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Antibody isolation and purification is the concentration of an antibody or antibodies that recognize a specific target molecule and the removal of non-specific antibodies and contaminants. Pure isolated antibodies tend to have greater activity and are less likely to cross-react with non-target molecules than impure mixtures.
Selective targeting individual subtypes of N-methyl-D-aspartate receptors (NMDARs) is a desirable therapeutic strategy for neurological disorders. Here, the authors report identification of a functional antibody that specifically targets and allosterically down-regulates ion channel activity of the GluN1—GluN2B NMDAR subtype.
Novoa, Mason and Mattick propose to use phage display technology and direct sequencing through nanopores to facilitate systematic interrogation of RNA modifications.
