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Research | 1 September 2001
Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells
- Yun-Cai
- Deyu Fang
- & Yun-Cai Liu
Nature Immunology 2 , 870–875

Rights & permissionsfor article Proteolysis-independent regulation of PI3K by Cbl-b–mediated ubiquitination in T cells . Opens in a new window.
Research | 24 August 2020 | Open
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
- Yun-Cai
- Mengze Lv
- , Meixia Chen
- , Rui Zhang
- , Wen Zhang
- , Chenguang Wang
- , Yan Zhang
- , Xiaoming Wei
- , Yukun Guan
- , Jiejie Liu
- , Kaichao Feng
- , Miao Jing
- , Xurui Wang
- , Yun-Cai Liu
- , Qian Mei
- , Weidong Han
- & Zhengfan Jiang
Cell Research 30 , 966–979

Rights & permissionsfor article Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy . Opens in a new window.
Research | 20 June 2018
The E3 ligases Itch and WWP2 cooperate to limit T_H2 differentiation by enhancing signaling through the TCR
- Yun-Cai
- Daisuke Aki
- , Hui Li
- , Wen Zhang
- , Mingke Zheng
- , Chris Elly
- , Jee H. Lee
- , Weiguo Zou
- & Yun-Cai Liu
Nature Immunology 19 , 766–775

Rights & permissionsfor article The E3 ligases Itch and WWP2 cooperate to limit T<sub>H</sub>2 differentiation by enhancing signaling through the TCR . Opens in a new window.
Research | 1 February 2016
SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex
- Yun-Cai
- Yoon Park
- , Hyung-seung Jin
- , Justine Lopez
- , Jeeho Lee
- , Lujian Liao
- , Chris Elly
- & Yun-Cai Liu
Nature Immunology 17 , 286–296

Rights & permissionsfor article SHARPIN controls regulatory T cells by negatively modulating the T cell antigen receptor complex . Opens in a new window.
Research | 25 May 2014
The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells
- Yun-Cai
- Nengming Xiao
- , Danelle Eto
- , Chris Elly
- , Guiying Peng
- , Shane Crotty
- & Yun-Cai Liu
Nature Immunology 15 , 657–666

Rights & permissionsfor article The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells . Opens in a new window.
Research | 11 May 2015
IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis
- Yun-Cai
- Petra Krause
- , Venetia Morris
- , Jason A. Greenbaum
- , Yoon Park
- , Unni Bjoerheden
- , Zbigniew Mikulski
- , Tracy Muffley
- , Jr-Wen Shui
- , Gisen Kim
- , Hilde Cheroutre
- , Yun-Cai Liu
- , Bjoern Peters
- , Mitchell Kronenberg
- & Masako Murai
Nature Communications 6 , 1–12

Rights & permissionsfor article IL-10-producing intestinal macrophages prevent excessive antibacterial innate immunity by limiting IL-23 synthesis . Opens in a new window.
Research | 15 February 2004
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins
- Yun-Cai
- Vigo Heissmeyer
- , Fernando Macián
- , Sin-Hyeog Im
- , Rajat Varma
- , Stefan Feske
- , K Venuprasad
- , Hua Gu
- , Yun-Cai Liu
- , Michael L Dustin
- & Anjana Rao
Nature Immunology 5 , 255–265

Rights & permissionsfor article Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteins . Opens in a new window.
Research | 17 February 2008
The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1
- Yun-Cai
- K Venuprasad
- , Haining Huang
- , Yousuke Harada
- , Chris Elly
- , Malayannan Subramaniam
- , Thomas Spelsberg
- , Jin Su
- & Yun-Cai Liu
Nature Immunology 9 , 245–253

Rights & permissionsfor article The E3 ubiquitin ligase Itch regulates expression of transcription factor Foxp3 and airway inflammation by enhancing the function of transcription factor TIEG1 . Opens in a new window.
Research | 4 February 2002
Dysregulation of T lymphocyte function in itchy mice: a role for Itch in T_H2 differentiation
- Yun-Cai
- Deyu Fang
- , Chris Elly
- , Baixue Gao
- , Nan Fang
- , Yoav Altman
- , Claudio Joazeiro
- , Tony Hunter
- , Neal Copeland
- , Nancy Jenkins
- & Yun-Cai Liu
Nature Immunology 3 , 281–287

Rights & permissionsfor article Dysregulation of T lymphocyte function in itchy mice: a role for Itch in T<sub>H</sub>2 differentiation . Opens in a new window.
Reviews | 1 December 2005
Immunity by ubiquitylation: a reversible process of modification
- Yun-Cai
Nature Reviews Immunology 5 , 941–952

Rights & permissionsfor article Immunity by ubiquitylation: a reversible process of modification . Opens in a new window.
Research Highlights | 7 June 2011
To go or not to go: the “Itchy” effect on the destiny of hematopoietic stem cells
- Yun-Cai
- Daisuke Aki
- & Yun-Cai Liu
Cell Research 21 , 1161–1163

Rights & permissionsfor article To go or not to go: the “Itchy” effect on the destiny of hematopoietic stem cells . Opens in a new window.
Research | 4 February 1999
Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation
- Yun-Cai
- Chris Elly
- , Stephan Witte
- , Zhihong Zhang
- , Olivier Rosnet
- , Stanley Lipkowitz
- , Amnon Altman
- & Yun-Cai Liu
Oncogene 18 , 1147–1156

Rights & permissionsfor article Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation . Opens in a new window.

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