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Research | 9 December 2020
Neddylation of PTEN regulates its nuclear import and promotes tumor development
- Ping Xie
- , Zhiqiang Peng
- , Yujiao Chen
- , Hongchang Li
- , Mengge Du
- , Yawen Tan
- , Xin Zhang
- , Zhe Lu
- , Chun-Ping Cui
- , Cui Hua Liu
- , Fuchu He
- & Lingqiang Zhang
Cell Research , 1–21

Rights & permissionsfor article Neddylation of PTEN regulates its nuclear import and promotes tumor development . Opens in a new window.
Research | 23 October 2020 | Open
Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis
- Qiyao Chai
- , Zhe Lu
- , Zhidong Liu
- , Yanzhao Zhong
- , Fuzhen Zhang
- , Changgen Qiu
- , Bingxi Li
- , Jing Wang
- , Lingqiang Zhang
- , Yu Pang
- & Cui Hua Liu
Communications Biology 3 , 1–17

Rights & permissionsfor article Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis . Opens in a new window.
Amendments and Corrections | 8 January 2019 | Open
Author Correction: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
- Chun-Ping Cui
- , Yuan Zhang
- , Chanjuan Wang
- , Fang Yuan
- , Hongchang Li
- , Yuying Yao
- , Yuhan Chen
- , Chunnan Li
- , Wenyi Wei
- , Cui Hua Liu
- , Fuchu He
- , Yan Liu
- & Lingqiang Zhang
Nature Communications 10 , 1–1

Rights & permissionsfor article Author Correction: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation . Opens in a new window.
Research | 24 September 2020
Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein
- Wenli Qian
- , Qi Li
- , Xinglong Wu
- , Wenguo Li
- , Qiwei Li
- , Jie Zhang
- , Mengying Li
- , Dan Zhang
- , Hongxia Zhao
- , Xiuqun Zou
- , Hao Jia
- , Lingqiang Zhang
- , Xiao-Dong Yang
- & Zhaoyuan Hou
Oncogene 39 , 6802–6815

Rights & permissionsfor article Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein . Opens in a new window.
Research | 2 September 2020
OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING
- Yunyun Guo
- , Fei Jiang
- , Lingli Kong
- , Haifeng Wu
- , Honghai Zhang
- , Xiaorong Chen
- , Jian Zhao
- , Baoshan Cai
- , Yanqi Li
- , Chunhong Ma
- , Fan Yi
- , Lei Zhang
- , Bingyu Liu
- , Yi Zheng
- , Lingqiang Zhang
- & Chengjiang Gao
Cellular & Molecular Immunology , 1–11

Rights & permissionsfor article OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING . Opens in a new window.
Amendments and Corrections | 1 June 2010
Erratum: Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1
- Kefeng Lu
- , Xiushan Yin
- , Tujun Weng
- , Shenli Xi
- , Li Li
- , Guichun Xing
- , Xuan Cheng
- , Xiao Yang
- , Lingqiang Zhang
- & Fuchu He
Nature Cell Biology 12 , 625–625

Rights & permissionsfor article Erratum: Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 . Opens in a new window.
Research Highlights | 10 May 2019 | Open
Serotonylation: A novel histone H3 marker
- Lin Fu
- & Lingqiang Zhang
Signal Transduction and Targeted Therapy 4 , 1–2

Rights & permissionsfor article Serotonylation: A novel histone H3 marker . Opens in a new window.
Research | 17 June 2020 | Open
The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor
- Lianlian Ouyang
- , Bin Yan
- , Yating Liu
- , Chao Mao
- , Min Wang
- , Na Liu
- , Zuli Wang
- , Shouping Liu
- , Ying Shi
- , Ling Chen
- , Xiang Wang
- , Yan Cheng
- , Ya Cao
- , Desheng Xiao
- , Lingqiang Zhang
- , Shuang Liu
- & Yongguang Tao
Signal Transduction and Targeted Therapy 5 , 1–14

