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Research | 6 January 2021
Mitochondrial sorting and assembly machinery operates by β-barrel switching
- Hironori Takeda
- , Akihisa Tsutsumi
- , Tomohiro Nishizawa
- , Caroline Lindau
- , Jon V. Busto
- , Lena-Sophie Wenz
- , Lars Ellenrieder
- , Kenichiro Imai
- , Sebastian P. Straub
- , Waltraut Mossmann
- , Jian Qiu
- , Yu Yamamori
- , Kentaro Tomii
- , Junko Suzuki
- , Takeshi Murata
- , Satoshi Ogasawara
- , Osamu Nureki
- , Thomas Becker
- , Nikolaus Pfanner
- , Nils Wiedemann
- , Masahide Kikkawa
- & Toshiya Endo
Nature , 1–7

Rights & permissionsfor article Mitochondrial sorting and assembly machinery operates by β-barrel switching . Opens in a new window.
Research | 9 November 2020 | Open
Isoprenoid-chained lipid EROCOC₁₇₊₄: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography
- Kentaro Ihara
- , Masakatsu Hato
- , Takanori Nakane
- , Keitaro Yamashita
- , Tomomi Kimura-Someya
- , Toshiaki Hosaka
- , Yoshiko Ishizuka-Katsura
- , Rie Tanaka
- , Tomoyuki Tanaka
- , Michihiro Sugahara
- , Kunio Hirata
- , Masaki Yamamoto
- , Osamu Nureki
- , Kensuke Tono
- , Eriko Nango
- , So Iwata
- & Mikako Shirouzu
Scientific Reports 10 , 1–12

Rights & permissionsfor article Isoprenoid-chained lipid EROCOC<sub>17+4</sub>: a new matrix for membrane protein crystallization and a crystal delivery medium in serial femtosecond crystallography . Opens in a new window.
Research | 5 November 2020 | Open
Structural insights into the mechanism of rhodopsin phosphodiesterase
- Tatsuya Ikuta
- , Wataru Shihoya
- , Masahiro Sugiura
- , Kazuho Yoshida
- , Masahito Watari
- , Takaya Tokano
- , Keitaro Yamashita
- , Kota Katayama
- , Satoshi P. Tsunoda
- , Takayuki Uchihashi
- , Hideki Kandori
- & Osamu Nureki
Nature Communications 11 , 1–12

Rights & permissionsfor article Structural insights into the mechanism of rhodopsin phosphodiesterase . Opens in a new window.
Amendments and Corrections | 5 June 2020
Publisher Correction: Base editors for simultaneous introduction of C-to-T and A-to-G mutations
- Rina C. Sakata
- , Soh Ishiguro
- , Hideto Mori
- , Mamoru Tanaka
- , Kenji Tatsuno
- , Hiroki Ueda
- , Shogo Yamamoto
- , Motoaki Seki
- , Nanami Masuyama
- , Keiji Nishida
- , Hiroshi Nishimasu
- , Kazuharu Arakawa
- , Akihiko Kondo
- , Osamu Nureki
- , Masaru Tomita
- , Hiroyuki Aburatani
- & Nozomu Yachie
Nature Biotechnology 38 , 901–901

Rights & permissionsfor article Publisher Correction: Base editors for simultaneous introduction of C-to-T and A-to-G mutations . Opens in a new window.
Research | 11 September 2020 | Open
Kidney GATA3⁺ regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury
- Ryota Sakai
- , Minako Ito
- , Kyoko Komai
- , Mana Iizuka-Koga
- , Kazuhiko Matsuo
- , Takashi Nakayama
- , Osamu Yoshie
- , Koichi Amano
- , Hiroshi Nishimasu
- , Osamu Nureki
- , Masato Kubo
- & Akihiko Yoshimura
Cellular & Molecular Immunology , 1–13

