Antivirals

Antivirals are substances that inhibit virus infection or replication. Antivirals can be used as drugs to prevent or treat diseases caused by viruses.

Latest Research and Reviews

News and Comment

  • News and Views |

    Innovative solutions are needed to overcome the global disparity in patients awaiting kidney transplantation versus donor organs available. A new study reports a promising new strategy of transplanting kidneys from HCV-infected donors into HCV-uninfected recipients and treating their HCV with direct-acting antivirals post-transplant — recipients achieved HCV cure with excellent one-year kidney allograft function.

    • Allison J. Kwong
    •  & Norah A. Terrault
  • Comments and Opinion |

    More than 250 million people worldwide are chronically infected with the hepatitis B virus (HBV). In this Comment, members of the International Coalition to Eliminate HBV appraise the current policy environment and the need for appropriate cure research and preparedness to complement the WHO global elimination strategy, the HBV vaccine and the well-tolerated but poorly accessed therapy.

    • Jeffrey V. Lazarus
    • , Timothy Block
    • , Christian Bréchot
    • , Anna Kramvis
    • , Veronica Miller
    • , Michael Ninburg
    • , Capucine Pénicaud
    • , Ulrike Protzer
    • , Homie Razavi
    • , Laura A. Thomas
    • , Jack Wallace
    •  & Benjamin C. Cowie
  • News and Views |

    Antibodies that potently neutralize highly diverse HIV-1 variants offer great potential for therapy and prevention. Passive administration of HIV-specific neutralizing antibodies genetically modified to have a long serum half-life has now been shown to confer long-lasting protection from infection in the rhesus macaque model.

    • Michelle Zanoni
    • , David Palesch
    •  & Guido Silvestri
    Nature Microbiology 3, 648-649
  • News and Views |

    Topical administration of aminoglycoside antibiotics has been shown to induce expression of interferon-stimulated genes in dendritic cells, inducing an antiviral state in the vaginal and lung mucosa that increases resistance to infection with herpes simplex virus 1, influenza and Zika viruses.

    • Jeffrey I. Cohen
    Nature Microbiology 3, 531-532
  • News and Views |

    Influenza B virus causes substantial illness globally, particularly in children. Treatment options are limited, as the most widely used antiviral drug appears to be less effective than against influenza A. A new antibody targeting the influenza B neuraminidase shows promise in mice as a therapeutic option.

    • Aeron C. Hurt
    •  & Kanta Subbarao
    Nature Microbiology 2, 1342-1343