Martins
Cell Death & Disease 14, 206
Research
16 March 2023 | Open Access

Dexmedetomidine improves acute lung injury by activating autophagy in a rat hemorrhagic shock and resuscitation model
- Yifu Lu
- , Hiroko Shimizu
- & Hiroshi Morimatsu
Scientific Reports 13, 4374
Research
16 March 2023 | Open Access

Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca²⁺-dependent FUNDC1 phosphorylation at the ER-mitochondria interface
- Ananth Ponneri Babuharisankar
- , Cheng-Liang Kuo
- & Alan Yueh-Luen Lee
Cell Death & Disease 14, 199
Research
13 March 2023 | Open Access

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver
- Giovan N. Cholico
- , Karina Orlowska
- & Tim Zacharewski
Scientific Reports 13, 4138
Research
13 March 2023 | Open Access

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

The function of de novo lipogenesis (DNL) in adipocytes has been a mystery as it contributes little to fat storage in these cells. Here, the authors show that DNL is a critical source of fatty acids for membrane-expanding processes like autophagy.
- Leslie A. Rowland
- , Adilson Guilherme
- & Michael P. Czech
Nature Communications 14, 1362

All Research & Reviews

News and Comment

News & Views | 16 March 2023

Structural basis for phosphorylation of TFEB by mTORC1
- Katarzyna Ciazynska
Nature Structural & Molecular Biology 30, 244
News & Views | 13 March 2023

STING is ESCRTed to degradation by microautophagy

Activation of a crucial immune adaptor protein, STING, is tightly regulated by subcellular trafficking, but how it is deactivated remains less well defined. A study now shows that ESCRT-dependent encapsulation of STING-carrying vesicles by lysosomal compartments — through the process of microautophagy — mediates the termination of STING signalling.
- Sonia Assil
- & Søren R. Paludan
Nature Cell Biology 25, 379-380
Research Highlights | 07 March 2023

The metabolic benefits of exercise-induced hepatic autophagy
- Claire Greenhill
Nature Reviews Endocrinology, 1
News & Views | 30 December 2022

Nuclear autophagy promotes longevity and germline immortality

Under conditions of stress, autophagic degradation of nuclear and nucleolar components was found to promot.e youthfulness and delay aging by preserving nuclear architecture and preventing nucleolar expansion, in somatic cells. We also found that nuclear-material autophagy serves as an essential quality-control mechanism that contributes to sustaining germline immortally.

Nature Aging 3, 11-12
Research Highlights | 18 November 2022

Adjusting the spikes
- Benjamin McIlwain
Nature Chemical Biology 18, 1290
Research Highlights | 09 November 2022

Autophagosomes need calcium
- Lucia Brunello
Nature Structural & Molecular Biology 29, 1037

All News & Comment

Autophagy articles from across Nature Portfolio

Featured

Structural basis for phosphorylation of TFEB by mTORC1

STING is ESCRTed to degradation by microautophagy

Latest Research and Reviews

SIM2s directed Parkin-mediated mitophagy promotes mammary epithelial cell differentiation

Blocking dPerk in the intestine suppresses neurodegeneration in a Drosophila model of Parkinson’s disease

Dexmedetomidine improves acute lung injury by activating autophagy in a rat hemorrhagic shock and resuscitation model

Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca²⁺-dependent FUNDC1 phosphorylation at the ER-mitochondria interface

Consequences of reprogramming acetyl-CoA metabolism by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the mouse liver

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

News and Comment

Structural basis for phosphorylation of TFEB by mTORC1

STING is ESCRTed to degradation by microautophagy

The metabolic benefits of exercise-induced hepatic autophagy

Nuclear autophagy promotes longevity and germline immortality

Adjusting the spikes

Autophagosomes need calcium

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Autophagy articles from across Nature Portfolio

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