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2 November 2020 | Open
Resolving individual atoms of protein complex by cryo-electron microscopy
- Kaiming Zhang
- , Grigore D. Pintilie
- , Shanshan Li
- , Michael F. Schmid
- & Wah Chiu
Cell Research 30 , 1136–1139

Rights & permissionsfor article Resolving individual atoms of protein complex by cryo-electron microscopy . Opens in a new window.
Amendments and Corrections | 28 August 2020 | Open
Publisher Correction: A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
- Stefan L. Oliver
- , Yi Xing
- , Dong-Hua Chen
- , Soung Hun Roh
- , Grigore D. Pintilie
- , David A. Bushnell
- , Marvin H. Sommer
- , Edward Yang
- , Andrea Carfi
- , Wah Chiu
- & Ann M. Arvin
Nature Communications 11 , 1–1

Rights & permissionsfor article Publisher Correction: A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation . Opens in a new window.
Research | 7 September 2020 | Open
Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells
- Aaron M. Muscarella
- , Wei Dai
- , Patrick G. Mitchell
- , Weijie Zhang
- , Hai Wang
- , Luyu Jia
- , Fabio Stossi
- , Michael A. Mancini
- , Wah Chiu
- & Xiang H.-F. Zhang
npj Breast Cancer 6 , 1–12

Rights & permissionsfor article Unique cellular protrusions mediate breast cancer cell migration by tethering to osteogenic cells . Opens in a new window.
Amendments and Corrections | 12 January 2015
Correction: Corrigendum: Protruding knob-like proteins violate local symmetries in an icosahedral marine virus
Nature Communications 6 , 1–1

Rights & permissionsfor article Correction: Corrigendum: Protruding knob-like proteins violate local symmetries in an icosahedral marine virus . Opens in a new window.
Amendments and Corrections | 29 October 2015 | Open
Erratum: Structural diversity of supercoiled DNA
Nature Communications 6 , 1–1

Rights & permissionsfor article Erratum: Structural diversity of supercoiled DNA . Opens in a new window.
Research | 18 August 2020 | Open
A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation
- Stefan L. Oliver
- , Yi Xing
- , Dong-Hua Chen
- , Soung Hun Roh
- , Grigore D. Pintilie
- , David A. Bushnell
- , Marvin H. Sommer
- , Edward Yang
- , Andrea Carfi
- , Wah Chiu
- & Ann M. Arvin
Nature Communications 11 , 1–15

Rights & permissionsfor article A glycoprotein B-neutralizing antibody structure at 2.8 Å uncovers a critical domain for herpesvirus fusion initiation . Opens in a new window.
Research | 3 December 2019 | Open
Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution
- Kaiming Zhang
- , Shanshan Li
- , Kalli Kappel
- , Grigore Pintilie
- , Zhaoming Su
- , Tung-Chung Mou
- , Michael F. Schmid
- , Rhiju Das
- & Wah Chiu
Nature Communications 10 , 1–6

Rights & permissionsfor article Cryo-EM structure of a 40 kDa SAM-IV riboswitch RNA at 3.7 Å resolution . Opens in a new window.
Research | 2 July 2020
Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures
- Kalli Kappel
- , Kaiming Zhang
- , Zhaoming Su
- , Andrew M. Watkins
- , Wipapat Kladwang
- , Shanshan Li
- , Grigore Pintilie
- , Ved V. Topkar
- , Ramya Rangan
- , Ivan N. Zheludev
- , Joseph D. Yesselman
- , Wah Chiu
- & Rhiju Das
Nature Methods 17 , 699–707

Rights & permissionsfor article Accelerated cryo-EM-guided determination of three-dimensional RNA-only structures . Opens in a new window.
Research | 27 February 2019 | Open
Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry
- Minghui Guo
- , Kaiming Zhang
- , Yuwei Zhu
- , Grigore D. Pintilie
- , Xiaoyu Guan
- , Shanshan Li
- , Michael F. Schmid
- , Zhuo Ma
- , Wah Chiu
- & Zhiwei Huang
Cell Research 29 , 305–312

Rights & permissionsfor article Coupling of ssRNA cleavage with DNase activity in type III-A CRISPR-Csm revealed by cryo-EM and biochemistry . Opens in a new window.
29 August 2017
Protocol for Convolutional Neural Networks based Automated Cellular Cryo-Electron Tomograms Annotation
- Chen Muyuan
- , Wei Dai
- , Sun Stella Y.
- , Jonasch Darius
- , He Cynthia Y.
- , Schmid Michael F.
- , Chiu Wah
- & Ludtke Steven J.
Protocol Exchange

