Analytical biochemistry

Analytical biochemistry is the study of biochemical components found in a cell or other biological sample. This scientific discipline uses a broad range of techniques for separation, identification, quantification and functional characterization of biological molecules.

Latest Research and Reviews

News and Comment

  • Comments and Opinion |

    Modern mass spectrometric technologies provide quantitative readouts for a wide variety of lipid specimens. However, many studies do not report absolute lipid concentrations and differ vastly in methodologies, workflows and data presentation. Therefore, we encourage researchers to engage with the Lipidomics Standards Initiative to develop common standards for minimum acceptable data quality and reporting for lipidomics data, to take lipidomics research to the next level.

    • Gerhard Liebisch
    • , Robert Ahrends
    • , Makoto Arita
    • , Masanori Arita
    • , John A. Bowden
    • , Christer S. Ejsing
    • , William J. Griffiths
    • , Michal Holčapek
    • , Harald Köfeler
    • , Todd W. Mitchell
    • , Markus R. Wenk
    •  & Kim Ekroos
    Nature Metabolism 1, 745-747
  • Comments and Opinion |

    LDL cholesterol is an important contributor to the risk of coronary heart disease, and its measurement is central to evaluating the effects of lipid-modifying therapies. Several ‘LDL-cholesterol’ assays exist but their methodologies differ, leading to between-assay heterogeneity in values of ‘LDL cholesterol’. We advocate the need for awareness of the potential implications.

    • Michael V. Holmes
    •  & Mika Ala-Korpela