Antibiotics articles from across Nature Portfolio

Antibiotics are substances that inhibit the growth of bacteria. They work by killing bacteria or preventing their reproduction, and may be synthesized chemically or by naturally-occurring or engineered organisms.

Latest Research and Reviews

Research
28 March 2023 | Open Access

Prediction of ciprofloxacin resistance in hospitalized patients using machine learning

Mintz et al. develop machine learning models to predict the probability of ciprofloxacin resistance in hospitalized patients. Resistance of previous infections, prior location of patients, sex and recent resistance frequencies in the hospital impact the probability of ciprofloxacin resistance in each patient.
- Igor Mintz
- , Michal Chowers
- & Uri Obolski
Communications Medicine 3, 43
Research
22 March 2023 | Open Access

Cooperative antibiotic resistance facilitates horizontal gene transfer
- Qinqin Wang
- , Shaodong Wei
- & Jonas Stenløkke Madsen
The ISME Journal, 1-9
Research
10 March 2023 | Open Access

YgfB increases β-lactam resistance in Pseudomonas aeruginosa by counteracting AlpA-mediated ampDh3 expression

YgfB regulates β-lactam resistance in Pseudomonas aeruginosa in part by interacting with the programmed cell death pathway regulator, AlpA, and repressing expression of the amidase, AmpDh3.
- Ole Eggers
- , Fabian A. Renschler
- & Erwin Bohn
Communications Biology 6, 254
Research
10 March 2023 | Open Access

Efficacy of ceftazidime in a murine model following a lethal aerosol exposure to Burkholderia pseudomallei
- Denise A. Pfefferle
- , Michael Hackett
- & Gabriel T. Meister
Scientific Reports 13, 4047
Research
02 March 2023 | Open Access

Population-level impacts of antibiotic usage on the human gut microbiome

Here, the authors study the population-level impact of antimicrobial resistance genes (ARGs). By analyzing 8972 metagenomes and 3,096 gut microbiomes from healthy individuals not taking antibiotics, they demonstrate significant correlations between both the total ARG abundance and diversity and per capita antibiotic usage rates across ten countries spanning three continents. Using a collection of 154,723 human-associated metagenome assembled genomes (MAGs) they link these ARGs to microbial taxa and horizontal gene transfer.
- Kihyun Lee
- , Sebastien Raguideau
- & Christopher Quince
Nature Communications 14, 1191
Reviews | 24 February 2023

Surveying membrane landscapes: a new look at the bacterial cell surface

In this Review, Lithgow and colleagues explore how imaging of the bacterial cell surface at nanoscale has revealed distinct zones and specific features, including functionally defined assembly precincts for protein insertion into the membrane and equivalent lipid-assembly precincts suggested from discrete lipopolysaccharide patches.
- Trevor Lithgow
- , Christopher J. Stubenrauch
- & Michael P. H. Stumpf
Nature Reviews Microbiology, 1-17

All Research & Reviews

News and Comment

Research Highlights | 22 March 2023

Heat up the antibiotics

This study reports that heat treatment can increase the bactericidal activity of aminoglycosides against multi-drug resistant pathogens.
- Agustina Taglialegna
Nature Reviews Microbiology, 1
News | 27 February 2023

One MRI for 4.7 million people: the battle to treat Syria’s earthquake survivors

With only 64 X-ray and 73 kidney-dialysis machines, 7 CT scanners and one MRI machine, doctors in northwest Syria are racing against the clock to treat 8,500 injuries.
- Miryam Naddaf
Nature 615, 193-194
Research Highlights | 23 February 2023

One dose of antibiotic reduces sepsis in childbirth

A single dose of azithromycin substantially reduced maternal sepsis and death, according to a large, international, randomized study.
- Karen O’Leary
Nature Medicine
News | 07 February 2023

An abundance of antibiotics, and more — this week’s best science graphics

Three charts from the world of research, selected by Nature editors.

Nature
News | 06 February 2023

Antibiotic use in farming set to soar despite drug-resistance fears

Analysis finds antimicrobial drug use in agriculture is much higher than reported.
- Sara Reardon
Nature 614, 397
News | 24 January 2023

How antidepressants help bacteria resist antibiotics

A laboratory study unravels ways non-antibiotic drugs can contribute to drug resistance.
- Liam Drew
Nature