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Correspondence | 1 December 2003
Response to 'Domain organization of activation-induced cytidine deaminase'
- Van-Thanh Ta
- & Tasuku Honjo
Nature Immunology 4 , 1154–1154

Rights & permissionsfor article Response to 'Domain organization of activation-induced cytidine deaminase' . Opens in a new window.
Research | 12 July 2019 | Open
Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma
- Megumi Goto
- , Kenji Chamoto
- , Keiko Higuchi
- , Saya Yamashita
- , Kenta Noda
- , Takuya Iino
- , Masahiro Miura
- , Toshinari Yamasaki
- , Osamu Ogawa
- , Makoto Sonobe
- , Hiroshi Date
- , Junzo Hamanishi
- , Masaki Mandai
- , Yoshimasa Tanaka
- , Shunsuke Chikuma
- , Ryusuke Hatae
- , Manabu Muto
- , Sachiko Minamiguchi
- , Nagahiro Minato
- & Tasuku Honjo
Scientific Reports 9 , 1–9

Rights & permissionsfor article Analytical performance of a new automated chemiluminescent magnetic immunoassays for soluble PD-1, PD-L1, and CTLA-4 in human plasma . Opens in a new window.
Research | 28 December 1989
A protein binding to the J_k recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif
- Norisada Matsunami
- , Yasushi Hamaguchi
- , Yoshiki Yamamoto
- , Kogo Kuze
- , Kenji Kangawa
- , Hisayuki Matsuo
- , Masashi Kawaichi
- & Tasuku Honjo
Nature 342 , 934–937

Rights & permissionsfor article A protein binding to the J<sub>k</sub> recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif . Opens in a new window.
Comments and Opinion | 1 April 2008
A memoir of AID, which engraves antibody memory on DNA
- Tasuku Honjo recounts his work aimed at...
- Tasuku Honjo
Nature Immunology 9 , 335–337

Rights & permissionsfor article A memoir of AID, which engraves antibody memory on DNA . Opens in a new window.
Research | 10 August 2003
AID mutant analyses indicate requirement for class-switch-specific cofactors
- Van-Thanh Ta
- , Hitoshi Nagaoka
- , Nadia Catalan
- , Anne Durandy
- , Alain Fischer
- , Kohsuke Imai
- , Shigeaki Nonoyama
- , Junko Tashiro
- , Masaya Ikegawa
- , Satomi Ito
- , Kazuo Kinoshita
- , Masamichi Muramatsu
- & Tasuku Honjo
Nature Immunology 4 , 843–848

Rights & permissionsfor article AID mutant analyses indicate requirement for class-switch-specific cofactors . Opens in a new window.
News and Views | 1 September 2002
Does AID need another aid?
- Tasuku Honjo
Nature Immunology 3 , 800–801

Rights & permissionsfor article Does AID need another aid? . Opens in a new window.
News and Views | 22 December 2004
Yasutomi Nishizuka (1932–2004)
- Tasuku Honjo
Nature 432 , 966–966

Rights & permissionsfor article Yasutomi Nishizuka (1932–2004) . Opens in a new window.
Research | 27 August 1981
Switch region of immunoglobulin C_μ gene is composed of simple tandem repetitive sequences
Nature 292 , 845–848

Rights & permissionsfor article Switch region of immunoglobulin C<sub>μ</sub> gene is composed of simple tandem repetitive sequences . Opens in a new window.
Research | 3 March 2002
The AID enzyme induces class switch recombination in fibroblasts
Nature 416 , 340–345

Rights & permissionsfor article The AID enzyme induces class switch recombination in fibroblasts . Opens in a new window.
Research | 6 December 2001
AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching
Nature 414 , 660–665

Rights & permissionsfor article AID is required to initiate Nbs1/γ-H2AX focus formation and mutations at sites of class switching . Opens in a new window.
Research | 24 May 1984
Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements
- Shigeru Katamine
- , Masayuki Otsu
- , Kotaro Tada
- , Shigeru Tsuchiya
- , Tetsuo Sato
- , Nakao Ishida
- , Tasuku Honjo
- & Yasushi Ono
Nature 309 , 369–372

