Research Highlight
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Open Access
Research Highlights
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Research Highlight
| Open AccessIdentification of MSA-2: An oral antitumor non-nucleotide STING agonist
- Jianhua Liu
- , Xu Huang
- & Jianxun Ding
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Research Highlight
| Open AccessConnections between biomechanics and higher infectivity: a tale of the D614G mutation in the SARS-CoV-2 spike protein
- Anshumali Mittal
- & Vikash Verma
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Research Highlight
| Open AccessAsynchronous actions of immune responses in COVID-19 patients
- Yufang Shi
- , Guoqiang Zhou
- & Qing Li
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Research Highlight
| Open AccessInhibition of tumor autophagy: a strategy to improve anti-tumor immunity?
- Andrew J. Freeman
- , Emily J. Lelliott
- & Jane Oliaro
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Research Highlight
| Open AccessFossicking for microbial defense system: novel antiviral immunity
- Ping Lin
- , Qun Wu
- & Min Wu
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Research Highlight
| Open AccessSERIneALanine Killer: SPT promiscuity inhibits tumour growth via intra-tumoral deoxysphingolipid production
- Mattia Falcone
- & Oliver D. K. Maddocks
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Research Highlight
| Open AccessPeroxisome: the new player in ferroptosis
- Daolin Tang
- & Guido Kroemer
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Research Highlight
| Open AccessBattle at the entrance gate: CIITA as a weapon to prevent the internalization of SARS-CoV-2 and Ebola viruses
- Rafal Butowt
- , Krzysztof Pyrc
- & Christopher S. von Bartheld
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Research Highlight
| Open AccessecDNA within tumors: a new mechanism that drives tumor heterogeneity and drug resistance
- Xixi Zeng
- , Maoping Wan
- & Jianmin Wu
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Research Highlight
| Open AccessAbove the dose threshold: a simple way to improve the delivery efficiency of nanomedicine
- Lei Yang
- , Yanqi Ye
- & Lulu Cai
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Research Highlight
| Open AccessTherapeutic utility of immunosuppressive TREM2+ macrophages: an important step forward in potentiating the immune checkpoint inhibitors
- Fulya Koksalar Alkan
- & Hasan Korkaya
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Research Highlight
| Open AccessExtracellular vesicle fingerprinting: the next generation for cancer diagnosis?
- Vanessa Sandim
- & Robson Q. Monteiro
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Research Highlight
| Open AccessSmall is beautiful–a glycolytic metabolite signals mTORC1 activation in cancer cell metabolism
- Angela M. Otto
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Research Highlight
| Open AccessA high-fat diet: an unexpected role in preventing the metastatic seeding of colorectal cancer
- Min Long
- , Wenjing Wang
- & Qiu Sun
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Research Highlight
| Open AccessHuman recombinant soluble ACE2 (hrsACE2) shows promise for treating severe COVID19
- Tarek Mohamed Abd El-Aziz
- , Ahmed Al-Sabi
- & James D. Stockand
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Research Highlight
| Open AccessOutsmarting SARS-CoV-2 by empowering a decoy ACE2
- Milena Sokolowska
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Research Highlight
| Open AccessThrombin-mediated vasculogenic mimicry: important lessons to improve anticoagulant therapy of selected cancer patients
- C. Arnold Spek
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Research Highlight
| Open AccessSARS-CoV-2 spike protein: flexibility as a new target for fighting infection
- Ciro Leonardo Pierri
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Research Highlight
| Open AccessCancer vaccines: shared tumor antigens return to the spotlight
- Lijin Li
- , S. Peter Goedegebuure
- & William Gillanders
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Research Highlight
| Open AccessSARS-CoV-2 spike behavior in situ: a Cryo-EM images for a better understanding of the COVID-19 pandemic
- Alaa M. Ismail
- & Abdo A. Elfiky
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Research Highlight
| Open AccessAzvudine (FNC): a promising clinical candidate for COVID-19 treatment
- Bin Yu
- & Junbiao Chang
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Research Highlight
| Open AccessInhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2
- Kendra R. Vann
- , Adam H. Tencer
- & Tatiana G. Kutateladze
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Research Highlight
| Open AccessGut microbiome alters functions of mutant p53 to promote tumorigenesis
- Harry Cheuk Hay Lau
- & Jun Yu
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Research Highlight
| Open AccessTREM2 marks tumor-associated macrophages
- Kyohei Nakamura
- & Mark J. Smyth
