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Research |
Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale
- Xihao Li
- , Zilin Li
- , Hufeng Zhou
- , Sheila M. Gaynor
- , Yaowu Liu
- , Han Chen
- , Ryan Sun
- , Rounak Dey
- , Donna K. Arnett
- , Stella Aslibekyan
- , Christie M. Ballantyne
- , Lawrence F. Bielak
- , John Blangero
- , Eric Boerwinkle
- , Donald W. Bowden
- , Jai G. Broome
- , Matthew P. Conomos
- , Adolfo Correa
- , L. Adrienne Cupples
- , Joanne E. Curran
- , Barry I. Freedman
- , Xiuqing Guo
- , George Hindy
- , Marguerite R. Irvin
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Alyna T. Khan
- , Charles L. Kooperberg
- , Cathy C. Laurie
- , X. Shirley Liu
- , Michael C. Mahaney
- , Ani W. Manichaikul
- , Lisa W. Martin
- , Rasika A. Mathias
- , Stephen T. McGarvey
- , Braxton D. Mitchell
- , May E. Montasser
- , Jill E. Moore
- , Alanna C. Morrison
- , Jeffrey R. O’Connell
- , Nicholette D. Palmer
- , Akhil Pampana
- , Juan M. Peralta
- , Patricia A. Peyser
- , Bruce M. Psaty
- , Susan Redline
- , Kenneth M. Rice
- , Stephen S. Rich
- , Jennifer A. Smith
- , Hemant K. Tiwari
- , Michael Y. Tsai
- , Ramachandran S. Vasan
- , Fei Fei Wang
- , Daniel E. Weeks
- , Zhiping Weng
- , James G. Wilson
- , Lisa R. Yanek
- , Namiko Abe
- , Gonçalo R. Abecasis
- , Francois Aguet
- , Christine Albert
- , Laura Almasy
- , Alvaro Alonso
- , Seth Ament
- , Peter Anderson
- , Pramod Anugu
- , Deborah Applebaum-Bowden
- , Kristin Ardlie
- , Dan Arking
- , Donna K. Arnett
- , Allison Ashley-Koch
- , Stella Aslibekyan
- , Tim Assimes
- , Paul Auer
- , Dimitrios Avramopoulos
- , John Barnard
- , Kathleen Barnes
- , R. Graham Barr
- , Emily Barron-Casella
- , Lucas Barwick
- , Terri Beaty
- , Gerald Beck
- , Diane Becker
- , Lewis Becker
- , Rebecca Beer
- , Amber Beitelshees
- , Emelia Benjamin
- , Takis Benos
- , Marcos Bezerra
- , Lawrence F. Bielak
- , Joshua Bis
- , Thomas Blackwell
- , John Blangero
- , Eric Boerwinkle
- , Donald W. Bowden
- , Russell Bowler
- , Jennifer Brody
- , Ulrich Broeckel
- , Jai G. Broome
- , Karen Bunting
- , Esteban Burchard
- , Carlos Bustamante
- , Erin Buth
- , Brian Cade
- , Jonathan Cardwell
- , Vincent Carey
- , Cara Carty
- , Richard Casaburi
- , James Casella
- , Peter Castaldi
- , Mark Chaffin
- , Christy Chang
- , Yi-Cheng Chang
- , Daniel Chasman
- , Sameer Chavan
- , Bo-Juen Chen
- , Wei-Min Chen
- , Yii-Der Ida Chen
- , Michael Cho
- , Seung Hoan Choi
- , Lee-Ming Chuang
- , Mina Chung
- , Ren-Hua Chung
- , Clary Clish
- , Suzy Comhair
- , Matthew P. Conomos
- , Elaine Cornell
- , Adolfo Correa
- , Carolyn Crandall
- , James Crapo
- , L. Adrienne Cupples
- , Joanne E. Curran
- , Jeffrey Curtis
- , Brian Custer
- , Coleen Damcott
- , Dawood Darbar
- , Sayantan Das
- , Sean David
- , Colleen Davis
- , Michelle Daya
- , Mariza de Andrade
- , Lisa de las Fuentes
- , Michael DeBaun
- , Ranjan Deka
- , Dawn DeMeo
- , Scott Devine
- , Qing Duan
- , Ravi Duggirala
- , Jon Peter Durda
- , Susan Dutcher
- , Charles Eaton
- , Lynette Ekunwe
- , Adel El Boueiz
- , Patrick Ellinor
- , Leslie Emery
- , Serpil Erzurum
- , Charles Farber
- , Tasha Fingerlin
- , Matthew Flickinger
- , Myriam Fornage
- , Nora Franceschini
- , Chris Frazar
- , Mao Fu
- , Stephanie M. Fullerton
- , Lucinda Fulton
- , Stacey Gabriel
- , Weiniu Gan
- , Shanshan Gao
- , Yan Gao
- , Margery Gass
- , Bruce Gelb
- , Xiaoqi (Priscilla) Geng
- , Mark Geraci
- , Soren Germer
- , Robert Gerszten
- , Auyon Ghosh
- , Richard Gibbs
- , Chris Gignoux
- , Mark Gladwin
- , David Glahn
- , Stephanie Gogarten
- , Da-Wei Gong
- , Harald Goring
- , Sharon Graw
- , Daniel Grine
- , C. Charles Gu
- , Yue Guan
- , Xiuqing Guo
- , Namrata Gupta
- , Jeff Haessler
- , Michael Hall
- , Daniel Harris
- , Nicola L. Hawley
- , Jiang He
- , Susan Heckbert
- , Ryan Hernandez
- , David Herrington
- , Craig Hersh
- , Bertha Hidalgo
- , James Hixson
- , Brian Hobbs
- , John Hokanson
- , Elliott Hong
- , Karin Hoth
- , Chao (Agnes) Hsiung
- , Yi-Jen Hung
- , Haley Huston
- , Chii Min Hwu
- , Marguerite R. Irvin
- , Rebecca Jackson
- , Deepti Jain
- , Cashell Jaquish
- , Min A. Jhun
- , Jill Johnsen
