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Correspondence | 4 November 2004
Reply to Krejci et al
- W A G Stams
- , M L den Boer
- , H B Beverloo
- , E R van Wering
- & R Pieters
Leukemia 19 , 320–321

Rights & permissionsfor article Reply to Krejci <i>et al</i> . Opens in a new window.
12 April 2017 | Open
Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche
- B de Rooij
- , R Polak
- , F Stalpers
- , R Pieters
- & M L den Boer
Leukemia 31 , 1651–1654

Rights & permissionsfor article Tunneling nanotubes facilitate autophagosome transfer in the leukemic niche . Opens in a new window.
Correspondence | 4 November 2004
Upregulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL
- W A G Stams
- , M L den Boer
- , H B Beverloo
- , E R van Wering
- & R Pieters
Leukemia 19 , 318–319

Rights & permissionsfor article Upregulation of asparagine synthetase and cell cycle arrest in t(12;21)-positive ALL . Opens in a new window.
Correspondence | 18 September 2003
Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL
- I M Appel
- , J P V Pinheiro
- , M L den Boer
- , C Lanvers
- , N C M Reniers
- , J Boos
- & R Pieters
Leukemia 17 , 2254–2256

Rights & permissionsfor article Lack of asparagine depletion in the cerebrospinal fluid after one intravenous dose of PEG-asparaginase: a window study at initial diagnosis of childhood ALL . Opens in a new window.
24 November 2005
MLL gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia
- R W Stam
- , I Hubeek
- , M L den Boer
- , J G C A M Buijs-Gladdines
- , U Creutzig
- , G J L Kaspers
- & R Pieters
Leukemia 20 , 179–182

Rights & permissionsfor article <i>MLL</i> gene rearrangements have no direct impact on Ara-C sensitivity in infant acute lymphoblastic leukemia and childhood M4/M5 acute myeloid leukemia . Opens in a new window.
19 January 2006
Reply to ‘ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia’ by Gumy-Pause et al.
- M Meier
- , M L den Boer
- , A G Hall
- , J A E Irving
- , M Passier
- , L Minto
- , E R van Wering
- , G E Janka-Schaub
- & R Pieters
Leukemia 20 , 527–527

Rights & permissionsfor article Reply to ‘ATM variants and predisposition to childhood T-lineage acute lymphoblastic leukaemia’ by Gumy-Pause <i>et al.</i> . Opens in a new window.
Correspondence | 21 April 2005
CDKN2 deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia
- L J C M van Zutven
- , E van Drunen
- , J M de Bont
- , M M Wattel
- , M L Den Boer
- , R Pieters
- , A Hagemeijer
- , R M Slater
- & H B Beverloo
Leukemia 19 , 1281–1284

Rights & permissionsfor article <i>CDKN2</i> deletions have no prognostic value in childhood precursor-B acute lymphoblastic leukaemia . Opens in a new window.
23 September 2013
The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia
- I M Ariës
- , E S R van den Dungen
- , R Pieters
- & M L den Boer
Leukemia 28 , 422–425

Rights & permissionsfor article The NR4A orphan nuclear receptors do not confer prednisolone resistance in pediatric acute lymphoblastic leukemia . Opens in a new window.
Research | 23 October 2013
Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood TCF3-rearranged leukemia cells
- F Akbari Moqadam
- , J M Boer
- , E A M Lange-Turenhout
- , R Pieters
- & M L den Boer
Leukemia 28 , 1008–1014

Rights & permissionsfor article Altered expression of miR-24, miR-126 and miR-365 does not affect viability of childhood <i>TCF3</i>-rearranged leukemia cells . Opens in a new window.
17 March 2015
Refinement of IKZF1 status in pediatric Philadelphia-positive acute lymphoblastic leukemia
- T Lana
- , P de Lorenzo
- , S Bresolin
- , I Bronzini
- , M L den Boer
- , H Cavé
- , E Froňková
- , M Stanulla
- , M Zaliova
- , C J Harrison
- , H de Groot
- , M G Valsecchi
- , A Biondi
- , G Basso
- , G Cazzaniga
- & G te Kronnie
Leukemia 29 , 2107–2110

