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News and Views | 29 July 2019
Lessons about early neurodevelopment in children exposed to ZIKV in utero
- William J. Muller
- & Sarah B. Mulkey
Nature Medicine 25 , 1192–1193

Rights & permissionsfor article Lessons about early neurodevelopment in children exposed to ZIKV in utero . Opens in a new window.
Research | 22 July 2020 | Open
An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis
Bone Research 8 , 1–12

Rights & permissionsfor article An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis . Opens in a new window.
Research | 9 August 2018 | Open
c-Src regulates cargo transit via the Golgi in pancreatic acinar cells
Scientific Reports 8 , 1–10

Rights & permissionsfor article c-Src regulates cargo transit via the Golgi in pancreatic acinar cells . Opens in a new window.
27 September 2016
Treatment of perinatal viral infections to improve neurologic outcomes
- William J. Muller
Pediatric Research 81 , 162–169

Rights & permissionsfor article Treatment of perinatal viral infections to improve neurologic outcomes . Opens in a new window.
8 September 2014
Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV
Pediatric Research 76 , 528–534

Rights & permissionsfor article Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV . Opens in a new window.
19 September 2005
The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation
- Harold Kim
- , Richard Chan
- , David L Dankort
- , Dongmei Zuo
- , Monica Najoukas
- , Morag Park
- & William J Muller
Oncogene 24 , 7599–7607

Rights & permissionsfor article The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation . Opens in a new window.
7 March 2000
Signal transduction in mammary tumorigenesis: a transgenic perspective
- David L Dankort
- & William J Muller
Oncogene 19 , 1038–1044

Rights & permissionsfor article Signal transduction in mammary tumorigenesis: a transgenic perspective . Opens in a new window.
Research | 23 May 2004
Memo mediates ErbB2-driven cell motility
- Romina Marone
- , Daniel Hess
- , David Dankort
- , William J. Muller
- , Nancy E. Hynes
- & Ali Badache
Nature Cell Biology 6 , 515–522

Rights & permissionsfor article Memo mediates ErbB2-driven cell motility . Opens in a new window.
Research | 2 November 1999
A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity
- Robert A Marr
- , Mary Hitt
- , Jack Gauldie
- , William J Muller
- & Frank L Graham
Cancer Gene Therapy 6 , 465–474

Rights & permissionsfor article A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity . Opens in a new window.
11 December 2000
Transgenic mouse models of human breast cancer
- John N Hutchinson
- & William J Muller
Oncogene 19 , 6130–6137

Rights & permissionsfor article Transgenic mouse models of human breast cancer . Opens in a new window.
12 February 2002
Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu
Oncogene 21 , 890–898

Rights & permissionsfor article Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu . Opens in a new window.
9 April 2001
Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor
Oncogene 20 , 788–799

Rights & permissionsfor article Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor . Opens in a new window.
20 June 2005
Ets2-dependent microenvironmental support of mouse mammary tumors
- John A Tynan
- , Fang Wen
- , William J Muller
- & Robert G Oshima
Oncogene 24 , 6870–6876

Rights & permissionsfor article Ets2-dependent microenvironmental support of mouse mammary tumors . Opens in a new window.
6 December 2004
Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth
Oncogene 24 , 932–937

Rights & permissionsfor article Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth . Opens in a new window.
11 December 2003
Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression
- Amy Gillgrass
- , Robert D Cardiff
- , Niki Sharan
- , Subha Kannan
- & William J Muller
Oncogene 22 , 9151–9155

Rights & permissionsfor article Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression . Opens in a new window.
1 November 2001
Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice
Oncogene 20 , 7064–7072

Rights & permissionsfor article Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice . Opens in a new window.
29 April 1998
The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members
Oncogene 16 , 1963–1972

Rights & permissionsfor article The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members . Opens in a new window.
Research | 1 March 2000
Suppression of tumor growth and metastasis in Mgat5-deficient mice
- Maria Granovsky
- , Jimmie Fata
- , Judy Pawling
- , William J. Muller
- , Rama Khokha
- & James W. Dennis
Nature Medicine 6 , 306–312