- , Andrew Johnson
- , Craig Johnson
- , Rich Johnston
- , Kimberly Jones
- , Hyun Min Kang
- , Robert Kaplan
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Shannon Kelly
- , Eimear Kenny
- , Michael Kessler
- , Alyna T. Khan
- , Wonji Kim
- , Greg Kinney
- , Barbara Konkle
- , Charles L. Kooperberg
- , Holly Kramer
- , Christoph Lange
- , Ethan Lange
- , Leslie Lange
- , Cathy C. Laurie
- , Cecelia Laurie
- , Meryl LeBoff
- , Jiwon Lee
- , Seunggeun Shawn Lee
- , Wen-Jane Lee
- , Jonathon LeFaive
- , David Levine
- , Dan Levy
- , Joshua Lewis
- , Xiaohui Li
- , Yun Li
- , Henry Lin
- , Honghuang Lin
- , Keng Han Lin
- , Xihong Lin
- , Simin Liu
- , Yongmei Liu
- , Yu Liu
- , Ruth J. F. Loos
- , Steven Lubitz
- , Kathryn Lunetta
- , James Luo
- , Michael C. Mahaney
- , Barry Make
- , Ani W. Manichaikul
- , JoAnn Manson
- , Lauren Margolin
- , Lisa W. Martin
- , Susan Mathai
- , Rasika A. Mathias
- , Susanne May
- , Patrick McArdle
- , Merry-Lynn McDonald
- , Sean McFarland
- , Stephen T. McGarvey
- , Daniel McGoldrick
- , Caitlin McHugh
- , Hao Mei
- , Luisa Mestroni
- , Deborah A. Meyers
- , Julie Mikulla
- , Nancy Min
- , Mollie Minear
- , Ryan L. Minster
- , Braxton D. Mitchell
- , Matt Moll
- , May E. Montasser
- , Courtney Montgomery
- , Arden Moscati
- , Solomon Musani
- , Stanford Mwasongwe
- , Josyf C. Mychaleckyj
- , Girish Nadkarni
- , Rakhi Naik
- , Take Naseri
- , Pradeep Natarajan
- , Sergei Nekhai
- , Sarah C. Nelson
- , Bonnie Neltner
- , Deborah Nickerson
- , Kari North
- , Jeffrey R. O’Connell
- , Tim O’Connor
- , Heather Ochs-Balcom
- , David Paik
- , Nicholette D. Palmer
- , James Pankow
- , George Papanicolaou
- , Afshin Parsa
- , Juan M. Peralta
- , Marco Perez
- , James Perry
- , Ulrike Peters
- , Patricia A. Peyser
- , Lawrence S. Phillips
- , Toni Pollin
- , Wendy Post
- , Julia Powers Becker
- , Meher Preethi Boorgula
- , Michael Preuss
- , Bruce M. Psaty
- , Pankaj Qasba
- , Dandi Qiao
- , Zhaohui Qin
- , Nicholas Rafaels
- , Laura Raffield
- , Ramachandran S. Vasan
- , D. C. Rao
- , Laura Rasmussen-Torvik
- , Aakrosh Ratan
- , Susan Redline
- , Robert Reed
- , Elizabeth Regan
- , Alex Reiner
- , Muagututi‘a Sefuiva Reupena
- , Kenneth M. Rice
- , Stephen S. Rich
- , Dan Roden
- , Carolina Roselli
- , Jerome I. Rotter
- , Ingo Ruczinski
- , Pamela Russell
- , Sarah Ruuska
- , Kathleen Ryan
- , Ester Cerdeira Sabino
- , Danish Saleheen
- , Shabnam Salimi
- , Steven Salzberg
- , Kevin Sandow
- , Vijay G. Sankaran
- , Christopher Scheller
- , Ellen Schmidt
- , Karen Schwander
- , David Schwartz
- , Frank Sciurba
- , Christine Seidman
- , Jonathan Seidman
- , Vivien Sheehan
- , Stephanie L. Sherman
- , Amol Shetty
- , Aniket Shetty
- , Wayne Hui-Heng Sheu
- , M. Benjamin Shoemaker
- , Brian Silver
- , Edwin Silverman
- , Jennifer A. Smith
- , Josh Smith
- , Nicholas Smith
- , Tanja Smith
- , Sylvia Smoller
- , Beverly Snively
- , Michael Snyder
- , Tamar Sofer
- , Nona Sotoodehnia
- , Adrienne M. Stilp
- , Garrett Storm
- , Elizabeth Streeten
- , Jessica Lasky Su
- , Yun Ju Sung
- , Jody Sylvia
- , Adam Szpiro
- , Carole Sztalryd
- , Daniel Taliun
- , Hua Tang
- , Margaret Taub
- , Kent D. Taylor
- , Matthew Taylor
- , Simeon Taylor
- , Marilyn Telen
- , Timothy A. Thornton
- , Machiko Threlkeld
- , Lesley Tinker
- , David Tirschwell
- , Sarah Tishkoff
- , Hemant K. Tiwari
- , Catherine Tong
- , Russell Tracy
- , Michael Y. Tsai
- , Dhananjay Vaidya
- , David Van Den Berg
- , Peter VandeHaar
- , Scott Vrieze
- , Tarik Walker
- , Robert Wallace
- , Avram Walts
- , Fei Fei Wang
- , Heming Wang
- , Karol Watson
- , Daniel E. Weeks
- , Bruce Weir
- , Scott Weiss
- , Lu-Chen Weng
- , Jennifer Wessel
- , Cristen J. Willer
- , Kayleen Williams
- , L. Keoki Williams
- , Carla Wilson
- , James G. Wilson
- , Quenna Wong
- , Joseph Wu
- , Huichun Xu
- , Lisa R. Yanek
- , Ivana Yang
- , Rongze Yang
- , Norann Zaghloul
- , Maryam Zekavat
- , Yingze Zhang
- , Snow Xueyan Zhao
- , Wei Zhao
- , Degui Zhi
- , Xiang Zhou
- , Xiaofeng Zhu
- , Michael Zody
- , Sebastian Zoellner
- , Moustafa Abdalla
- , Gonçalo R. Abecasis
- , Donna K. Arnett
- , Stella Aslibekyan
- , Tim Assimes
