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Research | 28 October 2020 | Open
YAP and TAZ protect against white adipocyte cell death during obesity
- Lei Wang
- , ShengPeng Wang
- , Yue Shi
- , Rui Li
- , Stefan Günther
- , Yu Ting Ong
- , Michael Potente
- , Zuyi Yuan
- , Enqi Liu
- & Stefan Offermanns
Nature Communications 11 , 1–13

Rights & permissionsfor article YAP and TAZ protect against white adipocyte cell death during obesity . Opens in a new window.
Amendments and Corrections | 1 February 2008
Correction: Corrigendum: G₁₂-G₁₃–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
- Angela Wirth
- , Zoltán Benyó
- , Martina Lukasova
- , Barbara Leutgeb
- , Nina Wettschureck
- , Stefan Gorbey
- , Petra Örsy
- , Béla Horváth
- , Christiane Maser-Gluth
- , Erich Greiner
- , Björn Lemmer
- , Günther Schütz
- , Silvio Gutkind
- & Stefan Offermanns
Nature Medicine 14 , 222–222

Rights & permissionsfor article Correction: Corrigendum: G<sub>12</sub>-G<sub>13</sub>–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension . Opens in a new window.
Research | 15 July 2020 | Open
Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling
- Eman Khatib-Massalha
- , Suditi Bhattacharya
- , Hassan Massalha
- , Adi Biram
- , Karin Golan
- , Orit Kollet
- , Anju Kumari
- , Francesca Avemaria
- , Ekaterina Petrovich-Kopitman
- , Shiri Gur-Cohen
- , Tomer Itkin
- , Isabell Brandenburger
- , Asaf Spiegel
- , Ziv Shulman
- , Zachary Gerhart-Hines
- , Shalev Itzkovitz
- , Matthias Gunzer
- , Stefan Offermanns
- , Ronen Alon
- , Amiram Ariel
- & Tsvee Lapidot
Nature Communications 11 , 1–18

Rights & permissionsfor article Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling . Opens in a new window.
Research | 12 June 2020 | Open
Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance
- Hosung Bae
- , Ki Yong Hong
- , Choong-kun Lee
- , Cholsoon Jang
- , Seung-Jun Lee
- , Kibaek Choe
- , Stefan Offermanns
- , Yulong He
- , Hyuek Jong Lee
- & Gou Young Koh
Nature Communications 11 , 1–17

Rights & permissionsfor article Angiopoietin-2–integrin α5β1 signaling enhances vascular fatty acid transport and prevents ectopic lipid-induced insulin resistance . Opens in a new window.
Research | 26 May 2020 | Open
Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function
- Laura Stanicek
- , Noelia Lozano-Vidal
- , Diewertje Ilse Bink
- , Aukie Hooglugt
- , Wenjie Yao
- , Ilka Wittig
- , Jos van Rijssel
- , Jaap Diederik van Buul
- , Anke van Bergen
- , Alina Klems
- , Anne Sophie Ramms
- , Ferdinand Le Noble
- , Patrick Hofmann
- , Robert Szulcek
- , ShengPeng Wang
- , Stefan Offermanns
- , Meryem Seda Ercanoglu
- , Hyouk-Bum Kwon
- , Didier Stainier
- , Stephan Huveneers
- , Leo Kurian
- , Stefanie Dimmeler
- & Reinier Abraham Boon
Communications Biology 3 , 1–13

Rights & permissionsfor article Long non-coding RNA LASSIE regulates shear stress sensing and endothelial barrier function . Opens in a new window.
Research | 8 May 2020 | Open
Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice
- ShengPeng Wang
- , Shuang Cao
- , Malika Arhatte
- , Dahui Li
- , Yue Shi
- , Sabrina Kurz
- , Jiong Hu
- , Lei Wang
- , Jingchen Shao
- , Ann Atzberger
- , Zheng Wang
- , Changhe Wang
- , Weijin Zang
- , Ingrid Fleming
- , Nina Wettschureck
- , Eric Honoré
- & Stefan Offermanns
Nature Communications 11 , 1–13

