Showing 1–50 of 3913 results

  1. Research | | Open

    • ...uncovered an association between spinal osteoarthritis and height loss that was... ...(HHL) for discriminating spinal osteoarthritis has not been reported.... ...for prevalent vertebral fracture, spinal osteoarthritis, and other co-morbidities... ....55–2.29), spinal osteoarthritis (OR 1.57; 95...
  2. Reviews |

  3. Reviews |

    • ...in chronic pain states including osteoarthritis and chronic low back pain... ...with painful knee and hip osteoarthritis have revealed that NGF inhibitors... ...the risk of rapidly progressive osteoarthritis in a small percentage of... ...in rapidly progressive osteoarthritis are also discussed...
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    • The number of osteoarthritis patients is increasing with the... ...elderly people in developed countries. Osteoarthritis, which causes joint pain... ...chondrocyte apoptosis and leading to osteoarthritis development in a rat model... ...(NAC). In vivo, osteoarthritis development in a rat osteoarthritis
  10. Research | | Open

    • Osteoarthritis is the most common joint... ...and risk factors of appendicular osteoarthritis in dogs under primary veterinary... ...veterinary care during 2013. Candidate osteoarthritis cases were identified using multiple... ...dogs, 16,437 candidate osteoarthritis cases were identified;...
  11. Research | | Open

    • Osteoarthritis affects one in eight American... ...the potential of naturally occurring osteoarthritis in the domestic rabbit as... ...the presence and severity of osteoarthritis were significantly influenced by both... ...excellent model of spontaneously arising osteoarthritis that may be useful in...
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  13. Research |

    • ...component of arthritis and knee osteoarthritis risk than is accounted for... ...years and older. The knee osteoarthritis analyses included 2323 participants aged... ...by self-report) and knee osteoarthritis (determined by radiograph).... ...arthritis and knee osteoarthritis increased in a...
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  18. Research |

    • Osteoarthritis is the most common form... ...articular cartilage of individuals with osteoarthritis, in the pathogenesis of osteoarthritis. Here we report a... ...encoding asporin (ASPN) and osteoarthritis. In two independent populations... of individuals with knee osteoarthritis, the D14 allele of...
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  20. Research |

    • Osteoarthritis is associated with the irreversible... ...Hh signaling in chondrocytes in osteoarthritis is unknown. Here we... ...samples and mice in which osteoarthritis was surgically induced and find... ...Hh signaling is activated in osteoarthritis. Using several genetically modified...
  21. Reviews | | Open

    • Rheumatoid arthritis and osteoarthritis, the most common forms... ...by aging-related mechanisms in osteoarthritis. Furthermore, these models indicate... ...rheumatoid arthritis. Conversely, in osteoarthritis, endogenous glucocorticoid signaling in...
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  23. Reviews |

    • ...the onset and progression of osteoarthritis. Of the four FGF... ...FGFR3 are strongly implicated in osteoarthritis, and FGFR1 antagonists, as... ...of spontaneous and surgically induced osteoarthritis. FGF18, a high affinity... ...in clinical trials for osteoarthritis. This Review covers...
  24. Research | | Open

    • Osteoarthritis is a common cause of... ...involved in the development of osteoarthritis. However, the molecular mechanism... ...of chondrogenesis in patients with osteoarthritis requires further elucidation, particularly... ...in 10 patients with knee osteoarthritis and 10 traumatic amputees....
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  26. Research |

    • Osteoarthritis is a highly prevalent and... ...(ACLT) mouse model of osteoarthritis. TGF-β1 concentrations are... ...subchondral bone from humans with osteoarthritis. High concentrations of TGF-... ...β1 in osteoblastic cells induced osteoarthritis, whereas inhibition of TGF-... ...osteoarthritis...
  27. Research | | Open

  28. News and Views |

  29. Research |

    • The pathological changes in osteoarthritis—a degenerative joint disease prevalent... ...to monitor the progression of osteoarthritis are therefore important for developing... ...Changes due to aging and osteoarthritis are clearly depicted at the... ...diagnose the early onset of osteoarthritis in situ.
  30. Research |

    • ...links to the pathogenesis of osteoarthritis remain poorly understood, but... ...–producing chondrocytes both in human osteoarthritis and in murine models of... ...a surgically induced model of osteoarthritis. The occurrence of less... severe osteoarthritis-like cartilage destruction in both...
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  37. Comments and Opinion |

  38. Research | | Open

    • Osteoarthritis is the most prevalent and... ...chondrocytes in vitro and causes osteoarthritis in mice. Mechanistically, the... ...Inhibition of SIRT1 protects against osteoarthritis triggered by loss of DOT1L... ...to protect the cartilage against osteoarthritis.
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  41. Research | | Open

    • ...degenerate in some patients with osteoarthritis. The purpose of this... ...with subject ages and knee osteoarthritis grades. The anteroposterior and... ...was used to evaluate knee osteoarthritis. The degeneration grades of... ...their relationships with knee osteoarthritis were analysed by the...
  42. Research | | Open

  43. Research | | Open

    • Osteoarthritis is a common debilitating joint... disorder. Risk factors for osteoarthritis include age, which is... ...mice that are resistant to osteoarthritis with thickened articular cartilage owing... ...hypertrophy and protects cartilage from osteoarthritis. Collectively, our results suggest...
  44. Research | | Open

    • Osteoarthritis is a common and progressive... ...practice only late phases of osteoarthritis that are characterized by severe... ...damage are routinely detected. Since osteoarthritis cannot be cured but relatively... ...would lower the burden of osteoarthritis. Here we evaluated if...
  45. Research | | Open

    • ...ROP) in retinal photographs and osteoarthritis in knee radiographs. Our... ...3021 patients in the Multicenter Osteoarthritis Study (MOST), both... ...for severity of ROP and osteoarthritis, respectively. The Siamese neural... ...ρ = 0.89 for osteoarthritis), both within and between...osteoarthritis
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  48. News and Views |

  49. Research | | Open