Rights & permissionsfor article Refinement of <i>IKZF1</i> status in pediatric Philadelphia-positive acute lymphoblastic leukemia . Opens in a new window.
14 February 2014 | Open
Interference with pre-B-cell receptor signaling offers a therapeutic option for TCF3-rearranged childhood acute lymphoblastic leukemia
- A van der Veer
- , V H J van der Velden
- , M E Willemse
- , P G Hoogeveen
- , E F Petricoin
- , H B Beverloo
- , G Escherich
- , M A Horstmann
- , R Pieters
- & M L den Boer
Blood Cancer Journal 4 , e181–e181

Rights & permissionsfor article Interference with pre-B-cell receptor signaling offers a therapeutic option for <i>TCF3-</i>rearranged childhood acute lymphoblastic leukemia . Opens in a new window.
Research | 23 July 2015
Prognostic value of rare IKZF1 deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study
- J M Boer
- , A van der Veer
- , D Rizopoulos
- , M Fiocco
- , E Sonneveld
- , H A de Groot-Kruseman
- , R P Kuiper
- , P Hoogerbrugge
- , M Horstmann
- , M Zaliova
- , C Palmi
- , J Trka
- , E Fronkova
- , M Emerenciano
- , M do Socorro Pombo-de-Oliveira
- , W Mlynarski
- , T Szczepanski
- , K Nebral
- , A Attarbaschi
- , N Venn
- , R Sutton
- , C J Schwab
- , A Enshaei
- , A Vora
- , M Stanulla
- , M Schrappe
- , G Cazzaniga
- , V Conter
- , M Zimmermann
- , A V Moorman
- , R Pieters
- & M L den Boer
Leukemia 30 , 32–38

Rights & permissionsfor article Prognostic value of rare <i>IKZF1</i> deletion in childhood B-cell precursor acute lymphoblastic leukemia: an international collaborative study . Opens in a new window.
18 February 2010
Bimodal distribution of genomic MLL breakpoints in infant acute lymphoblastic leukemia treatment
- R Jung
- , U Jacobs
- , M Krumbholz
- , T Langer
- , T Keller
- , P De Lorenzo
- , M G Valsecchi
- , V H J van der Velden
- , A Moericke
- , M Stanulla
- , A Teigler-Schlegel
- , E R Panzer-Gruemayer
- , J J M van Dongen
- , M Schrappe
- , M L den Boer
- , R Pieters
- , W Rascher
- & M Metzler
Leukemia 24 , 903–907

Rights & permissionsfor article Bimodal distribution of genomic <i>MLL</i> breakpoints in infant acute lymphoblastic leukemia treatment . Opens in a new window.
Research | 2 March 2006
The MLL recombinome of acute leukemias
- C Meyer
- , B Schneider
- , S Jakob
- , S Strehl
- , A Attarbaschi
- , S Schnittger
- , C Schoch
- , M W J C Jansen
- , J J M van Dongen
- , M L den Boer
- , R Pieters
- , M-G Ennas
- , E Angelucci
- , U Koehl
- , J Greil
- , F Griesinger
- , U zur Stadt
- , C Eckert
- , T Szczepański
- , F K Niggli
- , B W Schäfer
- , H Kempski
- , H J M Brady
- , J Zuna
- , J Trka
- , L L Nigro
- , A Biondi
- , E Delabesse
- , E Macintyre
- , M Stanulla
- , M Schrappe
- , O A Haas
- , T Burmeister
- , T Dingermann
- , T Klingebiel
- & R Marschalek
Leukemia 20 , 777–784

Rights & permissionsfor article The MLL recombinome of acute leukemias . Opens in a new window.
23 October 2003
Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein
- R W Stam
- , M M van den Heuvel-Eibrink
- , M L den Boer
- , M E G Ebus
- , G E Janka-Schaub
- , J D Allen
- & R Pieters
Leukemia 18 , 78–83

