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News and Views | 1 April 1997
Managed care for viruses
- Ronald G. Crystal
Nature Medicine 3 , 383–384

Rights & permissionsfor article Managed care for viruses . Opens in a new window.
News and Views | 1 January 2002
Fooling Mother Nature
- Ronald G. Crystal
Nature Biotechnology 20 , 32–33

Rights & permissionsfor article Fooling Mother Nature . Opens in a new window.
1 April 1999
The body as a manufacturer of endostatin
- Ronald G. Crystal
Nature Biotechnology 17 , 336–337

Rights & permissionsfor article The body as a manufacturer of endostatin . Opens in a new window.
Research | 29 June 2020 | Open
Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS
Scientific Reports 10 , 1–13

Rights & permissionsfor article Increased airway iron parameters and risk for exacerbation in COPD: an analysis from SPIROMICS . Opens in a new window.
Research | 10 April 2020 | Open
Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture
Scientific Reports 10 , 1–17

Rights & permissionsfor article Intermittent exposure to whole cigarette smoke alters the differentiation of primary small airway epithelial cells in the air-liquid interface culture . Opens in a new window.
Research | 9 January 1986
Activated human monocytes express the c-sis proto-oncogene and release a mediator showing PDGF-like activity
Nature 319 , 158–160

Rights & permissionsfor article Activated human monocytes express the c-<i>sis</i> proto-oncogene and release a mediator showing PDGF-like activity . Opens in a new window.
Research | 6 December 1999
Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma
Cancer Gene Therapy 6 , 491–498

Rights & permissionsfor article Regional treatment of hepatic micrometastasis by adenovirus vector-mediated delivery of interleukin-2 and interleukin-12 cDNAs to the hepatic parenchyma . Opens in a new window.
Research | 22 October 1999
Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells
Cancer Gene Therapy 6 , 99–106

Rights & permissionsfor article Use of L-plastin promoter to develop an adenoviral system that confers transgene expression in ovarian cancer cells but not in normal mesothelial cells . Opens in a new window.
Research | 1 March 1996
Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH
Nature Genetics 12 , 274–279

Rights & permissionsfor article Ectopic expression of thyrotropin releasing hormone (TRH) receptors in liver modulates organ function to regulate blood glucose by TRH . Opens in a new window.
News and Views | 1 January 1995
The gene as the drug
- Ronald G. Crystal
Nature Medicine 1 , 15–17

Rights & permissionsfor article The gene as the drug . Opens in a new window.
Research | 1 October 2000
Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4⁺ T cells
Nature Medicine 6 , 1154–1159

Rights & permissionsfor article Dendritic cells genetically modified to express CD40 ligand and pulsed with antigen can initiate antigen-specific humoral immunity independent of CD4<sup>+</sup> T cells . Opens in a new window.
Research | 1 March 1993
Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
Nature Genetics 3 , 229–234

Rights & permissionsfor article Direct <i>in vivo</i> gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors . Opens in a new window.
Research | 14 July 1977
Rigid control of synthesis of collagen Types I and III by cells in culture
- ALLAN J. HANCE
- & RONALD G. CRYSTAL
Nature 268 , 152–154

Rights & permissionsfor article Rigid control of synthesis of collagen Types I and III by cells in culture . Opens in a new window.
1 March 1995
IL-6 release and airway administration of human CFTR cDNA adenovirus vector
- Noel G. McElvaney
- & Ronald G. Crystal
Nature Medicine 1 , 182–184

Rights & permissionsfor article IL-6 release and airway administration of human CFTR cDNA adenovirus vector . Opens in a new window.
Research | 23 November 1978
Fibroblasts degrade newly synthesised collagen within the cell before secretion
Nature 276 , 413–416

Rights & permissionsfor article Fibroblasts degrade newly synthesised collagen within the cell before secretion . Opens in a new window.
1 June 1997
Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA
- Salvatore J. Cannizzo
- , Beat M. Frey
- , Shahin Raffi
- , Malcolm A.S. Moore
- , Dan Eaton
- , Motoyoshi Suzuki
- , Ravi Singh
- , Charles A. Mack
- & Ronald G. Crystal
Nature Biotechnology 15 , 570–573

