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News and Views | 19 July 2016
The Itch to degrade ROR-γt
- Sascha Rutz
- & Wenjun Ouyang
Nature Immunology 17 , 898–900

Rights & permissionsfor article The Itch to degrade ROR-γt . Opens in a new window.
Research | 17 October 2012
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine
- Samuel Huber
- , Nicola Gagliani
- , Lauren A. Zenewicz
- , Francis J. Huber
- , Lidia Bosurgi
- , Bo Hu
- , Matija Hedl
- , Wei Zhang
- , William O’Connor
- , Andrew J. Murphy
- , David M. Valenzuela
- , George D. Yancopoulos
- , Carmen J. Booth
- , Judy H. Cho
- , Wenjun Ouyang
- , Clara Abraham
- & Richard A. Flavell
Nature 491 , 259–263

Rights & permissionsfor article IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine . Opens in a new window.
Research | 18 August 2005
ERM is required for transcriptional control of the spermatogonial stem cell niche
- Chen Chen
- , Wenjun Ouyang
- , Vadim Grigura
- , Qing Zhou
- , Kay Carnes
- , Hyunjung Lim
- , Guang-Quan Zhao
- , Silvia Arber
- , Natasza Kurpios
- , Theresa L. Murphy
- , Alec M. Cheng
- , John A. Hassell
- , Varadaraj Chandrashekar
- , Marie-Claude Hofmann
- , Rex A. Hess
- & Kenneth M. Murphy
Nature 436 , 1030–1034

Rights & permissionsfor article ERM is required for transcriptional control of the spermatogonial stem cell niche . Opens in a new window.
Research | 24 December 2006
Interleukin-22, a T_H17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis
- Yan Zheng
- , Dimitry M. Danilenko
- , Patricia Valdez
- , Ian Kasman
- , Jeffrey Eastham-Anderson
- , Jianfeng Wu
- & Wenjun Ouyang
Nature 445 , 648–651

Rights & permissionsfor article Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis . Opens in a new window.
Research | 30 October 2019
The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity
- Jude Canon
- , Karen Rex
- , Anne Y. Saiki
- , Christopher Mohr
- , Keegan Cooke
- , Dhanashri Bagal
- , Kevin Gaida
- , Tyler Holt
- , Charles G. Knutson
- , Neelima Koppada
- , Brian A. Lanman
- , Jonathan Werner
- , Aaron S. Rapaport
- , Tisha San Miguel
- , Roberto Ortiz
- , Tao Osgood
- , Ji-Rong Sun
- , Xiaochun Zhu
- , John D. McCarter
- , Laurie P. Volak
- , Brett E. Houk
- , Marwan G. Fakih
- , Bert H. O’Neil
- , Timothy J. Price
- , Gerald S. Falchook
- , Jayesh Desai
- , James Kuo
- , Ramaswamy Govindan
- , David S. Hong
- , Wenjun Ouyang
- , Haby Henary
- , Tara Arvedson
- , Victor J. Cee
- & J. Russell Lipford
Nature 575 , 217–223

Rights & permissionsfor article The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity . Opens in a new window.
Research | 29 October 2018
Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
- Lei Zhang
- , Xin Yu
- , Liangtao Zheng
- , Yuanyuan Zhang
- , Yansen Li
- , Qiao Fang
- , Ranran Gao
- , Boxi Kang
- , Qiming Zhang
- , Julie Y. Huang
- , Hiroyasu Konno
- , Xinyi Guo
- , Yingjiang Ye
- , Songyuan Gao
- , Shan Wang
- , Xueda Hu
- , Xianwen Ren
- , Zhanlong Shen
- , Wenjun Ouyang
- & Zemin Zhang
Nature 564 , 268–272

Rights & permissionsfor article Lineage tracking reveals dynamic relationships of T cells in colorectal cancer . Opens in a new window.
Research | 1 May 2017
Mice deficient in NRROS show abnormal microglial development and neurological disorders
- Kit Wong
- , Rajkumar Noubade
- , Paolo Manzanillo
- , Naruhisa Ota
- , Oded Foreman
- , Jason A Hackney
- , Brad A Friedman
- , Rajita Pappu
- , Kimberly Scearce-Levie
- & Wenjun Ouyang
Nature Immunology 18 , 633–641

