Acute kidney injury

Acute kidney injury (AKI) is a rapid deterioration in kidney function that occurs within 48 hours of an initiating event and is associated with an absolute increase in serum creatinine of ≥26.4 μmol/l. Main causes of AKI include sepsis, ischaemia-reperfusion injury and nephrotoxins. Symptoms include fatigue, loss of appetite, headache, nausea and vomiting.

Latest Research and Reviews

News and Comment

  • News & Views |

    A new study examined post-mortem kidney tissue from 63 patients with COVID-19. The results suggest that SARS-CoV-2 has kidney tropism, including the ability to replicate in kidney cells, and that kidney transduction by SARS-CoV-2 is associated with shorter survival time and increased incidence of acute kidney injury.

    • Anitha Vijayan
    •  & Benjamin D. Humphreys
  • News & Views |

    Timing of dialysis initiation in critically ill patients is controversial. The STARRT-AKI trial reports that an accelerated initiation strategy did not improve 90-day survival and increased dialysis dependency compared with a standard approach in which patients had greater fluid accumulation and metabolic complications at initiation but 38% avoided dialysis.

    • Josée Bouchard
    •  & Ravindra Mehta
  • Comments & Opinion |

    The COVID-19 pandemic has placed a tremendous strain on sustaining the clinical research enterprise and will also likely affect key study outcomes; these effects must be considered during data analysis and interpretation. Nevertheless, the responses to the pandemic have also introduced innovations that will advance the conduct of clinical research.

    • Katherine R. Tuttle
  • Comments & Opinion |

    Continuous kidney replacement therapy (CKRT) can be a lifesaving intervention for critically ill patients; however, mortality remains high. The adaptation of existing innovations, including anti-clotting measures; cloud-computing for optimized treatment prescribing and therapy monitoring; and real-time sensing of blood and/or filter effluent composition to CKRT devices has the potential to enable personalized care and improve the safety and efficacy of this therapy.

    • Balazs Szamosfalvi
    •  & Lenar Yessayan