Rights & permissionsfor article Multidrug resistance genes in infant acute lymphoblastic leukemia: Ara-C is not a substrate for the breast cancer resistance protein . Opens in a new window.
Research | 19 January 2006
Incidence of additional genetic changes in the TEL and AML1 genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome
- W A G Stams
- , H B Beverloo
- , M L den Boer
- , R X de Menezes
- , R L Stigter
- , E van Drunen
- , N L Ramakers-van-Woerden
- , A H Loonen
- , E R van Wering
- , G E Janka-Schaub
- & R Pieters
Leukemia 20 , 410–416

Rights & permissionsfor article Incidence of additional genetic changes in the <i>TEL</i> and <i>AML1</i> genes in DCOG and COALL-treated t(12;21)-positive pediatric ALL, and their relation with drug sensitivity and clinical outcome . Opens in a new window.
Research | 23 September 2010
High BRE expression in pediatric MLL-rearranged AML is associated with favorable outcome
- B V Balgobind
- , C M Zwaan
- , D Reinhardt
- , T J C M Arentsen-Peters
- , I H I M Hollink
- , V de Haas
- , G J L Kaspers
- , E S J M de Bont
- , A Baruchel
- , J Stary
- , C Meyer
- , R Marschalek
- , U Creutzig
- , M L den Boer
- , R Pieters
- & M M van den Heuvel-Eibrink
Leukemia 24 , 2048–2055

Rights & permissionsfor article High <i>BRE</i> expression in pediatric <i>MLL</i>-rearranged AML is associated with favorable outcome . Opens in a new window.
10 March 2005
mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL
- W J E Tissing
- , J P P Meijerink
- , M L den Boer
- , B Brinkhof
- & R Pieters
Leukemia 19 , 727–733

Rights & permissionsfor article mRNA expression levels of (co)chaperone molecules of the glucocorticoid receptor are not involved in glucocorticoid resistance in pediatric ALL . Opens in a new window.
Research | 12 February 2009
Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol
- V H J Van der Velden
- , L Corral
- , M G Valsecchi
- , M W J C Jansen
- , P De Lorenzo
- , G Cazzaniga
- , E R Panzer-Grümayer
- , M Schrappe
- , A Schrauder
- , C Meyer
- , R Marschalek
- , L L Nigro
- , M Metzler
- , G Basso
- , G Mann
- , M L Den Boer
- , A Biondi
- , R Pieters
- & J J M Van Dongen
Leukemia 23 , 1073–1079

Rights & permissionsfor article Prognostic significance of minimal residual disease in infants with acute lymphoblastic leukemia treated within the Interfant-99 protocol . Opens in a new window.
15 September 2005
Relation between genetic variants of the ataxia telangiectasia-mutated (ATM) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia
- M Meier
- , M L den Boer
- , A G Hall
- , J A E Irving
- , M Passier
- , L Minto
- , E R van Wering
- , G E Janka-Schaub
- & R Pieters
Leukemia 19 , 1887–1895

Rights & permissionsfor article Relation between genetic variants of the ataxia telangiectasia-mutated (<i>ATM</i>) gene, drug resistance, clinical outcome and predisposition to childhood T-lineage acute lymphoblastic leukaemia . Opens in a new window.
Research | 22 June 2006
Differential expression of p73 isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia
- M Meier
- , M L den Boer
- , J P P Meijerink
- , M J C Broekhuis
- , M M C J Passier
- , E R van Wering
- , G E Janka-Schaub
- & R Pieters
Leukemia 20 , 1377–1384

Rights & permissionsfor article Differential expression of <i>p73</i> isoforms in relation to drug resistance in childhood T-lineage acute lymphoblastic leukaemia . Opens in a new window.
Research | 3 October 2017 | Open
RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia
- I S Jerchel
- , A Q Hoogkamer
- , I M Ariës
- , E M P Steeghs
- , J M Boer
- , N J M Besselink
- , A Boeree
- , C van de Ven
- , H A de Groot-Kruseman
- , V de Haas
- , M A Horstmann
- , G Escherich
- , C M Zwaan
- , E Cuppen
- , M J Koudijs
- , R Pieters
- & M L den Boer
Leukemia 32 , 931–940