- , Elizabeth Atkinson
- , Christie M. Ballantyne
- , Amber Beitelshees
- , Lawrence F. Bielak
- , Joshua Bis
- , Corneliu Bodea
- , Eric Boerwinkle
- , Donald W. Bowden
- , Jennifer Brody
- , Brian Cade
- , Jenna Carlson
- , I-Shou Chang
- , Yii-Der Ida Chen
- , Sung Chun
- , Ren-Hua Chung
- , Matthew P. Conomos
- , Adolfo Correa
- , L. Adrienne Cupples
- , Coleen Damcott
- , Paul de Vries
- , Ron Do
- , Amanda Elliott
- , Mao Fu
- , Andrea Ganna
- , Da-Wei Gong
- , Sarah Graham
- , Mary Haas
- , Bernhard Haring
- , Jiang He
- , Susan Heckbert
- , Blanca Himes
- , James Hixson
- , Marguerite R. Irvin
- , Deepti Jain
- , Gail Jarvik
- , Min A. Jhun
- , Jicai Jiang
- , Goo Jun
- , Rita Kalyani
- , Sharon L. R. Kardia
- , Sekar Kathiresan
- , Amit Khera
- , Derek Klarin
- , Charles L. Kooperberg
- , Brian Kral
- , Leslie Lange
- , Cathy C. Laurie
- , Cecelia Laurie
- , Rozenn Lemaitre
- , Zilin Li
- , Xihao Li
- , Xihong Lin
- , Michael C. Mahaney
- , Ani W. Manichaikul
- , Lisa W. Martin
- , Rasika A. Mathias
- , Ravi Mathur
- , Stephen T. McGarvey
- , Caitlin McHugh
- , John McLenithan
- , Julie Mikulla
- , Braxton D. Mitchell
- , May E. Montasser
- , Andrew Moran
- , Alanna C. Morrison
- , Tetsushi Nakao
- , Pradeep Natarajan
- , Deborah Nickerson
- , Kari North
- , Jeffrey R. O’Connell
- , Christopher O’Donnell
- , Nicholette D. Palmer
- , Akhil Pampana
- , Aniruddh Patel
- , Gina M. Peloso
- , James Perry
- , Ulrike Peters
- , Patricia A. Peyser
- , James Pirruccello
- , Toni Pollin
- , Michael Preuss
- , Bruce M. Psaty
- , D. C. Rao
- , Susan Redline
- , Robert Reed
- , Alex Reiner
- , Stephen S. Rich
- , Samantha Rosenthal
- , Jerome I. Rotter
- , Jenny Schoenberg
- , Margaret Sunitha Selvaraj
- , Wayne Hui-Heng Sheu
- , Jennifer A. Smith
- , Tamar Sofer
- , Adrienne M. Stilp
- , Shamil R. Sunyaev
- , Ida Surakka
- , Carole Sztalryd
- , Hua Tang
- , Kent D. Taylor
- , Michael Y. Tsai
- , Md Mesbah Uddin
- , Sarah Urbut
- , Marie Verbanck
- , Ann Von Holle
- , Heming Wang
- , Fei Fei Wang
- , Kerri Wiggins
- , Cristen J. Willer
- , James G. Wilson
- , Brooke Wolford
- , Huichun Xu
- , Lisa R. Yanek
- , Norann Zaghloul
- , Maryam Zekavat
- , Jingwen Zhang
- , Benjamin M. Neale
- , Shamil R. Sunyaev
- , Gonçalo R. Abecasis
- , Jerome I. Rotter
- , Cristen J. Willer
- , Gina M. Peloso
- , Pradeep Natarajan
- & Xihong Lin
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Research |
Evidence for secondary-variant genetic burden and non-random distribution across biological modules in a recessive ciliopathy
- Maria Kousi
- , Onuralp Söylemez
- , Aysegül Ozanturk
- , Niki Mourtzi
- , Sebastian Akle
- , Irwin Jungreis
- , Jean Muller
- , Christopher A. Cassa
- , Harrison Brand
- , Jill Anne Mokry
- , Maxim Y. Wolf
- , Azita Sadeghpour
- , Kelsey McFadden
- , Richard A. Lewis
- , Michael E. Talkowski
- , Hélène Dollfus
- , Manolis Kellis
- , Erica E. Davis
- , Shamil R. Sunyaev
- & Nicholas Katsanis
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Correspondence |
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Correspondence |
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Research | | Open
Improved imputation quality of low-frequency and rare variants in European samples using the ‘Genome of The Netherlands’
- Patrick Deelen
- , Androniki Menelaou
- , Elisabeth M van Leeuwen
- , Alexandros Kanterakis
- , Freerk van Dijk
- , Carolina Medina-Gomez
- , Laurent C Francioli
- , Jouke Jan Hottenga
- , Lennart C Karssen
- , Karol Estrada
- , Eskil Kreiner-Møller
- , Fernando Rivadeneira
- , Jessica van Setten
- , Javier Gutierrez-Achury
- , Harm-Jan Westra
- , Lude Franke
- , David van Enckevort
- , Martijn Dijkstra
- , Heorhiy Byelas
- , Cornelia M van Duijn
- , Morris A Swertz
- , Laurent C Francioli
- , Freerk van Dijk
- , Androniki Menelaou
- , Pieter B T Neerincx
- , Sara L Pulit
- , Patrick Deelen
- , Clara C Elbers
- , Pier Francesco Palamara
- , Itsik Pe'er
- , Abdel Abdellaoui
- , Wigard P Kloosterman
- , Mannis van Oven
- , Martijn Vermaat
- , Mingkun Li
- , Jeroen F J Laros
- , Mark Stoneking
- , Peter de Knijff
- , Manfred Kayser
- , Jan H Veldink
- , Leonard H van den Berg
