Acne vulgaris articles within Nature Communications

Featured

  • Article
    | Open Access

    Cutibacterium acnes phylotypes can be catalogued based on their association with acneic or healthy skin. Here, Hajam et al show that the functional divergence of a hyaluronidase enzyme expressed by the phylotypes is a major determinant of acne severity.

    • Irshad A. Hajam
    • , Madhusudhanarao Katiki
    •  & George Y. Liu

  • Article
    | Open Access

    Rosacea is a common, multi-factorial chronic inflammatory skin disorder. Here authors provide evidence of genetic predisposition by whole genome sequencing and whole exome sequencing of samples from familial cases, and by recapitulating a recurrent mutation in the LRRC4 gene in a mouse model, they find that neuron-derived vasoactive intestinal peptide is an important pathogenic factor for neurogenic inflammation in rosacea.’

    • Zhili Deng
    • , Mengting Chen
    •  & Ji Li

  • Article
    | Open Access

    Bacteriophage therapy is evolving as a promising approach to tackling bacterial infection, even in the case of emerging antibiotic resistance. In this work, authors present the topical application of numerous Cutibacterium acnes phage in an in vivo mouse model of acne vulgaris.

    • Amit Rimon
    • , Chani Rakov
    •  & Ronen Hazan

  • Article
    | Open Access

    Better understanding of the genetic basis of acne can pave the way to more effective treatments. Here, the authors perform a genome-wide association study meta-analysis of >20,000 cases and identify 29 new acne susceptibility loci, uncovering genetic links to Mendelian hair and skin disorders and other complex traits.

    • Brittany L. Mitchell
    • , Jake R. Saklatvala
    •  & Michael A. Simpson

  • Article
    | Open Access

    Although acne vulgaris is the most common human inflammatory skin disease, its pathogenic mechanisms remain incompletely understood. Here the authors show that GATA6 is involved in maintaining homeostasis of the upper pilosebaceous unit of human skin and may contribute to acne pathogenesis.

    • Bénédicte Oulès
    • , Christina Philippeos
    •  & Fiona M. Watt

  • Article
    | Open Access

    Acne vulgaris is a chronic inflammation of the skin, the genetic basis of which is incompletely understood. Here, Petridis et al. perform GWAS and meta-analysis for acne in 26,722 individuals and identify 12 novel risk loci that implicate structure and maintenance of the skin in severe acne risk.

    • Christos Petridis
    • , Alexander A. Navarini
    •  & Michael A. Simpson

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