Adult stem cells articles from across Nature Portfolio

A new study collaboratively delivered by Valentina Greco’s and Smita Krishnaswamy’s labs provides new insight into patterns of calcium signalling in epithelial tissues using intravital imaging of the basal layer of the mouse epidermis.

Direct conversions offer an alternative approach to generate insulin-producing cells for cell therapy in diabetes. A study reports a method to convert human stomach-derived gastric stem cells into functional insulin-producing cells through a unique differentiation path.

The ability of adult neural stem cells to produce new neurons (neurogenesis) declines markedly during aging, but exactly how this occurs is largely unknown. Using sophisticated in vivo imaging, a study in Nature Aging shows that aging affects several steps of neurogenesis — most notably, increasing the death of newborn clones.

Cockburn et al. report that cells exiting the epidermal stem cell layer show a gradual progression of transcriptional changes during differentiation and retain the ability to divide once differentiation-committed.