Acute lymphocytic leukaemia articles from across Nature Portfolio

Acute lymphocytic leukaemia (ALL) is a cancer of the blood and bone marrow, specifically affecting lymphocytes. The disease progresses rapidly and creates immature blood cells, rather than mature ones. ALL is the most common type of cancer in children and can also occur in adults.

Latest Research and Reviews

Research
17 March 2023 | Open Access

Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer
- Elien Heylen
- , Paulien Verstraete
- & Kim R. Kampen
British Journal of Cancer, 1-17
Research
21 February 2023 | Open Access

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL
- Teresa Sadras
- , Fatimah B. Jalud
- & Paul G. Ekert
Leukemia, 1-5
Research
13 February 2023 | Open Access

Detection of acute promyelocytic leukemia in peripheral blood and bone marrow with annotation-free deep learning
- Petru Manescu
- , Priya Narayanan
- & Delmiro Fernandez-Reyes
Scientific Reports 13, 2562
Research
13 February 2023 | Open Access

Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

KMT2A rearranged infant acute lymphoblastic leukemia patients have a poor prognosis. Here, the authors use high throughput drug screening on primary infant specimens to identify a clinically active chemotherapy combination.
- Jennifer L. Kamens
- , Stephanie Nance
- & Tanja A. Gruber
Nature Communications 14, 809
Research | 01 February 2023

Fludarabine or cyclophosphamide in combination with total body irradiation as myeloablative conditioning prior to allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the EBMT
- Sebastian Giebel
- , Myriam Labopin
- & Mohamad Mohty
Bone Marrow Transplantation, 1-8
Research
20 January 2023 | Open Access

Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia
- Paul B. Sinclair
- , Ruth E. Cranston
- & Christine J. Harrison
Leukemia 37, 636-649

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News and Comment

Research Highlights | 21 October 2022

Allogeneic CAR T cells show promise
- Peter Sidaway
Nature Reviews Clinical Oncology 19, 748
Correspondence | 17 October 2022

CD19 chimeric antigen receptor T-cell therapy as a bridge therapy for allogeneic hematopoietic stem cell transplantation in patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia
- Zhenzhen Yao
- , Bin Gu
- & Ying Wang
Bone Marrow Transplantation 58, 103-105
News & Views | 01 September 2022

Generating a genetic road map of childhood acute lymphoblastic leukemia

We comprehensively define the genomic landscape of pediatric acute lymphoblastic leukemia (ALL) in the largest cohort assembled to date, and identify new driver genes and biological pathways that are targeted by genetic alteration. These findings serve as a road map to improve our understanding of disease development and identify therapeutic targets in pediatric ALL.

Nature Genetics 54, 1267-1268
Correspondence | 09 July 2022

Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy
- Omer Jamy
- , Sankalp Arora
- & Ayman Saad
Bone Marrow Transplantation 57, 1597-1599
Correspondence
01 June 2022 | Open Access

Unique characteristics and outcomes of therapy-related acute lymphoblastic leukemia following treatment for multiple myeloma
- Ricardo D. Parrondo
- , Zaid Abdel Rahman
- & James M. Foran
Blood Cancer Journal 12, 87
News & Views | 14 March 2022

A distinct hematopoietic differentiation state characterizes aggressive infant leukemia

The developmental state of KMT2A-rearranged infant B-cell acute lymphoblastic leukemia (B-ALL) was identified by comparison of bulk and single-cell leukemia transcriptomes with those of a human fetal bone marrow reference. Unlike standard-risk childhood B-ALL, this aggressive leukemia was characterized by early lymphocyte precursor (ELP) differentiation. Moreover, in contrast to healthy ELPs, KMT2A-rearranged infant B-ALL cells had both myeloid and lymphoid features and expressed potentially targetable novel combinations of antigens.

Nature Medicine 28, 641-642

All News & Comment

Acute lymphocytic leukaemia articles from across Nature Portfolio

Latest Research and Reviews

Transcription factor NKX2–1 drives serine and glycine synthesis addiction in cancer

Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL

Detection of acute promyelocytic leukemia in peripheral blood and bone marrow with annotation-free deep learning

Proteasome inhibition targets the KMT2A transcriptional complex in acute lymphoblastic leukemia

Fludarabine or cyclophosphamide in combination with total body irradiation as myeloablative conditioning prior to allogeneic hematopoietic cell transplantation for acute lymphoblastic leukemia: an analysis by the Acute Leukemia Working Party of the EBMT

Disruption to the FOXO-PRDM1 axis resulting from deletions of chromosome 6 in acute lymphoblastic leukaemia

News and Comment

Allogeneic CAR T cells show promise

CD19 chimeric antigen receptor T-cell therapy as a bridge therapy for allogeneic hematopoietic stem cell transplantation in patients with relapsed Philadelphia chromosome-positive acute lymphoblastic leukemia

Generating a genetic road map of childhood acute lymphoblastic leukemia

Phase II study of myeloablative allogeneic hematopoietic stem cell transplantation for acute lymphoblastic leukemia in adults using fludarabine and total body irradiation 12 Gy

Unique characteristics and outcomes of therapy-related acute lymphoblastic leukemia following treatment for multiple myeloma

A distinct hematopoietic differentiation state characterizes aggressive infant leukemia

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