Antagomir and RNA sponge articles within Nature Communications

Featured

• Article
  26 June 2018 | Open Access

  miR-23b and miR-218 silencing increase Muscleblind-like expression and alleviate myotonic dystrophy phenotypes in mammalian models

  Depletion of the splicing factors MBNL 1 and 2 causes myotonic dystrophy. Here, the authors show that miR-23b and miR-218 target MBNL proteins, and that antagonists to these miRNAs rescue mis-splicing events in myoblasts and boost MBNL expression and rescue pathology in mouse models.

  • Estefania Cerro-Herreros
  • , Maria Sabater-Arcis
  •  & Ruben Artero

• Article
  03 January 2017 | Open Access

  Small RNA zippers lock miRNA molecules and block miRNA function in mammalian cells

  MicroRNAs regulate a wide range of biological processes and being able to inhibit their function could allow the development of therapeutic options. Here the authors describe a ‘small RNA zipper’ that sequesters miRNAs by forming a chain of DNA:RNA duplexes.

  • Lingyu Meng
  • , Cuicui Liu
  •  & Zuoren Yu