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News and Views | 16 January 2018
Allosteric inhibitors hit USP7 hard
- Wei Zhang
- & Sachdev S Sidhu
Nature Chemical Biology 14 , 110–111

Rights & permissionsfor article Allosteric inhibitors hit USP7 hard . Opens in a new window.
News and Views | 1 May 2007
Full-length antibodies on display
- Sachdev S Sidhu
Nature Biotechnology 25 , 537–538

Rights & permissionsfor article Full-length antibodies on display . Opens in a new window.
News and Views | 26 November 2012
Evolving superkines for selectivity
- Shane Miersch
- & Sachdev S Sidhu
Nature Chemical Biology 8 , 955–956

Rights & permissionsfor article Evolving superkines for selectivity . Opens in a new window.
Reviews | 1 December 2006
Synthetic therapeutic antibodies
- Sachdev S Sidhu
- & Frederic A Fellouse
Nature Chemical Biology 2 , 682–688

Rights & permissionsfor article Synthetic therapeutic antibodies . Opens in a new window.
Research | 1 March 2009
Inhibition of Wnt signaling by Dishevelled PDZ peptides
- Yingnan Zhang
- , Brent A Appleton
- , Christian Wiesmann
- , Ted Lau
- , Mike Costa
- , Rami N Hannoush
- & Sachdev S Sidhu
Nature Chemical Biology 5 , 217–219

Rights & permissionsfor article Inhibition of Wnt signaling by Dishevelled PDZ peptides . Opens in a new window.
1 June 2008
Submitting antibodies to binding arbitration
- Stephen W Michnick
- & Sachdev S Sidhu
Nature Chemical Biology 4 , 326–329

Rights & permissionsfor article Submitting antibodies to binding arbitration . Opens in a new window.
Research | 29 January 2019 | Open
A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations
- Allison M. L. Nixon
- , Alejandro Duque
- , Nicholas Yelle
- , Megan McLaughlin
- , Sadegh Davoudi
- , Nicolas M. Pedley
- , Jennifer Haynes
- , Kevin R. Brown
- , James Pan
- , Traver Hart
- , Penney M. Gilbert
- , Sheila K. Singh
- , Catherine A. O’Brien
- , Sachdev S. Sidhu
- & Jason Moffat
Scientific Reports 9 , 1–13

Rights & permissionsfor article A rapid <i>in vitro</i> methodology for simultaneous target discovery and antibody generation against functional cell subpopulations . Opens in a new window.
Research | 11 March 2019 | Open
The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency
- Noah Manczyk
- , Gianluca Veggiani
- , Joan Teyra
- , Amy W. Strilchuk
- , Sachdev S. Sidhu
- & Frank Sicheri
Scientific Reports 9 , 1–11

Rights & permissionsfor article The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency . Opens in a new window.
Research | 21 November 2018
Protocadherin-1 is essential for cell entry by New World hantaviruses
- Rohit K. Jangra
- , Andrew S. Herbert
- , Rong Li
- , Lucas T. Jae
- , Lara M. Kleinfelter
- , Megan M. Slough
- , Sarah L. Barker
- , Pablo Guardado-Calvo
- , Gleyder Román-Sosa
- , M. Eugenia Dieterle
- , Ana I. Kuehne
- , Nicolás A. Muena
- , Ariel S. Wirchnianski
- , Elisabeth K. Nyakatura
- , J. Maximilian Fels
- , Melinda Ng
- , Eva Mittler
- , James Pan
- , Sushma Bharrhan
- , Anna Z. Wec
- , Jonathan R. Lai
- , Sachdev S. Sidhu
- , Nicole D. Tischler
- , Félix A. Rey
- , Jason Moffat
- , Thijn R. Brummelkamp
- , Zhongde Wang
- , John M. Dye
- & Kartik Chandran
Nature 563 , 559–563

Rights & permissionsfor article Protocadherin-1 is essential for cell entry by New World hantaviruses . Opens in a new window.
Research | 27 November 2017
Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency
- Marella D Canny
- , Nathalie Moatti
- , Leo C K Wan
- , Amélie Fradet-Turcotte
- , Danielle Krasner
- , Pedro A Mateos-Gomez
- , Michal Zimmermann
- , Alexandre Orthwein
- , Yu-Chi Juang
- , Wei Zhang
- , Sylvie M Noordermeer
- , Eduardo Seclen
- , Marcus D Wilson
- , Andrew Vorobyov
- , Meagan Munro
- , Andreas Ernst
- , Timothy F Ng
- , Tiffany Cho
- , Paula M Cannon
- , Sachdev S Sidhu
- , Frank Sicheri
- & Daniel Durocher
Nature Biotechnology 36 , 95–102

Rights & permissionsfor article Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency . Opens in a new window.
Research | 2 October 2017
A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis
- Eshan Ghosh
- , Ashish Srivastava
- , Mithu Baidya
- , Punita Kumari
- , Hemlata Dwivedi
- , Kumari Nidhi
- , Ravi Ranjan
- , Shalini Dogra
- , Akiko Koide
- , Prem N. Yadav
- , Sachdev S. Sidhu
- , Shohei Koide
- & Arun K. Shukla
Nature Nanotechnology 12 , 1190–1198

Rights & permissionsfor article A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis . Opens in a new window.
Research | 20 June 2016
PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia
- Robert S. Banh
- , Caterina Iorio
- , Richard Marcotte
- , Yang Xu
- , Dan Cojocari
- , Anas Abdel Rahman
- , Judy Pawling
- , Wei Zhang
- , Ankit Sinha
- , Christopher M. Rose
- , Marta Isasa
- , Shuang Zhang
- , Ronald Wu
- , Carl Virtanen
- , Toshiaki Hitomi
- , Toshiyuki Habu
- , Sachdev S. Sidhu
- , Akio Koizumi
- , Sarah E. Wilkins
- , Thomas Kislinger
- , Steven P. Gygi
- , Christopher J. Schofield
- , James W. Dennis
- , Bradly G. Wouters
- & Benjamin G. Neel
Nature Cell Biology 18 , 803–813