- , Heorhiy Byelas
- , Johan T den Dunnen
- , Martijn Dijkstra
- , Najaf Amin
- , K Joeri van der Velde
- , Jouke Jan Hottenga
- , Jessica van Setten
- , Elisabeth M van Leeuwen
- , Alexandros Kanterakis
- , Mathijs Kattenberg
- , Lennart C Karssen
- , Barbera D C van Schaik
- , Jan Bot
- , Isaäuc J Nijman
- , David van Enckevort
- , Hailiang Mei
- , Vyacheslav Koval
- , Kai Ye
- , Eric-Wubbo Lameijer
- , Matthijs H Moed
- , Jayne Y Hehir-Kwa
- , Robert E Handsaker
- , Shamil R Sunyaev
- , Mashaal Sohail
- , Fereydoun Hormozdiari
- , Tobias Marschall
- , Schönhuth Marschall
- , Victor Guryev
- , Paul I W de Bakker
- , P Eline Slagboom
- , Marian B Beekman
- , Anton J M de Craen
- , H Eka D Suchiman
- , Albert Hofman
- , Cornelia van Duijn
- , Dorret I Boomsma
- , Gonneke Willemsen
- , Bruce H Wolffenbuttel
- , Mathieu Platteel
- , Steven J Pitts
- , Shobha Potluri
- , David R Cox
- , Qibin Li
- , Yingrui Li
- , Yuanping Du
- , Ruoyan Chen
- , Hongzhi Cao
- , Ning Li
- , Sujie Cao
- , Jun Wang
- , Jasper A Bovenberg
- , Steering committee
- , Cisca Wijmenga
- , Morris A Swertz
- , Cornelia M van Duijn
- , Dorret I Boomsma
- , P Eline Slagboom
- , Gertjan B van Ommen
- , Paul I W de Bakker
- , Paul I W de Bakker
- , Cisca Wijmenga
- & Morris A Swertz
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Research | | Open
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Research | | Open
Genome sequencing reveals insights into physiology and longevity of the naked mole rat
- Eun Bae Kim
- , Xiaodong Fang
- , Alexey A. Fushan
- , Zhiyong Huang
- , Alexei V. Lobanov
- , Lijuan Han
- , Stefano M. Marino
- , Xiaoqing Sun
- , Anton A. Turanov
- , Pengcheng Yang
- , Sun Hee Yim
- , Xiang Zhao
- , Marina V. Kasaikina
- , Nina Stoletzki
- , Chunfang Peng
- , Paz Polak
- , Zhiqiang Xiong
- , Adam Kiezun
- , Yabing Zhu
- , Yuanxin Chen
- , Gregory V. Kryukov
- , Qiang Zhang
- , Leonid Peshkin
- , Lan Yang
- , Roderick T. Bronson
- , Rochelle Buffenstein
- , Bo Wang
- , Changlei Han
- , Qiye Li
- , Li Chen
- , Wei Zhao
- , Shamil R. Sunyaev
- , Thomas J. Park
- , Guojie Zhang
- , Jun Wang
- & Vadim N. Gladyshev
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Research |
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Research | | Open
WGS-based telomere length analysis in Dutch family trios implicates stronger maternal inheritance and a role for RRM1 gene
- Lilit Nersisyan
- , Maria Nikoghosyan
- , Laurent C. Francioli
- , Androniki Menelaou
- , Sara L. Pulit
- , Clara C. Elbers
- , Wigard P. Kloosterman
- , Jessica van Setten
- , Isaäc J. Nijman
- , Ivo Renkens
- , Paul I. W. de Bakker
- , Freerk van Dijk
- , Pieter B. T. Neerincx
- , Patrick Deelen
- , Alexandros Kanterakis
- , Martijn Dijkstra
- , Heorhiy Byelas
- , K. Joeri van der Velde
- , Mathieu Platteel
- , Morris A. Swertz
- , Cisca Wijmenga
- , Pier Francesco Palamara
- , Itsik Pe’er
- , Kai Ye
- , Kai Ye
- , Eric-Wubbo Lameijer
- , Matthijs H. Moed
- , Marian Beekman
- , Anton J. M. de Craen
- , H. Eka D. Suchiman
- , P. Eline Slagboom
- , Victor Guryev
- , Abdel Abdellaoui
- , Jouke Jan Hottenga
- , Mathijs Kattenberg
- , Gonneke Willemsen
- , Dorret I. Boomsma
- , Elisabeth M. van Leeuwen
- , Lennart C. Karssen
- , Najaf Amin
- , Fernando Rivadeneira
- , Aaron Isaacs
- , Albert Hofman
- , André G. Uitterlinden
- , Cornelia M. van Duijn
- , Mannis van Oven
- , Manfred Kayser
- , Martijn Vermaat
- , Jeroen F. J. Laros
- , Johan T. den Dunnen
- , David van Enckevort
- , Hailiang Mei
- , Mingkun Li
- , Mark Stoneking
- , Barbera D. C. van Schaik
- , Jan Bot
- , Tobias Marschall
- , Alexander Schönhuth
- , Jayne Y. Hehir-Kwa
- , Robert E. Handsaker
- , Paz Polak
- , Mashaal Sohail
- , Dana Vuzman
- , Karol Estrada
- , Steven A. McCarroll
- , Shamil R. Sunyaev
- , Fereydoun Hormozdiari
- , Vyacheslav Koval
- , Carolina Medina-Gomez
- , Ben Oostra
- , Jan H. Veldink
- , Leonard H. van den Berg
- , Steven J. Pitts
- , Shobha Potluri
- , Purnima Sundar
- , David R. Cox
- , Peter de Knijff
- , Qibin Li
- , Yingrui Li
- , Yuanping Du
- , Ruoyan Chen
- , Hongzhi Cao
- , Jun Wang
- , Ning Li
- , Sujie Cao
- , Jasper A. Bovenberg
- , Gert-Jan B. van Ommen
