Adult stem cells

Adult stem cells are cells in the adult that can both self-renew by dividing and give rise to more specialised cell types present in the tissue in which they reside. They serve to maintain and repair the tissue.

Latest Research and Reviews

News and Comment

  • News & Views |

    Studies of stem cell behaviour during regeneration have largely focused on understanding how cells make the choice between self-renewal and differentiation. It remains unclear whether cells undergo smooth transitions during differentiation or pause at selective intermediate states. Three studies now explore this question in lung regeneration.

    • Jamie M. Verheyden
    •  & Xin Sun
    Nature Cell Biology 22, 1025-1026
  • News & Views |

    Stem cells tightly link their metabolism to cell fate decisions; however, how cancers co-opt and bypass metabolic pathways for growth advantage remains unclear. New evidence in this issue highlights how cancer stem cells avoid epigenetically driven differentiation by shutting down endogenous serine synthesis and becoming serine auxotrophs.

    • Daniel Haensel
    •  & Anthony E. Oro
    Nature Cell Biology 22, 755-757
  • Research Highlights |

    Snake venom gland organoids provide a glimpse into the cell biology of the respective organ and serve as a platform for producing snake toxins.

    • Nina Vogt
    Nature Methods 17, 360
  • News & Views |

    Macrophages are required for postinjury skeletal muscle regeneration. A new study reveals that proinflammatory macrophages produce meteorin-like, which promotes muscle stem cell expansion through the Stat3–IGF1 axis and then shifts their inflammatory profile to allow return to homeostasis.

    • Bénédicte Chazaud
    Nature Metabolism 2, 213-214