Rights & permissionsfor article Adipocyte Piezo1 mediates obesogenic adipogenesis through the FGF1/FGFR1 signaling pathway in mice . Opens in a new window.
Research | 12 March 2020 | Open
Digenic inheritance of mutations in EPHA2 and SLC26A4 in Pendred syndrome
- Mengnan Li
- , Shin-ya Nishio
- , Chie Naruse
- , Meghan Riddell
- , Sabrina Sapski
- , Tatsuya Katsuno
- , Takao Hikita
- , Fatemeh Mizapourshafiyi
- , Fiona M. Smith
- , Leanne T. Cooper
- , Min Goo Lee
- , Masahide Asano
- , Thomas Boettger
- , Marcus Krueger
- , Astrid Wietelmann
- , Johannes Graumann
- , Bryan W. Day
- , Andrew W. Boyd
- , Stefan Offermanns
- , Shin-ichiro Kitajiri
- , Shin-ichi Usami
- & Masanori Nakayama
Nature Communications 11 , 1–15

Rights & permissionsfor article Digenic inheritance of mutations in <i>EPHA2</i> and <i>SLC26A4</i> in Pendred syndrome . Opens in a new window.
Research | 16 December 2007
G₁₂-G₁₃–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension
- Angela Wirth
- , Zoltán Benyó
- , Martina Lukasova
- , Barbara Leutgeb
- , Nina Wettschureck
- , Stefan Gorbey
- , Petra Örsy
- , Béla Horváth
- , Christiane Maser-Gluth
- , Erich Greiner
- , Björn Lemmer
- , Günther Schütz
- , J. Silvio Gutkind
- & Stefan Offermanns
Nature Medicine 14 , 64–68

Rights & permissionsfor article G<sub>12</sub>-G<sub>13</sub>–LARG–mediated signaling in vascular smooth muscle is required for salt-induced hypertension . Opens in a new window.
Research | 5 October 2003
G₁₃ is an essential mediator of platelet activation in hemostasis and thrombosis
- Alexandra Moers
- , Bernhard Nieswandt
- , Steffen Massberg
- , Nina Wettschureck
- , Sabine Grüner
- , Ildiko Konrad
- , Valerie Schulte
- , Barsom Aktas
- , Marie-Pierre Gratacap
- , Melvin I Simon
- , Meinrad Gawaz
- & Stefan Offermanns
Nature Medicine 9 , 1418–1422

Rights & permissionsfor article G<sub>13</sub> is an essential mediator of platelet activation in hemostasis and thrombosis . Opens in a new window.
Reviews | 26 March 2001
In vivo functions of heterotrimeric G-proteins: studies in Gα-deficient mice
- Stefan Offermanns
Oncogene 20 , 1635–1642

Rights & permissionsfor article <i>In vivo</i> functions of heterotrimeric G-proteins: studies in Gα-deficient mice . Opens in a new window.
Research | 1 November 2001
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα_q/Gα₁₁ in cardiomyocytes
- Nina Wettschureck
- , Hartmut Rütten
- , Alexandra Zywietz
- , Doris Gehring
- , Tom M. Wilkie
- , Ju Chen
- , Kenneth R. Chien
- & Stefan Offermanns
Nature Medicine 7 , 1236–1240

Rights & permissionsfor article Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα<sub>q</sub>/Gα<sub>11</sub> in cardiomyocytes . Opens in a new window.
Reviews | 22 September 1998
Genetic analysis of mammalian G-protein signalling
- Stefan Offermanns
- & Melvin I Simon
Oncogene 17 , 1375–1381

Rights & permissionsfor article Genetic analysis of mammalian G-protein signalling . Opens in a new window.
Research | 3 February 2003
PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect
- Sorin Tunaru
- , Jukka Kero
- , Annette Schaub
- , Christian Wufka
- , Andree Blaukat
- , Klaus Pfeffer
- & Stefan Offermanns
Nature Medicine 9 , 352–355

Rights & permissionsfor article PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect . Opens in a new window.
Research | 11 September 1997
Defective platelet activation in Gα_q-deficient mice
Nature 389 , 183–186

Rights & permissionsfor article Defective platelet activation in Gα<sub>q</sub>-deficient mice . Opens in a new window.
Research | 19 December 2019 | Open
Helix 8 is the essential structural motif of mechanosensitive GPCRs
- Serap Erdogmus
- , Ursula Storch
- , Laura Danner
- , Jasmin Becker
- , Michaela Winter
- , Nicole Ziegler
- , Angela Wirth
- , Stefan Offermanns
- , Carsten Hoffmann
- , Thomas Gudermann
- & Michael Mederos y Schnitzler
Nature Communications 10 , 1–15