Rights & permissionsfor article Protocol for Convolutional Neural Networks based Automated Cellular Cryo-Electron Tomograms Annotation . Opens in a new window.
Research | 20 February 2020 | Open
Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy
- Sijin Guo
- , Mario Vieweger
- , Kaiming Zhang
- , Hongran Yin
- , Hongzhi Wang
- , Xin Li
- , Shanshan Li
- , Shuiying Hu
- , Alex Sparreboom
- , B. Mark Evers
- , Yizhou Dong
- , Wah Chiu
- & Peixuan Guo
Nature Communications 11 , 1–11

Rights & permissionsfor article Ultra-thermostable RNA nanoparticles for solubilizing and high-yield loading of paclitaxel for breast cancer therapy . Opens in a new window.
Research | 26 February 2020 | Open
Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1
- Levi J. McClelland
- , Kaiming Zhang
- , Tung-Chung Mou
- , Jake Johnston
- , Cindee Yates-Hansen
- , Shanshan Li
- , Celestine J. Thomas
- , Tzanko I. Doukov
- , Sarah Triest
- , Alexandre Wohlkonig
- , Gregory G. Tall
- , Jan Steyaert
- , Wah Chiu
- & Stephen R. Sprang
Nature Communications 11 , 1–10

Rights & permissionsfor article Structure of the G protein chaperone and guanine nucleotide exchange factor Ric-8A bound to Gαi1 . Opens in a new window.
7 October 2014 | Open
A 3D cellular context for the macromolecular world
- Ardan Patwardhan
- , Alun Ashton
- , Robert Brandt
- , Sarah Butcher
- , Raffaella Carzaniga
- , Wah Chiu
- , Lucy Collinson
- , Pascal Doux
- , Elizabeth Duke
- , Mark H Ellisman
- , Erik Franken
- , Kay Grünewald
- , Jean-Karim Heriche
- , Abraham Koster
- , Werner Kühlbrandt
- , Ingvar Lagerstedt
- , Carolyn Larabell
- , Catherine L Lawson
- , Helen R Saibil
- , Eduardo Sanz-García
- , Sriram Subramaniam
- , Paul Verkade
- , Jason R Swedlow
- & Gerard J Kleywegt
Nature Structural & Molecular Biology 21 , 841–845

Rights & permissionsfor article A 3D cellular context for the macromolecular world . Opens in a new window.
Research | 9 October 2013
Visualizing virus assembly intermediates inside marine cyanobacteria
- Wah Chiu and colleagues report the first...
- Wei Dai
- , Caroline Fu
- , Desislava Raytcheva
- , John Flanagan
- , Htet A. Khant
- , Xiangan Liu
- , Ryan H. Rochat
- , Cameron Haase-Pettingell
- , Jacqueline Piret
- , Steve J. Ludtke
- , Kuniaki Nagayama
- , Michael F. Schmid
- , Jonathan A. King
- & Wah Chiu
Nature 502 , 707–710

Rights & permissionsfor article Visualizing virus assembly intermediates inside marine cyanobacteria . Opens in a new window.
Research | 24 November 2013
Reprogramming an ATP-driven protein machine into a light-gated nanocage
- Daniel Hoersch
- , Soung-Hun Roh
- , Wah Chiu
- & Tanja Kortemme
Nature Nanotechnology 8 , 928–932

Rights & permissionsfor article Reprogramming an ATP-driven protein machine into a light-gated nanocage . Opens in a new window.
Research | 10 February 2020
Measurement of atom resolvability in cryo-EM maps with Q-scores
- Grigore Pintilie
- , Kaiming Zhang
- , Zhaoming Su
- , Shanshan Li
- , Michael F. Schmid
- & Wah Chiu
Nature Methods 17 , 328–334

Rights & permissionsfor article Measurement of atom resolvability in cryo-EM maps with <i>Q</i>-scores . Opens in a new window.
Research | 28 January 2020 | Open
TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential
- Hanzhi Zhang
- , Yaping Pan
- , Liya Hu
- , M. Ashley Hudson
- , Katrina S. Hofstetter
- , Zhichun Xu
- , Mingqiang Rong
- , Zhao Wang
- , B. V. Venkataram Prasad
- , Steve W. Lockless
- , Wah Chiu
- & Ming Zhou
Nature Communications 11 , 1–11

