Autoimmunity

Autoimmunity is a process by which the immune system reacts against the body's own tissues. Chronic and/or excessive autoimmune responses can result in autoimmune diseases.

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Latest Research and Reviews

  • Research |

    Nephritis is a major cause of lupus morbidity. Putterman and colleagues use single-cell RNA sequencing on human renal and skin biopsies to describe the expression landscape associated with lupus nephritis.

    • Evan Der
    • , Hemant Suryawanshi
    • , Pavel Morozov
    • , Manjunath Kustagi
    • , Beatrice Goilav
    • , Saritha Ranabathou
    • , Peter Izmirly
    • , Robert Clancy
    • , H. Michael Belmont
    • , Mordecai Koenigsberg
    • , Michele Mokrzycki
    • , Helen Rominieki
    • , Jay A. Graham
    • , Juan P. Rocca
    • , Nicole Bornkamp
    • , Nicole Jordan
    • , Emma Schulte
    • , Ming Wu
    • , James Pullman
    • , Kamil Slowikowski
    • , Soumya Raychaudhuri
    • , Joel Guthridge
    • , Judith James
    • , Jill Buyon
    • , Thomas Tuschl
    • , Chaim Putterman
    • , Jennifer Anolik
    • , William Apruzzese
    • , Arnon Arazi
    • , Celine Berthier
    • , Michael Brenner
    • , Jill Buyon
    • , Robert Clancy
    • , Sean Connery
    • , Melissa Cunningham
    • , Maria Dall’Era
    • , Anne Davidson
    • , Evan Der
    • , Andrea Fava
    • , Chamith Fonseka
    • , Richard Furie
    • , Dan Goldman
    • , Rohit Gupta
    • , Joel Guthridge
    • , Nir Hacohen
    • , David Hildeman
    • , Paul Hoover
    • , Raymond Hsu
    • , Judith James
    • , Ruba Kado
    • , Kenneth Kalunian
    • , Diane Kamen
    • , Mattias Kretzler
    • , Holden Maecker
    • , Elena Massarotti
    • , William McCune
    • , Maureen McMahon
    • , Meyeon Park
    • , Fernanda Payan-Schober
    • , William Pendergraft
    • , Michelle Petri
    • , Mina Pichavant
    • , Chaim Putterman
    • , Deepak Rao
    • , Soumya Raychaudhuri
    • , Kamil Slowikowski
    • , Hemant Suryawanshi
    • , Thomas Tuschl
    • , Paul Utz
    • , Dia Waguespack
    • , David Wofsy
    •  & Fan Zhang
  • Research | | open

    Function-altering variants of immune-related genes cause rare autoimmune syndromes, whereas their contribution to common autoimmune diseases remains uncharacterized. Here the authors show that rare variants of lupus-associated genes are present in the majority of lupus patients and healthy controls, but only the variants found in lupus patients alter gene function.

    • Simon H. Jiang
    • , Vicki Athanasopoulos
    • , Julia I. Ellyard
    • , Aaron Chuah
    • , Jean Cappello
    • , Amelia Cook
    • , Savit B. Prabhu
    • , Jacob Cardenas
    • , Jinghua Gu
    • , Maurice Stanley
    • , Jonathan A. Roco
    • , Ilenia Papa
    • , Mehmet Yabas
    • , Giles D. Walters
    • , Gaetan Burgio
    • , Kathryn McKeon
    • , James M. Byers
    • , Charlotte Burrin
    • , Anselm Enders
    • , Lisa A. Miosge
    • , Pablo F. Canete
    • , Marija Jelusic
    • , Velibor Tasic
    • , Adrian C. Lungu
    • , Stephen I. Alexander
    • , Arthur R. Kitching
    • , David A. Fulcher
    • , Nan Shen
    • , Todor Arsov
    • , Paul A. Gatenby
    • , Jeff J. Babon
    • , Dominic F. Mallon
    • , Carmen de Lucas Collantes
    • , Eric A. Stone
    • , Philip Wu
    • , Matthew A. Field
    • , Thomas D. Andrews
    • , Eun Cho
    • , Virginia Pascual
    • , Matthew C. Cook
    •  & Carola G. Vinuesa
  • Research | | open

    Tissue signals that prime autoreactive T cells at the onset of autoimmunity remain enigmatic. Here the authors show NK and ILC1 cells are increased in vitiligo patients, and induce melanocyte apoptosis via CXCR3B, which in turn leads to increased priming of T cell responses in cell culture.

    • Meri K. Tulic
    • , Elisa Cavazza
    • , Yann Cheli
    • , Arnaud Jacquel
    • , Carmelo Luci
    • , Nathalie Cardot-Leccia
    • , Hanene Hadhiri-Bzioueche
    • , Patricia Abbe
    • , Maéva Gesson
    • , Laura Sormani
    • , Claire Regazzetti
    • , Guillaume E. Beranger
    • , Cedric Lereverend
    • , Caroline Pons
    • , Abdallah Khemis
    • , Robert Ballotti
    • , Corine Bertolotto
    • , Stéphane Rocchi
    •  & Thierry Passeron
  • Research | | open

    Immune response against tissue-specific antigens is a hallmark of autoimmunity. Here the authors show that a single autoantigen-based nanomedicine can ameliorate pathology in a broad range of liver autoimmunity models without impairing host defenses, suggesting organ-wide tolerization.

    • Channakeshava Sokke Umeshappa
    • , Santiswarup Singha
    • , Jesus Blanco
    • , Kun Shao
    • , Roopa Hebbandi Nanjundappa
    • , Jun Yamanouchi
    • , Albert Parés
    • , Pau Serra
    • , Yang Yang
    •  & Pere Santamaria

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