Rights & permissionsfor article Kidney GATA3<sup>+</sup> regulatory T cells play roles in the convalescence stage after antibody-mediated renal injury . Opens in a new window.
Amendments and Corrections | 30 January 2020
Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter
- Yoshiki Tanaka
- , Christopher J. Hipolito
- , Andrés D. Maturana
- , Koichi Ito
- , Teruo Kuroda
- , Takashi Higuchi
- , Takayuki Katoh
- , Hideaki E. Kato
- , Motoyuki Hattori
- , Kaoru Kumazaki
- , Tomoya Tsukazaki
- , Ryuichiro Ishitani
- , Hiroaki Suga
- & Osamu Nureki
Nature 578 , E19–E19

Rights & permissionsfor article Author Correction: Structural basis for the drug extrusion mechanism by a MATE multidrug transporter . Opens in a new window.
Amendments and Corrections | 13 November 2008
Erratum: Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains
- Yusuke Sato
- , Azusa Yoshikawa
- , Atsushi Yamagata
- , Hisatoshi Mimura
- , Masami Yamashita
- , Kayoko Ookata
- , Osamu Nureki
- , Kazuhiro Iwai
- , Masayuki Komada
- & Shuya Fukai
Nature 456 , 274–274

Rights & permissionsfor article Erratum: Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains . Opens in a new window.
Research | 22 June 2020
The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism
Nature Structural & Molecular Biology 27 , 645–652

Rights & permissionsfor article The structure of lipid nanodisc-reconstituted TRPV3 reveals the gating mechanism . Opens in a new window.
Research | 2 June 2020
Base editors for simultaneous introduction of C-to-T and A-to-G mutations
- Rina C. Sakata
- , Soh Ishiguro
- , Hideto Mori
- , Mamoru Tanaka
- , Kenji Tatsuno
- , Hiroki Ueda
- , Shogo Yamamoto
- , Motoaki Seki
- , Nanami Masuyama
- , Keiji Nishida
- , Hiroshi Nishimasu
- , Kazuharu Arakawa
- , Akihiko Kondo
- , Osamu Nureki
- , Masaru Tomita
- , Hiroyuki Aburatani
- & Nozomu Yachie
Nature Biotechnology 38 , 865–869

Rights & permissionsfor article Base editors for simultaneous introduction of C-to-T and A-to-G mutations . Opens in a new window.
Research | 24 October 2018 | Open
Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1
- Kazuki Kato
- , Hiroshi Nishimasu
- , Daisuke Oikawa
- , Seiichi Hirano
- , Hisato Hirano
- , Go Kasuya
- , Ryuichiro Ishitani
- , Fuminori Tokunaga
- & Osamu Nureki
Nature Communications 9 , 1–8

Rights & permissionsfor article Structural insights into cGAMP degradation by Ecto-nucleotide pyrophosphatase phosphodiesterase 1 . Opens in a new window.
Research | 10 December 2018
Genome editing in plants by engineered CRISPR–Cas9 recognizing NG PAM
- Masaki Endo
- , Masafumi Mikami
- , Akira Endo
- , Hidetaka Kaya
- , Takeshi Itoh
- , Hiroshi Nishimasu
- , Osamu Nureki
- & Seiichi Toki
Nature Plants 5 , 14–17

Rights & permissionsfor article Genome editing in plants by engineered CRISPR–Cas9 recognizing NG PAM . Opens in a new window.
Research | 15 May 2020 | Open
Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation
- Ryoki Nakamura
- , Tomohiro Numata
- , Go Kasuya
- , Takeshi Yokoyama
- , Tomohiro Nishizawa
- , Tsukasa Kusakizako
- , Takafumi Kato
- , Tatsuya Hagino
- , Naoshi Dohmae
- , Masato Inoue
- , Kengo Watanabe
- , Hidenori Ichijo
- , Masahide Kikkawa
- , Mikako Shirouzu
- , Thomas J. Jentsch
- , Ryuichiro Ishitani
- , Yasunobu Okada
- & Osamu Nureki
Communications Biology 3 , 1–10

