Antibody fragment therapy

Antibody fragment therapies are a type of biologic. They are typically fragments of monoclonal antibodies selected to bind to a particular protein (often a cell-surface protein), and produced using recombinant DNA technology.

Latest Research and Reviews

  • Research | | open

    Enhanced Wnt receptor activity is a major cause of cancer development. Here the authors identify camelid single-domain antibody fragments (VHHs) that bind to the Wnt receptor LRP5/6 ectodomain, determine the crystal structures and show that these VHHs selectively inhibit Wnt3- mediated cellular responses and block the growth of mutant Wnt-hypersensitive intestinal tumor organoids.

    • Nicola Fenderico
    • , Revina C. van Scherpenzeel
    • , Michael Goldflam
    • , Davide Proverbio
    • , Ingrid Jordens
    • , Tomica Kralj
    • , Sarah Stryeck
    • , Tarek Z. Bass
    • , Guy Hermans
    • , Christopher Ullman
    • , Teodor Aastrup
    • , Piet Gros
    •  & Madelon M. Maurice
  • Research |

    Osteoclasts secrete small extracellular vesicles that stimulate osteoblasts, promoting bone formation via receptor activator of nuclear factor-kappa B ligand (RANKL), thereby linking bone formation and resorption.

    • Yuki Ikebuchi
    • , Shigeki Aoki
    • , Masashi Honma
    • , Madoka Hayashi
    • , Yasutaka Sugamori
    • , Masud Khan
    • , Yoshiaki Kariya
    • , Genki Kato
    • , Yasuhiko Tabata
    • , Josef M. Penninger
    • , Nobuyuki Udagawa
    • , Kazuhiro Aoki
    •  & Hiroshi Suzuki
    Nature 561, 195-200
  • Research | | open

    Atherosclerosis and osteoporosis are epidemiologically associated, and oxidation specific epitopes (OSEs), which can be neutralized by innate antibodies, are pathogenic for both. Here, the authors show that mice expressing antibody fragments targeted to OSEs are protected from the bone loss induced by high-fat diet and have increased bone mass when fed a normal diet, and that levels of innate antibodies to OSEs decrease with ageing.

    • Elena Ambrogini
    • , Xuchu Que
    • , Shuling Wang
    • , Fumihiro Yamaguchi
    • , Robert S. Weinstein
    • , Sotirios Tsimikas
    • , Stavros C. Manolagas
    • , Joseph L. Witztum
    •  & Robert L. Jilka

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