Ankylosing spondylitis articles from across Nature Portfolio

In screening for post-translational modifications associated with ankylosing spondylitis, researchers have identified a microbiome-metabolite-mediated modification that can lead to neoantigen generation and subsequent autoimmunity.

The mechanosensitive ion channel Piezo1 is involved in pathogenic new bone formation in entheseal tissues in ankylosing spondylitis.

The mechanisms underlying the genetic association between HLA-B27 and ankylosing spondylitis, including the contribution of endoplasmic reticulum aminopeptidase 1 (ERAP1), continue to elude the field. New findings support the involvement of the unfolded protein response and highlight the therapeutic potential and limitations of targeting ERAP1 in this disease.

Results of a new study implicate tenascin C in entheseal new bone formation in ankylosing spondylitis and suggest this protein could be targeted therapeutically.