Autoimmunity

Autoimmunity is a process by which the immune system reacts against the body's own tissues. Chronic and/or excessive autoimmune responses can result in autoimmune diseases.

Latest Research and Reviews

  • Research
    | Open Access

    How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription of autoimmunity-related genes to suppress Th17 responses and uveitis.

    • Ruth J. Napier
    • , Ellen J. Lee
    • , Michael P. Davey
    • , Emily E. Vance
    • , João M. Furtado
    • , Paige E. Snow
    • , Kimberly A. Samson
    • , Sydney J. Lashley
    • , Brieanna R. Brown
    • , Reiko Horai
    • , Mary J. Mattapallil
    • , Biying Xu
    • , Michelle C. Callegan
    • , Luke S. Uebelhoer
    • , Christina L. Lancioni
    • , Richard K. Vehe
    • , Bryce A. Binstadt
    • , Justine R. Smith
    • , Rachel R. Caspi
    •  & Holly L. Rosenzweig
  • Research
    | Open Access

    SOCS1 is a potent suppressor of JAK-STAT signalling responses to IFNγ and γ-chain cytokines and thereby limits inflammation. Here the authors identify and characterize heterozygous SOCS1 mutations in 10 patients from 5 unrelated families with autoimmune diseases.

    • Jérôme Hadjadj
    • , Carla Noemi Castro
    • , Maud Tusseau
    • , Marie-Claude Stolzenberg
    • , Fabienne Mazerolles
    • , Nathalie Aladjidi
    • , Martin Armstrong
    • , Houman Ashrafian
    • , Ioana Cutcutache
    • , Georg Ebetsberger-Dachs
    • , Katherine S. Elliott
    • , Isabelle Durieu
    • , Nicole Fabien
    • , Mathieu Fusaro
    • , Maximilian Heeg
    • , Yohan Schmitt
    • , Marc Bras
    • , Julian C. Knight
    • , Jean-Christophe Lega
    • , Gaetan Lesca
    • , Anne-Laure Mathieu
    • , Marion Moreews
    • , Baptiste Moreira
    • , Audrey Nosbaum
    • , Matthew Page
    • , Cécile Picard
    • , T. Ronan Leahy
    • , Isabelle Rouvet
    • , Ethel Ryan
    • , Damien Sanlaville
    • , Klaus Schwarz
    • , Andrew Skelton
    • , Jean-Francois Viallard
    • , Sebastien Viel
    • , Marine Villard
    • , Isabelle Callebaut
    • , Capucine Picard
    • , Thierry Walzer
    • , Stephan Ehl
    • , Alain Fischer
    • , Bénédicte Neven
    • , Alexandre Belot
    •  & Frédéric Rieux-Laucat
  • Research |

    The enhanced accumulation and residence time of systemically administered interleukin-4 fused to serum albumin in lymph nodes and in the spleen prevents the development of multiple sclerosis in mice.

    • Ako Ishihara
    • , Jun Ishihara
    • , Elyse A. Watkins
    • , Andrew C. Tremain
    • , Mindy Nguyen
    • , Ani Solanki
    • , Kiyomitsu Katsumata
    • , Aslan Mansurov
    • , Erica Budina
    • , Aaron T. Alpar
    • , Peyman Hosseinchi
    • , Lea Maillat
    • , Joseph W. Reda
    • , Takahiro Kageyama
    • , Melody A. Swartz
    • , Eiji Yuba
    •  & Jeffrey A. Hubbell

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