Rights & permissionsfor article Mice deficient in NRROS show abnormal microglial development and neurological disorders . Opens in a new window.
Research | 4 August 2013
Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
- Ansuman T Satpathy
- , Carlos G Briseño
- , Jacob S Lee
- , Dennis Ng
- , Nicholas A Manieri
- , Wumesh KC
- , Xiaodi Wu
- , Stephanie R Thomas
- , Wan-Ling Lee
- , Mustafa Turkoz
- , Keely G McDonald
- , Matthew M Meredith
- , Christina Song
- , Cynthia J Guidos
- , Rodney D Newberry
- , Wenjun Ouyang
- , Theresa L Murphy
- , Thaddeus S Stappenbeck
- , Jennifer L Gommerman
- , Michel C Nussenzweig
- , Marco Colonna
- , Raphael Kopan
- & Kenneth M Murphy
Nature Immunology 14 , 937–948

Rights & permissionsfor article Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens . Opens in a new window.
Reviews | 25 November 2014
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
Nature Reviews Immunology 14 , 783–795

Rights & permissionsfor article The IL-20 subfamily of cytokines — from host defence to tissue homeostasis . Opens in a new window.
Research | 6 August 2014
Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes
- Xiaoting Wang
- , Naruhisa Ota
- , Paolo Manzanillo
- , Lance Kates
- , Jose Zavala-Solorio
- , Celine Eidenschenk
- , Juan Zhang
- , Justin Lesch
- , Wyne P. Lee
- , Jed Ross
- , Lauri Diehl
- , Nicholas van Bruggen
- , Ganesh Kolumam
- & Wenjun Ouyang
Nature 514 , 237–241

Rights & permissionsfor article Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes . Opens in a new window.
Research | 4 August 2013
An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
- Alicia S Chung
- , Xiumin Wu
- , Guanglei Zhuang
- , Hai Ngu
- , Ian Kasman
- , Jianhuan Zhang
- , Jean-Michel Vernes
- , Zhaoshi Jiang
- , Y Gloria Meng
- , Franklin V Peale
- , Wenjun Ouyang
- & Napoleone Ferrara
Nature Medicine 19 , 1114–1123

Rights & permissionsfor article An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy . Opens in a new window.
Reviews | 31 December 2013
Therapeutic opportunities of the IL-22–IL-22R1 system
Nature Reviews Drug Discovery 13 , 21–38

Rights & permissionsfor article Therapeutic opportunities of the IL-22–IL-22R1 system . Opens in a new window.
Research | 23 June 2013
Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus
- Ian A Myles
- , Natalia M Fontecilla
- , Patricia A Valdez
- , Paul J Vithayathil
- , Shruti Naik
- , Yasmine Belkaid
- , Wenjun Ouyang
- & Sandip K Datta
Nature Immunology 14 , 804–811

Rights & permissionsfor article Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus . Opens in a new window.
Research | 13 April 2014
NRROS negatively regulates reactive oxygen species during host defence and autoimmunity
- Rajkumar Noubade
- , Kit Wong
- , Naruhisa Ota
- , Sascha Rutz
- , Celine Eidenschenk
- , Patricia A. Valdez
- , Jiabing Ding
- , Ivan Peng
- , Andrew Sebrell
- , Patrick Caplazi
- , Jason DeVoss
- , Robert H. Soriano
- , Tao Sai
- , Rongze Lu
- , Zora Modrusan
- , Jason Hackney
- & Wenjun Ouyang
Nature 509 , 235–239

Rights & permissionsfor article NRROS negatively regulates reactive oxygen species during host defence and autoimmunity . Opens in a new window.
Research | 3 December 2014
Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells
- Sascha Rutz
- , Nobuhiko Kayagaki
- , Qui T. Phung
- , Celine Eidenschenk
- , Rajkumar Noubade
- , Xiaoting Wang
- , Justin Lesch
- , Rongze Lu
- , Kim Newton
- , Oscar W. Huang
- , Andrea G. Cochran
- , Mark Vasser
- , Benjamin P. Fauber
- , Jason DeVoss
- , Joshua Webster
- , Lauri Diehl
- , Zora Modrusan
- , Donald S. Kirkpatrick
- , Jennie R. Lill
- , Wenjun Ouyang
- & Vishva M. Dixit
Nature 518 , 417–421