Rights & permissionsfor article Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation . Opens in a new window.
Research | 10 November 2017 | Open
Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy
Nature Communications 8 , 1–9

Rights & permissionsfor article Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy . Opens in a new window.
Research | 30 March 2020 | Open
Structural insights into tetraspanin CD9 function
- Rie Umeda
- , Yuhkoh Satouh
- , Mizuki Takemoto
- , Yoshiko Nakada-Nakura
- , Kehong Liu
- , Takeshi Yokoyama
- , Mikako Shirouzu
- , So Iwata
- , Norimichi Nomura
- , Ken Sato
- , Masahito Ikawa
- , Tomohiro Nishizawa
- & Osamu Nureki
Nature Communications 11 , 1–11

Rights & permissionsfor article Structural insights into tetraspanin CD9 function . Opens in a new window.
Research | 15 July 2016 | Open
Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization
- Kazuki Kato
- , Yuhkoh Satouh
- , Hiroshi Nishimasu
- , Arisa Kurabayashi
- , Junko Morita
- , Yoshitaka Fujihara
- , Asami Oji
- , Ryuichiro Ishitani
- , Masahito Ikawa
- & Osamu Nureki
Nature Communications 7 , 1–9

Rights & permissionsfor article Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization . Opens in a new window.
Research | 23 March 2017 | Open
Structural insights into the nucleotide base specificity of P2X receptors
- Go Kasuya
- , Yuichiro Fujiwara
- , Hisao Tsukamoto
- , Satoshi Morinaga
- , Satoshi Ryu
- , Kazushige Touhara
- , Ryuichiro Ishitani
- , Yuji Furutani
- , Motoyuki Hattori
- & Osamu Nureki
Scientific Reports 7 , 1–10

Rights & permissionsfor article Structural insights into the nucleotide base specificity of P2X receptors . Opens in a new window.
Research | 8 August 2016 | Open
Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide
- Junko Morita
- , Kazuki Kato
- , Takanori Nakane
- , Yuki Kondo
- , Hiroo Fukuda
- , Hiroshi Nishimasu
- , Ryuichiro Ishitani
- & Osamu Nureki
Nature Communications 7 , 1–9

Rights & permissionsfor article Crystal structure of the plant receptor-like kinase TDR in complex with the TDIF peptide . Opens in a new window.
Research | 18 April 2016 | Open
Oil-free hyaluronic acid matrix for serial femtosecond crystallography
- Michihiro Sugahara
- , Changyong Song
- , Mamoru Suzuki
- , Tetsuya Masuda
- , Shigeyuki Inoue
- , Takanori Nakane
- , Fumiaki Yumoto
- , Eriko Nango
- , Rie Tanaka
- , Kensuke Tono
- , Yasumasa Joti
- , Takashi Kameshima
- , Takaki Hatsui
- , Makina Yabashi
- , Osamu Nureki
- , Keiji Numata
- & So Iwata
Scientific Reports 6 , 1–6

Rights & permissionsfor article Oil-free hyaluronic acid matrix for serial femtosecond crystallography . Opens in a new window.
Research | 10 October 2016 | Open
Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide
- Hiroki Omura
- , Daisuke Oikawa
- , Takanori Nakane
- , Megumi Kato
- , Ryohei Ishii
- , Ryuichiro Ishitani
- , Fuminori Tokunaga
- & Osamu Nureki
Scientific Reports 6 , 1–11

Rights & permissionsfor article Structural and Functional Analysis of DDX41: a bispecific immune receptor for DNA and cyclic dinucleotide . Opens in a new window.
Research | 9 March 2020
Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein
Nature Structural & Molecular Biology 27 , 274–280

Rights & permissionsfor article Cryo-EM structure of the human PAC1 receptor coupled to an engineered heterotrimeric G protein . Opens in a new window.
Research | 3 December 2014 | Open
Crystal structure of Escherichia coli YidC, a membrane protein chaperone and insertase
- Kaoru Kumazaki
- , Toshiki Kishimoto
- , Arata Furukawa
- , Hiroyuki Mori
- , Yoshiki Tanaka
- , Naoshi Dohmae
- , Ryuichiro Ishitani
- , Tomoya Tsukazaki
- & Osamu Nureki
Scientific Reports 4 , 1–6