Rights & permissionsfor article Augmentation of blood platelet levels by intratracheal administration of an adenovirus vector encoding human thrombopoietin cDNA . Opens in a new window.
Research | 1 February 1993
Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA
Nature Genetics 3 , 151–156

Rights & permissionsfor article Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA . Opens in a new window.
Reviews | 10 October 2012 | Open
A call for transparent reporting to optimize the predictive value of preclinical research
- Story C. Landis
- , Susan G. Amara
- , Khusru Asadullah
- , Chris P. Austin
- , Robi Blumenstein
- , Eileen W. Bradley
- , Ronald G. Crystal
- , Robert B. Darnell
- , Robert J. Ferrante
- , Howard Fillit
- , Robert Finkelstein
- , Marc Fisher
- , Howard E. Gendelman
- , Robert M. Golub
- , John L. Goudreau
- , Robert A. Gross
- , Amelie K. Gubitz
- , Sharon E. Hesterlee
- , David W. Howells
- , John Huguenard
- , Katrina Kelner
- , Walter Koroshetz
- , Dimitri Krainc
- , Stanley E. Lazic
- , Michael S. Levine
- , Malcolm R. Macleod
- , John M. McCall
- , Richard T. Moxley III
- , Kalyani Narasimhan
- , Linda J. Noble
- , Steve Perrin
- , John D. Porter
- , Oswald Steward
- , Ellis Unger
- , Ursula Utz
- & Shai D. Silberberg
Nature 490 , 187–191

Rights & permissionsfor article A call for transparent reporting to optimize the predictive value of preclinical research . Opens in a new window.
Research | 10 January 1985
Synthesis in E. coli of α₁-antitrypsin variants of therapeutic potential for emphysema and thrombosis
Nature 313 , 149–151

Rights & permissionsfor article Synthesis in <i>E. coli</i> of <i>α</i><sub>1</sub>-antitrypsin variants of therapeutic potential for emphysema and thrombosis . Opens in a new window.
Research | 26 December 1991
Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation
- Wilfried Dalemans
- , Pascal Barbry
- , Guy Champigny
- , Sophie Jallat
- , Sophie Jallat
- , Karin Dott
- , Dominique Dreyer
- , Ronald G. Crystal
- , Andréa Pavirani
- , Jean-Pierre Lecocq
- & Michel Lazdunski
Nature 354 , 526–528

Rights & permissionsfor article Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation . Opens in a new window.
Research | 23 December 1976
Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell
Nature 264 , 772–774

Rights & permissionsfor article Activation of alveolar macrophage collagenase by a neutral protease secreted by the same cell . Opens in a new window.
Research | 15 October 2018 | Open
Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (CLN2, Batten Disease)
Scientific Reports 8 , 1–12

Rights & permissionsfor article Untargeted Metabolite Profiling of Cerebrospinal Fluid Uncovers Biomarkers for Severity of Late Infantile Neuronal Ceroid Lipofuscinosis (<i>CLN2</i>, Batten Disease) . Opens in a new window.
Research | 23 January 2018 | Open
Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population
- Noha A. Yousri
- , Khalid A. Fakhro
- , Amal Robay
- , Juan L. Rodriguez-Flores
- , Robert P. Mohney
- , Hassina Zeriri
- , Tala Odeh
- , Sara Abdul Kader
- , Eman K. Aldous
- , Gaurav Thareja
- , Manish Kumar
- , Alya Al-Shakaki
- , Omar M. Chidiac
- , Yasmin A. Mohamoud
- , Jason G. Mezey
- , Joel A. Malek
- , Ronald G. Crystal
- & Karsten Suhre
Nature Communications 9 , 1–13

