Ageing

Ageing is the process during which structural and functional changes accumulate in an organism as a result of the passage of time. The changes manifest as a decline from the organism’s peak fertility and physiological functions until death.

Featured

Latest Research and Reviews

News and Comment

  • Comments and Opinion | | open

    Fabien Pifferi et al. discuss the latest research in using caloric restriction for promoting healthspan and lifespan in primates. Their Comment touches on their previous study, addressing how to combine nutrition-based clinical protocols with interventions to delay the onset of age-related diseases.

    • Fabien Pifferi
    • , Jérémy Terrien
    • , Martine Perret
    • , Jacques Epelbaum
    • , Stéphane Blanc
    • , Jean-Luc Picq
    • , Marc Dhenain
    •  & Fabienne Aujard
  • News and Views |

    Continence in nursing home residents declines over time, probably owing to an increase in physical disability and impaired mobility as much as to lower urinary tract dysfunction. A need remains for appropriately skilled assessments of continence care, leading to multicomponent management of continence in this vulnerable group of patients.

    • Adrian Wagg
  • News and Views |

    Long-term exercise is an important lifestyle factor that can substantially improve the health of older individuals. A new meta-analysis and systematic review builds on previous studies and provides further evidence that exercise interventions can prevent fall-related injuries and fractures in people aged >60 years.

    • Stephen Lord
  • News and Views |

    DNA sequences called retrotransposons can copy themselves and reintegrate at new sites in the genome, causing damage. It now seems that inhibiting this process can prevent age-related health decline in mice.

    • Bennett Childs
    •  & Jan van Deursen
    Nature 566, 46-48