Rights & permissionsfor article TrkA undergoes a tetramer-to-dimer conversion to open TrkH which enables changes in membrane potential . Opens in a new window.
Research | 21 January 2010
Mechanism of folding chamber closure in a group II chaperonin
- ...domain. In this study, Wah Chiu and colleagues determine the cryo...
- Junjie Zhang
- , Matthew L. Baker
- , Gunnar F. Schröder
- , Nicholai R. Douglas
- , Stefanie Reissmann
- , Joanita Jakana
- , Matthew Dougherty
- , Caroline J. Fu
- , Michael Levitt
- , Steven J. Ludtke
- , Judith Frydman
- & Wah Chiu
Nature 463 , 379–383

Rights & permissionsfor article Mechanism of folding chamber closure in a group II chaperonin . Opens in a new window.
Research | 21 January 2003
Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions
- Wen Jiang
- , Zongli Li
- , Zhixian Zhang
- , Matthew L. Baker
- , Peter E. Prevelige Jr.
- & Wah Chiu
Nature Structural & Molecular Biology 10 , 131–135

Rights & permissionsfor article Coat protein fold and maturation transition of bacteriophage P22 seen at subnanometer resolutions . Opens in a new window.
Research | 1 October 2001
Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus
- Z. Hong Zhou
- , Matthew L. Baker
- , Wen Jiang
- , Matthew Dougherty
- , Joanita Jakana
- , Gang Dong
- , Guangying Lu
- & Wah Chiu
Nature Structural & Molecular Biology 8 , 868–873

Rights & permissionsfor article Electron cryomicroscopy and bioinformatics suggest protein fold models for rice dwarf virus . Opens in a new window.
15 June 2010
Reconstructing Cyano-bacteriophage P-SSP7 structure without imposing symmetry
- Liu Xiangan
- , Rochat Ryan H.
- & Chiu Wah
Protocol Exchange

Rights & permissionsfor article Reconstructing Cyano-bacteriophage P-SSP7 structure without imposing symmetry . Opens in a new window.
Research | 28 February 2008
Backbone structure of the infectious ε15 virus capsid revealed by electron cryomicroscopy
- Wen Jiang
- , Matthew L. Baker
- , Joanita Jakana
- , Peter R. Weigele
- , Jonathan King
- & Wah Chiu
Nature 451 , 1130–1134

Rights & permissionsfor article Backbone structure of the infectious ε15 virus capsid revealed by electron cryomicroscopy . Opens in a new window.
Research | 2 September 2004
Structure of the acrosomal bundle
Nature 431 , 104–107

Rights & permissionsfor article Structure of the acrosomal bundle . Opens in a new window.
Research | 2 February 2006
Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus
- Wen Jiang
- , Juan Chang
- , Joanita Jakana
- , Peter Weigele
- , Jonathan King
- & Wah Chiu
Nature 439 , 612–616

Rights & permissionsfor article Structure of epsilon15 bacteriophage reveals genome organization and DNA packaging/injection apparatus . Opens in a new window.
Research | 1 June 1996
Two structural configurations of the skeletal muscle calcium release channel
Nature Structural & Molecular Biology 3 , 547–552

Rights & permissionsfor article Two structural configurations of the skeletal muscle calcium release channel . Opens in a new window.
News and Views | 1 May 1997
Pushing back the limits of electron cryomicroscopy
- Wah Chiu
- & Michael F. Schmid
Nature Structural & Molecular Biology 4 , 331–333

Rights & permissionsfor article Pushing back the limits of electron cryomicroscopy . Opens in a new window.
Research | 1 November 1995
Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids
- Z. Hong Zhou
- , Jing He
- , Joanita Jakana
- , Jacqueline D. Tatman
- , Frazer J. Rixon
- & Wah Chiu
Nature Structural & Molecular Biology 2 , 1026–1030

Rights & permissionsfor article Assembly of VP26 in herpes simplex virus-1 inferred from structures of wild-type and recombinant capsids . Opens in a new window.
1 January 1995
Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel
Nature Structural & Molecular Biology 2 , 18–24

Rights & permissionsfor article Electron cryomicroscopy and angular reconstitution used to visualize the skeletal muscle calcium release channel . Opens in a new window.
Research | 18 November 2019
Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions
- Shuang Li
- , Zhaoming Su
- , Jean Lehmann
- , Vassiliki Stamatopoulou
- , Nikoleta Giarimoglou
- , Frances E. Henderson
- , Lixin Fan
- , Grigore D. Pintilie
- , Kaiming Zhang
- , Muyuan Chen
- , Steven J. Ludtke
- , Yun-Xing Wang
- , Constantinos Stathopoulos
- , Wah Chiu
- & Jinwei Zhang
Nature Structural & Molecular Biology 26 , 1094–1105