Rights & permissionsfor article The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor . Opens in a new window.
Research | 1 June 2020
Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer
- Pengfei Zhang
- , Chaonan Li
- , Hongchang Li
- , Lin Yuan
- , Hongmiao Dai
- , Zhiqiang Peng
- , Zhikang Deng
- , Zhijie Chang
- , Chun-Ping Cui
- & Lingqiang Zhang
Cell Death and Differentiation 27 , 3177–3195

Rights & permissionsfor article Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer . Opens in a new window.
Amendments and Corrections | 23 March 2018
Author Correction: KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration
- Shan Wang
- , Zhiqiang Peng
- , Siying Wang
- , Lihua Yang
- , Yuhan Chen
- , Xue Kong
- , Shanshan Song
- , Pei Pei
- , Chunyan Tian
- , Hui Yan
- , Peipei Ding
- , Weiguo Hu
- , Cui Hua Liu
- , Xin Zhang
- , Fuchu He
- & Lingqiang Zhang
Cell Research 28 , 605–605

Rights & permissionsfor article Author Correction: KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration . Opens in a new window.
Research | 17 July 2017 | Open
MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma
- Shuai Tong
- , Yang Si
- , Hefen Yu
- , Lingqiang Zhang
- , Ping Xie
- & Wenguo Jiang
Scientific Reports 7 , 1–9

Rights & permissionsfor article MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma . Opens in a new window.
Amendments and Corrections | 3 February 2017
Erratum: USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
- Xingyu Liu
- , Yuying Yao
- , Huiguo Ding
- , Chuanchun Han
- , Yuhan Chen
- , Yuan Zhang
- , Chanjuan Wang
- , Xin Zhang
- , Yiling Zhang
- , Yun Zhai
- , Ping Wang
- , Wenyi Wei
- , Jing Zhang
- & Lingqiang Zhang
Signal Transduction and Targeted Therapy 2 , 1–2

Rights & permissionsfor article Erratum: USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency . Opens in a new window.
Research | 29 January 2012
A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy
- Ge Zhang
- , Baosheng Guo
- , Heng Wu
- , Tao Tang
- , Bao-Ting Zhang
- , Lizhen Zheng
- , Yixin He
- , Zhijun Yang
- , Xiaohua Pan
- , Heelum Chow
- , Kinwah To
- , Yaping Li
- , Dahu Li
- , Xinluan Wang
- , Yixiang Wang
- , Kwongman Lee
- , Zhibo Hou
- , Nan Dong
- , Gang Li
- , Kwoksui Leung
- , Leungkim Hung
- , Fuchu He
- , Lingqiang Zhang
- & Ling Qin
Nature Medicine 18 , 307–314

Rights & permissionsfor article A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy . Opens in a new window.
Research | 20 November 2019
The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis
- Xingyun Wang
- , Shilin Xia
- , Hongchang Li
- , Xiang Wang
- , Chaonan Li
- , Yulin Chao
- , Lingqiang Zhang
- & Chuanchun Han
Cell Death and Differentiation 27 , 1747–1764

Rights & permissionsfor article The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis . Opens in a new window.
Research | 29 April 2019 | Open
A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy
- Qiyao Chai
- , Xudong Wang
- , Lihua Qiang
- , Yong Zhang
- , Pupu Ge
- , Zhe Lu
- , Yanzhao Zhong
- , Bingxi Li
- , Jing Wang
- , Lingqiang Zhang
- , Dawang Zhou
- , Wei Li
- , Wenzhu Dong
- , Yu Pang
- , George Fu Gao
- & Cui Hua Liu
Nature Communications 10 , 1–17