- & Arsen Arakelyan
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Research |
Mutations in RABL3 alter KRAS prenylation and are associated with hereditary pancreatic cancer
- Sahar Nissim
- , Ignaty Leshchiner
- , Joseph D. Mancias
- , Matthew B. Greenblatt
- , Ophélia Maertens
- , Christopher A. Cassa
- , Jill A. Rosenfeld
- , Andrew G. Cox
- , John Hedgepeth
- , Julia I. Wucherpfennig
- , Andrew J. Kim
- , Jake E. Henderson
- , Patrick Gonyo
- , Anthony Brandt
- , Ellen Lorimer
- , Bethany Unger
- , Jeremy W. Prokop
- , Jerry R. Heidel
- , Xiao-Xu Wang
- , Chinedu I. Ukaegbu
- , Benjamin C. Jennings
- , Joao A. Paulo
- , Sebastian Gableske
- , Carol A. Fierke
- , Gad Getz
- , Shamil R. Sunyaev
- , J. Wade Harper
- , Karen Cichowski
- , Alec C. Kimmelman
- , Yariv Houvras
- , Sapna Syngal
- , Carol Williams
- & Wolfram Goessling
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Research | | Open
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Reviews | | Open
An integrated clinical program and crowdsourcing strategy for genomic sequencing and Mendelian disease gene discovery
- Alireza Haghighi
- , Joel B. Krier
- , Agnes Toth-Petroczy
- , Christopher A. Cassa
- , Natasha Y. Frank
- , Nikkola Carmichael
- , Elizabeth Fieg
- , Andrew Bjonnes
- , Anwoy Mohanty
- , Lauren C. Briere
- , Sharyn Lincoln
- , Stephanie Lucia
- , Vandana A. Gupta
- , Onuralp Söylemez
- , Sheila Sutti
- , Kameron Kooshesh
- , Haiyan Qiu
- , Christopher J. Fay
- , Victoria Perroni
- , Jamie Valerius
- , Meredith Hanna
- , Alexander Frank
- , Jodie Ouahed
- , Scott B. Snapper
- , Angeliki Pantazi
- , Sameer S. Chopra
- , Ignaty Leshchiner
- , Nathan O. Stitziel
- , Anna Feldweg
- , Michael Mannstadt
- , Joseph Loscalzo
- , David A. Sweetser
- , Eric Liao
- , Joan M. Stoler
- , Catherine B. Nowak
- , Pedro A. Sanchez-Lara
- , Ophir D. Klein
- , Hazel Perry
- , Nikolaos A. Patsopoulos
- , Soumya Raychaudhuri
- , Wolfram Goessling
- , Robert C. Green
- , Christine E. Seidman
- , Calum A. MacRae
- , Shamil R. Sunyaev
- , Richard L. Maas
- & Dana Vuzman
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Research |
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Research | | Open
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Research | | Open
A framework for the detection of de novo mutations in family-based sequencing data
- Laurent C Francioli
- , Mircea Cretu-Stancu
- , Kiran V Garimella
- , Menachem Fromer
- , Wigard P Kloosterman
- , Cisca Wijmenga
- , Principal Investigator
- , Morris A Swertz
- , Cornelia M van Duijn
- , Dorret I Boomsma
- , PEline Slagboom
- , Gertjan B van Ommen
- , Paul IW de Bakker
- , Morris A Swertz
- , Laurent C Francioli
- , Freerk van Dijk
- , Androniki Menelaou
- , Pieter BT Neerincx
- , Sara L Pulit
- , Patrick Deelen
- , Clara C Elbers
- , Pier Francesco Palamara
- , Itsik Pe'er
- , Abdel Abdellaoui
- , Wigard P Kloosterman
- , Mannis van Oven
- , Martijn Vermaat
- , Mingkun Li
- , Jeroen FJ Laros
- , Mark Stoneking
- , Peter de Knijff
- , Manfred Kayser
- , Jan H Veldink
- , Leonard H van den Berg
- , Heorhiy Byelas
- , Johan T den Dunnen
- , Martijn Dijkstra
- , Najaf Amin
- , K Joeri van der Velde
- , Jouke Jan Hottenga
- , Jessica van Setten
- , Elisabeth M van Leeuwen
- , Alexandros Kanterakis
- , Mathijs Kattenberg
- , Lennart C Karssen
- , Barbera DC van Schaik
- , Jan Bot
- , Isaäc J Nijman
- , Ivo Renkens
- , David van Enckevort
- , Hailiang Mei
- , Vyacheslav Koval
- , Karol Estrada
- , Carolina Medina-Gomez
- , Kai Ye
- , Eric-Wubbo Lameijer
- , Matthijs H Moed
- , Jayne Y Hehir-Kwa
- , Robert E Handsaker
- , Steven A McCarroll
- , Shamil R Sunyaev
- , Paz Polak
- , Dana Vuzman
- , Mashaal Sohail
- , Fereydoun Hormozdiari
- , Tobias Marschall
- , Alexander Schönhuth
- , Victor Guryev
- , Paul IW de Bakker
- , P Eline Slagboom
- , Marian B Beekman
- , Anton JM de Craen
- , H Eka D Suchiman
- , Albert Hofman
- , Cornelia M van Duijn
- , Ben Oostra
- , Aaron Isaacs
- , Najaf Amin
- , Fernando Rivadeneira
- , André G Uitterlinden
- , Dorret I Boomsma
- , Gonneke Willemsen
- , Mathieu Platteel
- , Steven J Pitts
- , Shobha Potluri
- , Purnima Sundar