Rights & permissionsfor article Helix 8 is the essential structural motif of mechanosensitive GPCRs . Opens in a new window.
Research | 23 August 2019 | Open
The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology
- Manuela Simonetti
- , Eszter Paldy
- , Christian Njoo
- , Kiran Kumar Bali
- , Thomas Worzfeld
- , Claudia Pitzer
- , Thomas Kuner
- , Stefan Offermanns
- , Daniela Mauceri
- & Rohini Kuner
Molecular Psychiatry , 1–23

Rights & permissionsfor article The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology . Opens in a new window.
Research | 25 January 2019
TAK1 regulates endothelial cell necroptosis and tumor metastasis
- Lida Yang
- , Sayali Joseph
- , Tianliang Sun
- , Julia Hoffmann
- , Sophia Thevissen
- , Stefan Offermanns
- & Boris Strilic
Cell Death and Differentiation 26 , 1987–1997

Rights & permissionsfor article TAK1 regulates endothelial cell necroptosis and tumor metastasis . Opens in a new window.
Research | 15 November 2018 | Open
Conditional deletion of Rcan1 predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture
Nature Communications 9 , 1–16

Rights & permissionsfor article Conditional deletion of <i>Rcan1</i> predisposes to hypertension-mediated intramural hematoma and subsequent aneurysm and aortic rupture . Opens in a new window.
Research | 2 November 2018 | Open
Myh10 deficiency leads to defective extracellular matrix remodeling and pulmonary disease
- Hyun-Taek Kim
- , Wenguang Yin
- , Young-June Jin
- , Paolo Panza
- , Felix Gunawan
- , Beate Grohmann
- , Carmen Buettner
- , Anna M. Sokol
- , Jens Preussner
- , Stefan Guenther
- , Sawa Kostin
- , Clemens Ruppert
- , Aditya M. Bhagwat
- , Xuefei Ma
- , Johannes Graumann
- , Mario Looso
- , Andreas Guenther
- , Robert S. Adelstein
- , Stefan Offermanns
- & Didier Y. R. Stainier
Nature Communications 9 , 1–13

Rights & permissionsfor article <i>Myh10</i> deficiency leads to defective extracellular matrix remodeling and pulmonary disease . Opens in a new window.
Research | 19 July 2018 | Open
The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis
- Wenguang Yin
- , Hyun-Taek Kim
- , ShengPeng Wang
- , Felix Gunawan
- , Lei Wang
- , Keishi Kishimoto
- , Hua Zhong
- , Dany Roman
- , Jens Preussner
- , Stefan Guenther
- , Viola Graef
- , Carmen Buettner
- , Beate Grohmann
- , Mario Looso
- , Mitsuru Morimoto
- , Graeme Mardon
- , Stefan Offermanns
- & Didier Y. R. Stainier
Nature Communications 9 , 1–13

Rights & permissionsfor article The potassium channel KCNJ13 is essential for smooth muscle cytoskeletal organization during mouse tracheal tubulogenesis . Opens in a new window.
Research | 12 January 2018 | Open
20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1
Nature Communications 9 , 1–11

Rights & permissionsfor article 20-HETE promotes glucose-stimulated insulin secretion in an autocrine manner through FFAR1 . Opens in a new window.
Research | 23 May 2017 | Open
Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1
- Cecilie Morland
- , Krister A. Andersson
- , Øyvind P. Haugen
- , Alena Hadzic
- , Liv Kleppa
- , Andreas Gille
- , Johanne E. Rinholm
- , Vuk Palibrk
- , Elisabeth H. Diget
- , Lauritz H. Kennedy
- , Tomas Stølen
- , Eivind Hennestad
- , Olve Moldestad
- , Yiqing Cai
- , Maja Puchades
- , Stefan Offermanns
- , Koen Vervaeke
- , Magnar Bjørås
- , Ulrik Wisløff
- , Jon Storm-Mathisen
- & Linda H. Bergersen
Nature Communications 8 , 1–9

