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Showing 1–11 of 11 results

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Research | 15 November 2017 | Open
Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome
- Wei Sun
- , Xiao-Lin Kuang
- , Yan-Ping Liu
- , Li-Fei Tian
- , Xiao-Xue Yan
- & Wenqing Xu
Scientific Reports 7 , 1–9

Rights & permissionsfor article Crystal structure of the N-terminal domain of human CDC73 and its implications for the hyperparathyroidism-jaw tumor (HPT-JT) syndrome . Opens in a new window.
Research | 9 April 2020
Structure of M^pro from SARS-CoV-2 and discovery of its inhibitors
- Zhenming Jin
- , Xiaoyu Du
- , Yechun Xu
- , Yongqiang Deng
- , Meiqin Liu
- , Yao Zhao
- , Bing Zhang
- , Xiaofeng Li
- , Leike Zhang
- , Chao Peng
- , Yinkai Duan
- , Jing Yu
- , Lin Wang
- , Kailin Yang
- , Fengjiang Liu
- , Rendi Jiang
- , Xinglou Yang
- , Tian You
- , Xiaoce Liu
- , Xiuna Yang
- , Fang Bai
- , Hong Liu
- , Xiang Liu
- , Luke W. Guddat
- , Wenqing Xu
- , Gengfu Xiao
- , Chengfeng Qin
- , Zhengli Shi
- , Hualiang Jiang
- , Zihe Rao
- & Haitao Yang
Nature 582 , 289–293

Rights & permissionsfor article Structure of M<sup>pro</sup> from SARS-CoV-2 and discovery of its inhibitors . Opens in a new window.
Research | 16 July 2013
Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations
- Wei Sun
- , Ye Julia Zhu
- , Zhizhi Wang
- , Qiang Zhong
- , Feng Gao
- , Jizhong Lou
- , Weimin Gong
- & Wenqing Xu
Nature Communications 4 , 1–8

Rights & permissionsfor article Crystal structure of the yeast TSC1 core domain and implications for tuberous sclerosis pathological mutations . Opens in a new window.
31 July 2015
Structural basis of the Norrin-Frizzled 4 interaction
- Guobo Shen
- , Jiyuan Ke
- , Zhizhi Wang
- , Zhihong Cheng
- , Xin Gu
- , Yuquan Wei
- , Karsten Melcher
- , H Eric Xu
- & Wenqing Xu
Cell Research 25 , 1078–1081

Rights & permissionsfor article Structural basis of the Norrin-Frizzled 4 interaction . Opens in a new window.
Research | 1 November 2006
Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme
- Uhn Soo Cho
- & Wenqing Xu
Nature 445 , 53–57

Rights & permissionsfor article Crystal structure of a protein phosphatase 2A heterotrimeric holoenzyme . Opens in a new window.
Research | 19 November 2001
Tcf4 can specifically recognize β-catenin using alternative conformations
- Thomas A. Graham
- , Denise M. Ferkey
- , Feng Mao
- , David Kimelman
- & Wenqing Xu
Nature Structural & Molecular Biology 8 , 1048–1052

Rights & permissionsfor article Tcf4 can specifically recognize β-catenin using alternative conformations . Opens in a new window.
Research | 20 September 2019
Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors
- Caitlin M. O’Connor
- , Daniel Leonard
- , Danica Wiredja
- , Rita A. Avelar
- , Zhizhi Wang
- , Daniela Schlatzer
- , Benjamin Bryson
- , Eesha Tokala
- , Sarah E. Taylor
- , Aditya Upadhyay
- , Jaya Sangodkar
- , Anne-Claude Gingras
- , Jukka Westermarck
- , Wenqing Xu
- , Analisa DiFeo
- , David L. Brautigan
- , Shozeb Haider
- , Mark Jackson
- & Goutham Narla
Oncogene 39 , 703–717

Rights & permissionsfor article Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors . Opens in a new window.
Research | 3 October 2018
Crystal structure of a membrane-bound O-acyltransferase
- Dan Ma
- , Zhizhi Wang
- , Christopher N. Merrikh
- , Kevin S. Lang
- , Peilong Lu
- , Xin Li
- , Houra Merrikh
- , Zihe Rao
- & Wenqing Xu
Nature 562 , 286–290

Rights & permissionsfor article Crystal structure of a membrane-bound <i>O</i>-acyltransferase . Opens in a new window.
Research | 19 October 2014
Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal
- ...such as Axin and PTEN. Wenqing Xu and colleagues use structural and...
- Paul A. DaRosa
- , Zhizhi Wang
- , Xiaomo Jiang
- , Jonathan N. Pruneda
- , Feng Cong
- , Rachel E. Klevit
- & Wenqing Xu
Nature 517 , 223–226

Rights & permissionsfor article Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal . Opens in a new window.
Research | 9 October 2011
Crystal structures of the extracellular domain of LRP6 and its complex with DKK1
- Zhihong Cheng
- , Travis Biechele
- , Zhiyi Wei
- , Seamus Morrone
- , Randall T Moon
- , Liguo Wang
- & Wenqing Xu
Nature Structural & Molecular Biology 18 , 1204–1210

Rights & permissionsfor article Crystal structures of the extracellular domain of LRP6 and its complex with DKK1 . Opens in a new window.
Research | 13 February 1997
Three-dimensional structure of the tyrosine kinase c-Src
Nature 385 , 595–602

Rights & permissionsfor article Three-dimensional structure of the tyrosine kinase c-Src . Opens in a new window.

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