Rights & permissionsfor article Whole-exome sequencing identifies common and rare variant metabolic QTLs in a Middle Eastern population . Opens in a new window.
Research | 12 April 2018
Point-of-care whole-exome sequencing of idiopathic male infertility
- Khalid A Fakhro
- , Haitham Elbardisi
- , Mohamed Arafa
- , Amal Robay
- , Juan L Rodriguez-Flores
- , Alya Al-Shakaki
- , Najeeb Syed
- , Jason G Mezey
- , Charbel Abi Khalil
- , Joel A Malek
- , Abdulla Al-Ansari
- , Sami Al Said
- & Ronald G Crystal
Genetics in Medicine 20 , 1365–1373

Rights & permissionsfor article Point-of-care whole-exome sequencing of idiopathic male infertility . Opens in a new window.
Research | 30 June 2016 | Open
The Qatar genome: a population-specific tool for precision medicine in the Middle East
- Khalid A Fakhro
- , Michelle R Staudt
- , Monica Denise Ramstetter
- , Amal Robay
- , Joel A Malek
- , Ramin Badii
- , Ajayeb Al-Nabet Al-Marri
- , Charbel Abi Khalil
- , Alya Al-Shakaki
- , Omar Chidiac
- , Dora Stadler
- , Mahmoud Zirie
- , Amin Jayyousi
- , Jacqueline Salit
- , Jason G Mezey
- , Ronald G Crystal
- & Juan L Rodriguez-Flores
Human Genome Variation 3 , 1–7

Rights & permissionsfor article The Qatar genome: a population-specific tool for precision medicine in the Middle East . Opens in a new window.
Research | 10 May 2013
Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter
- Anat Maoz
- , Martin J Hicks
- , Shankar Vallabhjosula
- , Michael Synan
- , Paresh J Kothari
- , Jonathan P Dyke
- , Douglas J Ballon
- , Stephen M Kaminsky
- , Bishnu P De
- , Jonathan B Rosenberg
- , Diana Martinez
- , George F Koob
- , Kim D Janda
- & Ronald G Crystal
Neuropsychopharmacology 38 , 2170–2178

Rights & permissionsfor article Adenovirus Capsid-Based Anti-Cocaine Vaccine Prevents Cocaine from Binding to the Nonhuman Primate CNS Dopamine Transporter . Opens in a new window.
Research | 6 April 2014
Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia
Nature Medicine 20 , 542–547

Rights & permissionsfor article Prevention and reversal of severe mitochondrial cardiomyopathy by gene therapy in a mouse model of Friedreich's ataxia . Opens in a new window.
Research | 1 September 1994
Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
- Ronald G. Crystal
- , Noel G. McElvaney
- , Melissa A. Rosenfeld
- , Chin-Shyan Chu
- , Andrea Mastrangeli
- , John G. Hay
- , Steven L. Brody
- , H. Ari Jaffe
- , N. Tony Eissa
- & Claire Danel
Nature Genetics 8 , 42–51

Rights & permissionsfor article Administration of an adenovirus containing the human <i>CFTR</i> cDNA to the respiratory tract of individuals with cystic fibrosis . Opens in a new window.
Research | 25 July 2004
Trans-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency
Nature Medicine 10 , 835–841

Rights & permissionsfor article <i>Trans</i>-splicing repair of CD40 ligand deficiency results in naturally regulated correction of a mouse model of hyper-IgM X-linked immunodeficiency . Opens in a new window.
Research | 14 September 2011
Novel Cocaine Vaccine Linked to a Disrupted Adenovirus Gene Transfer Vector Blocks Cocaine Psychostimulant and Reinforcing Effects
- Sunmee Wee
- , Martin J Hicks
- , Bishnu P De
- , Jonathan B Rosenberg
- , Amira Y Moreno
- , Stephen M Kaminsky
- , Kim D Janda
- , Ronald G Crystal
- & George F Koob
Neuropsychopharmacology 37 , 1083–1091

Rights & permissionsfor article Novel Cocaine Vaccine Linked to a Disrupted Adenovirus Gene Transfer Vector Blocks Cocaine Psychostimulant and Reinforcing Effects . Opens in a new window.
Research | 1 November 2001
Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth
- David Lyden
- , Koichi Hattori
- , Sergio Dias
- , Carla Costa
- , Pamela Blaikie
- , Linda Butros
- , Amy Chadburn
- , Beate Heissig
- , Willy Marks
- , Larry Witte
- , Yan Wu
- , Daniel Hicklin
- , Zhenping Zhu
- , Neil R. Hackett
- , Ronald G. Crystal
- , Malcolm A.S. Moore
- , Katherine A. Hajjar
- , Katia Manova
- , Robert Benezra
- & Shahin Rafii
Nature Medicine 7 , 1194–1201