Rights & permissionsfor article Crystal structure of <i>Escherichia coli</i> YidC, a membrane protein chaperone and insertase . Opens in a new window.
Research | 12 February 2020 | Open
Crystal structure of Drosophila Piwi
- Sonomi Yamaguchi
- , Akira Oe
- , Kazumichi M. Nishida
- , Keitaro Yamashita
- , Asako Kajiya
- , Seiichi Hirano
- , Naoki Matsumoto
- , Naoshi Dohmae
- , Ryuichiro Ishitani
- , Kuniaki Saito
- , Haruhiko Siomi
- , Hiroshi Nishimasu
- , Mikiko C. Siomi
- & Osamu Nureki
Nature Communications 11 , 1–13

Rights & permissionsfor article Crystal structure of <i>Drosophila</i> Piwi . Opens in a new window.
Research | 31 December 2008
Pyrrolysyl-tRNA synthetase–tRNA^Pyl structure reveals the molecular basis of orthogonality
- Kayo Nozawa
- , Patrick O’Donoghue
- , Sarath Gundllapalli
- , Yuhei Araiso
- , Ryuichiro Ishitani
- , Takuya Umehara
- , Dieter Söll
- & Osamu Nureki
Nature 457 , 1163–1167

Rights & permissionsfor article Pyrrolysyl-tRNA synthetase–tRNA<sup>Pyl</sup> structure reveals the molecular basis of orthogonality . Opens in a new window.
Research | 11 March 2002
Functional convergence of two lysyl-tRNA synthetases with unrelated topologies
Nature Structural & Molecular Biology 9 , 257–262

Rights & permissionsfor article Functional convergence of two lysyl-tRNA synthetases with unrelated topologies . Opens in a new window.
Research | 5 August 2004
Structural basis for template-independent RNA polymerization
- Kozo Tomita
- , Shuya Fukai
- , Ryuichiro Ishitani
- , Takuya Ueda
- , Nono Takeuchi
- , Dmitry G. Vassylyev
- & Osamu Nureki
Nature 430 , 700–704

Rights & permissionsfor article Structural basis for template-independent RNA polymerization . Opens in a new window.
Research | 16 October 2008
Conformational transition of Sec machinery inferred from bacterial SecYE structures
- .... In a third paper, Osamu Nureki and colleagues present a crystal...
- Tomoya Tsukazaki
- , Hiroyuki Mori
- , Shuya Fukai
- , Ryuichiro Ishitani
- , Takaharu Mori
- , Naoshi Dohmae
- , Anna Perederina
- , Yuji Sugita
- , Dmitry G. Vassylyev
- , Koreaki Ito
- & Osamu Nureki
Nature 455 , 988–991

Rights & permissionsfor article Conformational transition of Sec machinery inferred from bacterial SecYE structures . Opens in a new window.
Research | 15 October 2006
Complete crystallographic analysis of the dynamics of CCA sequence addition
Nature 443 , 956–960

Rights & permissionsfor article Complete crystallographic analysis of the dynamics of CCA sequence addition . Opens in a new window.
Research | 11 September 2005
Structural basis for anticodon recognition by methionyl-tRNA synthetase
- Kotaro Nakanishi
- , Yuri Ogiso
- , Takashi Nakama
- , Shuya Fukai
- & Osamu Nureki
Nature Structural & Molecular Biology 12 , 931–932

Rights & permissionsfor article Structural basis for anticodon recognition by methionyl-tRNA synthetase . Opens in a new window.
Research | 15 August 2007
Crystal structure of the MgtE Mg²⁺ transporter
Nature 448 , 1072–1075