Rights & permissionsfor article Suppression of tumor growth and metastasis in Mgat5-deficient mice . Opens in a new window.
Research | 1 July 2019 | Open
An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
- Harvey W. Smith
- , Alison Hirukawa
- , Virginie Sanguin-Gendreau
- , Ipshita Nandi
- , Catherine R. Dufour
- , Dongmei Zuo
- , Kristofferson Tandoc
- , Matthew Leibovitch
- , Salendra Singh
- , Jonathan P. Rennhack
- , Matthew Swiatnicki
- , Cynthia Lavoie
- , Vasilios Papavasiliou
- , Carolin Temps
- , Neil O. Carragher
- , Asier Unciti-Broceta
- , Paul Savage
- , Mark Basik
- , Vincent van Hoef
- , Ola Larsson
- , Caroline L. Cooper
- , Ana Cristina Vargas Calderon
- , Jane Beith
- , Ewan Millar
- , Christina Selinger
- , Vincent Giguère
- , Morag Park
- , Lyndsay N. Harris
- , Vinay Varadan
- , Eran R. Andrechek
- , Sandra A. O’Toole
- , Ivan Topisirovic
- & William J. Muller
Nature Communications 10 , 1–19

Rights & permissionsfor article An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis . Opens in a new window.
Research | 29 June 2018 | Open
Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program
- Alison Hirukawa
- , Harvey W. Smith
- , Dongmei Zuo
- , Catherine R. Dufour
- , Paul Savage
- , Nicholas Bertos
- , Radia M. Johnson
- , Tung Bui
- , Guillaume Bourque
- , Mark Basik
- , Vincent Giguère
- , Morag Park
- & William J. Muller
Nature Communications 9 , 1–15

Rights & permissionsfor article Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program . Opens in a new window.
Research | 5 May 2017 | Open
Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1
Nature Communications 8 , 1–15

Rights & permissionsfor article Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1 . Opens in a new window.
Research | 24 April 2017 | Open
LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis
Nature Communications 8 , 1–15

Rights & permissionsfor article LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis . Opens in a new window.
Research | 3 March 2017 | Open
Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage
Scientific Reports 7 , 1–12

Rights & permissionsfor article Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage . Opens in a new window.
Research | 9 March 2017 | Open
The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression
- Ryuhjin Ahn
- , Valérie Sabourin
- , Alicia M. Bolt
- , Steven Hébert
- , Stephanie Totten
- , Nicolas De Jay
- , Maria Carolina Festa
- , Yoon Kow Young
- , Young Kyuen Im
- , Tony Pawson
- , Antonis E. Koromilas
- , William J. Muller
- , Koren K. Mann
- , Claudia L. Kleinman
- & Josie Ursini-Siegel
Nature Communications 8 , 1–14

Rights & permissionsfor article The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression . Opens in a new window.
Research | 12 July 2016 | Open
ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
- Geneviève Deblois
- , Harvey W. Smith
- , Ingrid S. Tam
- , Simon-Pierre Gravel
- , Maxime Caron
- , Paul Savage
- , David P. Labbé
- , Louis R. Bégin
- , Michel L. Tremblay
- , Morag Park
- , Guillaume Bourque
- , Julie St-Pierre
- , William J. Muller
- & Vincent Giguère
Nature Communications 7 , 1–14

Rights & permissionsfor article ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer . Opens in a new window.
Research | 28 March 2014
Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors
- Ozgur Sahin
- , Qingfei Wang
- , Samuel W Brady
- , Kenneth Ellis
- , Hai Wang
- , Chia-Chi Chang
- , Qingling Zhang
- , Preety Priya
- , Rui Zhu
- , Stephen T Wong
- , Melissa D Landis
- , William J Muller
- , Francisco J Esteva
- , Jenny Chang
- & Dihua Yu
Cell Research 24 , 542–559

Rights & permissionsfor article Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors . Opens in a new window.
Research | 20 December 2013 | Open
Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase
Nature Communications 4 , 1–12

