Acute inflammation articles from across Nature Portfolio

Acute inflammation is a short-term process occurring in response to tissue injury, usually appearing within minutes or hours. It is characterized by five cardinal signs: pain, redness, immobility (loss of function), swelling and heat.

Featured

News & Views | 15 May 2023

Inflammaging aggravates stroke pathology
- Christian Schulz
- & Steffen Massberg
Nature Immunology 24, 887-888

Latest Research and Reviews

Research
05 June 2023 | Open Access

Neutrophil-derived catecholamines mediate negative stress effects on bone

Authors present both preclinical data in mice and clinical data from humans in support of the hypothesis that stress negatively affects bone growth and repair. These effects are mediated by neutrophil-derived catecholamines inhibiting cartilage-to-bone transition via β2-adrenoceptor signaling in chondrocytes.
- Miriam E. A. Tschaffon-Müller
- , Elena Kempter
- & Stefan O. Reber
Nature Communications 14, 3262
Research | 15 May 2023

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

Bacigaluppi and colleagues report that the accumulation of atypical mature and immature neutrophil subsets and a dysregulated emergency granulopoiesis response in aged mice and humans affect the outcome of stroke.
- Giorgia Serena Gullotta
- , Donatella De Feo
- & Marco Bacigaluppi
Nature Immunology 24, 925-940
Research
03 April 2023 | Open Access

CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury
- Chao Ma
- , Juan Gao
- & Guangwang Liu
Experimental & Molecular Medicine 55, 818-830
Research
30 March 2023 | Open Access

Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death
- Chang-Ung Kim
- , Dahwan Lim
- & Doo-Jin Kim
Cell Death & Disease 14, 228
Research
28 March 2023 | Open Access

Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver
- Mingwei Sheng
- , Yiqi Weng
- & Wenli Yu
Cell Death Discovery 9, 106
Research
18 March 2023 | Open Access

Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock
- N. Patel
- , M. A. Johnson
- & G. L. Hoareau
Scientific Reports 13, 4496

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News and Comment

News & Views | 15 May 2023

Inflammaging aggravates stroke pathology

In mice and humans, changes in neutrophil phenotypes and functionality during aging aggravate thromboinflammation in ischemic brain injury and determine the pathology associated with strokes. In mice, inhibition of CXCL3 signaling and rejuvenation of bone marrow offer ways of restricting brain injury and improving stroke outcomes.
- Christian Schulz
- & Steffen Massberg
Nature Immunology 24, 887-888
News & Views | 04 May 2023

ERADication of STING limits inflammation

The cGAS–STING cytosolic double-stranded-DNA-sensing pathway provides protection against infection but also contributes to inflammatory pathology and thus must be tightly regulated. In this issue, Jie et al. find that endoplasmic-reticulum-associated degradation of the adaptor STING by SEL1L–HRD1 controls steady-state STING levels to limit STING-driven inflammation.
- Kevin MingJie Gao
- & Katherine A. Fitzgerald
Nature Cell Biology 25, 635-636
Comments & Opinion | 27 March 2023

New insights into immune cell diversity in acute kidney injury
- Bo Deng
- , Sutian Wang
- & Feng Ding
Cellular & Molecular Immunology 20, 680-682
Research Highlights | 24 February 2023

Local complement protection
- Laurie A. Dempsey
Nature Immunology 24, 378
News & Views | 05 January 2023

Microbial metabolite harmaline protects against virus-induced systemic inflammation

This work shows that Akkermansia muciniphila and its metabolite, harmaline, upregulate the production of bile acid-coenzyme A: amino acid N-acyltransferase (BAAT) in hepatocytes. As a result of enhanced BAAT production, increased synthesis of conjugated primary bile acids suppresses the severe systemic inflammation caused by severe fever with thrombocytopenia syndrome virus infection.

Nature Microbiology 8, 10-11
Research Highlights | 16 November 2022

Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells
- Xinping Lv
- , Shan Zhu
- & Jingtao Chen
Cellular & Molecular Immunology 20, 115-116

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Acute inflammation articles from across Nature Portfolio

Featured

Inflammaging aggravates stroke pathology

Latest Research and Reviews

Neutrophil-derived catecholamines mediate negative stress effects on bone

Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology

CCL12 induces trabecular bone loss by stimulating RANKL production in BMSCs during acute lung injury

Influenza viral matrix 1 protein aggravates viral pathogenicity by inducing TLR4-mediated reactive oxygen species production and apoptotic cell death

Caspase 6/NR4A1/SOX9 signaling axis regulates hepatic inflammation and pyroptosis in ischemia-stressed fatty liver

Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock

News and Comment

Inflammaging aggravates stroke pathology

ERADication of STING limits inflammation

New insights into immune cell diversity in acute kidney injury

Local complement protection

Microbial metabolite harmaline protects against virus-induced systemic inflammation

Group 3 innate lymphoid cells: intestinal patrolling guardians bullied by T cells

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