Amino sugars - Latest research and news

Latest Research and Reviews

Periplasmic chitooligosaccharide-binding protein requires a three-domain organization for substrate translocation
- Takayuki Ohnuma
- Jun Tsujii
- Tamo Fukamizo
ResearchOpen Access23 Nov 2023 Scientific Reports
Volume: 13, P: 20558
Investigation of in vitro histone H3 glycosylation using H3 tail peptides
- Jona Merx
- Jordi C. J. Hintzen
- Thomas J. Boltje
ResearchOpen Access10 Nov 2022 Scientific Reports
Volume: 12, P: 19251
Complete biosynthetic pathway to the antidiabetic drug acarbose

The market demand for acarbose, a drug used for treatment of patients affected by type-2 diabetes, has increased. In this article, the authors report the acarbose complete biosynthetic pathway, clarifying previously unknown steps and identifying a pseudoglycosyltransferase enzyme, AcbS, a homologue of AcbI that catalyzes the formation of a non-glycosidic C-N bond.
- Takeshi Tsunoda
- Arash Samadi
- Taifo Mahmud
ResearchOpen Access15 Jun 2022 Nature Communications
Volume: 13, P: 3455
Discovery of exolytic heparinases and their catalytic mechanism and potential application

Exolytic heparinases are needed for sequencing of heparin and heparan sulfate (HP), but have not yet been reported. Here, the authors identify exolytic heparinases from different bacteria and show that the heparinases preferentially digest HP, determine the crystal structure of the exoheparinase BlexoHep and perform sequencing of HP octasaccharides using the enzyme.
- Qingdong Zhang
- Hai-Yan Cao
- Fuchuan Li
ResearchOpen Access24 Feb 2021 Nature Communications
Volume: 12, P: 1263
Development of a nebramine-cyclam conjugate as an antibacterial adjuvant to potentiate β-lactam antibiotics against multidrug-resistant P. aeruginosa
- Derek Ammeter
- Temilolu Idowu
- Frank Schweizer
Research16 Aug 2019 The Journal of Antibiotics
Volume: 72, P: 816-826
The hydrolase LpqI primes mycobacterial peptidoglycan recycling

Bacterial growth and division require remodelling of the cell wall, which generates free peptidoglycan fragments. Here, Moynihan et al. show that Mycobacterium tuberculosis can recycle components of their peptidoglycan, and characterise a crucial enzyme required for this process.
- Patrick J. Moynihan
- Ian T. Cadby
- Gurdyal S. Besra
ResearchOpen Access14 Jun 2019 Nature Communications
Volume: 10, P: 2647