Rights & permissionsfor article Structural basis of amino acid surveillance by higher-order tRNA-mRNA interactions . Opens in a new window.
Research | 31 December 2018
Structures of TRPV2 in distinct conformations provide insight into role of the pore turret
- Timothy L. Dosey
- , Zhao Wang
- , Guizhen Fan
- , Zhixian Zhang
- , Irina I. Serysheva
- , Wah Chiu
- & Theodore G. Wensel
Nature Structural & Molecular Biology 26 , 40–49

Rights & permissionsfor article Structures of TRPV2 in distinct conformations provide insight into role of the pore turret . Opens in a new window.
Research | 2 November 2018 | Open
Programming molecular topologies from single-stranded nucleic acids
- Xiaodong Qi
- , Fei Zhang
- , Zhaoming Su
- , Shuoxing Jiang
- , Dongran Han
- , Baoquan Ding
- , Yan Liu
- , Wah Chiu
- , Peng Yin
- & Hao Yan
Nature Communications 9 , 1–9

Rights & permissionsfor article Programming molecular topologies from single-stranded nucleic acids . Opens in a new window.
Research | 28 August 2017
Convolutional neural networks for automated annotation of cellular cryo-electron tomograms
- Muyuan Chen
- , Wei Dai
- , Stella Y Sun
- , Darius Jonasch
- , Cynthia Y He
- , Michael F Schmid
- , Wah Chiu
- & Steven J Ludtke
Nature Methods 14 , 983–985

Rights & permissionsfor article Convolutional neural networks for automated annotation of cellular cryo-electron tomograms . Opens in a new window.
Research | 5 September 2017 | Open
GENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging
- Alan Pryor Jr.
- , Yongsoo Yang
- , Arjun Rana
- , Marcus Gallagher-Jones
- , Jihan Zhou
- , Yuan Hung Lo
- , Georgian Melinte
- , Wah Chiu
- , Jose A. Rodriguez
- & Jianwei Miao
Scientific Reports 7 , 1–12

Rights & permissionsfor article GENFIRE: A generalized Fourier iterative reconstruction algorithm for high-resolution 3D imaging . Opens in a new window.
Research | 19 December 2016
A chikungunya fever vaccine utilizing an insect-specific virus platform
- Jesse H Erasmus
- , Albert J Auguste
- , Jason T Kaelber
- , Huanle Luo
- , Shannan L Rossi
- , Karla Fenton
- , Grace Leal
- , Dal Y Kim
- , Wah Chiu
- , Tian Wang
- , Ilya Frolov
- , Farooq Nasar
- & Scott C Weaver
Nature Medicine 23 , 192–199

Rights & permissionsfor article A chikungunya fever vaccine utilizing an insect-specific virus platform . Opens in a new window.
Research | 10 March 2017 | Open
Visualizing Adsorption of Cyanophage P-SSP7 onto Marine Prochlorococcus
Scientific Reports 7 , 1–10

Rights & permissionsfor article Visualizing Adsorption of Cyanophage P-SSP7 onto Marine <i>Prochlorococcus</i> . Opens in a new window.
Research | 2 July 2014 | Open
Protruding knob-like proteins violate local symmetries in an icosahedral marine virus
Nature Communications 5 , 1–11

Rights & permissionsfor article Protruding knob-like proteins violate local symmetries in an icosahedral marine virus . Opens in a new window.
Research | 12 October 2015 | Open
Structural diversity of supercoiled DNA
Nature Communications 6 , 1–11

Rights & permissionsfor article Structural diversity of supercoiled DNA . Opens in a new window.
Research | 20 April 2014
Structure of the AcrAB–TolC multidrug efflux pump
- Dijun Du
- , Zhao Wang
- , Nathan R. James
- , Jarrod E. Voss
- , Ewa Klimont
- , Thelma Ohene-Agyei
- , Henrietta Venter
- , Wah Chiu
- & Ben F. Luisi
Nature 509 , 512–515

