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Amendments and Corrections | 21 April 2015
Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
- Ajithkumar Vasanthakumar
- , Kazuyo Moro
- , Annie Xin
- , Yang Liao
- , Renee Gloury
- , Shimpei Kawamoto
- , Sidonia Fagarasan
- , Lisa A Mielke
- , Shoukat Afshar-Sterle
- , Seth L Masters
- , Susumu Nakae
- , Hirohisa Saito
- , John M Wentworth
- , Peng Li
- , Wei Liao
- , Warren J Leonard
- , Gordon K Smyth
- , Wei Shi
- , Stephen L Nutt
- , Shigeo Koyasu
- & Axel Kallies
Nature Immunology 16 , 544–544

Rights & permissionsfor article Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells . Opens in a new window.
Amendments and Corrections | 16 September 2014
Correction: Autoimmunity: Regulatory B cells—IL-35 and IL-21 regulate the regulators
- Thomas F. Tedder
- & Warren J. Leonard
Nature Reviews Rheumatology 10 , 636–636

Rights & permissionsfor article Correction: Autoimmunity: Regulatory B cells—IL-35 and IL-21 regulate the regulators . Opens in a new window.
News and Views | 19 April 2016
JAK3 inhibition—is it sufficient?
Nature Chemical Biology 12 , 308–310

Rights & permissionsfor article JAK3 inhibition—is it sufficient? . Opens in a new window.
News and Views | 17 June 2014
Regulatory B cells—IL-35 and IL-21 regulate the regulators
- Thomas F. Tedder
- & Warren J. Leonard
Nature Reviews Rheumatology 10 , 452–453

Rights & permissionsfor article Regulatory B cells—IL-35 and IL-21 regulate the regulators . Opens in a new window.
News and Views | 1 September 1996
STATs and cytokine specificity
- Warren J. Leonard
Nature Medicine 2 , 968–969

Rights & permissionsfor article STATs and cytokine specificity . Opens in a new window.
News and Views | 1 July 2002
TSLP: finally in the limelight
- Warren J. Leonard
Nature Immunology 3 , 605–607

Rights & permissionsfor article TSLP: finally in the limelight . Opens in a new window.
Research | 19 March 2020 | Open
Transcription factor p73 regulates Th1 differentiation
- Min Ren
- , Majid Kazemian
- , Ming Zheng
- , JianPing He
- , Peng Li
- , Jangsuk Oh
- , Wei Liao
- , Jessica Li
- , Jonathan Rajaseelan
- , Brian L. Kelsall
- , Gary Peltz
- & Warren J. Leonard
Nature Communications 11 , 1–12

Rights & permissionsfor article Transcription factor p73 regulates Th1 differentiation . Opens in a new window.
Research | 18 November 1982
A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor
Nature 300 , 267–269

Rights & permissionsfor article A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor . Opens in a new window.
Research | 19 September 2012
BATF–JUN is critical for IRF4-mediated transcription in T cells
- Peng Li
- , Rosanne Spolski
- , Wei Liao
- , Lu Wang
- , Theresa L. Murphy
- , Kenneth M. Murphy
- & Warren J. Leonard
Nature 490 , 543–546

Rights & permissionsfor article BATF–JUN is critical for IRF4-mediated transcription in T cells . Opens in a new window.
Research | 26 May 1994
Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling
Nature 369 , 330–333

Rights & permissionsfor article Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling . Opens in a new window.
Research | 1 July 2000
Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin
- Akhilesh Pandey
- , Katsutoshi Ozaki
- , Heinz Baumann
- , Steven D. Levin
- , Anne Puel
- , Andrew G. Farr
- , Steven F. Ziegler
- , Warren J. Leonard
- & Harvey F. Lodish
Nature Immunology 1 , 59–64

Rights & permissionsfor article Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin . Opens in a new window.
Research | 1 December 1998
Defective IL7R expression in T^-B⁺NK⁺ severe combined immunodeficiency
Nature Genetics 20 , 394–397