Rights & permissionsfor article Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells . Opens in a new window.
Research | 1 February 2001
IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
- Jianfei Yang
- , Hong Zhu
- , Theresa L. Murphy
- , Wenjun Ouyang
- & Kenneth M. Murphy
Nature Immunology 2 , 157–164

Rights & permissionsfor article IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production . Opens in a new window.
Research | 2 December 2012
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90
- Chenhui Wang
- , Ling Wu
- , Katarzyna Bulek
- , Bradley N Martin
- , Jarod A Zepp
- , Zizhen Kang
- , Caini Liu
- , Tomasz Herjan
- , Saurav Misra
- , Julie A Carman
- , Ji Gao
- , Ashok Dongre
- , Shujie Han
- , Kevin D Bunting
- , Jennifer S Ko
- , Hui Xiao
- , Vijay K Kuchroo
- , Wenjun Ouyang
- & Xiaoxia Li
Nature Immunology 14 , 72–81

Rights & permissionsfor article The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 . Opens in a new window.
Research | 10 February 2008
Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
- Yan Zheng
- , Patricia A Valdez
- , Dimitry M Danilenko
- , Yan Hu
- , Susan M Sa
- , Qian Gong
- , Alexander R Abbas
- , Zora Modrusan
- , Nico Ghilardi
- , Frederic J de Sauvage
- & Wenjun Ouyang
Nature Medicine 14 , 282–289

Rights & permissionsfor article Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens . Opens in a new window.
Research | 16 October 2011
Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T_H17 cells
- Sascha Rutz
- , Rajkumar Noubade
- , Céline Eidenschenk
- , Naruhisa Ota
- , Wenwen Zeng
- , Yan Zheng
- , Jason Hackney
- , Jiabing Ding
- , Harinder Singh
- & Wenjun Ouyang
Nature Immunology 12 , 1238–1245

Rights & permissionsfor article Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in TH17 cells . Opens in a new window.
Research | 12 October 2011
IL-17C regulates the innate immune function of epithelial cells in an autocrine manner
- Vladimir Ramirez-Carrozzi
- , Arivazhagan Sambandam
- , Elizabeth Luis
- , Zhongua Lin
- , Surinder Jeet
- , Justin Lesch
- , Jason Hackney
- , Janice Kim
- , Meijuan Zhou
- , Joyce Lai
- , Zora Modrusan
- , Tao Sai
- , Wyne Lee
- , Min Xu
- , Patrick Caplazi
- , Lauri Diehl
- , Jason de Voss
- , Mercedesz Balazs
- , Lino Gonzalez Jr
- , Harinder Singh
- , Wenjun Ouyang
- & Rajita Pappu
Nature Immunology 12 , 1159–1166

Rights & permissionsfor article IL-17C regulates the innate immune function of epithelial cells in an autocrine manner . Opens in a new window.
Research | 28 August 2011
IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium
- Naruhisa Ota
- , Kit Wong
- , Patricia A Valdez
- , Yan Zheng
- , Natasha K Crellin
- , Lauri Diehl
- & Wenjun Ouyang
Nature Immunology 12 , 941–948

Rights & permissionsfor article IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium . Opens in a new window.

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The Itch to degrade ROR-γt

IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine

ERM is required for transcriptional control of the spermatogonial stem cell niche

Interleukin-22, a T_H17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Lineage tracking reveals dynamic relationships of T cells in colorectal cancer

Mice deficient in NRROS show abnormal microglial development and neurological disorders

Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens

The IL-20 subfamily of cytokines — from host defence to tissue homeostasis

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

Therapeutic opportunities of the IL-22–IL-22R1 system

Signaling via the IL-20 receptor inhibits cutaneous production of IL-1β and IL-17A to promote infection with methicillin-resistant Staphylococcus aureus

NRROS negatively regulates reactive oxygen species during host defence and autoimmunity

Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells

IL-18–stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens

Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T_H17 cells

IL-17C regulates the innate immune function of epithelial cells in an autocrine manner

IL-22 bridges the lymphotoxin pathway with the maintenance of colonic lymphoid structures during infection with Citrobacter rodentium

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