Antivirals articles from across Nature Portfolio

Antivirals are substances that inhibit virus infection or replication. Antivirals can be used as drugs to prevent or treat diseases caused by viruses.

Latest Research and Reviews

Research
22 March 2023 | Open Access

In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk
- Ana Lidia Madeira de Sousa
- , Raymundo Rizaldo Pinheiro
- & Maria Fatima da Silva Teixeira
Scientific Reports 13, 4677
Research
13 February 2023 | Open Access

Cross-protective antibodies against common endemic respiratory viruses

Immunocompromised patients are vulnerable to respiratory viral infections. Here, the authors characterize cross-neutralizing antibodies to respiratory syncytial virus, human metapneumovirus, and human parainfluenza viruses and show effective protection in male hamsters.
- Madelyn Cabán
- , Justas V. Rodarte
- & Jim Boonyaratanakornkit
Nature Communications 14, 798
Research
30 January 2023 | Open Access

Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2
- James McNulty
- , Chanti Babu-Dokuburra
- & Leonardo D’Aiuto
Scientific Reports 13, 1639
Research
13 January 2023 | Open Access

Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation

The search for antivirals against SARS-CoV-2 continue due to the emergence of variants of concerns, able to escape the vaccinal humoral response. In this work, authors pre-clinically explore the potential of kinetin against SARS-CoV-2, which could be used alone or in combination with other antivirals.
- Thiago Moreno L. Souza
- , Vagner D. Pinho
- & Jaime A. Rabi
Nature Communications 14, 199
Research
15 December 2022 | Open Access

In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea
- Leena Hussein Bajrai
- , Sherif Ali El-Kafrawy
- & Esam Ibraheem Azhar
Scientific Reports 12, 21723
Research
07 December 2022 | Open Access

Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis
- Nagela Bernadelli Sousa Silva
- , Jonathan Henrique de Souza
- & Carlos Henrique Gomes Martins
Scientific Reports 12, 21165

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News and Comment

News & Views | 25 August 2022

Programmable antivirals to target conserved essential shapes in pandemic viral genomes

We identified and mapped at high-resolution RNA structures in viral genomes that are essential for virus reproduction. We then rapidly designed potent antivirals with high barriers to resistance that prevent or treat severe infections of these viruses with pandemic potential — via development of what we term ‘programmable antivirals’.

Nature Medicine 28, 1771-1772
Research Highlights | 01 March 2022

Evaluating an RSV inhibitor

This study presents the results of a respiratory syncytial virus (RSV) challenge trial with EDP-938, a nonfusion replication inhibitor of RSV, showing effective lowering of viral load and symptoms, without apparent safety concerns.
- Andrea Du Toit
Nature Reviews Microbiology 20, 254
News & Views | 12 October 2021

Hepatitis B: a new weapon against an old enemy

New strategies based on nucleic acid technologies are being exploited to treat chronic hepatitis B—a pilot clinical study of antisense oligonucleotide treatment shows the potential promise of this approach.
- T. Jake Liang
Nature Medicine 27, 1672-1673
Research Highlights | 23 August 2021

Drugging viral factories
- Majda Bratovič
Nature Chemical Biology 17, 929
Research Highlights | 16 July 2021

Targeting viral liquid–liquid phase separation

Two recent studies provide evidence that liquid–liquid phase separation during viral replication is a target for antiviral therapy.
- Ashley York
Nature Reviews Microbiology 19, 550
Editorial | 13 March 2020

Redeploying plant defences

Epidemic diseases are not a new phenomenon, but easy access to transport in the modern world has accelerated their spread. Perhaps some botanical understanding can help slow them down.

Nature Plants 6, 177

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Antivirals articles from across Nature Portfolio

Latest Research and Reviews

In vitro antiviral effect of ethanolic extracts from Azadirachta indica and Melia azedarach against goat lentivirus in colostrum and milk

Cross-protective antibodies against common endemic respiratory viruses

Truncated ring-A amaryllidaceae alkaloid modulates the host cell integrated stress response, exhibiting antiviral activity to HSV-1 and SARSCoV-2

Preclinical development of kinetin as a safe error-prone SARS-CoV-2 antiviral able to attenuate virus-induced inflammation

In vitro screening of anti-viral and virucidal effects against SARS-CoV-2 by Hypericum perforatum and Echinacea

Potential in vitro anti-periodontopathogenic, anti-Chikungunya activities and in vivo toxicity of Brazilian red propolis

News and Comment

Programmable antivirals to target conserved essential shapes in pandemic viral genomes

Evaluating an RSV inhibitor

Hepatitis B: a new weapon against an old enemy

Drugging viral factories

Targeting viral liquid–liquid phase separation

Redeploying plant defences

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