Rights & permissionsfor article Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth . Opens in a new window.
1 October 1989
Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice
- Andrea Pavirani
- , Tim Skern
- , Marianne Le Meur
- , Yves Lutz
- , Richard Lathe
- , Ronald G. Crystal
- , Jean-Paul Fuchs
- , Pierre Gerlinger
- & Michael Courtney
Nature Biotechnology 7 , 1049–1054

Rights & permissionsfor article Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice . Opens in a new window.
Research | 30 April 2006
Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4⁺ hemangiocytes
- David K Jin
- , Koji Shido
- , Hans-Georg Kopp
- , Isabelle Petit
- , Sergey V Shmelkov
- , Lauren M Young
- , Andrea T Hooper
- , Hideki Amano
- , Scott T Avecilla
- , Beate Heissig
- , Koichi Hattori
- , Fan Zhang
- , Daniel J Hicklin
- , Yan Wu
- , Zhenping Zhu
- , Ashley Dunn
- , Hassan Salari
- , Zena Werb
- , Neil R Hackett
- , Ronald G Crystal
- , David Lyden
- & Shahin Rafii
Nature Medicine 12 , 557–567

Rights & permissionsfor article Cytokine-mediated deployment of SDF-1 induces revascularization through recruitment of CXCR4<sup>+</sup> hemangiocytes . Opens in a new window.
Research | 13 July 2009
A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition
Nature Cell Biology 11 , 943–950

Rights & permissionsfor article A SNAIL1–SMAD3/4 transcriptional repressor complex promotes TGF-β mediated epithelial–mesenchymal transition . Opens in a new window.
Research | 21 December 2003
Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis
- Scott T Avecilla
- , Koichi Hattori
- , Beate Heissig
- , Rafael Tejada
- , Fang Liao
- , Koji Shido
- , David K Jin
- , Sergio Dias
- , Fan Zhang
- , Travis E Hartman
- , Neil R Hackett
- , Ronald G Crystal
- , Larry Witte
- , Daniel J. Hicklin
- , Peter Bohlen
- , Dan Eaton
- , David Lyden
- , Fredric de Sauvage
- & Shahin Rafii
Nature Medicine 10 , 64–71

Rights & permissionsfor article Chemokine-mediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis . Opens in a new window.
Reviews | 1 April 2006
Genetic medicines: treatment strategies for hereditary disorders
- Timothy P. O'Connor
- & Ronald G. Crystal
Nature Reviews Genetics 7 , 261–276

Rights & permissionsfor article Genetic medicines: treatment strategies for hereditary disorders . Opens in a new window.
Research | 1 July 2002
Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1⁺ stem cells from bone-marrow microenvironment
- Koichi Hattori
- , Beate Heissig
- , Yan Wu
- , Sergio Dias
- , Rafael Tejada
- , Barbara Ferris
- , Daniel J. Hicklin
- , Zhenping Zhu
- , Peter Bohlen
- , Larry Witte
- , Jan Hendrikx
- , Neil R. Hackett
- , Ronald G. Crystal
- , Malcolm A.S. Moore
- , Zena Werb
- , David Lyden
- & Shahin Rafii
Nature Medicine 8 , 841–849

Rights & permissionsfor article Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1<sup>+</sup> stem cells from bone-marrow microenvironment . Opens in a new window.
Research | 1 November 2002
Apoptosis Induced by Pseudomonas aeruginosa in Antigen Presenting Cells Is Diminished by Genetic Modification with CD40 Ligand
Pediatric Research 52 , 636–644

Rights & permissionsfor article Apoptosis Induced by <i>Pseudomonas aeruginosa</i> in Antigen Presenting Cells Is Diminished by Genetic Modification with CD40 Ligand . Opens in a new window.

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