Rights & permissionsfor article RAS pathway mutations as a predictive biomarker for treatment adaptation in pediatric B-cell precursor acute lymphoblastic leukemia . Opens in a new window.
Research | 20 February 2014
EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion
- I M Ariës
- , I S Jerchel
- , R E S R van den Dungen
- , L C J van den Berk
- , J M Boer
- , M A Horstmann
- , G Escherich
- , R Pieters
- & M L den Boer
Leukemia 28 , 1828–1837

Rights & permissionsfor article EMP1, a novel poor prognostic factor in pediatric leukemia regulates prednisolone resistance, cell proliferation, migration and adhesion . Opens in a new window.
Research | 25 November 2013
miR-9 is a tumor suppressor in pediatric AML with t(8;21)
- S Emmrich
- , J E Katsman-Kuipers
- , K Henke
- , M E Khatib
- , R Jammal
- , F Engeland
- , F Dasci
- , C M Zwaan
- , M L den Boer
- , L Verboon
- , J Stary
- , A Baruchel
- , V de Haas
- , A A Danen-van Oorschot
- , M Fornerod
- , R Pieters
- , D Reinhardt
- , J H Klusmann
- & M M van den Heuvel-Eibrink
Leukemia 28 , 1022–1032

Rights & permissionsfor article miR-9 is a tumor suppressor in pediatric AML with t(8;21) . Opens in a new window.
Research | 3 July 2014 | Open
PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity
- S A Hartsink-Segers
- , J J Beaudoin
- , M W J Luijendijk
- , C Exalto
- , R Pieters
- & M L Den Boer
Leukemia 29 , 304–311

Rights & permissionsfor article PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity . Opens in a new window.
Research | 16 October 2008
Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia
- D Schotte
- , J C K Chau
- , G Sylvester
- , G Liu
- , C Chen
- , V H J van der Velden
- , M J C Broekhuis
- , T C J M Peters
- , R Pieters
- & M L den Boer
Leukemia 23 , 313–322

Rights & permissionsfor article Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia . Opens in a new window.
Research | 3 September 2012 | Open
Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target
- S A Hartsink-Segers
- , C M Zwaan
- , C Exalto
- , M W J Luijendijk
- , V S Calvert
- , E F Petricoin
- , W E Evans
- , D Reinhardt
- , V de Haas
- , M Hedtjärn
- , B R Hansen
- , T Koch
- , H N Caron
- , R Pieters
- & M L Den Boer
Leukemia 27 , 560–568

Rights & permissionsfor article Aurora kinases in childhood acute leukemia: the promise of aurora B as therapeutic target . Opens in a new window.
Research | 26 August 2011
The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells
- J F de Vries
- , C M Zwaan
- , M De Bie
- , J S A Voerman
- , M L den Boer
- , J J M van Dongen
- & V H J van der Velden
Leukemia 26 , 255–264

Rights & permissionsfor article The novel calicheamicin-conjugated CD22 antibody inotuzumab ozogamicin (CMC-544) effectively kills primary pediatric acute lymphoblastic leukemia cells . Opens in a new window.
Research | 26 June 2008
Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study
- I M Appel
- , K M Kazemier
- , J Boos
- , C Lanvers
- , J Huijmans
- , A J P Veerman
- , E van Wering
- , M L den Boer
- & R Pieters
Leukemia 22 , 1665–1679

Rights & permissionsfor article Pharmacokinetic, pharmacodynamic and intracellular effects of PEG-asparaginase in newly diagnosed childhood acute lymphoblastic leukemia: results from a single agent window study . Opens in a new window.
24 June 2011
MicroRNAs in acute leukemia: from biological players to clinical contributors
- D Schotte
- , R Pieters
- & M L Den Boer
Leukemia 26 , 1–12