Rights & permissionsfor article A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy . Opens in a new window.
Research | 2 July 2019 | Open
The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
- Tongde Du
- , Hongchang Li
- , Yongsheng Fan
- , Lin Yuan
- , Xiaodan Guo
- , Qiong Zhu
- , Yuying Yao
- , Xin Li
- , Chunlei Liu
- , Xinhe Yu
- , Zhaofei Liu
- , Chun-Ping Cui
- , Chuanchun Han
- & Lingqiang Zhang
Nature Communications 10 , 1–15

Rights & permissionsfor article The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis . Opens in a new window.
Research | 25 January 2019 | Open
CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ
- Jiao Fan
- , Lifeng Liu
- , Qingyan Liu
- , Yu Cui
- , Binwei Yao
- , Minghua Zhang
- , Yabing Gao
- , Yesheng Fu
- , Hongmiao Dai
- , Jingkun Pan
- , Ya Qiu
- , Cui Hua Liu
- , Fuchu He
- , Yu Wang
- & Lingqiang Zhang
Nature Communications 10 , 1–14

Rights & permissionsfor article CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ . Opens in a new window.
Research | 7 November 2018 | Open
Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation
- Chun-Ping Cui
- , Yuan Zhang
- , Chanjuan Wang
- , Fang Yuan
- , Hongchang Li
- , Yuying Yao
- , Yuhan Chen
- , Chunnan Li
- , Wenyi Wei
- , Cui Hua Liu
- , Fuchu He
- , Yan Liu
- & Lingqiang Zhang
Nature Communications 9 , 1–15

Rights & permissionsfor article Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation . Opens in a new window.
Research | 25 June 2018 | Open
Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth
- Yuhan Chen
- , Qingyang Huang
- , Wen Liu
- , Qiong Zhu
- , Chun-Ping Cui
- , Liang Xu
- , Xing Guo
- , Ping Wang
- , Jingwen Liu
- , Guanglong Dong
- , Wenyi Wei
- , Cui Hua Liu
- , Zhichun Feng
- , Fuchu He
- & Lingqiang Zhang
Nature Communications 9 , 1–21

Rights & permissionsfor article Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth . Opens in a new window.
Research | 21 February 2018 | Open
KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration
- Shan Wang
- , Zhiqiang Peng
- , Siying Wang
- , Lihua Yang
- , Yuhan Chen
- , Xue Kong
- , Shanshan Song
- , Pei Pei
- , Chunyan Tian
- , Hui Yan
- , Peipei Ding
- , Weiguo Hu
- , Cui Hua Liu
- , Xin Zhang
- , Fuchu He
- & Lingqiang Zhang
Cell Research 28 , 572–592

Rights & permissionsfor article KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration . Opens in a new window.
Research | 23 March 2018
Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation
- Lihua Qiang
- , Jing Wang
- , Yong Zhang
- , Pupu Ge
- , Qiyao Chai
- , Bingxi Li
- , Yi Shi
- , Lingqiang Zhang
- , George Fu Gao
- & Cui Hua Liu
Cellular & Molecular Immunology 16 , 380–391

Rights & permissionsfor article Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation . Opens in a new window.
Research | 10 May 2017
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
- Bin Wang
- , Zuliang Jie
- , Donghyun Joo
- , Alban Ordureau
- , Pengda Liu
- , Wenjian Gan
- , Jianping Guo
- , Jinfang Zhang
- , Brian J. North
- , Xiangpeng Dai
- , Xuhong Cheng
- , Xiuwu Bian
- , Lingqiang Zhang
- , J. Wade Harper
- , Shao-Cong Sun
- & Wenyi Wei
Nature 545 , 365–369

Rights & permissionsfor article TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling . Opens in a new window.
Research | 4 November 2016 | Open
USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency
- ...unknown. A team led by Lingqiang Zhang from the Beijing Institute of...
- Xingyu Liu
- , Yuying Yao
- , Huiguo Ding
- , Chuanchun Han
- , Yuhan Chen
- , Yuan Zhang
- , Chanjuan Wang
- , Xin Zhang
- , Yiling Zhang
- , Yun Zhai
- , Ping Wang
- , Wenyi Wei
- , Jing Zhang
- & Lingqiang Zhang
Signal Transduction and Targeted Therapy 1 , 1–10