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Research Highlight
| Open AccessSARS-CoV-2: the many pros of targeting PLpro
- Christopher B. McClain
- & Nicolas Vabret
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Research Highlight
| Open AccessSARS-CoV-2-specific T-cells in unexposed humans: presence of cross-reactive memory cells does not equal protective immunity
- Rory D. de Vries
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Research Highlight
| Open AccessIs smaller better? Vaccine targeting recombinant receptor-binding domain might hold the key for mass production of effective prophylactics to fight the COVID-19 pandemic
- Manish Muhuri
- & Guangping Gao
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Research Highlight
| Open AccessCysteine-113 covalency inspires the development of Pin1 inhibitor
- Wenchen Pu
- , Jiao Li
- & Yong Peng
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Research Highlight
| Open AccessTargeting metabolic/epigenetic pathways: a potential strategy for cancer therapy in diffuse intrinsic pontine gliomas
- Kun Zhao
- & Hongming Miao
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Research Highlight
| Open AccessSupramolecular attack particle: the way cytotoxic T lymphocytes kill target cells
- Jiaqi Liu
- , Yanqi Ye
- & Lulu Cai
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Research Highlight
| Open AccessMicrobiota-mediated phytate metabolism activates HDAC3 to contribute intestinal homeostasis
- Xiaoxing Li
- , Harry Cheuk Hay Lau
- & Jun Yu
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Research Highlight
| Open AccessSemaphorins or Frizzled –it is the receptor that direct the action of clostridial glucosylating toxins
- Klaus Aktories
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Research Highlight
| Open AccessTargeting multiple epitopes on the spike protein: a new hope for COVID-19 antibody therapy
- Yeping Sun
- , Bostjan Kobe
- & Jianxun Qi
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Research Highlight
| Open AccessTH17 cells…Sorting the good out from the bad
- Junwei Li
- , Le Jiang
- , Yongxiang Yi
- & Pradeep Kumar Sacitharan
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Research Highlight
| Open AccessA genome-wide screening for DNA repair genes: much more players than hitherto known
- Bernd Kaina
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Research Highlight
| Open AccessType I IFN deficiency: an immunological characteristic of severe COVID-19 patients
- Zhenling Wang
- , Hailong Pan
- & Boguang Jiang
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Research Highlight
| Open AccessHow mammalian piRNAs instruct de novo DNA methylation of transposons
- Zhiqing Li
- , Xiaoyin Tang
- & En-Zhi Shen
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Research Highlight
| Open AccessThe p(l)ot thickens: cannabinoid receptors on astroglial mitochondria coordinate animal behaviors by regulating lactate availability for neurons
- Erik Keimpema
- , Tibor Harkany
- & Alán Alpár
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Research Highlight
| Open AccessProfiling and characterization of SARS-CoV-2 mutants’ infectivity and antigenicity
- Lin Wang
- , Ling Wang
- & Hui Zhuang
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Research Highlight
| Open AccessA new player in the beneficial effects of exercise on the aged brain
- M. Llorens-Martín
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Research Highlight
| Open AccessH3.3S31 phosphorylation: linking transcription elongation to stimulation responses
- Hong Wen
- & Xiaobing Shi
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Research Highlight
| Open AccessPromising inhibitors targeting Mpro: an ideal strategy for anti-SARS-CoV-2 drug discovery
- Yi Chen
- , Guan Wang
- & Liang Ouyang
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Research Highlight
| Open AccessThe first human trial of CRISPR-based cell therapy clears safety concerns as new treatment for late-stage lung cancer
- Shenghui He
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Research Highlight
| Open AccessHuman-viral chimera: a novel protein affecting viral virulence and driving host T-cell immunity
- Zhenling Wang
- , Li Zhang
- & Min Wu
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Research Highlight
| Open AccessMolecular features of IGHV3-53-encoded antibodies elicited by SARS-CoV-2
- Francesca Fagiani
- , Michele Catanzaro
- & Cristina Lanni
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Research Highlight
| Open AccessRab22a-NeoF1: a promising target for osteosarcoma patients with lung metastasis
- Kai Xie
- , Xinyi Zhang
- & Yongguang Tao
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Research Highlight
| Open AccessCCDC25: precise navigator for neutrophil extracellular traps on the prometastatic road
- Ruochen Liu
- , Erhu Zhao
- , Feng Wang
- & Hongjuan Cui
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Research Highlight
| Open AccessDietary intervention, a promising adjunct for cancer therapy
- Rongchen Shi
- & Hongming Miao
