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12 August 2011
Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model
- I H I M Hollink
- , Q Feng
- , A A Danen-van Oorschot
- , S T C J M Arentsen-Peters
- , L J Verboon
- , P Zhang
- , V de Haas
- , D Reinhardt
- , U Creutzig
- , J Trka
- , R Pieters
- , M M van den Heuvel-Eibrink
- , J Wang
- & C M Zwaan
Leukemia 26 , 371–373

Rights & permissionsfor article Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model . Opens in a new window.
16 August 2012
The clinical relevance of BAALC and ERG expression levels in pediatric AML
- M C H Hermkens
- , M M van den Heuvel-Eibrink
- , S T C J M Arentsen-Peters
- , A Baruchel
- , J Stary
- , D Reinhardt
- , M Zimmerman
- , V de Haas
- , R Pieters
- & C M Zwaan
Leukemia 27 , 735–737

Rights & permissionsfor article The clinical relevance of BAALC and ERG expression levels in pediatric AML . Opens in a new window.
17 July 2012
BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia
- T D Buitenkamp
- , R Pieters
- , M Zimmermann
- , V de Haas
- , S M Richards
- , A J Vora
- , C D Mitchell
- , C Schwab
- , C J Harrison
- , A V Moorman
- , M M van den Heuvel-Eibrink
- & C M Zwaan
Leukemia 27 , 251–252

Rights & permissionsfor article BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia . Opens in a new window.
6 November 2008
Gene expression profile of slowly responding subclones might represent different profiles already at diagnosis and might be used for prediction of outcome
- V de Haas
- , R Dee
- , G Cheroutre
- , H van den Berg
- & C E van der Schoot
Leukemia 23 , 816–819

Rights & permissionsfor article Gene expression profile of slowly responding subclones might represent different profiles already at diagnosis and might be used for prediction of outcome . Opens in a new window.
24 February 2014
Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)
- E A Coenen
- , C M Zwaan
- , J Stary
- , A Baruchel
- , V de Haas
- , R W Stam
- , D Reinhardt
- , G J L Kaspers
- , S T C J M Arentsen-Peters
- , C Meyer
- , R Marschalek
- , L L Nigro
- , M Dworzak
- , R Pieters
- & M M van den Heuvel-Eibrink
Leukemia 28 , 1564–1568

Rights & permissionsfor article Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23) . Opens in a new window.
23 January 2001
Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy
- V de Haas
- , OJHM Verhagen
- , AEGKr von dem Borne
- , W Kroes
- , H van den Berg
- & CE van der Schoot
Leukemia 15 , 134–140

Rights & permissionsfor article Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy . Opens in a new window.
3 May 2011
Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia
- M Blink
- , T D Buitenkamp
- , M M van den Heuvel-Eibrink
- , A A Danen-van Oorschot
- , V de Haas
- , D Reinhardt
- , J-H Klusmann
- , M Zimmermann
- , M Devidas
- , A J Carroll
- , G Basso
- , A Pession
- , H Hasle
- , R Pieters
- , K R Rabin
- , S Izraeli
- & C M Zwaan
Leukemia 25 , 1365–1368

Rights & permissionsfor article Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia . Opens in a new window.
15 March 2013
Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood
- A M Aalbers
- , M M van den Heuvel-Eibrink
- , V de Haas
- , J G te Marvelde
- , A X de Jong
- , M van der Burg
- , M Dworzak
- , H Hasle
- , F Locatelli
- , B De Moerloose
- , M Schmugge
- , J Stary
- , M Zecca
- , C M Zwaan
- , A A van de Loosdrecht
- , J J M van Dongen
- , C M Niemeyer
- & V H J van der Velden
Leukemia 27 , 1923–1925

Rights & permissionsfor article Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood . Opens in a new window.
Research | 14 February 2013
High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation
- G M Marshall
- , L Dalla Pozza
- , R Sutton
- , A Ng
- , H A de Groot-Kruseman
- , V H van der Velden
- , N C Venn
- , H van den Berg
- , E S J M de Bont
- , R Maarten Egeler
- , P M Hoogerbrugge
- , G J L Kaspers
- , M B Bierings
- , E van der Schoot
- , J van Dongen
- , T Law
- , S Cross
- , H Mueller
- , V de Haas
- , M Haber
- , T Révész
- , F Alvaro
- , R Suppiah
- , M D Norris
- & R Pieters
Leukemia 27 , 1497–1503

Rights & permissionsfor article High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation . Opens in a new window.
Research | 19 November 2010
Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia
- E Waanders
- , V H J van der Velden
- , C E van der Schoot
- , F N van Leeuwen
- , S V van Reijmersdal
- , V de Haas
- , A J Veerman
- , A Geurts van Kessel
- , P M Hoogerbrugge
- , R P Kuiper
- & J J M van Dongen
Leukemia 25 , 254–258