- , David R Cox
- , Qibin Li
- , Yingrui Li
- , Yuanping Du
- , Ruoyan Chen
- , Hongzhi Cao
- , Ning Li
- , Sujie Cao
- , Jun Wang
- , Jasper A Bovenberg
- , Margreet Brandsma
- , Kaitlin E Samocha
- , Benjamin M Neale
- , Mark J Daly
- , Eric Banks
- , Mark A DePristo
- & Paul IW de Bakker
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Research |
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Research |
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Research |
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Research | | Open
Genome of the Netherlands population-specific imputations identify an ABCA6 variant associated with cholesterol levels
- Elisabeth M. van Leeuwen
- , Lennart C. Karssen
- , Joris Deelen
- , Aaron Isaacs
- , Carolina Medina-Gomez
- , Hamdi Mbarek
- , Alexandros Kanterakis
- , Stella Trompet
- , Iris Postmus
- , Niek Verweij
- , David J. van Enckevort
- , Jennifer E. Huffman
- , Charles C. White
- , Mary F. Feitosa
- , Traci M. Bartz
- , Ani Manichaikul
- , Peter K. Joshi
- , Gina M. Peloso
- , Patrick Deelen
- , Freerk van Dijk
- , Gonneke Willemsen
- , Eco J. de Geus
- , Yuri Milaneschi
- , Brenda W.J.H. Penninx
- , Laurent C. Francioli
- , Androniki Menelaou
- , Sara L. Pulit
- , Fernando Rivadeneira
- , Albert Hofman
- , Ben A. Oostra
- , Oscar H. Franco
- , Irene Mateo Leach
- , Marian Beekman
- , Anton J.M. de Craen
- , Hae-Won Uh
- , Holly Trochet
- , Lynne J. Hocking
- , David J. Porteous
- , Naveed Sattar
- , Chris J. Packard
- , Brendan M. Buckley
- , Jennifer A. Brody
- , Joshua C. Bis
- , Jerome I. Rotter
- , Josyf C. Mychaleckyj
- , Harry Campbell
- , Qing Duan
- , Leslie A. Lange
- , James F. Wilson
- , Caroline Hayward
- , Ozren Polasek
- , Veronique Vitart
- , Igor Rudan
- , Alan F. Wright
- , Stephen S. Rich
- , Bruce M. Psaty
- , Ingrid B. Borecki
- , Patricia M. Kearney
- , David J. Stott
- , L. Adrienne Cupples
- , Pieter B.T. Neerincx
- , Clara C. Elbers
- , Pier Francesco Palamara
- , Itsik Pe’er
- , Abdel Abdellaoui
- , Wigard P. Kloosterman
- , Mannis van Oven
- , Martijn Vermaat
- , Mingkun Li
- , Jeroen F.J. Laros
- , Mark Stoneking
- , Peter de Knijff
- , Manfred Kayser
- , Jan H. Veldink
- , Leonard H. van den Berg
- , Heorhiy Byelas
- , Johan T. den Dunnen
- , Martijn Dijkstra
- , Najaf Amin
- , K. Joeri van der Velde
- , Jessica van Setten
- , Mathijs Kattenberg
- , Barbera D.C. van Schaik
- , Jan Bot
- , Isaäc J. Nijman
- , Hailiang Mei
- , Vyacheslav Koval
- , Kai Ye
- , Eric-Wubbo Lameijer
- , Matthijs H. Moed
- , Jayne Y. Hehir-Kwa
- , Robert E. Handsaker
- , Shamil R. Sunyaev
- , Mashaal Sohail
- , Fereydoun Hormozdiari
- , Tobias Marschall
- , Alexander Schönhuth
- , Victor Guryev
- , H. Eka D. Suchiman
- , Bruce H. Wolffenbuttel
- , Mathieu Platteel
- , Steven J. Pitts
- , Shobha Potluri
- , David R. Cox
- , Qibin Li
- , Yingrui Li
- , Yuanping Du
- , Ruoyan Chen
- , Hongzhi Cao
- , Ning Li
- , Sujie Cao
- , Jun Wang
- , Jasper A. Bovenberg
- , J. Wouter Jukema
- , Pim van der Harst
- , Eric J. Sijbrands
- , Jouke-Jan Hottenga
- , Andre G. Uitterlinden
- , Morris A. Swertz
- , Gert-Jan B. van Ommen
- , Paul I.W. de Bakker
- , P. Eline Slagboom
- , Dorret I. Boomsma
- , Cisca Wijmenga
- & Cornelia M. van Duijn
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Research |
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Protocols |
Population-specific genotype imputations using minimac or IMPUTE2
- Elisabeth M van Leeuwen
- , Alexandros Kanterakis
- , Patrick Deelen
- , Mathijs V Kattenberg
- , Abdel Abdellaoui
- , Albert Hofman
- , Alexander Schönhuth
- , Alexandros Kanterakis
- , Androniki Menelaou
- , Anton J M de Craen
- , Barbera D C van Schaik
- , Bruce H Wolffenbuttel
- , Cisca Wijmenga
- , Clara C Elbers
- , Cornelia M van Duijn
- , Cornelia van Duijn
- , David R Cox
- , David van Enckevort
- , Dorret I Boomsma
- , Elisabeth M van Leeuwen
- , Eric-Wubbo Lameijer
- , Fereydoun Hormozdiari
- , Freerk van Dijk
- , Gertjan B van Ommen
- , Gonneke Willemsen
- , H Eka D Suchiman
- , Hailiang Mei
- , Heorhiy Byelas
- , Hongzhi Cao
- , Isaäc J Nijman
- , Itsik Pe'er
- , Jan Bot
- , Jan H Veldink
- , Jasper A Bovenberg