Rights & permissionsfor article Defective IL7R expression in T-B+NK+ severe combined immunodeficiency . Opens in a new window.
Reviews | 8 August 2018
Biology and regulation of IL-2: from molecular mechanisms to human therapy
Nature Reviews Immunology 18 , 648–659

Rights & permissionsfor article Biology and regulation of IL-2: from molecular mechanisms to human therapy . Opens in a new window.
Research | 16 July 2018 | Open
Act1 is a negative regulator in T and B cells via direct inhibition of STAT3
- Cun-Jin Zhang
- , Chenhui Wang
- , Meiling Jiang
- , Chunfang Gu
- , Jianxin Xiao
- , Xing Chen
- , Bradley N. Martin
- , Fangqiang Tang
- , Erin Yamamoto
- , Yibo Xian
- , Han Wang
- , Fengling Li
- , R. Balfour Sartor
- , Howard Smith
- , M. Elaine Husni
- , Fu-Dong Shi
- , Ji Gao
- , Julie Carman
- , Ashok Dongre
- , Susan C. McKarns
- , Ken Coppieters
- , Trine N. Jørgensen
- , Warren J. Leonard
- & Xiaoxia Li
Nature Communications 9 , 1–14

Rights & permissionsfor article Act1 is a negative regulator in T and B cells via direct inhibition of STAT3 . Opens in a new window.
Research | 7 August 2018 | Open
Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity
- Hyeseon Cho
- , Henrique Jaime
- , Rafael Pires de Oliveira
- , Byunghyun Kang
- , Rosanne Spolski
- , Tina Vaziri
- , Timothy G. Myers
- , Vishal Thovarai
- , Zeli Shen
- , James G. Fox
- , Warren J. Leonard
- & Brian L. Kelsall
Mucosal Immunology 12 , 85–96

Rights & permissionsfor article Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity . Opens in a new window.
Research | 6 November 2017 | Open
Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells
- Jian-Xin Lin
- , Ning Du
- , Peng Li
- , Majid Kazemian
- , Tesfay Gebregiorgis
- , Rosanne Spolski
- & Warren J. Leonard
Nature Communications 8 , 1–12

Rights & permissionsfor article Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells . Opens in a new window.
Research | 9 May 2016
BACH2 regulates CD8⁺ T cell differentiation by controlling access of AP-1 factors to enhancers
- Rahul Roychoudhuri
- , David Clever
- , Peng Li
- , Yoshiyuki Wakabayashi
- , Kylie M Quinn
- , Christopher A Klebanoff
- , Yun Ji
- , Madhusudhanan Sukumar
- , Robert L Eil
- , Zhiya Yu
- , Rosanne Spolski
- , Douglas C Palmer
- , Jenny H Pan
- , Shashank J Patel
- , Derek C Macallan
- , Giulia Fabozzi
- , Han-Yu Shih
- , Yuka Kanno
- , Akihiko Muto
- , Jun Zhu
- , Luca Gattinoni
- , John J O'Shea
- , Klaus Okkenhaug
- , Kazuhiko Igarashi
- , Warren J Leonard
- & Nicholas P Restifo
Nature Immunology 17 , 851–860

Rights & permissionsfor article BACH2 regulates CD8+ T cell differentiation by controlling access of AP-1 factors to enhancers . Opens in a new window.
Research | 7 March 2016
A molecular threshold for effector CD8⁺ T cell differentiation controlled by transcription factors Blimp-1 and T-bet
- Annie Xin
- , Frederick Masson
- , Yang Liao
- , Simon Preston
- , Tianxia Guan
- , Renee Gloury
- , Moshe Olshansky
- , Jian-Xin Lin
- , Peng Li
- , Terence P Speed
- , Gordon K Smyth
- , Matthias Ernst
- , Warren J Leonard
- , Marc Pellegrini
- , Susan M Kaech
- , Stephen L Nutt
- , Wei Shi
- , Gabrielle T Belz
- & Axel Kallies
Nature Immunology 17 , 422–432

