• Article
    | Open Access

    The shortening of telomeres—a structure that protects chromosome ends—is associated with cellular aging. Here, Wood et al.present evidence that interaction between the telomere-binding protein TRF2 and lamin A/C facilitates the formation of interstitial t-loops and stabilizes telomeres.

    • Ashley M. Wood
    • , Jannie M. Rendtlew Danielsen
    •  & Steven T. Kosak
  • Article |

    White matter in the human brain is known to change its properties during an individual's lifespan. Here, Yeatman et al. use quantitative imaging measurements of the living human brain to model changes in white mater structure based on tissue development and decline between the ages of 7–85 years.

    • Jason D. Yeatman
    • , Brian A. Wandell
    •  & Aviv A. Mezer
  • Article |

    Changes in serum metabolites can indicate the development of disease. Here, the authors measure serum metabolite and lipoprotein levels in a large cohort of Northern Europeans, creating metabolic fingerprints for various age groups and, specifically, for women at the onset of menopause.

    • Kirsi Auro
    • , Anni Joensuu
    •  & Markus Perola
  • Article |

    Senescence is the decline in physiological function associated with age, and the genetic basis of this phenomenon is poorly understood. Here, the authors identify genetic variants in Drosophilathat affect reproduction and lifespan in an age-specific manner, and provide support for the mutation accumulation theory of aging.

    • Mary F. Durham
    • , Michael M. Magwire
    •  & Jeff Leips
  • Article |

    Brain-imaging studies have shown that compared with younger adults, older adults experience an increase in distractibility during working memory tasks. Here, the authors show that the increase in distractibility is in part due to reduced integrity and connectivity of the medial prefrontal cortex in older adults.

    • James Z. Chadick
    • , Theodore P. Zanto
    •  & Adam Gazzaley
  • Review Article |

    Sirtuins have been implicated in the ageing process in a variety of organisms, but their role in mammalian ageing remains somewhat controversial. Here the authors discuss sirtuin proteins in the brain, providing an overview of their physiological functions as well as their implication in mammalian ageing.

    • Akiko Satoh
    •  & Shin-ichiro Imai
  • Article |

    The age-related decline in the regenerative capacity of muscle can be reversed in mice by exposure to young circulation. Elabd et al.identify the hormone, oxytocin, as a potential mediator of this effect, showing that its plasma levels decline with age and that administration of oxytocin to aged mice improves muscle regeneration.

    • Christian Elabd
    • , Wendy Cousin
    •  & Irina M. Conboy
  • Article
    | Open Access

    Mitochondria are involved in ageing but exactly how they are involved is controversial. Here the authors show that optimal assembly of mitochondrial complex I predicts longevity in mice, whereas partial complex I assembly increases the production of reactive oxygen species.

    • Satomi Miwa
    • , Howsun Jow
    •  & Thomas von Zglinicki
  • Article |

    The ubiquitin ligase WWP-1 mediates the lifespan-increasing effect of dietary restriction (DR) in worms. Here the authors show that WWP-1 mono-ubiquitinylates the transcription factor Klf-1 in cultured cells and demonstrate that WWP-1 acts upstream of Klf-1 to regulate DR-induced longevity in worms.

    • Andrea C. Carrano
    • , Andrew Dillin
    •  & Tony Hunter
  • Article
    | Open Access

    D-Glucosamine is a dietary supplement widely used for the treatment of osteoarthritis. Here Weimer et al. show that D-glucosamine extends the life span of Caenorhabditis elegans and of mice by mimicking the molecular effects of a diet low in carbohydrates.

    • Sandra Weimer
    • , Josephine Priebs
    •  & Michael Ristow
  • Article |

    Haematopoietic stem cell populations contain subgroups with distinct gene expression signatures and functional properties. Here, the authors present a method to uncover such subpopulations, based on flow cytometry to sort single cells into a microwell array followed by RNA expression measurements and statistical analyses.

    • Ivan K. Dimov
    • , Rong Lu
    •  & Luke P. Lee
  • Article
    | Open Access

    Mutations in the metalloproteinase Zmpste24 preclude prelamin A processing and cause premature ageing. Here, de la Rosaet al.create mosaic Zmpste24 mice, revealing that cell-extrinsic effects are essential for accelerated ageing caused by prelamin A accumulation and that prelamin A reduces invasiveness of cancer cells.

    • Jorge de la Rosa
    • , José M.P. Freije
    •  & Carlos López-Otín
  • Article
    | Open Access

    Tissue regeneration is of great interest; however the number of times a given tissue can regenerate is unknown. Now, Eguchiet al. demonstrate that the lens of the Japanese newt—Cynops pyrrhogaster—can regenerate 18 times over a 16-year period, and that the new lenses are similar to those of control adult animals.

    • Goro Eguchi
    • , Yukiko Eguchi
    •  & Panagiotis A. Tsonis