- , Jayne Y Hehir-Kwa
- , Jeroen F J Laros
- , Jessica van Setten
- , Johan T den Dunnen
- , Jouke Jan Hottenga
- , Jun Wang
- , K Joeri der Velde
- , Kai Ye
- , Laurent C Francioli
- , Lennart C Karssen
- , Leonard H den Berg
- , Manfred Kayser
- , Mannis van Oven
- , Marian B Beekman
- , Mark Stoneking
- , Martijn Dijkstra
- , Martijn Vermaat
- , Mashaal Sohail
- , Mathieu Plattee
- , Mathijs Kattenberg
- , Matthijs H Moed
- , Mingkun Li
- , Morris A Swertz
- , Najaf Amin
- , Ning Li
- , P Eline Slagboom
- , Patrick Deelen
- , Paul I W de Bakker
- , Peter de Knijff
- , Pier Francesco Palamara
- , Pieter B T Neerincx
- , Qibin Li
- , Robert E Handsaker
- , Ruoyan Chen
- , Sara L Pulit
- , Shamil R Sunyaev
- , Shobha Potluri
- , Steven J Pitts
- , Sujie Cao
- , Tobias Marschall
- , Victor Guryev
- , Vyacheslav Koval
- , Wigard P Kloosterman
- , Yingrui Li
- , Yuanping Du
- , P Eline Slagboom
- , Paul I W de Bakker
- , Cisca Wijmenga
- , Morris A Swertz
- , Dorret I Boomsma
- , Cornelia M van Duijn
- , Lennart C Karssen
- & Jouke Jan Hottenga
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Research |
Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases
- Tobias L Lenz
- , Aaron J Deutsch
- , Buhm Han
- , Xinli Hu
- , Yukinori Okada
- , Stephen Eyre
- , Michael Knapp
- , Alexandra Zhernakova
- , Tom W J Huizinga
- , Gonçalo Abecasis
- , Jessica Becker
- , Guy E Boeckxstaens
- , Wei-Min Chen
- , Andre Franke
- , Dafna D Gladman
- , Ines Gockel
- , Javier Gutierrez-Achury
- , Javier Martin
- , Rajan P Nair
- , Markus M Nöthen
- , Suna Onengut-Gumuscu
- , Proton Rahman
- , Solbritt Rantapää-Dahlqvist
- , Philip E Stuart
- , Lam C Tsoi
- , David A van Heel
- , Jane Worthington
- , Mira M Wouters
- , Lars Klareskog
- , James T Elder
- , Peter K Gregersen
- , Johannes Schumacher
- , Stephen S Rich
- , Cisca Wijmenga
- , Shamil R Sunyaev
- , Paul I W de Bakker
- & Soumya Raychaudhuri
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Research | | Open
Genome analysis reveals insights into physiology and longevity of the Brandt’s bat Myotis brandtii
- Inge Seim
- , Xiaodong Fang
- , Zhiqiang Xiong
- , Alexey V. Lobanov
- , Zhiyong Huang
- , Siming Ma
- , Yue Feng
- , Anton A. Turanov
- , Yabing Zhu
- , Tobias L. Lenz
- , Maxim V. Gerashchenko
- , Dingding Fan
- , Sun Hee Yim
- , Xiaoming Yao
- , Daniel Jordan
- , Yingqi Xiong
- , Yong Ma
- , Andrey N. Lyapunov
- , Guanxing Chen
- , Oksana I. Kulakova
- , Yudong Sun
- , Sang-Goo Lee
- , Roderick T. Bronson
- , Alexey A. Moskalev
- , Shamil R. Sunyaev
- , Guojie Zhang
- , Anders Krogh
- , Jun Wang
- & Vadim N. Gladyshev
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Research |
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Research |
Whole-genome sequence variation, population structure and demographic history of the Dutch population
- Laurent C Francioli
- , Androniki Menelaou
- , Sara L Pulit
- , Freerk van Dijk
- , Pier Francesco Palamara
- , Clara C Elbers
- , Pieter B T Neerincx
- , Kai Ye
- , Victor Guryev
- , Wigard P Kloosterman
- , Patrick Deelen
- , Abdel Abdellaoui
- , Elisabeth M van Leeuwen
- , Mannis van Oven
- , Martijn Vermaat
- , Mingkun Li
- , Jeroen F J Laros
- , Lennart C Karssen
- , Alexandros Kanterakis
- , Najaf Amin
- , Jouke Jan Hottenga
- , Eric-Wubbo Lameijer
- , Mathijs Kattenberg
- , Martijn Dijkstra
- , Heorhiy Byelas
- , Jessica van Setten
- , Barbera D C van Schaik
- , Jan Bot
- , Isaäc J Nijman
- , Ivo Renkens
- , Tobias Marschall
- , Alexander Schönhuth
- , Jayne Y Hehir-Kwa
- , Robert E Handsaker
- , Paz Polak
- , Mashaal Sohail
- , Dana Vuzman
- , Fereydoun Hormozdiari
- , David van Enckevort
- , Hailiang Mei
- , Vyacheslav Koval
- , Matthijs H Moed
- , K Joeri van der Velde
- , Fernando Rivadeneira
- , Karol Estrada
- , Carolina Medina-Gomez
- , Aaron Isaacs
- , Steven A McCarroll
- , Marian Beekman
- , Anton J M de Craen
- , H Eka D Suchiman
- , Albert Hofman
- , Ben Oostra
- , André G Uitterlinden
- , Gonneke Willemsen
- , LifeLines Cohort Study
- , Mathieu Platteel
- , Jan H Veldink
- , Leonard H van den Berg
- , Steven J Pitts
- , Shobha Potluri
- , Purnima Sundar
- , David R Cox