Rights & permissionsfor article Structure of the AcrAB–TolC multidrug efflux pump . Opens in a new window.
Research | 12 October 2015
Gating machinery of InsP₃R channels revealed by electron cryomicroscopy
- Guizhen Fan
- , Matthew L. Baker
- , Zhao Wang
- , Mariah R. Baker
- , Pavel A. Sinyagovskiy
- , Wah Chiu
- , Steven J. Ludtke
- & Irina I. Serysheva
Nature 527 , 336–341

Rights & permissionsfor article Gating machinery of InsP<sub>3</sub>R channels revealed by electron cryomicroscopy . Opens in a new window.
Research | 4 September 2014 | Open
An atomic model of brome mosaic virus using direct electron detection and real-space optimization
- Zhao Wang
- , Corey F. Hryc
- , Benjamin Bammes
- , Pavel V. Afonine
- , Joanita Jakana
- , Dong-Hua Chen
- , Xiangan Liu
- , Matthew L. Baker
- , Cheng Kao
- , Steven J. Ludtke
- , Michael F. Schmid
- , Paul D. Adams
- & Wah Chiu
Nature Communications 5 , 1–12

Rights & permissionsfor article An atomic model of brome mosaic virus using direct electron detection and real-space optimization . Opens in a new window.
Protocols | 16 October 2014
Zernike phase-contrast electron cryotomography applied to marine cyanobacteria infected with cyanophages
- Wei Dai
- , Caroline Fu
- , Htet A Khant
- , Steven J Ludtke
- , Michael F Schmid
- & Wah Chiu
Nature Protocols 9 , 2630–2642

Rights & permissionsfor article Zernike phase-contrast electron cryotomography applied to marine cyanobacteria infected with cyanophages . Opens in a new window.
Protocols | 30 September 2010
Cryo-EM of macromolecular assemblies at near-atomic resolution
- Matthew L Baker
- , Junjie Zhang
- , Steven J Ludtke
- & Wah Chiu
Nature Protocols 5 , 1697–1708

Rights & permissionsfor article Cryo-EM of macromolecular assemblies at near-atomic resolution . Opens in a new window.
Research | 19 February 2006
Close membrane-membrane proximity induced by Ca²⁺-dependent multivalent binding of synaptotagmin-1 to phospholipids
- Demet Araç
- , Xiaocheng Chen
- , Htet A Khant
- , Josep Ubach
- , Steven J Ludtke
- , Masahide Kikkawa
- , Arthur E Johnson
- , Wah Chiu
- , Thomas C Südhof
- & Josep Rizo
Nature Structural & Molecular Biology 13 , 209–217

Rights & permissionsfor article Close membrane-membrane proximity induced by Ca<sup>2+</sup>-dependent multivalent binding of synaptotagmin-1 to phospholipids . Opens in a new window.
Research | 20 February 2011
Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses
- James J. Moon
- , Heikyung Suh
- , Anna Bershteyn
- , Matthias T. Stephan
- , Haipeng Liu
- , Bonnie Huang
- , Mashaal Sohail
- , Samantha Luo
- , Soong Ho Um
- , Htet Khant
- , Jessica T. Goodwin
- , Jenelyn Ramos
- , Wah Chiu
- & Darrell J. Irvine
Nature Materials 10 , 243–251

Rights & permissionsfor article Interbilayer-crosslinked multilamellar vesicles as synthetic vaccines for potent humoral and cellular immune responses . Opens in a new window.
Research | 29 April 2007
Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins
Nature Structural & Molecular Biology 14 , 432–440

Rights & permissionsfor article Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins . Opens in a new window.
Research | 13 June 2010
Structural changes in a marine podovirus associated with release of its genome into Prochlorococcus
- Xiangan Liu
- , Qinfen Zhang
- , Kazuyoshi Murata
- , Matthew L Baker
- , Matthew B Sullivan
- , Caroline Fu
- , Matthew T Dougherty
- , Michael F Schmid
- , Marcia S Osburne
- , Sallie W Chisholm
- & Wah Chiu
Nature Structural & Molecular Biology 17 , 830–836

Rights & permissionsfor article Structural changes in a marine podovirus associated with release of its genome into <i>Prochlorococcus</i> . Opens in a new window.
Research | 8 June 2008
Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT
- Christopher R Booth
- , Anne S Meyer
- , Yao Cong
- , Maya Topf
- , Andrej Sali
- , Steven J Ludtke
- , Wah Chiu
- & Judith Frydman
Nature Structural & Molecular Biology 15 , 746–753

Rights & permissionsfor article Mechanism of lid closure in the eukaryotic chaperonin TRiC/CCT . Opens in a new window.

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