Rights & permissionsfor article Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1 . Opens in a new window.
Research | 7 September 2017 | Open
Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis
- Helge Müller-Fielitz
- , Marcus Stahr
- , Mareike Bernau
- , Marius Richter
- , Sebastian Abele
- , Victor Krajka
- , Anika Benzin
- , Jan Wenzel
- , Kathrin Kalies
- , Jens Mittag
- , Heike Heuer
- , Stefan Offermanns
- & Markus Schwaninger
Nature Communications 8 , 1–13

Rights & permissionsfor article Tanycytes control the hormonal output of the hypothalamic-pituitary-thyroid axis . Opens in a new window.
Research | 2 August 2017 | Open
Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain
- Eszter Paldy
- , Manuela Simonetti
- , Thomas Worzfeld
- , Kiran Kumar Bali
- , Lucas Vicuña
- , Stefan Offermanns
- & Rohini Kuner
Nature Communications 8 , 1–15

Rights & permissionsfor article Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain . Opens in a new window.
Research | 1 June 2016 | Open
In vivo modulation of endothelial polarization by Apelin receptor signalling
Nature Communications 7 , 1–12

Rights & permissionsfor article <i>In vivo</i> modulation of endothelial polarization by Apelin receptor signalling . Opens in a new window.
Research | 27 March 2017 | Open
The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity
- Stephan W. Hohmann
- , Carlo Angioni
- , Sorin Tunaru
- , Seungkyu Lee
- , Clifford J. Woolf
- , Stefan Offermanns
- , Gerd Geisslinger
- , Klaus Scholich
- & Marco Sisignano
Scientific Reports 7 , 1–11

Rights & permissionsfor article The G2A receptor (GPR132) contributes to oxaliplatin-induced mechanical pain hypersensitivity . Opens in a new window.
Research | 7 November 2016
SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
- Rebecca Kring Hansen
- , Andreas Mund
- , Sara Lund Poulsen
- , Maria Sandoval
- , Karolin Klement
- , Katerina Tsouroula
- , Maxim A. X. Tollenaere
- , Markus Räschle
- , Rebeca Soria
- , Stefan Offermanns
- , Thomas Worzfeld
- , Robert Grosse
- , Dominique T. Brandt
- , Björn Rozell
- , Matthias Mann
- , Francesca Cole
- , Evi Soutoglou
- , Aaron A. Goodarzi
- , Jeremy A. Daniel
- , Niels Mailand
- & Simon Bekker-Jensen
Nature Cell Biology 18 , 1357–1366

Rights & permissionsfor article SCAI promotes DNA double-strand break repair in distinct chromosomal contexts . Opens in a new window.
Research | 3 August 2016
Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis
Nature 536 , 215–218

Rights & permissionsfor article Tumour-cell-induced endothelial cell necroptosis via death receptor 6 promotes metastasis . Opens in a new window.
Research | 5 April 2017 | Open
Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure
Nature Communications 8 , 1–14

Rights & permissionsfor article Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure . Opens in a new window.
Reviews | 1 August 2014
Semaphorins and plexins as therapeutic targets
- Thomas Worzfeld
- & Stefan Offermanns
Nature Reviews Drug Discovery 13 , 603–621

Rights & permissionsfor article Semaphorins and plexins as therapeutic targets . Opens in a new window.
Research | 1 April 2015
Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome
- Laurence Macia
- , Jian Tan
- , Angelica T. Vieira
- , Katie Leach
- , Dragana Stanley
- , Suzanne Luong
- , Mikako Maruya
- , Craig Ian McKenzie
- , Atsushi Hijikata
- , Connie Wong
- , Lauren Binge
- , Alison N. Thorburn
- , Nina Chevalier
- , Caroline Ang
- , Eliana Marino
- , Remy Robert
- , Stefan Offermanns
- , Mauro M. Teixeira
- , Robert J. Moore
- , Richard A. Flavell
- , Sidonia Fagarasan
- & Charles R. Mackay
Nature Communications 6 , 1–15

Rights & permissionsfor article Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome . Opens in a new window.
Research | 2 April 2015 | Open
Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin
Nature Communications 6 , 1–12

