Acute inflammatory arthritis articles within Nature Communications

Featured

• Article
  18 May 2023 | Open Access

  Association of gout with brain reserve and vulnerability to neurodegenerative disease

  The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia.

  • Anya Topiwala
  • , Kulveer Mankia
  •  & Thomas E. Nichols

• Article
  02 June 2020 | Open Access

  The ABCG2 Q141K hyperuricemia and gout associated variant illuminates the physiology of human urate excretion

  The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant role for ABCG2 in urate excretion in both the kidney and intestine.

  • Kazi Mirajul Hoque
  • , Eryn E. Dixon
  •  & Owen M. Woodward

• Article
  23 April 2019 | Open Access

  A small molecule promotes cartilage extracellular matrix generation and inhibits osteoarthritis development

  Loss of cartilage tissue is a hallmark of osteoarthritis. Here the authors show that BNTA, a small molecule identified in a chemical screen, promotes ECM generation in human osteoarthritic chondrocytes and cartilage explants, and suppresses pathology in a rat model of osteoarthritis.

  • Yuanyuan Shi
  • , Xiaoqing Hu
  •  & Yingfang Ao

• Article
  06 February 2017 | Open Access

  DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

  DEK is a secreted protein abundant in the synovia of patients with juvenile idiopathic arthritis. Here the authors show DEK is important for neutrophil extracellular trap formation and joint inflammation, and demonstrate therapeutic efficacy of DEK-targeting aptamers in a mouse model of arthritis.

  • Nirit Mor-Vaknin
  • , Anjan Saha
  •  & David M. Markovitz

• Article
  07 June 2016 | Open Access

  Th2 and eosinophil responses suppress inflammatory arthritis

  Type 2 immune responses are viewed as opposites of Type 1 and 17 responses. Here the authors show that activation of Type 2 immunity by helminth infection counteracts the development of inflammatory arthritis, a type 17-mediated pathology, via IL-4/IL-13- STAT6 signalling and eosinophil activation.

  • Zhu Chen
  • , Darja Andreev
  •  & Aline Bozec

• Article
  09 February 2016 | Open Access

  Genomic insights into the Ixodes scapularis tick vector of Lyme disease

  Ticks transmit a large number of pathogens that cause human diseases. Here, the authors sequence the genome of the tick Ixodes scapularisand uncover expansion of genes associated with parasitic processes unique to ticks and tick-host interactions.

  • Monika Gulia-Nuss
  • , Andrew B. Nuss
  •  & Catherine A. Hill

• Article
  13 May 2015 | Open Access

  Genome-wide association analysis identifies three new risk loci for gout arthritis in Han Chinese

  Raised serum urate levels are a risk factor for gout, a common form of inflammatory arthritis. Here Li et al.conduct a multistage genome-wide association study in a Han Chinese population and identify three novel loci likely associated with the progression from hyperuricemia to gout.

  • Changgui Li
  • , Zhiqiang Li
  •  & Yongyong Shi