Rights & permissionsfor article Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase . Opens in a new window.
Research | 20 January 2008
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
- Jer-Yen Yang
- , Cong S. Zong
- , Weiya Xia
- , Hirohito Yamaguchi
- , Qingqing Ding
- , Xiaoming Xie
- , Jing-Yu Lang
- , Chien-Chen Lai
- , Chun-Ju Chang
- , Wei-Chien Huang
- , Hsin Huang
- , Hsu-Ping Kuo
- , Dung-Fang Lee
- , Long-Yuan Li
- , Huang-Chun Lien
- , Xiaoyun Cheng
- , King-Jen Chang
- , Chwan-Deng Hsiao
- , Fuu-Jen Tsai
- , Chang-Hai Tsai
- , Aysegul A. Sahin
- , William J. Muller
- , Gordon B. Mills
- , Dihua Yu
- , Gabriel N. Hortobagyi
- & Mien-Chie Hung
Nature Cell Biology 10 , 138–148

Rights & permissionsfor article ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation . Opens in a new window.
15 March 1999
Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16^INK4A, p18^INK4C, p19^INK4D, p21^WAF1/CIP1 and p27^KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity
Oncogene 18 , 1663–1676

Rights & permissionsfor article Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16INK4A, p18INK4C, p19INK4D, p21WAF1/CIP1 and p27KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity . Opens in a new window.
Research | 28 January 2007
Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis
- Sofi G Julien
- , Nadia Dubé
- , Michelle Read
- , Janice Penney
- , Marilene Paquet
- , Yongxin Han
- , Brian P Kennedy
- , William J Muller
- & Michel L Tremblay
Nature Genetics 39 , 338–346

Rights & permissionsfor article Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis . Opens in a new window.
19 April 2007
Insights from transgenic mouse models of ERBB2-induced breast cancer
Nature Reviews Cancer 7 , 389–397

Rights & permissionsfor article Insights from transgenic mouse models of ERBB2-induced breast cancer . Opens in a new window.

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Lessons about early neurodevelopment in children exposed to ZIKV in utero

An enhanced chemopreventive effect of methyl donor S-adenosylmethionine in combination with 25-hydroxyvitamin D in blocking mammary tumor growth and metastasis

c-Src regulates cargo transit via the Golgi in pancreatic acinar cells

Treatment of perinatal viral infections to improve neurologic outcomes

Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV

The c-Src tyrosine kinase associates with the catalytic domain of ErbB-2: implications for ErbB-2 mediated signaling and transformation

Signal transduction in mammary tumorigenesis: a transgenic perspective

Memo mediates ErbB2-driven cell motility

A p75 tumor necrosis factor receptor-specific mutant of murine tumor necrosis factor α expressed from an adenovirus vector induces an antitumor response with reduced toxicity

Transgenic mouse models of human breast cancer

Centrosome abnormalities, recurring deletions of chromosome 4, and genomic amplification of HER2/neu define mouse mammary gland adenocarcinomas induced by mutant HER2/neu

Distinct tyrosine autophosphorylation sites mediate induction of epithelial mesenchymal like transition by an activated ErbB-2/Neu receptor

Ets2-dependent microenvironmental support of mouse mammary tumors

Targeted disruption of ErbB2/Neu in the mammary epithelium results in impaired ductal outgrowth

Epidermal growth factor receptor-dependent activation of Gab1 is involved in ErbB-2-mediated mammary tumor progression

Mammary epithelial-specific expression of the integrin linked kinase (ILK) results in the induction of mammary gland hyperplasias and tumors in transgenic mice

The induction of uterine leiomyomas and mammary tumors in transgenic mice expressing polyomavirus (PyV) large T (LT) antigen is associated with the ability of PyV LT antigen to form specific complexes with retinoblastoma and CUTL1 family members

Suppression of tumor growth and metastasis in Mgat5-deficient mice

An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis

Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program

Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1

LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis

Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage

The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors

Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

Comparison of the effectiveness of adenovirus vectors expressing cyclin kinase inhibitors p16^INK4A, p18^INK4C, p19^INK4D, p21^WAF1/CIP1 and p27^KIP1 in inducing cell cycle arrest, apoptosis and inhibition of tumorigenicity

Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis

Insights from transgenic mouse models of ERBB2-induced breast cancer

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