Rights & permissionsfor article Epstein–Barr virus transforms precursor B cells even before immunoglobulin gene rearrangements . Opens in a new window.
Research | 1 April 2007
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium
- Yuko Matsumoto
- , Hiroyuki Marusawa
- , Kazuo Kinoshita
- , Yoko Endo
- , Tadayuki Kou
- , Toshiyuki Morisawa
- , Takeshi Azuma
- , Il-Mi Okazaki
- , Tasuku Honjo
- & Tsutomu Chiba
Nature Medicine 13 , 470–476

Rights & permissionsfor article <i>Helicobacter pylori</i> infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium . Opens in a new window.
Research | 15 January 1981
Ordering of mouse immunoglobulin heavy chain genes by molecular cloning
Nature 289 , 149–153

Rights & permissionsfor article Ordering of mouse immunoglobulin heavy chain genes by molecular cloning . Opens in a new window.
Research | 13 June 2004
Separate domains of AID are required for somatic hypermutation and class-switch recombination
- Reiko Shinkura
- , Satomi Ito
- , Nasim A Begum
- , Hitoshi Nagaoka
- , Masamichi Muramatsu
- , Kazuo Kinoshita
- , Yoshimasa Sakakibara
- , Hiroko Hijikata
- & Tasuku Honjo
Nature Immunology 5 , 707–712

Rights & permissionsfor article Separate domains of AID are required for somatic hypermutation and class-switch recombination . Opens in a new window.
Research | 7 May 1987
Expression and functional characterization of artificial mutants of interleukin-2 receptor
- Shigeru Kondo
- , Masahiko Kinoshita
- , Akira Shimizu
- , Yuji Saito
- , Mikio Konishi
- , Hisataka Sabe
- & Tasuku Honjo
Nature 327 , 64–67

Rights & permissionsfor article Expression and functional characterization of artificial mutants of interleukin-2 receptor . Opens in a new window.
Research | 12 August 1993
B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40
- Takeshi Tsubata
- , Jing Wu
- & Tasuku Honjo
Nature 364 , 645–648

Rights & permissionsfor article B-cell apoptosis induced by antigen receptor crosslinking is blocked by a T-cell signal through CD40 . Opens in a new window.
Research | 21 February 1980
Complete nucleotide sequence of immunoglobulin γ2b chain gene cloned from newborn mouse DNA
Nature 283 , 786–789

Rights & permissionsfor article Complete nucleotide sequence of immunoglobulin <i>γ</i>2b chain gene cloned from newborn mouse DNA . Opens in a new window.
Research | 26 August 1999
Notch signalling controls pancreatic cell differentiation
- Åsa Apelqvist
- , Hao Li
- , Lukas Sommer
- , Paul Beatus
- , David J. Anderson
- , Tasuku Honjo
- , Martin Hrabě de Angelis
- , Urban Lendahl
- & Helena Edlund
Nature 400 , 877–881

Rights & permissionsfor article Notch signalling controls pancreatic cell differentiation . Opens in a new window.
30 July 1999
Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis
Oncogene 18 , 4091–4098

Rights & permissionsfor article Signaling through the antigen receptor of B lymphocytes activates a p53-independent pathway of c-Myc-induced apoptosis . Opens in a new window.
Research | 2 November 2003
Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice
- Taku Okazaki
- , Yoshimasa Tanaka
- , Ryosuke Nishio
- , Tamotsu Mitsuiye
- , Akira Mizoguchi
- , Jian Wang
- , Masayoshi Ishida
- , Hiroshi Hiai
- , Akira Matsumori
- , Nagahiro Minato
- & Tasuku Honjo
Nature Medicine 9 , 1477–1483

Rights & permissionsfor article Autoantibodies against cardiac troponin I are responsible for dilated cardiomyopathy in PD-1-deficient mice . Opens in a new window.
Research | 8 July 1982
Reconstitution of antigen-specific suppressor activity with translation products of mRNA
- Masaru Taniguchi
- , Takeshi Tokuhisa
- , Masamoto Kanno
- , Yoshio Yaoita
- , Akira Shimizu
- & Tasuku Honjo
Nature 298 , 172–174

Rights & permissionsfor article Reconstitution of antigen-specific suppressor activity with translation products of mRNA . Opens in a new window.
Research | 11 October 2001
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
Nature 413 , 639–643

