Antiparasitic agents

Antiparasitic agents are drugs used to treat parasitic diseases. Parasites can live on or in a host and feed off of it. Human parasites include protozoa, flatworms, roundworms and ectoparasites such as ticks, fleas, lice, and mites. They cause diseases such as malaria, trichomoniasis and Leishmaniasis.

Latest Research and Reviews

News and Comment

  • Comments & Opinion
    | Open Access

    Malaria cases and deaths remain unacceptably high and are resurgent in several settings, though recent developments inspire optimism. This includes the approval of the world’s first malaria vaccine and results from novel vaccine candidates and trials testing innovative combinatorial interventions.

    • Prasanna Jagannathan
    •  & Abel Kakuru
  • Research Highlights |

    A recent study finds that upregulation of nutrient-permeable channels in the parasitophorous vacuole membrane increases the acquisition of amino acids by artemisinin-resistant parasites to compensate for fitness costs.

    • Ashley York
  • Research Highlights |

    Researchers show that Plasmodium falciparum glutamic-acid-rich protein (PfGARP), a 80 kDa antigen expressed on the surface of P. falciparum-infected erythrocytes, is a malaria vaccine candidate for specifically targeting the blood stage of this parasite.

    • Katharine H. Wrighton
  • Comments & Opinion |

    Resistance to the current first-line antimalarials threatens the control of malaria caused by Plasmodium falciparum and underscores the urgent need for new drugs with novel modes of action. Small-Saunders, Hagenah and Fidock present the argument that the parasite’s chloroquine resistance transporter (PfCRT) constitutes a promising target to combat multidrug-resistant malaria.

    • Jennifer L. Small-Saunders
    • , Laura M. Hagenah
    •  & David A. Fidock