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Research | 11 January 2021
Cryo-EM structures of Toll-like receptors in complex with UNC93B1
- Hanako Ishida
- , Jinta Asami
- , Zhikuan Zhang
- , Tomohiro Nishizawa
- , Hideki Shigematsu
- , Umeharu Ohto
- & Toshiyuki Shimizu
Nature Structural & Molecular Biology , 1–8

Rights & permissionsfor article Cryo-EM structures of Toll-like receptors in complex with UNC93B1 . Opens in a new window.
Research | 15 October 2020 | Open
Structural analysis reveals TLR7 dynamics underlying antagonism
- Shingo Tojo
- , Zhikuan Zhang
- , Hiroyuki Matsui
- , Masahiro Tahara
- , Mitsunori Ikeguchi
- , Mami Kochi
- , Mami Kamada
- , Hideki Shigematsu
- , Akihisa Tsutsumi
- , Naruhiko Adachi
- , Takuma Shibata
- , Masaki Yamamoto
- , Masahide Kikkawa
- , Toshiya Senda
- , Yoshiaki Isobe
- , Umeharu Ohto
- & Toshiyuki Shimizu
Nature Communications 11 , 1–11

Rights & permissionsfor article Structural analysis reveals TLR7 dynamics underlying antagonism . Opens in a new window.
Research | 26 September 2018 | Open
Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in Striga
- Yuqun Xu
- , Takuya Miyakawa
- , Shohei Nosaki
- , Akira Nakamura
- , Ying Lyu
- , Hidemitsu Nakamura
- , Umeharu Ohto
- , Hanako Ishida
- , Toshiyuki Shimizu
- , Tadao Asami
- & Masaru Tanokura
Nature Communications 9 , 1–11

Rights & permissionsfor article Structural analysis of HTL and D14 proteins reveals the basis for ligand selectivity in <i>Striga</i> . Opens in a new window.
Research | 20 November 2017
Small-molecule inhibition of TLR8 through stabilization of its resting state
- Shuting Zhang
- , Zhenyi Hu
- , Hiromi Tanji
- , Shuangshuang Jiang
- , Nabanita Das
- , Jing Li
- , Kentaro Sakaniwa
- , Jin Jin
- , Yanyan Bian
- , Umeharu Ohto
- , Toshiyuki Shimizu
- & Hang Yin
Nature Chemical Biology 14 , 58–64

Rights & permissionsfor article Small-molecule inhibition of TLR8 through stabilization of its resting state . Opens in a new window.
Research | 15 June 2016
Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization
- ...Halil Aydin et al. and Umeharu Ohto et al. present the...
Nature 534 , 566–569

Rights & permissionsfor article Structure of IZUMO1–JUNO reveals sperm–oocyte recognition during mammalian fertilization . Opens in a new window.
Research | 10 June 2016 | Open
Crystal structure of NOD2 and its implications in human disease
Nature Communications 7 , 1–11

Rights & permissionsfor article Crystal structure of NOD2 and its implications in human disease . Opens in a new window.
Research | 19 January 2015
Toll-like receptor 8 senses degradation products of single-stranded RNA
- Hiromi Tanji
- , Umeharu Ohto
- , Takuma Shibata
- , Masato Taoka
- , Yoshio Yamauchi
- , Toshiaki Isobe
- , Kensuke Miyake
- & Toshiyuki Shimizu
Nature Structural & Molecular Biology 22 , 109–115

Rights & permissionsfor article Toll-like receptor 8 senses degradation products of single-stranded RNA . Opens in a new window.
Research | 4 February 2015
Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases
- Atsuo Kanno
- , Natsuko Tanimura
- , Masayuki Ishizaki
- , Kentaro Ohko
- , Yuji Motoi
- , Masahiro Onji
- , Ryutaro Fukui
- , Takaichi Shimozato
- , Kazuhide Yamamoto
- , Takuma Shibata
- , Shigetoshi Sano
- , Akiko Sugahara-Tobinai
- , Toshiyuki Takai
- , Umeharu Ohto
- , Toshiyuki Shimizu
- , Shin-ichiroh Saitoh
- & Kensuke Miyake
Nature Communications 6 , 1–12

Rights & permissionsfor article Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases . Opens in a new window.
Research | 9 February 2015
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
- Umeharu Ohto
- , Takuma Shibata
- , Hiromi Tanji
- , Hanako Ishida
- , Elena Krayukhina
- , Susumu Uchiyama
- , Kensuke Miyake
- & Toshiyuki Shimizu
Nature 520 , 702–705

Rights & permissionsfor article Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9 . Opens in a new window.
Research | 20 January 2015
DNase II-dependent DNA digestion is required for DNA sensing by TLR9
- Mei Po Chan
- , Masahiro Onji
- , Ryutaro Fukui
- , Kohki Kawane
- , Takuma Shibata
- , Shin-ichiroh Saitoh
- , Umeharu Ohto
- , Toshiyuki Shimizu
- , Glen N. Barber
- & Kensuke Miyake
Nature Communications 6 , 1–10

Rights & permissionsfor article DNase II-dependent DNA digestion is required for DNA sensing by TLR9 . Opens in a new window.

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