Rights & permissionsfor article <i>In situ</i> class switching and differentiation to IgA-producing cells in the gut lamina propria . Opens in a new window.
Research | 6 March 1986
Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection
- Shigeru Kondo
- , Akira Shimizu
- , Michiyuki Maeda
- , Yutaka Tagaya
- , Junji Yodoi
- & Tasuku Honjo
Nature 320 , 75–77

Rights & permissionsfor article Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection . Opens in a new window.
Research | 6 November 1986
Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II
- Tatsuo Kinashi
- , Nobuyuki Harada
- , Eva Severinson
- , Toshizumi Tanabe
- , Paschalis Sideras
- , Mikio Konishi
- , Chihiro Azuma
- , Akira Tominaga
- , Susanne Bergstedt-Lindqvist
- , Masazumi Takahashi
- , Fumihiko Matsuda
- , Yoshio Yaoita
- , Kiyoshi Takatsu
- & Tasuku Honjo
Nature 324 , 70–73

Rights & permissionsfor article Cloning of complementary DNA encoding T-cell replacing factor and identity with B-cell growth factor II . Opens in a new window.
Research | 28 August 1980
Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome
- Yoshio Yaoita
- & Tasuku Honjo
Nature 286 , 850–853

Rights & permissionsfor article Deletion of immunoglobulin heavy chain genes from expressed allelic chromosome . Opens in a new window.
Research | 9 December 2007
AID is required for germinal center–derived lymphomagenesis
Nature Genetics 40 , 108–112

Rights & permissionsfor article AID is required for germinal center–derived lymphomagenesis . Opens in a new window.
Research | 1 July 1982
Japanese wild mouse, Mus musculus molossinus, has duplicated immunoglobulin γ2a genes
- Akira Shimizu
- , Yasushi Hamaguchi
- , Yoshio Yaoita
- , Kazuo Moriwaki
- , Kyoji Kondo
- & Tasuku Honjo
Nature 298 , 82–84

Rights & permissionsfor article Japanese wild mouse, <i>Mus musculus molossinus</i>, has duplicated immunoglobulin <i>γ</i>2a genes . Opens in a new window.
Research | 1 September 1986
Isolation of DNA clones revealing restriction fragment length polymorphisms in the human genome
- Isamu Nishisho
- , Tetsuro Miki
- , Hideo Tateishi
- , Shin-ichiro Takai
- , Kazuyoshi Motomura
- , Jun Nakura
- , Yuichi Kumahara
- , Takesada Mori
- & Tasuku Honjo
Journal of Human Genetics 31 , 249–258

Rights & permissionsfor article Isolation of DNA clones revealing restriction fragment length polymorphisms in the human genome . Opens in a new window.
Research | 7 May 1992
Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice
- Masao Murakami
- , Takeshi Tsubata
- , Masaya Okamoto
- , Akira Shimizu
- , Shunichi Kumagai
- , Hiroo Imura
- & Tasuku Honjo
Nature 357 , 77–80

Rights & permissionsfor article Antigen-induced apoptotic death of Ly-1 B cells responsible for autoimmune disease in transgenic mice . Opens in a new window.
Research | 1 April 1985
Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences
- Shun-ichi Takeda
- , Takayuki Naito
- , Kazuaki Hama
- , Takafumi Noma
- & Tasuku Honjo
Nature 314 , 452–454

Rights & permissionsfor article Construction of chimaeric processed immunoglobulin genes containing mouse variable and human constant region sequences . Opens in a new window.
14 June 2007
Detection of activation-induced cytidine deaminase in gastric epithelial cells infected with cag pathogenicity island-positive Helicobacter pylori
Protocol Exchange

Rights & permissionsfor article Detection of activation-induced cytidine deaminase in gastric epithelial cells infected with cag pathogenicity island-positive Helicobacter pylori . Opens in a new window.
Research | 20 June 2005
Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers
- Yuji Takemoto
- , Tetsuro Miki
- , Jun Nakura
- , Kumi Nishikawa
- , Kouzin Kamino
- , Shunichi Takeda
- , Kogo Kuzu
- , Mitsuhiro Osame
- , Masanori Nakagawa
- , Itsuro Higuchi
- , Takeshi Yamada
- , Tetsuya Takayanagi
- , Shiro Matsubara
- , Kyoko Saita
- , Shin-ichiro Takai
- , Tasuku Honjo
- & Toshio Ogihara
Journal of Human Genetics 34 , 189–194