Rights & permissionsfor article Crystal structure of the MgtE Mg<sup>2+</sup> transporter . Opens in a new window.
Research | 15 April 1999
Structural basis for recognition of the tra mRNA precursor by the Sex-lethal protein
- Noriko Handa
- , Osamu Nureki
- , Kazuki Kurimoto
- , Insil Kim
- , Hiroshi Sakamoto
- , Yoshiro Shimura
- , Yutaka Muto
- & Shigeyuki Yokoyama
Nature 398 , 579–585

Rights & permissionsfor article Structural basis for recognition of the <i>tra</i> mRNA precursor by the Sex-lethal protein . Opens in a new window.
Research | 11 May 2011
Structure and function of a membrane component SecDF that enhances protein export
- ...unknown. In this study, Osamu Nureki and colleagues present a structural...
- Tomoya Tsukazaki
- , Hiroyuki Mori
- , Yuka Echizen
- , Ryuichiro Ishitani
- , Shuya Fukai
- , Takeshi Tanaka
- , Anna Perederina
- , Dmitry G. Vassylyev
- , Toshiyuki Kohno
- , Andrés D. Maturana
- , Koreaki Ito
- & Osamu Nureki
Nature 474 , 235–238

Rights & permissionsfor article Structure and function of a membrane component SecDF that enhances protein export . Opens in a new window.
Research | 11 January 2004
A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase
- Yoshiaki Kise
- , Sang Won Lee
- , Sang Gyu Park
- , Shuya Fukai
- , Toru Sengoku
- , Ryohei Ishii
- , Shigeyuki Yokoyama
- , Sunghoon Kim
- & Osamu Nureki
Nature Structural & Molecular Biology 11 , 149–156

Rights & permissionsfor article A short peptide insertion crucial for angiostatic activity of human tryptophanyl-tRNA synthetase . Opens in a new window.
Research | 14 October 2012
Structure and function of Zucchini endoribonuclease in piRNA biogenesis
- ...laboratories of Greg Hannon and Osamu Nureki now implicate the phosphodiesterase Zucchini...
- Hiroshi Nishimasu
- , Hirotsugu Ishizu
- , Kuniaki Saito
- , Satoshi Fukuhara
- , Miharu K. Kamatani
- , Luc Bonnefond
- , Naoki Matsumoto
- , Tomohiro Nishizawa
- , Keita Nakanaga
- , Junken Aoki
- , Ryuichiro Ishitani
- , Haruhiko Siomi
- , Mikiko C. Siomi
- & Osamu Nureki
Nature 491 , 284–287

Rights & permissionsfor article Structure and function of Zucchini endoribonuclease in piRNA biogenesis . Opens in a new window.
Research | 19 May 2003
Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion
Nature Structural & Molecular Biology 10 , 425–432

Rights & permissionsfor article Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion . Opens in a new window.
Research | 27 July 2006
Snapshots of tRNA sulphuration via an adenylated intermediate
- Tomoyuki Numata
- , Yoshiho Ikeuchi
- , Shuya Fukai
- , Tsutomu Suzuki
- & Osamu Nureki
Nature 442 , 419–424

Rights & permissionsfor article Snapshots of tRNA sulphuration via an adenylated intermediate . Opens in a new window.
Research | 1 March 2001
Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase
Nature Structural & Molecular Biology 8 , 203–206

Rights & permissionsfor article Structural basis for anticodon recognition by discriminating glutamyl-tRNA synthetase . Opens in a new window.
Research | 22 October 2009
Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase
Nature 461 , 1144–1148

Rights & permissionsfor article Structural basis for translational fidelity ensured by transfer RNA lysidine synthetase . Opens in a new window.
Research | 25 September 2019
Crystal structure of heliorhodopsin
- Wataru Shihoya
- , Keiichi Inoue
- , Manish Singh
- , Masae Konno
- , Shoko Hososhima
- , Keitaro Yamashita
- , Kento Ikeda
- , Akimitsu Higuchi
- , Tamaki Izume
- , Sae Okazaki
- , Masanori Hashimoto
- , Ritsu Mizutori
- , Sahoko Tomida
- , Yumeka Yamauchi
- , Rei Abe-Yoshizumi
- , Kota Katayama
- , Satoshi P. Tsunoda
- , Mikihiro Shibata
- , Yuji Furutani
- , Alina Pushkarev
- , Oded Béjà
- , Takayuki Uchihashi
- , Hideki Kandori
- & Osamu Nureki
Nature 574 , 132–136