Rights & permissionsfor article Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia . Opens in a new window.
Research | 23 September 2010
High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome
- B V Balgobind
- , C M Zwaan
- , D Reinhardt
- , T J C M Arentsen-Peters
- , I H I M Hollink
- , V de Haas
- , G J L Kaspers
- , E S J M de Bont
- , A Baruchel
- , J Stary
- , C Meyer
- , R Marschalek
- , U Creutzig
- , M L den Boer
- , R Pieters
- & M M van den Heuvel-Eibrink
Leukemia 24 , 2048–2055

Rights & permissionsfor article High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome . Opens in a new window.
9 December 2011 | Open
Highly sensitive MRD tests for ALL based on the IKZF1 Δ3–6 microdeletion
- N C Venn
- , V H J van der Velden
- , M de Bie
- , E Waanders
- , J E Giles
- , T Law
- , R P Kuiper
- , V de Haas
- , C G Mullighan
- , M Haber
- , G M Marshall
- , Norris MD
- , J J M van Dongen
- & R Sutton
Leukemia 26 , 1414–1416

Rights & permissionsfor article Highly sensitive MRD tests for ALL based on the IKZF1 Δ3–6 microdeletion . Opens in a new window.
Research | 7 June 2011
Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups
- F Damm
- , F Thol
- , I Hollink
- , M Zimmermann
- , K Reinhardt
- , M M van den Heuvel-Eibrink
- , C M Zwaan
- , V de Haas
- , U Creutzig
- , J-H Klusmann
- , J Krauter
- , M Heuser
- , A Ganser
- , D Reinhardt
- & C Thiede
Leukemia 25 , 1704–1710

Rights & permissionsfor article Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups . Opens in a new window.
21 February 2013
Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia
- A M Aalbers
- , R T Calado
- , N S Young
- , C M Zwaan
- , C Wu
- , S Kajigaya
- , E A Coenen
- , A Baruchel
- , K Geleijns
- , V de Haas
- , G J L Kaspers
- , T W Kuijpers
- , D Reinhardt
- , J Trka
- , M Zimmermann
- , R Pieters
- , V H J van der Velden
- & M M van den Heuvel-Eibrink
Leukemia 27 , 1786–1789

Rights & permissionsfor article Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia . Opens in a new window.
Research | 19 December 2018
Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality
- A. M. J. Reedijk
- , K. Klein
- , J. W. W. Coebergh
- , L. C. Kremer
- , A. G. Dinmohamed
- , V. de Haas
- , A. B. Versluijs
- , G. J. Ossenkoppele
- , H. B. Beverloo
- , R. Pieters
- , C. M. Zwaan
- , G. J. L. Kaspers
- & H. E. Karim-Kos
Leukemia 33 , 1349–1359

Rights & permissionsfor article Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality . Opens in a new window.
Research | 11 September 2017
MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML
- N S D Larmonie
- , T C J M Arentsen-Peters
- , A Obulkasim
- , D Valerio
- , E Sonneveld
- , A A Danen-van Oorschot
- , V de Haas
- , D Reinhardt
- , M Zimmermann
- , J Trka
- , A Baruchel
- , R Pieters
- , M M van den Heuvel-Eibrink
- , C M Zwaan
- & M Fornerod
Oncogene 37 , 107–115

Rights & permissionsfor article MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML . Opens in a new window.
Research | 3 October 2017 | Open
RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia
- I S Jerchel
- , A Q Hoogkamer
- , I M Ariës
- , E M P Steeghs
- , J M Boer
- , N J M Besselink
- , A Boeree
- , C van de Ven
- , H A de Groot-Kruseman
- , V de Haas
- , M A Horstmann
- , G Escherich
- , C M Zwaan
- , E Cuppen
- , M J Koudijs
- , R Pieters
- & M L den Boer
Leukemia 32 , 931–940

Rights & permissionsfor article RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia . Opens in a new window.
Research | 13 July 2015
miR-139-5p controls translation in myeloid leukemia through EIF4G2
- S Emmrich
- , F Engeland
- , M El-Khatib
- , K Henke
- , A Obulkasim
- , J Schöning
- , J E Katsman-Kuipers
- , C Michel Zwaan
- , A Pich
- , J Stary
- , A Baruchel
- , V de Haas
- , D Reinhardt
- , M Fornerod
- , M M van den Heuvel-Eibrink
- & J H Klusmann
Oncogene 35 , 1822–1831