Rights & permissionsfor article MicroRNAs in acute leukemia: from biological players to clinical contributors . Opens in a new window.
Research | 1 February 2007
Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of MLL gene rearrangement
- M W J C Jansen
- , L Corral
- , V H J van der Velden
- , R Panzer-Grümayer
- , M Schrappe
- , A Schrauder
- , R Marschalek
- , C Meyer
- , M L den Boer
- , W J C Hop
- , M G Valsecchi
- , G Basso
- , A Biondi
- , R Pieters
- & J J M van Dongen
Leukemia 21 , 633–641

Rights & permissionsfor article Immunobiological diversity in infant acute lymphoblastic leukemia is related to the occurrence and type of <i>MLL</i> gene rearrangement . Opens in a new window.
3 January 2003
Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia
- W J E Tissing
- , J P P Meijerink
- , M L den Boer
- & R Pieters
Leukemia 17 , 17–25

Rights & permissionsfor article Molecular determinants of glucocorticoid sensitivity and resistance in acute lymphoblastic leukemia . Opens in a new window.
8 January 2004
In vitro drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, MLL rearrangements and immunophenotype
- N L Ramakers-van Woerden
- , H B Beverloo
- , A J P Veerman
- , B M Camitta
- , A H Loonen
- , E R van Wering
- , R M Slater
- , J Harbott
- , M L den Boer
- , W D Ludwig
- , O A Haas
- , G E Janka-Schaub
- & R Pieters
Leukemia 18 , 521–529

Rights & permissionsfor article <i>In vitro</i> drug-resistance profile in infant acute lymphoblastic leukemia in relation to age, <i>MLL</i> rearrangements and immunophenotype . Opens in a new window.
24 May 2011
Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia
- D Schotte
- , F Akbari Moqadam
- , E A M Lange-Turenhout
- , C Chen
- , W F J van IJcken
- , R Pieters
- & M L den Boer
Leukemia 25 , 1389–1399

Rights & permissionsfor article Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia . Opens in a new window.
Research | 15 December 2005
Silencing of the tumor suppressor gene FHIT is highly characteristic for MLL gene rearranged infant acute lymphoblastic leukemia
- R W Stam
- , M L den Boer
- , M M C J Passier
- , G E Janka-Schaub
- , S E Sallan
- , S A Armstrong
- & R Pieters
Leukemia 20 , 264–271

Rights & permissionsfor article Silencing of the tumor suppressor gene <i>FHIT</i> is highly characteristic for <i>MLL</i> gene rearranged infant acute lymphoblastic leukemia . Opens in a new window.
Research | 30 November 2010
Hypermethylation of specific microRNA genes in MLL-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale
- D J P M Stumpel
- , D Schotte
- , E A M Lange-Turenhout
- , P Schneider
- , L Seslija
- , R X de Menezes
- , V E Marquez
- , R Pieters
- , M L den Boer
- & R W Stam
Leukemia 25 , 429–439

Rights & permissionsfor article Hypermethylation of specific microRNA genes in <i>MLL</i>-rearranged infant acute lymphoblastic leukemia: major matters at a micro scale . Opens in a new window.
Research | 22 March 2012
Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of IKZF1 deletions and CRLF2 aberrations
- T D Buitenkamp
- , R Pieters
- , N E Gallimore
- , A van der Veer
- , J P P Meijerink
- , H B Beverloo
- , M Zimmermann
- , V de Haas
- , S M Richards
- , A J Vora
- , C D Mitchell
- , L J Russell
- , C Schwab
- , C J Harrison
- , A V Moorman
- , M M van den Heuvel-Eibrink
- , M L den Boer
- & C M Zwaan
Leukemia 26 , 2204–2211

Rights & permissionsfor article Outcome in children with Down's syndrome and acute lymphoblastic leukemia: role of <i>IKZF1</i> deletions and <i>CRLF2</i> aberrations . Opens in a new window.
3 July 2012
The hunting of targets: challenge in miRNA research
Leukemia 27 , 16–23

Rights & permissionsfor article The hunting of targets: challenge in miRNA research . Opens in a new window.

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