Rights & permissionsfor article Preclinical detection in Japanese families with myotonic dystrophy using polymorphic DNA markers . Opens in a new window.
Research | 21 January 1988
Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice
Nature 331 , 267–269

Rights & permissionsfor article Expression of functional interleukin-2 receptors in human light chain/Tac ransgenic mice . Opens in a new window.
Reviews | 17 April 2007
Regulation of lymphocyte development by Notch signaling
- Kenji Tanigaki
- & Tasuku Honjo
Nature Immunology 8 , 451–456

Rights & permissionsfor article Regulation of lymphocyte development by Notch signaling . Opens in a new window.
Research | 24 June 1982
Expression of lymphocyte surface IgE does not require switch recombination
Nature 297 , 697–699

Rights & permissionsfor article Expression of lymphocyte surface IgE does not require switch recombination . Opens in a new window.
Research | 10 January 2002
Fibulin-5/DANCE is essential for elastogenesis in vivo
- Tomoyuki Nakamura
- , Pilar Ruiz Lozano
- , Yasuhiro Ikeda
- , Yoshitaka Iwanaga
- , Aleksander Hinek
- , Susumu Minamisawa
- , Ching-Feng Cheng
- , Kazuhiro Kobuke
- , Nancy Dalton
- , Yoshikazu Takada
- , Kei Tashiro
- , John Ross Jr
- , Tasuku Honjo
- & Kenneth R. Chien
Nature 415 , 171–175

Rights & permissionsfor article Fibulin-5/DANCE is essential for elastogenesis <i>in vivo</i> . Opens in a new window.
Research | 1 May 1999
Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase
- Reiko Shinkura
- , Kazuhiro Kitada
- , Fumihiko Matsuda
- , Kei Tashiro
- , Koichi Ikuta
- , Misao Suzuki
- , Katsumi Kogishi
- , Tadao Serikawa
- & Tasuku Honjo
Nature Genetics 22 , 74–77

Rights & permissionsfor article Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase . Opens in a new window.
Research | 23 October 2017
Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior
- Michio Miyajima
- , Baihao Zhang
- , Yuki Sugiura
- , Kazuhiro Sonomura
- , Matteo M Guerrini
- , Yumi Tsutsui
- , Mikako Maruya
- , Alexis Vogelzang
- , Kenji Chamoto
- , Kurara Honda
- , Takatoshi Hikida
- , Satomi Ito
- , Hongyan Qin
- , Rikako Sanuki
- , Keiichiro Suzuki
- , Takahisa Furukawa
- , Yasushi Ishihama
- , Fumihiko Matsuda
- , Makoto Suematsu
- , Tasuku Honjo
- & Sidonia Fagarasan
Nature Immunology 18 , 1342–1352

Rights & permissionsfor article Metabolic shift induced by systemic activation of T cells in PD-1-deficient mice perturbs brain monoamines and emotional behavior . Opens in a new window.
Research | 4 February 2016 | Open
Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability
- Afzal Husain
- , Nasim A. Begum
- , Takako Taniguchi
- , Hisaaki Taniguchi
- , Maki Kobayashi
- & Tasuku Honjo
Nature Communications 7 , 1–15

Rights & permissionsfor article Chromatin remodeller SMARCA4 recruits topoisomerase 1 and suppresses transcription-associated genomic instability . Opens in a new window.
Reviews | 15 November 2013
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
Nature Immunology 14 , 1212–1218

Rights & permissionsfor article A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application . Opens in a new window.
Research | 6 December 2009
B cell–specific and stimulation-responsive enhancers derepress Aicda by overcoming the effects of silencers
- Thinh Huy Tran
- , Mikiyo Nakata
- , Keiichiro Suzuki
- , Nasim A Begum
- , Reiko Shinkura
- , Sidonia Fagarasan
- , Tasuku Honjo
- & Hitoshi Nagaoka
Nature Immunology 11 , 148–154

