Showing 1–50 of 5165 results

  1. Research | | Open

    • ...ryanodine receptor (RyR) modulator caffeine on Na+ current (INa... ...0.5 and 2 mM caffeine prior to establishing the patch... ...shifts, following 0.5 mM caffeine challenge. In contrast, 2...  mM caffeine elicited delayed negative shifts in... ...were abrogated if caffeine was added after...caffeine
  2. Research | | Open

    • ...use psychoactive substances such as caffeine to enhance cognitive performance.... ...acute exercise in comparison to caffeine on cognition remain unknown.... Furthermore, caffeine use is associated with withdrawal... ...moderate intensity aerobic exercise to caffeine on working memory (WM)...
  3. Reviews |

    • Background Caffeine is indicated for the management... ...preterm infants. Early initiation of caffeine administration has increased in the... ...assess whether early administration of caffeine reduces morbidity and mortality in... ...late caffeine administration...caffeine
  4. Research |

    • ...related to the timing of caffeine discontinuation, and compare clinical... ...characteristics of infants who discontinued caffeine before vs. within the... ...The mean postmenstrual age at caffeine discontinuation ranged from 32 to... ...airway pressure at caffeine discontinuation by site...caffeine
  5. Research | | Open

    • ...ototoxicity. Inhibition of A1AR by caffeine, a widely consumed psychoactive... ...ototoxicity following oral administration of caffeine. We report here that... single-dose administration of caffeine exacerbates cisplatin-induced hearing loss... .... These effects of caffeine were mediated by...
  6. Research | | Open

    • ...pain models, oral intake of caffeine, a potent adenosine receptor... ...low dose. Local administration of caffeine at the acupuncture point was... ...dismissing the systemic action of caffeine. Such interference was reversible,... as caffeine withdrawal fully restored the efficacy... ...caffeine...
  7. Research |

    • Background Neonatal caffeine treatment might affect brain development... ...long-term effects of neonatal caffeine administration in a rabbit model... ...to treatment with saline or caffeine for 7 or 17 days... ...in controls, whereas caffeine-treated preterm pups...
  8. Research | | Open

    • ...therapies. Here, utilizing a caffeine-binding single-domain antibody we... establish a caffeine-inducible protein dimerization system,... ...to physiologically relevant concentrations of caffeine generated by routine intake of... ...Coffee containing different caffeine concentrations dose-...
  9. Research | | Open

    • ...mutations in putative Ca2+ and caffeine-binding sites were functionally analysed... ...a tryptophan residue in the caffeine-binding site controls the structure... ...mechanism of Ca2+ sensitization by caffeine and disease-causing mutations.
  10. Research |

    • Caffeine, a widely consumed adenosine... ...ADORA2A gene (rs5751876) and caffeine-induced anxiety has been reported... ...individuals who habitually consume little caffeine. This study investigated whether... ...SNP) might also affect habitual caffeine intake, and whether habitual... ...of caffeine....
  11. Research | | Open

    • ...cannot be administered to humans. Caffeine is one of the world... .... Nevertheless, the influence of caffeine administration on fear memory processing... ...conditioning in rats and acute caffeine administration under a standard memory... ...effects induced by caffeine were evaluated by...
  12. Research | | Open

    • Consume of stimulants (as caffeine) is very usual in... ...to examine the effect of caffeine intake on attention (alerting,... ...groups of participants with different caffeine consumption profiles (moderate consumers... ...vs. exercise) and intake (caffeine vs. placebo). Results... ..., caffeine...
  13. Research | | Open

    • Caffeine, an antagonist of the... ...Central or peripheral administration of caffeine reduces the body weight of... ...expenditure. We also show that caffeine excites oxytocin expressing neurons,... ...significantly attenuates the effect of caffeine on energy balance. These... ...caffeine inhibits...
  14. Research |

    • Caffeine is the most commonly used... ...identified the effects of adolescent caffeine consumption on cocaine sensitivity and... ...(NAc) that may underlie caffeine-induced hypersensitivity to cocaine.... ...Male Sprague-Dawley rats consumed caffeine (0.3 g/l)... ...of caffeine during adulthood...
  15. Research |