Rights & permissionsfor article Crystal structure of heliorhodopsin . Opens in a new window.
Research | 21 June 2019 | Open
Crystal structure of human endothelin ET_B receptor in complex with peptide inverse agonist IRL2500
Communications Biology 2 , 1–10

Rights & permissionsfor article Crystal structure of human endothelin ET<sub>B</sub> receptor in complex with peptide inverse agonist IRL2500 . Opens in a new window.
Research | 29 April 2019 | Open
Structural basis for the promiscuous PAM recognition by Corynebacterium diphtheriae Cas9
- Seiichi Hirano
- , Omar O. Abudayyeh
- , Jonathan S. Gootenberg
- , Takuro Horii
- , Ryuichiro Ishitani
- , Izuho Hatada
- , Feng Zhang
- , Hiroshi Nishimasu
- & Osamu Nureki
Nature Communications 10 , 1–11

Rights & permissionsfor article Structural basis for the promiscuous PAM recognition by <i>Corynebacterium diphtheriae</i> Cas9 . Opens in a new window.
Research | 3 June 2019
Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc
- Yongchan Lee
- , Pattama Wiriyasermkul
- , Chunhuan Jin
- , Lili Quan
- , Ryuichi Ohgaki
- , Suguru Okuda
- , Tsukasa Kusakizako
- , Tomohiro Nishizawa
- , Kazumasa Oda
- , Ryuichiro Ishitani
- , Takeshi Yokoyama
- , Takanori Nakane
- , Mikako Shirouzu
- , Hitoshi Endou
- , Shushi Nagamori
- , Yoshikatsu Kanai
- & Osamu Nureki
Nature Structural & Molecular Biology 26 , 510–517

Rights & permissionsfor article Cryo-EM structure of the human L-type amino acid transporter 1 in complex with glycoprotein CD98hc . Opens in a new window.
Research | 11 February 2019
Crystal structure of plant vacuolar iron transporter VIT1
- Takafumi Kato
- , Kaoru Kumazaki
- , Miki Wada
- , Reiya Taniguchi
- , Takanori Nakane
- , Keitaro Yamashita
- , Kunio Hirata
- , Ryuichiro Ishitani
- , Koichi Ito
- , Tomohiro Nishizawa
- & Osamu Nureki
Nature Plants 5 , 308–315

Rights & permissionsfor article Crystal structure of plant vacuolar iron transporter VIT1 . Opens in a new window.
Research | 20 August 2018
Cryo-EM structures of the human volume-regulated anion channel LRRC8
- Go Kasuya
- , Takanori Nakane
- , Takeshi Yokoyama
- , Yanyan Jia
- , Masato Inoue
- , Kengo Watanabe
- , Ryoki Nakamura
- , Tomohiro Nishizawa
- , Tsukasa Kusakizako
- , Akihisa Tsutsumi
- , Haruaki Yanagisawa
- , Naoshi Dohmae
- , Motoyuki Hattori
- , Hidenori Ichijo
- , Zhiqiang Yan
- , Masahide Kikkawa
- , Mikako Shirouzu
- , Ryuichiro Ishitani
- & Osamu Nureki
Nature Structural & Molecular Biology 25 , 797–804

Rights & permissionsfor article Cryo-EM structures of the human volume-regulated anion channel LRRC8 . Opens in a new window.
Research | 12 October 2018 | Open
DUSP10 constrains innate IL-33-mediated cytokine production in ST2^hi memory-type pathogenic Th2 cells
- Takeshi Yamamoto
- , Yusuke Endo
- , Atsushi Onodera
- , Kiyoshi Hirahara
- , Hikari K. Asou
- , Takahiro Nakajima
- , Toshio Kanno
- , Yasuo Ouchi
- , Satoshi Uematsu
- , Hiroshi Nishimasu
- , Osamu Nureki
- , Damon J. Tumes
- , Naoki Shimojo
- & Toshinori Nakayama
Nature Communications 9 , 1–15

