Antimicrobial resistance

Antimicrobial resistance is the ability of microorganisms such as bacteria, fungi or protozoans to grow despite exposure to antimicrobial substances designed to inhibit their growth. Microbes can evolve antimicrobial resistance when, for example, populations are subjected to selective pressure through drug use in medicine.

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Latest Research and Reviews

  • Reviews |

    Whole genome sequencing (WGS) offers new opportunities in the clinical management and surveillance of Mycobacterium tuberculosis. In this Review, Meehan and colleagues explore the current landscape of WGS pipelines and applications, and set out best practices for M. tuberculosis WGS, including standards for bioinformatics pipelines, curated repositories of resistance-causing variants, phylogenetic analyses, quality control and standardized reporting.

    • Conor J. Meehan
    • , Galo A. Goig
    • , Thomas A. Kohl
    • , Lennert Verboven
    • , Anzaan Dippenaar
    • , Matthew Ezewudo
    • , Maha R. Farhat
    • , Jennifer L. Guthrie
    • , Kris Laukens
    • , Paolo Miotto
    • , Boatema Ofori-Anyinam
    • , Viola Dreyer
    • , Philip Supply
    • , Anita Suresh
    • , Christian Utpatel
    • , Dick van Soolingen
    • , Yang Zhou
    • , Philip M. Ashton
    • , Daniela Brites
    • , Andrea M. Cabibbe
    • , Bouke C. de Jong
    • , Margaretha de Vos
    • , Fabrizio Menardo
    • , Sebastien Gagneux
    • , Qian Gao
    • , Tim H. Heupink
    • , Qingyun Liu
    • , Chloé Loiseau
    • , Leen Rigouts
    • , Timothy C. Rodwell
    • , Elisa Tagliani
    • , Timothy M. Walker
    • , Robin M. Warren
    • , Yanlin Zhao
    • , Matteo Zignol
    • , Marco Schito
    • , Jennifer Gardy
    • , Daniela M. Cirillo
    • , Stefan Niemann
    • , Inaki Comas
    •  & Annelies Van Rie
  • Research | | open

    It is expected that plasmids are costly and therefore that selection is required to maintain them within bacterial populations. Here, Wein et al. show that plasmid stability can emerge even in the absence of positive selection and that loss may be determined by transcription-replication conflict.

    • Tanita Wein
    • , Nils F. Hülter
    • , Itzhak Mizrahi
    •  & Tal Dagan
  • Reviews |

    Lipopolysaccharide is a key component of the Gram-negative cell envelope and functions, for example, as a permeability barrier or determinant of host immune responses. In this Review, Simpson and Trent guide us through lipopolysaccharide biogenesis and modifications and their functional and therapeutic implications.

    • Brent W. Simpson
    •  & M. Stephen Trent
  • Research |

    Mobile tet(X3) and tet(X4) genes are identified on conjugative plasmids in Enterobacteriaceae and Acinetobacter isolated from humans, meat for consumption and animals that confer resistance to tetracyclines, including tigecycline, eravacycline and omadacycline.

    • Tao He
    • , Ran Wang
    • , Dejun Liu
    • , Timothy R. Walsh
    • , Rong Zhang
    • , Yuan Lv
    • , Yuebin Ke
    • , Quanjiang Ji
    • , Ruicheng Wei
    • , Zhihai Liu
    • , Yingbo Shen
    • , Gang Wang
    • , Lichang Sun
    • , Lei Lei
    • , Ziquan Lv
    • , Yun Li
    • , Maoda Pang
    • , Liyuan Wang
    • , Qiaoling Sun
    • , Yulin Fu
    • , Huangwei Song
    • , Yuxin Hao
    • , Zhangqi Shen
    • , Shaolin Wang
    • , Gongxiang Chen
    • , Congming Wu
    • , Jianzhong Shen
    •  & Yang Wang
  • Research |

    VacA promotes Helicobacter pylori intracellular localization and persistence in the face of antibiotics. Activation of the lysosomal TRPML1 calcium channel reverses VacA toxicity and promotes bacterial clearance during drug treatment.

    • Mariana I. Capurro
    • , Laura K. Greenfield
    • , Akriti Prashar
    • , Sunny Xia
    • , Majd Abdullah
    • , Harikesh Wong
    • , Xi Zoe Zhong
    • , Nina Bertaux-Skeirik
    • , Jayati Chakrabarti
    • , Iram Siddiqui
    • , Catherine O’Brien
    • , Xianping Dong
    • , Lisa Robinson
    • , Richard M. Peek Jr
    • , Dana J. Philpott
    • , Yana Zavros
    • , Michael Helmrath
    •  & Nicola L. Jones

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