    • Background/Objectives: Assessment of caffeine intake as part of the... risk assessment of caffeine in adolescents and young adults... ...identify the main contributors to caffeine intake. Subjects/Methods: Assessment...
    • ...to intake of coffee and caffeine on blood pressure in man... ...actions of these effects of caffeine.Design: The MEDLINE and... ...the text words ‘coffee or caffeine’ and ‘blood pressure or... ...pressure effects of coffee or caffeine are reviewed. We also... ...effects of caffeine.Results:...
    • The radiosensitizing effect of caffeine has been associated with the... ...of DNA repair inhibition in caffeine radiosensitization remains uncharacterized, and... ...(HRR), displays significantly diminished caffeine radiosensitization that can be restored... ..., caffeine... ...reduced caffeine...
  16. Research |

  17. Research | | Open

    • ...factor for hypertension. Although acute caffeine intake produces moderate diuresis and... natriuresis, caffeine increases the blood pressure (... ...the long-term effects of caffeine on urinary sodium excretion and... ...we investigated whether chronic caffeine administration antagonizes salt...
  18. Research | | Open

    • ...pregnant woman are exposed to caffeine, which acts to antagonize... ...we exposed pregnant mice to caffeine equivalent to 2–4 cups... ...(F1 generation) exposed to caffeine early from embryonic (E)... ...of age. Embryos exposed to caffeine later (E10.5–13.... ...exposed to caffeine from E10.5–...
    • Background: Serum caffeine concentrations >20 μg/ml... ...linked to differential binding of caffeine to adenosine receptor subtypes (... ...19 infants were exposed to caffeine (0–200 μmol/l)... ...PCR) were measured. Results: Caffeine at ≤100 μmol/l... ...All caffeine...
  19. Research | | Open

    • Caffeine is the most widely-consumed... ...but our understanding of how caffeine affects our brains is relatively... ...studies focus on effects of caffeine on adenosine receptors, but... ...pattern of sleep/wake activity, caffeine reduces nighttime sleep behavior independently... ...of caffeine in...
    • Background: Caffeine is widely used to treat... ...apnea. Before higher doses of caffeine can be used, their... ...impact of daily high-dose caffeine administration on the developing white... ...brain. Methods: High-dose caffeine (25 mg/kg... ...caffeine base loading...
  20. Research | | Open

    • Caffeine has attracted abundant attention due... ...a novel aqueous phase fluorescent caffeine sensor named Caffeine Orange which exhibits 250-fold... fluorescence enhancement upon caffeine activation and high selectivity.... ...demonstrate the change of Caffeine Orange ambient environment induces...
  21. Reviews |

    • ..., by the early 2000s, caffeine had become the preferred methylxanthine... ...2004, confirmed significant benefits of caffeine therapy, including shorter duration... ...the safety and efficacy of caffeine therapy for AOP and other... ...neurodevelopmental outcomes. Caffeine has a very...
  22. Research |

    • ...shown that repeated exposure to caffeine sensitizes rats to the motor... ...in this effect, sensitization to caffeine and cross-sensitization between caffeine and amphetamine was evaluated by... ...hydroxydopamine-lesioned rats. Administration of caffeine (15 mg/kg) for... ...caffeine took...
  23. Research |

    • ...reduced radiosensitization after treatment with caffeine, thus implicating homology-directed... ...DSBs) in the mechanism of caffeine radiosensitization. Here, we investigate... directly the effect of caffeine on HDR initiated by DSBs... ...a strong inhibition by caffeine of HDR in wild-...caffeine
  24. Research |

  25. Research |

    • The effects of caffeine on extracellular dopamine and acetylcholine... ...prefrontal cortex. Intravenous administration of caffeine (0.25, 0.5... ...nucleus accumbens. Intraperitoneal administration of caffeine (1.5, 3,... ...receptors. The effect of caffeine on prefrontal dopamine and... ...caffeine...
    • ...state and norepinephrine kinetics after caffeine ingestion in younger and older... ...who were moderate consumers of caffeine (Y=126±30 mg/... ...fasting plasma glucose, insulin and caffeine levels, body composition, anthropometry... ...Before and after placebo and caffeine ingestion (5 mg/kg...
  26. Research | | Open

    • Caffeine is a widely consumed psychoactive... ...known about the effects of caffeine stimulation on global gene expression... ...with normal consumption levels of caffeine (3 μM and 10 ... ...processes were down-regulated by caffeine at 3 h. This... ...to acute caffeine stimulation and... ...caffeine...
  27. Research | | Open