- , Shamil R Sunyaev
- , Johan T den Dunnen
- , Mark Stoneking
- , Peter de Knijff
- , Manfred Kayser
- , Qibin Li
- , Yingrui Li
- , Yuanping Du
- , Ruoyan Chen
- , Hongzhi Cao
- , Ning Li
- , Sujie Cao
- , Jun Wang
- , Jasper A Bovenberg
- , Itsik Pe'er
- , P Eline Slagboom
- , Cornelia M van Duijn
- , Dorret I Boomsma
- , Gert-Jan B van Ommen
- , Paul I W de Bakker
- , Morris A Swertz
- & Cisca Wijmenga
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Research |
Exome sequencing identifies rare LDLR and APOA5 alleles conferring risk for myocardial infarction
- Ron Do
- , Nathan O. Stitziel
- , Hong-Hee Won
- , Anders Berg Jørgensen
- , Stefano Duga
- , Pier Angelica Merlini
- , Adam Kiezun
- , Martin Farrall
- , Anuj Goel
- , Or Zuk
- , Illaria Guella
- , Rosanna Asselta
- , Leslie A. Lange
- , Gina M. Peloso
- , Paul L. Auer
- , Domenico Girelli
- , Nicola Martinelli
- , Deborah N. Farlow
- , Mark A. DePristo
- , Robert Roberts
- , Alexander F. R. Stewart
- , Danish Saleheen
- , John Danesh
- , Stephen E. Epstein
- , Suthesh Sivapalaratnam
- , G. Kees Hovingh
- , John J. Kastelein
- , Nilesh J. Samani
- , Heribert Schunkert
- , Jeanette Erdmann
- , Svati H. Shah
- , William E. Kraus
- , Robert Davies
- , Majid Nikpay
- , Christopher T. Johansen
- , Jian Wang
- , Robert A. Hegele
- , Eliana Hechter
- , Winfried Marz
- , Marcus E. Kleber
- , Jie Huang
- , Andrew D. Johnson
- , Mingyao Li
- , Greg L. Burke
- , Myron Gross
- , Yongmei Liu
- , Themistocles L. Assimes
- , Gerardo Heiss
- , Ethan M. Lange
- , Aaron R. Folsom
- , Herman A. Taylor
- , Oliviero Olivieri
- , Anders Hamsten
- , Robert Clarke
- , Dermot F. Reilly
- , Wu Yin
- , Manuel A. Rivas
- , Peter Donnelly
- , Jacques E. Rossouw
- , Bruce M. Psaty
- , David M. Herrington
- , James G. Wilson
- , Stephen S. Rich
- , Michael J. Bamshad
- , Russell P. Tracy
- , L. Adrienne Cupples
- , Daniel J. Rader
- , Muredach P. Reilly
- , John A. Spertus
- , Sharon Cresci
- , Jaana Hartiala
- , W. H. Wilson Tang
- , Stanley L. Hazen
- , Hooman Allayee
- , Alex P. Reiner
- , Christopher S. Carlson
- , Charles Kooperberg
- , Rebecca D. Jackson
- , Eric Boerwinkle
- , Eric S. Lander
- , Stephen M. Schwartz
- , David S. Siscovick
- , Ruth McPherson
- , Anne Tybjaerg-Hansen
- , Goncalo R. Abecasis
- , Hugh Watkins
- , Deborah A. Nickerson
- , Diego Ardissino
- , Shamil R. Sunyaev
- , Christopher J. O'Donnell
- , David Altshuler
- , Stacey Gabriel
- & Sekar Kathiresan
-
Reviews |
Exome sequencing and the genetic basis of complex traits
- Adam Kiezun
- , Kiran Garimella
- , Ron Do
- , Nathan O Stitziel
- , Benjamin M Neale
- , Paul J McLaren
- , Namrata Gupta
- , Pamela Sklar
- , Patrick F Sullivan
- , Jennifer L Moran
- , Christina M Hultman
- , Paul Lichtenstein
- , Patrik Magnusson
- , Thomas Lehner
- , Yin Yao Shugart
- , Alkes L Price
- , Paul I W de Bakker
- , Shaun M Purcell
- & Shamil R Sunyaev
-
Research |
-
Research | | Open
The accessible chromatin landscape of the human genome
- Robert E. Thurman
- , Eric Rynes
- , Richard Humbert
- , Jeff Vierstra
- , Matthew T. Maurano
- , Eric Haugen
- , Nathan C. Sheffield
- , Andrew B. Stergachis
- , Hao Wang
- , Benjamin Vernot
- , Kavita Garg
- , Sam John
- , Richard Sandstrom
- , Daniel Bates
- , Lisa Boatman
- , Theresa K. Canfield
- , Morgan Diegel
- , Douglas Dunn
- , Abigail K. Ebersol
- , Tristan Frum
- , Erika Giste
- , Audra K. Johnson
- , Ericka M. Johnson
- , Tanya Kutyavin
- , Bryan Lajoie
- , Bum-Kyu Lee
- , Kristen Lee
- , Darin London
- , Dimitra Lotakis
- , Shane Neph
- , Fidencio Neri
- , Eric D. Nguyen
- , Hongzhu Qu
- , Alex P. Reynolds
- , Vaughn Roach
- , Alexias Safi
- , Minerva E. Sanchez
- , Amartya Sanyal
- , Anthony Shafer
- , Jeremy M. Simon
- , Lingyun Song
- , Shinny Vong
- , Molly Weaver
- , Yongqi Yan
- , Zhancheng Zhang
- , Zhuzhu Zhang
- , Boris Lenhard
- , Muneesh Tewari
- , Michael O. Dorschner
- , R. Scott Hansen
- , Patrick A. Navas
- , George Stamatoyannopoulos
- , Vishwanath R. Iyer
- , Jason D. Lieb
- , Shamil R. Sunyaev
- , Joshua M. Akey
- , Peter J. Sabo
- , Rajinder Kaul
- , Terrence S. Furey
- , Job Dekker
- , Gregory E. Crawford
- & John A. Stamatoyannopoulos