Rights & permissionsfor article B cell–specific and stimulation-responsive enhancers derepress <i>Aicda</i> by overcoming the effects of silencers . Opens in a new window.
Research | 1 March 2001
PD-L2 is a second ligand for PD-1 and inhibits T cell activation
- Yvette Latchman
- , Clive R. Wood
- , Tatyana Chernova
- , Divya Chaudhary
- , Madhuri Borde
- , Irene Chernova
- , Yoshiko Iwai
- , Andrew J. Long
- , Julia A. Brown
- , Raquel Nunes
- , Edward A. Greenfield
- , Karen Bourque
- , Vassiliki A. Boussiotis
- , Laura L. Carter
- , Beatriz M. Carreno
- , Nelly Malenkovich
- , Hiroyuki Nishimura
- , Taku Okazaki
- , Tasuku Honjo
- , Arlene H. Sharpe
- & Gordon J. Freeman
Nature Immunology 2 , 261–268

Rights & permissionsfor article PD-L2 is a second ligand for PD-1 and inhibits T cell activation . Opens in a new window.
Research | 22 April 2002
Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells
- Kenji Tanigaki
- , Hua Han
- , Norio Yamamoto
- , Kei Tashiro
- , Masaya Ikegawa
- , Kazuki Kuroda
- , Akira Suzuki
- , Toru Nakano
- & Tasuku Honjo
Nature Immunology 3 , 443–450

Rights & permissionsfor article Notch–RBP-J signaling is involved in cell fate determination of marginal zone B cells . Opens in a new window.
Reviews | 1 January 2003
Intestinal IgA synthesis: regulation of front-line body defences
- Sidonia Fagarasan
- & Tasuku Honjo
Nature Reviews Immunology 3 , 63–72

Rights & permissionsfor article Intestinal IgA synthesis: regulation of front-line body defences . Opens in a new window.
Reviews | 21 June 2005
AID to overcome the limitations of genomic information
Nature Immunology 6 , 655–661

Rights & permissionsfor article AID to overcome the limitations of genomic information . Opens in a new window.
Research | 20 February 1986
Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter
- Yoshihiko Noma
- , Paschalis Sideras
- , Takayuki Naito
- , Susanne Bergstedt-Lindquist
- , Chihiro Azuma
- , Eva Severinson
- , Toshizumi Tanabe
- , Tatsuo Kinashi
- , Fumihiko Matsuda
- , Yoshio Yaoita
- & Tasuku Honjo
Nature 319 , 640–646

Rights & permissionsfor article Cloning of cDNA encoding the murine IgG1 induction factor by a novel strategy using SP6 promoter . Opens in a new window.
Research | 1 January 1993
Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus
- Fumihiko Matsuda
- , Euy Kyun Shin
- , Hitoshi Nagaoka
- , Ryusuke Matsumura
- , Makoto Haino
- , Yosho Fukita
- , Shigeo Taka-ishi
- , Takashi Imai
- , John H. Riley
- , Rakesh Anand
- , Eiichi Soeda
- & Tasuku Honjo
Nature Genetics 3 , 88–94

Rights & permissionsfor article Structure and physical map of 64 variable segments in the 3′ 0.8–megabase region of the human immunoglobulin heavy–chain locus . Opens in a new window.
Research | 30 January 2005
Resting dendritic cells induce peripheral CD8⁺ T cell tolerance through PD-1 and CTLA-4
Nature Immunology 6 , 280–286

Rights & permissionsfor article Resting dendritic cells induce peripheral CD8<sup>+</sup> T cell tolerance through PD-1 and CTLA-4 . Opens in a new window.
Research | 22 February 2009
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
- Marie Carlén
- , Konstantinos Meletis
- , Christian Göritz
- , Vladimer Darsalia
- , Emma Evergren
- , Kenji Tanigaki
- , Mario Amendola
- , Fanie Barnabé-Heider
- , Maggie S Y Yeung
- , Luigi Naldini
- , Tasuku Honjo
- , Zaal Kokaia
- , Oleg Shupliakov
- , Robert M Cassidy
- , Olle Lindvall
- & Jonas Frisén
Nature Neuroscience 12 , 259–267

Rights & permissionsfor article Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke . Opens in a new window.
Reviews | 1 July 2001
Linking class-switch recombination with somatic hypermutation
- Kazuo Kinoshita
- & Tasuku Honjo
Nature Reviews Molecular Cell Biology 2 , 493–503

Rights & permissionsfor article Linking class-switch recombination with somatic hypermutation . Opens in a new window.

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