Showing 1–50 of 22758 results

  1. Research | | Open

    • HIV-1 env sequencing enables predictions... ...of patients with newly diagnosed HIV-1 infection between 2008–2014... ...including 46 patients with recent HIV-1 infection (RHI),... ...potential acquisition of non-R5 HIV-1 for at least 4...
  2. Research | | Open

    • ...a major barrier to curing HIV infection is the generation of... ...of these reservoirs are latently HIV-infected macrophages. Here, we... show that HIV infection of macrophages results in... ...show that while uninfected and HIV infected macrophages use fatty acids... ..., surviving HIV... ...HIV...
  3. Research | | Open

    • ...this aim, samples from 41 HIV-neg, 33 HIV+ ART-naïve and 32 HIV+ ART+ subjects were obtained... .../Treg proportions were normalized in HIV+ ART+, but certain... ...mononuclear cells (CMCs) from HIV+ women, even in those... from HIV+ ART+, compared to... the HIV-neg group. Moreover, these...
  4. Research |

  5. Research | | Open

    • ...diversity of Human Immunodeficiency virus (HIV), has hindered the development... ...identification of new antiviral targets. HIV exploits specific host proteins also... known as HIV-dependency factors during its replication... ..., we have identified that HIV utilizes distinct cellular potassium...
  6. Research | | Open

    • ...cellular entry of R5-tropic HIV-1, and is a... ...validated target for therapeutics against HIV-1 infections. In the... ...replication of wild-type R5-HIV-1 with a sub-nanomolar... ...retained activity against vicriviroc-resistant HIV-1s, but did not... ...(MVC)-resistant HIV-1. Structural...
  7. Research | | Open

    • Productive HIV-1 replication requires viral integrase... ...the cellular factors responsible for HIV-1 IN degradation, we... ...is a major determinant of HIV-1 IN stability. CD4-... ...TRIM33 knock down show increased HIV-1 replication and proviral DNA... ...phenotype of an HIV-1 molecular clone...
  8. Research | | Open

  9. Research | | Open

  10. Research |

    • Human immunodeficiency virus (HIV) actively modulates the protein... ...systematically examine this modulation in HIV infection, we used isobaric... ...over 14,000 proteins during HIV-1 infection of human primary... ...(PSGL-1) as an HIV-1 restriction factor downregulated by... ...HIV-1 Vpu, which...HIV
  11. News and Views |

    • ...to curing human immunodeficiency virus (HIV). The first challenge is... ...the cells and tissues where HIV hides. In this issue... ...are shown to retain infectious HIV particles, prompting us to...
  12. Research | | Open

    • Perinatal HIV infection is characterized by faster... HIV disease progression and higher initial... rate of HIV replication compared to adults.... ...(ART) has greatly reduced HIV replication to undetectable levels,... ...elevated inflammation associated with HIV disease progression. Alteration...
  13. Research | | Open

  14. Research | | Open

    • ...cycle the human immunodeficiency virus (HIV) relies on host-cell... ...promise in protecting cells against HIV infection. LEDGF/p75, encoded... ...the pre-integration complex of HIV to bind host-cell chromatin... .../p75 depletion results in defective HIV replication. However, as part... ...HIV IN...
  15. Research | | Open

    • ...the United Nations Programme on HIV/AIDS (UNAIDS), acquired... ...by the human immunodeficiency virus (HIV), remains a significant public... ...the discovery of novel anti-HIV drug candidates. The current... ...evaluated for cytotoxicity and anti-HIV properties. Molecular modelling studies...
  16. Research |

    • ...human immunodeficiency virus type 1 (HIV-1) is naturally inhibited... ...an effective postentry inhibitor of HIV-1, but is only... ...the pre-integration phases of HIV-1 infection, and identified... ...TRIM5α) as a potent anti-HIV-1 restriction factor. Human... ...substantial HIV-1... ...of HIV-1...
  17. Research | | Open

    • ...increase in life expectancy for HIV-1 seropositive individuals, following... ...examination of the progression of HIV-1 associated neurocognitive disorders (... ...call for animal models of HIV-1/AIDS in 1988,... ...Here, we demonstrate that the HIV-1 transgenic (Tg) rat... ...HIV-1... ...in HIV-...
  18. Research | | Open

  19. Research | | Open

  20. Research | | Open

  21. Research | | Open

    • ...) and human immunodeficiency virus (HIV) accelerates hepatic fibrosis progression.... ...active replication of HCV and HIV, and assessed the effect... ...hr post-infection with HCV, HIV or HCV/HIV in MLH co-cultures,... ...with or without HCV and HIV infection, revealed novel insights... ...HIV...HIV
  22. Research | | Open

