Autoimmunity articles from across Nature Portfolio

Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration.

An antibody screen of two distinct multiple sclerosis cohorts reveals an autoantibody signature that is detectable years before symptom onset and linked to a common microbial motif.

This study maps the peripheral immune landscape of childhood Sjogren’s disease at single-cell level, providing immune and molecular characterizations that necessitate a better understanding in the etiology of the rare autoimmune disease.

Although many autoimmune diseases are characterized by the presence of autoantibodies, complete characterisation of autoantibody repertoires is lacking. Here, the authors introduce an autoantigen-specific Fab profiling method to show that the autoantibody repertoire in rheumatoid arthritis is diverse yet dominated only by a few clones.

Multidimensional and single-cell profiling of peripheral blood and inflamed tissues is a powerful and high-resolution tool for the stratification of patients with autoimmune rheumatic diseases into distinct cellular and/or molecular endotypes. The road towards precision rheumatology is long, but the time has come to enter the territory of clinical validation.

Autoantibodies that develop in systemic lupus erythematosus (SLE) can cause long-term cognitive impairment that remains even after the systemic disease becomes quiescent. This study attributes the persistent cognitive symptoms of SLE to a self-sustaining neuroinflammatory process that continues indefinitely unless disrupted — which can be done using medications approved by the US Food and Drug Administration.