Rights & permissionsfor article DUSP10 constrains innate IL-33-mediated cytokine production in ST2<sup>hi</sup> memory-type pathogenic Th2 cells . Opens in a new window.
Research | 26 September 2018 | Open
Crystal structure of the red light-activated channelrhodopsin Chrimson
Nature Communications 9 , 1–11

Rights & permissionsfor article Crystal structure of the red light-activated channelrhodopsin Chrimson . Opens in a new window.
Research | 9 November 2018 | Open
Crystal structures of human ET_B receptor provide mechanistic insight into receptor activation and partial activation
- Wataru Shihoya
- , Tamaki Izume
- , Asuka Inoue
- , Keitaro Yamashita
- , Francois Marie Ngako Kadji
- , Kunio Hirata
- , Junken Aoki
- , Tomohiro Nishizawa
- & Osamu Nureki
Nature Communications 9 , 1–11

Rights & permissionsfor article Crystal structures of human ET<sub>B</sub> receptor provide mechanistic insight into receptor activation and partial activation . Opens in a new window.
Research | 17 November 2017 | Open
Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate
- Takehiko Tosha
- , Takashi Nomura
- , Takuma Nishida
- , Naoya Saeki
- , Kouta Okubayashi
- , Raika Yamagiwa
- , Michihiro Sugahara
- , Takanori Nakane
- , Keitaro Yamashita
- , Kunio Hirata
- , Go Ueno
- , Tetsunari Kimura
- , Tamao Hisano
- , Kazumasa Muramoto
- , Hitomi Sawai
- , Hanae Takeda
- , Eiichi Mizohata
- , Ayumi Yamashita
- , Yusuke Kanematsu
- , Yu Takano
- , Eriko Nango
- , Rie Tanaka
- , Osamu Nureki
- , Osami Shoji
- , Yuka Ikemoto
- , Hironori Murakami
- , Shigeki Owada
- , Kensuke Tono
- , Makina Yabashi
- , Masaki Yamamoto
- , Hideo Ago
- , So Iwata
- , Hiroshi Sugimoto
- , Yoshitsugu Shiro
- & Minoru Kubo
Nature Communications 8 , 1–9

Rights & permissionsfor article Capturing an initial intermediate during the P450nor enzymatic reaction using time-resolved XFEL crystallography and caged-substrate . Opens in a new window.
Research | 9 August 2017
Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA₆
- ...in this area. Here, Osamu Nureki and colleagues report the crystal...
- Reiya Taniguchi
- , Asuka Inoue
- , Misa Sayama
- , Akiharu Uwamizu
- , Keitaro Yamashita
- , Kunio Hirata
- , Masahito Yoshida
- , Yoshiki Tanaka
- , Hideaki E. Kato
- , Yoshiko Nakada-Nakura
- , Yuko Otani
- , Tomohiro Nishizawa
- , Takayuki Doi
- , Tomohiko Ohwada
- , Ryuichiro Ishitani
- , Junken Aoki
- & Osamu Nureki
Nature 548 , 356–360

Rights & permissionsfor article Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA<sub>6</sub> . Opens in a new window.
Research | 23 June 2017 | Open
CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice
- Tsukasa Ohmori
- , Yasumitsu Nagao
- , Hiroaki Mizukami
- , Asuka Sakata
- , Shin-ichi Muramatsu
- , Keiya Ozawa
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Research | 14 August 2017
X-ray structures of endothelin ET_B receptor bound to clinical antagonist bosentan and its analog
- Wataru Shihoya
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- & Osamu Nureki
Nature Structural & Molecular Biology 24 , 758–764

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