Rights & permissionsfor article Sphingosine-1-phosphate receptor 3 promotes leukocyte rolling by mobilizing endothelial P-selectin . Opens in a new window.
Research | 26 February 2015 | Open
Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling
- Tomokazu Sumida
- , Atsuhiko T. Naito
- , Seitaro Nomura
- , Akito Nakagawa
- , Tomoaki Higo
- , Akihito Hashimoto
- , Katsuki Okada
- , Taku Sakai
- , Masamichi Ito
- , Toshihiro Yamaguchi
- , Toru Oka
- , Hiroshi Akazawa
- , Jong-Kook Lee
- , Tohru Minamino
- , Stefan Offermanns
- , Tetsuo Noda
- , Marina Botto
- , Yoshio Kobayashi
- , Hiroyuki Morita
- , Ichiro Manabe
- , Toshio Nagai
- , Ichiro Shiojima
- & Issei Komuro
Nature Communications 6 , 1–12

Rights & permissionsfor article Complement C1q-induced activation of β-catenin signalling causes hypertensive arterial remodelling . Opens in a new window.
Research | 21 May 2014
The β-hydroxybutyrate receptor HCA₂ activates a neuroprotective subset of macrophages
- Mahbubur Rahman
- , Sajjad Muhammad
- , Mahtab A. Khan
- , Hui Chen
- , Dirk A. Ridder
- , Helge Müller-Fielitz
- , Barbora Pokorná
- , Tillman Vollbrandt
- , Ines Stölting
- , Roger Nadrowitz
- , Jürgen G Okun
- , Stefan Offermanns
- & Markus Schwaninger
Nature Communications 5 , 1–11

Rights & permissionsfor article The β-hydroxybutyrate receptor HCA<sub>2</sub> activates a neuroprotective subset of macrophages . Opens in a new window.
Research | 12 January 2015
Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes
- Cong Tang
- , Kashan Ahmed
- , Andreas Gille
- , Shun Lu
- , Hermann-Josef Gröne
- , Sorin Tunaru
- & Stefan Offermanns
Nature Medicine 21 , 173–177

Rights & permissionsfor article Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes . Opens in a new window.
Research | 10 April 2015
RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock
Nature Communications 6 , 1–11

Rights & permissionsfor article RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock . Opens in a new window.
Research | 30 April 2014
G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes
- Andrei S. Chagin
- , Karuna K. Vuppalapati
- , Tatsuya Kobayashi
- , Jun Guo
- , Takao Hirai
- , Min Chen
- , Stefan Offermanns
- , Lee S. Weinstein
- & Henry M. Kronenberg
Nature Communications 5 , 1–14

Rights & permissionsfor article G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes . Opens in a new window.
Research | 7 April 2015 | Open
Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate
Nature Communications 6 , 1–15

Rights & permissionsfor article Quantitative analysis of the TNF-α-induced phosphoproteome reveals AEG-1/MTDH/LYRIC as an IKKβ substrate . Opens in a new window.
Reviews | 13 July 2012
G protein-coupled receptors for energy metabolites as new therapeutic targets
Nature Reviews Drug Discovery 11 , 603–619

Rights & permissionsfor article G protein-coupled receptors for energy metabolites as new therapeutic targets . Opens in a new window.
Research | 20 May 2012
PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα₁₂
- Xiaoqing Gan
- , Jiyong Wang
- , Chen Wang
- , Eeva Sommer
- , Tohru Kozasa
- , Srinivasa Srinivasula
- , Dario Alessi
- , Stefan Offermanns
- , Melvin I. Simon
- & Dianqing Wu
Nature Cell Biology 14 , 686–696

Rights & permissionsfor article PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα<sub>12</sub> . Opens in a new window.
Research | 31 January 2012 | Open
Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice
- Norbert Weissmann
- , Akylbek Sydykov
- , Hermann Kalwa
- , Ursula Storch
- , Beate Fuchs
- , Michael Mederos y Schnitzler
- , Ralf P. Brandes
- , Friedrich Grimminger
- , Marcel Meissner
- , Marc Freichel
- , Stefan Offermanns
- , Florian Veit
- , Oleg Pak
- , Karl-Heinz Krause
- , Ralph T. Schermuly
- , Alison C Brewer
- , Harald H.H.W. Schmidt
- , Werner Seeger
- , Ajay M. Shah
- , Thomas Gudermann
- , Hossein A. Ghofrani
- & Alexander Dietrich
Nature Communications 3 , 1–10

Rights & permissionsfor article Activation of TRPC6 channels is essential for lung ischaemia–reperfusion induced oedema in mice . Opens in a new window.

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