Animal biotechnology

Animal biotechnology is a branch of biotechnology in which molecular biology techniques are used to genetically engineer (i.e. modify the genome of) animals in order to improve their suitability for pharmaceutical, agricultural or industrial applications. Animal biotechnology has been used to produce genetically modified animals that synthesize therapeutic proteins, have improved growth rates or are resistant to disease.

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  • News and Views |

    A new strategy based on a sophisticated and efficient system of modified pentatricopeptide repeat 10 proteins boost plastid transgene expression and the accumulation of foreign proteins by up to 40-fold.

    • Francis Quétier
    Nature Plants 5, 453-454
  • News and Views |

    Adenine base editors (ABEs) and cytosine base editors (CBEs) are powerful tools for targeted base conversions, but their editing specificities are largely unknown. Now, two reports demonstrate that ABEs are highly specific, but BE3-type CBEs tend to generate genome-wide off-target single nucleotide variations.

    • Jintao Tang
    • , Letian Chen
    •  & Yao-Guang Liu
    Nature Plants 5, 341-342
  • Research Highlights |

    Two studies in Science show that cytosine base editors, but not adenine base editors or CRISPR–Cas9, induce notable off-target single-nucleotide variants in rice and in mouse embryos.

    • Katharine H. Wrighton
  • Editorial |

    The development of CRISPR–Cas technology and its applications in biomedical research have generated much excitement. If fully realized, this technology has the potential to help treat or prevent severe diseases. However, these tools also carry considerable risk if improperly used. The scientific community must promote constructive dialogue among its members and within society at large to ensure that research on genome editing is conducted responsibly.

    Nature Genetics 51, 365