Showing 1–50 of 705 results

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  2. Research |

    • ...human induced pluripotent stem cell (hiPSC)-derived neurons well represent... .... Patient-derived NRXN1+/− hiPSC-neurons show a greater than... ...in patient-derived NRXN1+/− hiPSC-neurons is ameliorated by overexpression... ...neuronal activity levels in control hiPSC-neurons. In a genotype-...
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    • ...cells (hiPSCs) derived cardiomyocytes (hiPSC-CMs). hiPSC-CMs differentiated from PCBC hiPSCs... ...highest gene transfection efficiency in hiPSC-CMs on day 14 of... ...on day 23 of contraction) hiPSC-CMs not only improved gene... ...respectively, for P1C1 or DP3 hiPSC line that was derived from...
  5. Protocols |

    • ...pluripotent stem cell–derived cardiomyocytes (hiPSC-CMs) can be used... ...via high-throughput screening of hiPSC-CMs. This metric quantitatively... ...how to differentiate hiPSCs into hiPSC-CMs and subsequently implement contractility... ...drug-induced cardiotoxicity in hiPSC-CMs. We also...
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    • ...human induced pluripotent stem cell (hiPSC)-based studies to resolve... ...case/control schizophrenia (SZ) hiPSC-derived cohort of neural progenitor... ...predict a growing convergence between hiPSC and post-mortem studies as... ...to maximize the power of hiPSC cohorts currently feasible, in...
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  10. Reviews |

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    • ...pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have been developed... ...In order to establish the hiPSC-CM-based platform as an... ...-2 & Wk-4 in hiPSC-CMs in vitro. Functional... assessment of hiPSC-CMs was determined by multielectrode... ...that Wk-4 hiPSC-CMs showed improved...
  13. Research | | Open

    • ...human induced pluripotent stem cell (hiPSC)-derived neural progenitor cells... ...genes in a cell type (hiPSC NPC vs. CCL) and... ...of transcriptomic drug screening to hiPSC-based models, demonstrating that... ...differences observed with patient-derived hiPSC NPCs are enriched for SZ...
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    • ...pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) offer a novel... ...drugs in development. To date hiPSC-CMs used for cardiotoxicity testing... ...into question the applicability of hiPSC-CM findings to the adult... ...of cardiomyocyte maturation state on hiPSC-CM drug responsiveness. To...
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    • ...Human induced pluripotent stem cells (hiPSC) represent a powerful tool... ...osteoclasts can be differentiated from hiPSC-mesenchymal stem cells and macrophages... ...implantation in rodents, co-cultured hiPSC-MSC/-macrophage on such...
  20. Reviews |

    • ...human induced pluripotent stem cell (hiPSC) technology has revitalized the... ...any cell type of interest, hiPSC technology now enables the derivation... ...large-scale Precision Medicine Initiative, hiPSC technology will undoubtedly have a... ...in the field of hiPSC technology, with particular...
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  25. Research | | Open

    • ...pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) we found that... ...in cell cycle initiation in hiPSC-CMs, an effect mediated... ...to enhance β-catenin-mediated hiPSC-CM proliferation. In summary,... ...of bioactive lipids to enhance hiPSC-CM differentiation and proliferation via...
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  28. Research | | Open

    • ...differentiation efficiency and consistency from hiPSC lines to CMs. Here,... ...of that fate specification of hiPSC-CMs differentiation is dictated by... ...that regulate Wnt, we evaluate hiPSC-CM differentiation with: (1... ...Wnt activation in regulation of hiPSC-CMs differentiation, and more...
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  30. Research | | Open

    • ...Human induced pluripotent stem cell (hiPSC)-derived retinal pigment epithelium... (hiPSC-RPE) cells suspension have... ...However, practical regenerative applications with hiPSC-RPE cells require the development... ...non-freezing temperatures on suspended hiPSC-RPE cells in various conditions...
  31. Research | | Open

    • ...human induced pluripotent stem cell (hiPSC) lines with high cardiac... ...predicting cardiac differentiation potential of hiPSC lines by comparing the gene... ...expression profiles of six undifferentiated hiPSC lines with different cardiac differentiation... ...in 13 additional hiPSC lines. Our...
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  37. Research | | Open

    • ...gene expression comparisons of our hiPSC-derived neurons to the Allen... ...features of schizophrenia (SZ), hiPSC-based models may be better... ...the gene signature of SZ hiPSC-derived neurons is conserved in... SZ hiPSC neural progenitor cells (NPCs)... ...phenotypes in SZ hiPSC NPCs from four...
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  49. Research | | Open

    • ...from the undifferentiated state in hiPSC colonies. After HA treatment,... ...and delayed the recovery of hiPSC morphology, but this effect... ...E-cadherin–integrin interplay in hiPSC colonies exhibiting deviation, while...
  50. Research | | Open

    • ...from embryoid bodies of hiPSCs (hiPSC-EBs) for robust mass... ...the Wnt pathway. The resultant hiPSC-EB-HLCs expressed liver-specific... ...glycogen storage. Cell transplantation of hiPSC-EB-HLC in a rat... ...transplantation control animals. The transplanted hiPSC-EB-HLCs secreted human albumin...