  23. Reviews |

  24. Research Highlights |

  25. Research Highlights |

  26. Research | | Open

    • ...against latent human immunodeficiency virus (HIV) genome but the delivery... ...(BBB) to inhibit latent HIV-1 infection in microglial (... hμglia)/HIV (HC69) cells. An... ...intracellular release and inhibition of HIV. The outcomes suggested that... ...reduced HIV-LTR expression significantly...
  27. Research | | Open

    • ...pathogens transmitted by ticks in HIV-infected persons and blood donors... ...samples were collected from 227 HIV-infected patients and 199 blood... ...lymphocyte T CD4+ level in HIV infected patients. The seroprevalence... ...of tick-borne infections in HIV-infected patients is higher than...
  28. Research | | Open

  29. Research | | Open

    • ...1985–2000 during which time HIV prevalence increased exponentially. Epidemic... ...interventions. Here we identified distinct HIV clades from a large sequence... dataset of southern African HIV sequences (n = 15,... ...do not affect the HIV epidemic universally with major... ...tool in HIV...
  30. Research | | Open

    • HIV-1-infected people who take... ...from developing AIDS. Nonetheless, HIV-1 establishes proviruses in long... ...Here we show that the HIV-1 provirus activates innate immune... ...activation requires transcription from the HIV-1 provirus and expression of... ...RRE-containing, unspliced HIV-1 RNA...
  31. Research |

    • ...-MTase that is recruited to HIV RNA through TRBP. Using... ...residues on the viral genome. HIV-1 viruses produced in FTSJ3... ...leads to a reduction in HIV expression. We have identified... ...an unexpected mechanism used by HIV-1 to evade innate immune...
  32. Research | | Open

    • ...of CD4+ T cells against HIV infection, prompted us to... ...for their ability to inhibit HIV infection of activated blood CD4... ...but not apical secretions, suppressed HIV infection of CD4+ T... ...of CD4+ T cells from HIV infection. When added apically... ...sustained protection against HIV...
  33. Research | | Open

  34. Research | | Open

    • Throughout the HIV-1 replication cycle, complex... ...the dynamic host response to HIV-1 infection by systematically measuring... ...388 host genes specific for HIV-1 replication. Comprehensive functional... ...of dynamic host responses to HIV-1 infection that provides a...
  35. Research | | Open

  36. Research | | Open

  37. Research | | Open

  38. Research | | Open

    • HIV-1 Tat protein contributes to... HIV-neuropathogenesis in several ways including... ...that in the globally dominant HIV-1 clade C, Tat... ...we expressed Tat proteins of HIV-1 clade B (Tat-... ...which provide readout via an HIV-1 Tat-responsive luciferase gene... ...the ability of HIV-1 Tat to...
  39. Research | | Open

    • HIV-1 DNA quantification serves as... ...an important reservoir biomarker in HIV cure trials. However, the... high genetic diversity of HIV-1 represented by different subtypes... ...may bring inaccuracy in quantifying HIV-1 DNA and a sensitive... ...assay covering diverse HIV-1 subtypes is... ...HIV-...
  40. Research | | Open

  41. Research | | Open

    • Methamphetamine (Meth) exacerbates HIV-1 pathobiology by increasing virus... ...to alter the expression of HIV-1 co-receptors and impair... ...molecular mechanisms involved in augmenting HIV-1 replication in T-cells... ...of CD4+ T-cells enhanced HIV-1 replication. We observed... ...HIV-1 with...
  42. News |

  43. Research | | Open

    • While HIV kills most of the cells... ...posing a significant barrier to HIV eradication. However, the mechanism... ...by which immune cells resist HIV-induced apoptosis is still incompletely... ...we demonstrate that while acute HIV infection of human microglia/macrophages... ...population of HIV-...HIV
  44. Research | | Open

    • ...as a relevant pathogen for HIV-infected patients. However, there... ...data on HEV infection in HIV/HCV-coinfected individuals with advanced... ...and exposure to HEV in HIV/HCV-coinfected patients and to... ...cross-sectional study on 198 HIV/HCV-coinfected patients, 30... ...36 HIV-monoinfected...
  45. Research | | Open

    • The vertical transmission of HIV, from mother to child... ...prevention of mother to child HIV transmission (PMTCT) program from... ...Suzhou. A total of 107 HIV positive women were enrolled in... ...Only one infant was diagnosed HIV infected because the HIV positive mother did not enter... ...HIV...
  46. Research | | Open

  47. Research | | Open

  48. Research | | Open

    • The HIV-human metabolic relationship is a... ...of cART to undo the HIV induced metabolic dysregulation is unclear... ...samples obtained from 18 untreated HIV-1-infected adult patients and... ...compared these to a non-HIV infected (n = 23)... ...during an untreated HIV infection implicated altered...
  49. Research | | Open

  50. Research |