Antimicrobial resistance articles from across Nature Portfolio

The dihydrofolate reductase inhibitor, fluorofolin, shows potent activity against Pseudomonas aeruginosa and selectively eliminates P. aeruginosa from mixed-species bacterial cultures.

In hospitals, surfaces present as a reservoir for bacteria pathogens, potentially leading to nosocomial infections. In this work, authors aim to profile extended-spectrum β lactamase- and carbapenemase-carrying bacterial species colonising neonatal hospital wards and causing neonatal sepsis.

Known as tethered macrocyclic peptides, a new class of antibiotics show potent activity against drug-resistant strains of Acinetobacter baumannii — with one candidate already in clinical trials.

Antimicrobial peptides have the potential to combat the growing threat of antimicrobial resistance; however, their clinical translation remains challenging. Here, we discuss molecular farming as a sustainable approach to antimicrobial peptide production, outlining different platforms to produce antimicrobial peptides using plants and viral vectors.

Pallett et al. discuss the impact of human conflict on development of antimicrobial resistance. They overview approaches to limit the spread of antimicrobial resistance, using the ongoing conflict in Ukraine as an example of the challenges and opportunities.

We used functional genomics to understand how hospital biocides impact the human pathogen Acinetobacter baumannii. Low concentrations of various biocides dissipated the membrane potential of A. baumannii, which we demonstrated could antagonize the potency of antibiotics.