Rights & permissionsfor article miR-139-5p controls translation in myeloid leukemia through EIF4G2 . Opens in a new window.
Research | 25 November 2013
miR-9 is a tumor suppressor in pediatric AML with t(8;21)
- S Emmrich
- , J E Katsman-Kuipers
- , K Henke
- , M E Khatib
- , R Jammal
- , F Engeland
- , F Dasci
- , C M Zwaan
- , M L den Boer
- , L Verboon
- , J Stary
- , A Baruchel
- , V de Haas
- , A A Danen-van Oorschot
- , M Fornerod
- , R Pieters
- , D Reinhardt
- , J H Klusmann
- & M M van den Heuvel-Eibrink
Leukemia 28 , 1022–1032

Rights & permissionsfor article miR-9 is a tumor suppressor in pediatric AML with t(8;21) . Opens in a new window.
Research | 18 November 2013
Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML
- K R Kampen
- , A ter Elst
- , H Mahmud
- , F J G Scherpen
- , S H Diks
- , M P Peppelenbosch
- , V de Haas
- , V Guryev
- & E S J M de Bont
Leukemia 28 , 589–599

Rights & permissionsfor article Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML . Opens in a new window.
Research | 3 September 2012 | Open
Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target
- S A Hartsink-Segers
- , C M Zwaan
- , C Exalto
- , M W J Luijendijk
- , V S Calvert
- , E F Petricoin
- , W E Evans
- , D Reinhardt
- , V de Haas
- , M Hedtjärn
- , B R Hansen
- , T Koch
- , H N Caron
- , R Pieters
- & M L Den Boer
Leukemia 27 , 560–568

Rights & permissionsfor article Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target . Opens in a new window.
Research | 16 August 2012
Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia
- B Denys
- , A J van der Sluijs-Gelling
- , C Homburg
- , C E van der Schoot
- , V de Haas
- , J Philippé
- , R Pieters
- , J J M van Dongen
- & V H J van der Velden
Leukemia 27 , 635–641

Rights & permissionsfor article Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia . Opens in a new window.
8 December 1998
Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes
- MJ Pongers-Willemse
- , OJHM Verhagen
- , GJM Tibbe
- , AJM Wijkhuijs
- , V de Haas
- , E Roovers
- , CE van der Schoot
- & JJM van Dongen
Leukemia 12 , 2006–2014

Rights & permissionsfor article Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes . Opens in a new window.
Research | 22 March 2012
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations
- T D Buitenkamp
- , R Pieters
- , N E Gallimore
- , A van der Veer
- , J P P Meijerink
- , H B Beverloo
- , M Zimmermann
- , V de Haas
- , S M Richards
- , A J Vora
- , C D Mitchell
- , L J Russell
- , C Schwab
- , C J Harrison
- , A V Moorman
- , M M van den Heuvel-Eibrink
- , M L den Boer
- & C M Zwaan
Leukemia 26 , 2204–2211

Rights & permissionsfor article Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations . Opens in a new window.

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Low frequency of DNMT3A mutations in pediatric AML, and the identification of the OCI-AML3 cell line as an in vitro model

The clinical relevance of BAALC and ERG expression levels in pediatric AML

BTG1 deletions do not predict outcome in Down syndrome acute lymphoblastic leukemia

Gene expression profile of slowly responding subclones might represent different profiles already at diagnosis and might be used for prediction of outcome

Unique BHLHB3 overexpression in pediatric acute myeloid leukemia with t(6;11)(q27;q23)

Quantification of minimal residual disease in children with oligoclonal B-precursor acute lymphoblastic leukemia indicates that the clones that grow out during relapse already have the slowest rate of reduction during induction therapy

Frequency and prognostic implications of JAK 1-3 aberrations in Down syndrome acute lymphoblastic and myeloid leukemia

Applicability of a reproducible flow cytometry scoring system in the diagnosis of refractory cytopenia of childhood

High-risk childhood acute lymphoblastic leukemia in first remission treated with novel intensive chemotherapy and allogeneic transplantation

Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia

High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome

Highly sensitive MRD tests for ALL based on the IKZF1 Δ3–6 microdeletion

Prevalence and prognostic value of IDH1 and IDH2 mutations in childhood AML: a study of the AML–BFM and DCOG study groups

Telomere length and telomerase complex mutations in pediatric acute myeloid leukemia

Improved survival for children and young adolescents with acute myeloid leukemia: a Dutch study on incidence, survival and mortality

MN1 overexpression is driven by loss of DNMT3B methylation activity in inv(16) pediatric AML

RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia

miR-139-5p controls translation in myeloid leukemia through EIF4G2

miR-9 is a tumor suppressor in pediatric AML with t(8;21)

Insights in dynamic kinome reprogramming as a consequence of MEK inhibition in MLL-rearranged AML

Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target

Improved flow cytometric detection of minimal residual disease in childhood acute lymphoblastic leukemia

Real-time quantitative PCR for the detection of minimal residual disease in acute lymphoblastic leukemia using junctional region specific TaqMan probes

Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations

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