Rights & permissionsfor article PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia . Opens in a new window.
Research | 22 June 2014
Visualization of arrestin recruitment by a G-protein-coupled receptor
- Arun K. Shukla
- , Gerwin H. Westfield
- , Kunhong Xiao
- , Rosana I. Reis
- , Li-Yin Huang
- , Prachi Tripathi-Shukla
- , Jiang Qian
- , Sheng Li
- , Adi Blanc
- , Austin N. Oleskie
- , Anne M. Dosey
- , Min Su
- , Cui-Rong Liang
- , Ling-Ling Gu
- , Jin-Ming Shan
- , Xin Chen
- , Rachel Hanna
- , Minjung Choi
- , Xiao Jie Yao
- , Bjoern U. Klink
- , Alem W. Kahsai
- , Sachdev S. Sidhu
- , Shohei Koide
- , Pawel A. Penczek
- , Anthony A. Kossiakoff
- , Virgil L. Woods Jr
- , Brian K. Kobilka
- , Georgios Skiniotis
- & Robert J. Lefkowitz
Nature 512 , 218–222

Rights & permissionsfor article Visualization of arrestin recruitment by a G-protein-coupled receptor . Opens in a new window.
Research | 2 November 2015
Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity
Nature Immunology 17 , 87–94

Rights & permissionsfor article Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity . Opens in a new window.
Research | 29 June 2015
Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation
- Edyta Marcon
- , Harshika Jain
- , Anandi Bhattacharya
- , Hongbo Guo
- , Sadhna Phanse
- , Shuye Pu
- , Gregory Byram
- , Ben C Collins
- , Evan Dowdell
- , Maria Fenner
- , Xinghua Guo
- , Ashley Hutchinson
- , Jacob J Kennedy
- , Bryan Krastins
- , Brett Larsen
- , Zhen-Yuan Lin
- , Mary F Lopez
- , Peter Loppnau
- , Shane Miersch
- , Tin Nguyen
- , Jonathan B Olsen
- , Marcin Paduch
- , Mani Ravichandran
- , Alma Seitova
- , Gouri Vadali
- , Maryann S Vogelsang
- , Jeffrey R Whiteaker
- , Guoqing Zhong
- , Nan Zhong
- , Lei Zhao
- , Ruedi Aebersold
- , Cheryl H Arrowsmith
- , Andrew Emili
- , Lori Frappier
- , Anne-Claude Gingras
- , Matthias Gstaiger
- , Amanda G Paulovich
- , Shohei Koide
- , Anthony A Kossiakoff
- , Sachdev S Sidhu
- , Shoshana J Wodak
- , Susanne Gräslund
- , Jack F Greenblatt
- & Aled M Edwards
Nature Methods 12 , 725–731

Rights & permissionsfor article Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation . Opens in a new window.
Research | 6 July 2014
RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation
- Zuyao Ni
- , Chao Xu
- , Xinghua Guo
- , Gerald O Hunter
- , Olga V Kuznetsova
- , Wolfram Tempel
- , Edyta Marcon
- , Guoqing Zhong
- , Hongbo Guo
- , Wei-Hung William Kuo
- , Joyce Li
- , Peter Young
- , Jonathan B Olsen
- , Cuihong Wan
- , Peter Loppnau
- , Majida El Bakkouri
- , Guillermo A Senisterra
- , Hao He
- , Haiming Huang
- , Sachdev S Sidhu
- , Andrew Emili
- , Shona Murphy
- , Amber L Mosley
- , Cheryl H Arrowsmith
- , Jinrong Min
- & Jack F Greenblatt
Nature Structural & Molecular Biology 21 , 686–695

Rights & permissionsfor article RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation . Opens in a new window.
Research | 12 December 2010
A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination
Nature Structural & Molecular Biology 18 , 100–106

Rights & permissionsfor article A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination . Opens in a new window.
Protocols | 24 May 2007
Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries
Nature Protocols 2 , 1368–1386

Rights & permissionsfor article Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries . Opens in a new window.

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Allosteric inhibitors hit USP7 hard

Full-length antibodies on display

Evolving superkines for selectivity

Synthetic therapeutic antibodies

Inhibition of Wnt signaling by Dishevelled PDZ peptides

Submitting antibodies to binding arbitration

A rapid in vitro methodology for simultaneous target discovery and antibody generation against functional cell subpopulations

The ubiquitin interacting motifs of USP37 act on the proximal Ub of a di-Ub chain to enhance catalytic efficiency

Protocadherin-1 is essential for cell entry by New World hantaviruses

Inhibition of 53BP1 favors homology-dependent DNA repair and increases CRISPR–Cas9 genome-editing efficiency

A synthetic intrabody-based selective and generic inhibitor of GPCR endocytosis

PTP1B controls non-mitochondrial oxygen consumption by regulating RNF213 to promote tumour survival during hypoxia

Visualization of arrestin recruitment by a G-protein-coupled receptor

Structural interplay between germline interactions and adaptive recognition determines the bandwidth of TCR-peptide-MHC cross-reactivity

Assessment of a method to characterize antibody selectivity and specificity for use in immunoprecipitation

RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation

A portable RNA sequence whose recognition by a synthetic antibody facilitates structural determination

Identifying specificity profiles for peptide recognition modules from phage-displayed peptide libraries

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