Antimicrobials articles from across Nature Portfolio

This study reports the identification of an inhibitor of a Toxoplasma gondii myosin motor protein that could be exploited to prevent or treat infections with T. gondii and other apicomplexan parasites.

Shigella spp. that are resistant to almost all antimicrobial classes are increasing in prevalence and becoming globally dominant. The situation is critical and highlights a trend that is mirrored by other enteric bacterial pathogens. New interventions to prevent and treat these infections are essential to tackle a potential public health catastrophe.

In this study, Carfrae et al. show that inhibition of biotin and fatty acid synthesis restores colistin activity against Gram-negative bacteria and prevents colistin resistance.