Rights & permissionsfor article A molecular threshold for effector CD8+ T cell differentiation controlled by transcription factors Blimp-1 and T-bet . Opens in a new window.
Research | 19 January 2015
The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells
- Ajithkumar Vasanthakumar
- , Kazuyo Moro
- , Annie Xin
- , Yang Liao
- , Renee Gloury
- , Shimpei Kawamoto
- , Sidonia Fagarasan
- , Lisa A Mielke
- , Shoukat Afshar-Sterle
- , Seth L Masters
- , Susumu Nakae
- , Hirohisa Saito
- , John M Wentworth
- , Peng Li
- , Wei Liao
- , Warren J Leonard
- , Gordon K Smyth
- , Wei Shi
- , Stephen L Nutt
- , Shigeo Koyasu
- & Axel Kallies
Nature Immunology 16 , 276–285

Rights & permissionsfor article The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells . Opens in a new window.
Research | 13 August 2015 | Open
IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells
- Chi-Keung Wan
- , Peng Li
- , Rosanne Spolski
- , Jangsuk Oh
- , Allison B. Andraski
- , Ning Du
- , Zu-Xi Yu
- , Christopher P. Dillon
- , Douglas R. Green
- & Warren J. Leonard
Nature Communications 6 , 1–12

Rights & permissionsfor article IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells . Opens in a new window.
Reviews | 22 April 2014
Interleukin-21: a double-edged sword with therapeutic potential
- Rosanne Spolski
- & Warren J. Leonard
Nature Reviews Drug Discovery 13 , 379–395

Rights & permissionsfor article Interleukin-21: a double-edged sword with therapeutic potential . Opens in a new window.
Research | 28 September 2008
Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression
- Wei Liao
- , Dustin E Schones
- , Jangsuk Oh
- , Yongzhi Cui
- , Kairong Cui
- , Tae-Young Roh
- , Keji Zhao
- & Warren J Leonard
Nature Immunology 9 , 1288–1296

Rights & permissionsfor article Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression . Opens in a new window.
Research | 18 October 1984
Molecular cloning and expression of cDNAs for the human interleukin-2 receptor
Nature 311 , 626–631

Rights & permissionsfor article Molecular cloning and expression of cDNAs for the human interleukin-2 receptor . Opens in a new window.
Reviews | 1 September 2005
Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
- Warren J. Leonard
- & Rosanne Spolski
Nature Reviews Immunology 5 , 688–698

Rights & permissionsfor article Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation . Opens in a new window.
Reviews | 1 December 2001
Cytokines and immunodeficiency diseases
- Warren J. Leonard
Nature Reviews Immunology 1 , 200–208

Rights & permissionsfor article Cytokines and immunodeficiency diseases . Opens in a new window.
Reviews | 1 July 2009
New insights into the regulation of T cells by γ_c family cytokines
Nature Reviews Immunology 9 , 480–490

Rights & permissionsfor article New insights into the regulation of T cells by γc family cytokines . Opens in a new window.
Research | 24 April 2011
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages
- Wei Liao
- , Jian-Xin Lin
- , Lu Wang
- , Peng Li
- & Warren J Leonard
Nature Immunology 12 , 551–559

Rights & permissionsfor article Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages . Opens in a new window.
Research | 14 October 2012
Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions
Nature 491 , 264–268

Rights & permissionsfor article Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions . Opens in a new window.
25 May 2000
The role of Stat5a and Stat5b in signaling by IL-2 family cytokines
- Jian-Xin Lin
- & Warren J Leonard
Oncogene 19 , 2566–2576

Rights & permissionsfor article The role of Stat5a and Stat5b in signaling by IL-2 family cytokines . Opens in a new window.
Research | 7 September 2004
GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells
- Hai-Hui Xue
- , Julie Bollenbacher
- , Valentina Rovella
- , Radhika Tripuraneni
- , Yu-Bin Du
- , Cheng-Yu Liu
- , Ann Williams
- , J Philip McCoy
- & Warren J Leonard
Nature Immunology 5 , 1036–1044