Rights & permissionsfor article USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency . Opens in a new window.
Research | 7 February 2017 | Open
The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function
- Shan He
- , Yu Cao
- , Ping Xie
- , Guanglong Dong
- & Lingqiang Zhang
Scientific Reports 7 , 1–12

Rights & permissionsfor article The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function . Opens in a new window.
Research | 25 November 2016 | Open
The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog
- Jiali Jin
- , Jian Liu
- , Cong Chen
- , Zhenping Liu
- , Cong Jiang
- , Hongshang Chu
- , Weijuan Pan
- , Xinbo Wang
- , Lingqiang Zhang
- , Bin Li
- , Cizhong Jiang
- , Xin Ge
- , Xin Xie
- & Ping Wang
Nature Communications 7 , 1–15

Rights & permissionsfor article The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog . Opens in a new window.
Research | 13 May 2014
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
- Ping Xie
- , Minghua Zhang
- , Shan He
- , Kefeng Lu
- , Yuhan Chen
- , Guichun Xing
- , Yiming Lu
- , Ping Liu
- , Yang Li
- , Shaoxia Wang
- , Nan Chai
- , Jiawei Wu
- , Haiteng Deng
- , Hong-Rui Wang
- , Yu Cao
- , Fei Zhao
- , Yu Cui
- , Jian Wang
- , Fuchu He
- & Lingqiang Zhang
Nature Communications 5 , 1–16

Rights & permissionsfor article The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis . Opens in a new window.
Research | 17 August 2015
Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis
- Lin Yuan
- , Yanrong Lv
- , Hongchang Li
- , Haidong Gao
- , Shanshan Song
- , Yuan Zhang
- , Guichun Xing
- , Xiangzhen Kong
- , Lijing Wang
- , Yang Li
- , Tao Zhou
- , Daming Gao
- , Zhi-Xiong Xiao
- , Yuxin Yin
- , Wenyi Wei
- , Fuchu He
- & Lingqiang Zhang
Nature Cell Biology 17 , 1169–1181

Rights & permissionsfor article Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis . Opens in a new window.
Research | 14 May 2014 | Open
Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation
- Yu Cao
- , Cheng Wang
- , Xueli Zhang
- , Guichun Xing
- , Kefeng Lu
- , Yongqing Gu
- , Fuchu He
- & Lingqiang Zhang
Scientific Reports 4 , 1–11

Rights & permissionsfor article Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation . Opens in a new window.
Research | 9 February 2015
Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy
- Chao Liang
- , Baosheng Guo
- , Heng Wu
- , Ningsheng Shao
- , Defang Li
- , Jin Liu
- , Lei Dang
- , Cheng Wang
- , Hui Li
- , Shaohua Li
- , Wing Ki Lau
- , Yu Cao
- , Zhijun Yang
- , Cheng Lu
- , Xiaojuan He
- , D W T Au
- , Xiaohua Pan
- , Bao-Ting Zhang
- , Changwei Lu
- , Hongqi Zhang
- , Kinman Yue
- , Airong Qian
- , Peng Shang
- , Jiake Xu
- , Lianbo Xiao
- , Zhaoxiang Bian
- , Weihong Tan
- , Zicai Liang
- , Fuchu He
- , Lingqiang Zhang
- , Aiping Lu
- & Ge Zhang
Nature Medicine 21 , 288–294

Rights & permissionsfor article Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy . Opens in a new window.
Research | 29 April 2014
CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation
- Luo Zhang
- , Yiwu Wang
- , Fengjun Xiao
- , Shaoxia Wang
- , Guichun Xing
- , Yang Li
- , Xiushan Yin
- , Kefeng Lu
- , Rongfei Wei
- , Jiao Fan
- , Yuhan Chen
- , Tao Li
- , Ping Xie
- , Lin Yuan
- , Lei Song
- , Lanzhi Ma
- , Lujing Ding
- , Fuchu He
- & Lingqiang Zhang
Cell Research 24 , 742–761