    • ...is responsible for 90% of caffeine metabolism, while caffeine exerts many of its effects... ...rs762551) influence the effect of caffeine on the postprandial glucose (... ...elevated GLU levels after consuming caffeine and carbohydrate (CHO + ... ...data suggest that caffeine-induced impairments...
  28. Research |

    • ...PMA) can be attenuated using caffeine doses sufficient to maintain caffeine concentrations >20 μg ml−... ...<32 weeks were started on caffeine citrate at 10 mg kg... ...−1 day−1 when clinical caffeine was discontinued. At 36... ...to compensate for progressively increasing caffeine metabolism.
    • ...major contributor to BPD. Early caffeine treatment decreases the incidence of... ...with either 20 mg/kg caffeine or normal saline by an... ...) in the lungs. Early caffeine treatment increased cAMP levels in... ...lungs of hyperoxia-exposed pups. Caffeine also increased the levels of...
  29. Research | | Open

    • ...information and information about the caffeine content of a beverage on... caffeine withdrawal, specifically if: (... ...for a gene related to caffeine withdrawal can produce an exaggerated... caffeine withdrawal response during abstinence;... ...one has consumed caffeine leads to a...
  30. Research | | Open

    • ...UCP1 is not well established. Caffeine consumption has been associated with... ...study examined the effect of caffeine on BAT thermogenesis in vitro... ...cell-derived adipocytes exposed to caffeine (1 mM) showed increased... ...droplet content. Caffeine also increased peroxisome... ...caffeine...
  31. Research | | Open

    • ...commonly documented in premature infants. Caffeine is routinely utilized for apnea... ...) muscle tone, but the caffeine effect on the newborn gastrointestinal... ...is unknown. We hypothesized that caffeine impairs esophageal and gastrointestinal motor... ...The effects of caffeine on LES,...
    • ...interference (RNAi) screen using caffeine as a xenobiotic stress-inducing... .... Specifically, we examined how caffeine affects cell survival when Drosophila... ...essential for cell survival under caffeine-induced stress both in cell...
  32. Research | | Open

    • Caffeine modifies vascular/cardiac contractility.... Embryonic exposure to caffeine altered cardiac functions in offspring... ...determined chronic influence of prenatal caffeine on vessel functions in offspring... ...exposed to high dose of caffeine, their offspring (5-month... ...to caffeine...
  33. Research |

    • ...the half-life of serum caffeine concentrations and its relation to... ...of prematurity (AOP) after caffeine is discontinued in preparation for... ...33 weeks at birth. After caffeine was discontinued, serum caffeine concentrations and electronic detection of... ...Caffeine levels decreased from...
  34. Research | | Open

    • Caffeine, the most widely consumed... ...drugs (stimulants and modafinil), caffeine enhances dopamine (DA) signaling... ...However, it is unclear if caffeine, at the doses consumed... ...endogenous DA) to assess if caffeine increased DA release in striatum... ...healthy controls. Caffeine (300 mg p....
  35. Research | | Open

    • Caffeine is a globally consumed psychostimulant... ...apoptosis plays a role in caffeine-induced cell death, the... ...of cell death under high caffeine concentrations and to enhanced cell... ...cervical carcinoma cells under high caffeine concentrations, indicating that caffeine-induced cell death...
  36. Research |

    • ...is currently not known whether caffeine has an enhancing effect on... ...humans. We used post-study caffeine administration to test its effect... ...using a behavioral discrimination task. Caffeine enhanced performance 24 h after... .... We conclude that caffeine enhanced consolidation of long...
  37. Research | | Open

  38. Research |

    • ...coffee consumption and hypertension ascertained caffeine intake in terms of number... ...inter-individuals variability in the caffeine metabolism is known, the... relation of caffeine metabolites with hypertension remains unsettled... ...examined the association of caffeine and 13 direct and...
  39. Research |

    • ...mediates the psychoactive effects of caffeine, is also thought to... ...variations in anxiogenic responses to caffeine and polymorphisms in the A1... ...receptor genes. Healthy, infrequent caffeine users (N=94) recorded... ...150 mg oral dose of caffeine freebase or placebo in a... ...caffeine...