Rights & permissionsfor article GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells . Opens in a new window.
Research | 20 June 2007
IL-6 programs T_H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
- Liang Zhou
- , Ivaylo I Ivanov
- , Rosanne Spolski
- , Roy Min
- , Kevin Shenderov
- , Takeshi Egawa
- , David E Levy
- , Warren J Leonard
- & Dan R Littman
Nature Immunology 8 , 967–974

Rights & permissionsfor article IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways . Opens in a new window.
Research | 28 October 2012
Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15
- Aaron M Ring
- , Jian-Xin Lin
- , Dan Feng
- , Suman Mitra
- , Mathias Rickert
- , Gregory R Bowman
- , Vijay S Pande
- , Peng Li
- , Ignacio Moraga
- , Rosanne Spolski
- , Engin Özkan
- , Warren J Leonard
- & K Christopher Garcia
Nature Immunology 13 , 1187–1195

Rights & permissionsfor article Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15 . Opens in a new window.
Research | 19 September 2012
Compensatory dendritic cell development mediated by BATF–IRF interactions
- Roxane Tussiwand
- , Wan-Ling Lee
- , Theresa L. Murphy
- , Mona Mashayekhi
- , Wumesh KC
- , Jörn C. Albring
- , Ansuman T. Satpathy
- , Jeffrey A. Rotondo
- , Brian T. Edelson
- , Nicole M. Kretzer
- , Xiaodi Wu
- , Leslie A. Weiss
- , Elke Glasmacher
- , Peng Li
- , Wei Liao
- , Michael Behnke
- , Samuel S. K. Lam
- , Cora T. Aurthur
- , Warren J. Leonard
- , Harinder Singh
- , Christina L. Stallings
- , L. David Sibley
- , Robert D. Schreiber
- & Kenneth M. Murphy
Nature 490 , 502–507

Rights & permissionsfor article Compensatory dendritic cell development mediated by BATF–IRF interactions . Opens in a new window.

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Erratum: The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

Correction: Autoimmunity: Regulatory B cells—IL-35 and IL-21 regulate the regulators

JAK3 inhibition—is it sufficient?

Regulatory B cells—IL-35 and IL-21 regulate the regulators

STATs and cytokine specificity

TSLP: finally in the limelight

Transcription factor p73 regulates Th1 differentiation

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

BATF–JUN is critical for IRF4-mediated transcription in T cells

Heterodimerization of the IL-2 receptor β- and γ-chain cytoplasmic domains is required for signalling

Cloning of a receptor subunit required for signaling by thymic stromal lymphopoietin

Defective IL7R expression in T^-B⁺NK⁺ severe combined immunodeficiency

Biology and regulation of IL-2: from molecular mechanisms to human therapy

Act1 is a negative regulator in T and B cells via direct inhibition of STAT3

Defective IgA response to atypical intestinal commensals in IL-21 receptor deficiency reshapes immune cell homeostasis and mucosal immunity

Critical functions for STAT5 tetramers in the maturation and survival of natural killer cells

BACH2 regulates CD8⁺ T cell differentiation by controlling access of AP-1 factors to enhancers

A molecular threshold for effector CD8⁺ T cell differentiation controlled by transcription factors Blimp-1 and T-bet

The transcriptional regulators IRF4, BATF and IL-33 orchestrate development and maintenance of adipose tissue–resident regulatory T cells

IL-21-mediated non-canonical pathway for IL-1β production in conventional dendritic cells

Interleukin-21: a double-edged sword with therapeutic potential

Priming for T helper type 2 differentiation by interleukin 2–mediated induction of interleukin 4 receptor α-chain expression

Molecular cloning and expression of cDNAs for the human interleukin-2 receptor

Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation

Cytokines and immunodeficiency diseases

New insights into the regulation of T cells by γ_c family cytokines

Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages

Regulatory B cells control T-cell autoimmunity through IL-21-dependent cognate interactions

The role of Stat5a and Stat5b in signaling by IL-2 family cytokines

GA binding protein regulates interleukin 7 receptor α-chain gene expression in T cells

IL-6 programs T_H-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15

Compensatory dendritic cell development mediated by BATF–IRF interactions

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