Rights & permissionsfor article CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation . Opens in a new window.
Research | 17 July 2012
N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents
- Shanshan Song
- , Guichun Xing
- , Lin Yuan
- , Jian Wang
- , Shan Wang
- , Yuxin Yin
- , Chunyan Tian
- , Fuchu He
- & Lingqiang Zhang
Cell Research 22 , 1285–1303

Rights & permissionsfor article N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents . Opens in a new window.
Research | 19 April 2009
KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis
- Chunyan Tian
- , Guichun Xing
- , Ping Xie
- , Kefeng Lu
- , Jing Nie
- , Jian Wang
- , Li Li
- , Mei Gao
- , Lingqiang Zhang
- & Fuchu He
Nature Cell Biology 11 , 580–591

Rights & permissionsfor article KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis . Opens in a new window.
Research | 20 July 2008
Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1
- Kefeng Lu
- , Xiushan Yin
- , Tujun Weng
- , Shenli Xi
- , Li Li
- , Guichun Xing
- , Xuan Cheng
- , Xiao Yang
- , Lingqiang Zhang
- & Fuchu He
Nature Cell Biology 10 , 994–1002

Rights & permissionsfor article Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1 . Opens in a new window.

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Neddylation of PTEN regulates its nuclear import and promotes tumor development

Lung gene expression signatures suggest pathogenic links and molecular markers for pulmonary tuberculosis, adenocarcinoma and sarcoidosis

Author Correction: Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Deubiquitinase USP29 promotes gastric cancer cell migration by cooperating with phosphatase SCP1 to stabilize Snail protein

OTUD5 promotes innate antiviral and antitumor immunity through deubiquitinating and stabilizing STING

Erratum: Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

Serotonylation: A novel histone H3 marker

The deubiquitylase UCHL3 maintains cancer stem-like properties by stabilizing the aryl hydrocarbon receptor

Ubiquitin ligase CHIP regulates OTUD3 stability and suppresses tumour metastasis in lung cancer

Author Correction: KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

MLN4924 (Pevonedistat), a protein neddylation inhibitor, suppresses proliferation and migration of human clear cell renal cell carcinoma

Erratum: USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

A delivery system targeting bone formation surfaces to facilitate RNAi-based anabolic therapy

The deubiquitinase USP10 regulates KLF4 stability and suppresses lung tumorigenesis

A Mycobacterium tuberculosis surface protein recruits ubiquitin to trigger host xenophagy

The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis

CKIP-1 limits foam cell formation and inhibits atherosclerosis by promoting degradation of Oct-1 by REGγ

Dynamic ubiquitylation of Sox2 regulates proteostasis and governs neural progenitor cell differentiation

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth

KRAB-type zinc-finger proteins PITA and PISA specifically regulate p53-dependent glycolysis and mitochondrial respiration

Mycobacterium tuberculosis Mce2E suppresses the macrophage innate immune response and promotes epithelial cell proliferation

TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling

USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency

The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function

The deubiquitinase USP21 maintains the stemness of mouse embryonic stem cells via stabilization of Nanog

The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis

Deubiquitylase OTUD3 regulates PTEN stability and suppresses tumorigenesis

Selective Small Molecule Compounds Increase BMP-2 Responsiveness by Inhibiting Smurf1-mediated Smad1/5 Degradation

Aptamer-functionalized lipid nanoparticles targeting osteoblasts as a novel RNA interference–based bone anabolic strategy

CKIP-1 regulates macrophage proliferation by inhibiting TRAF6-mediated Akt activation

N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents

KRAB-type zinc-finger protein Apak specifically regulates p53-dependent apoptosis

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

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