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Research | 26 August 2020
Pharmacogenetics in clinical practice: current level of knowledge among Flemish physicians and pharmacists
The Pharmacogenomics Journal , 1–7

Rights & permissionsfor article Pharmacogenetics in clinical practice: current level of knowledge among Flemish physicians and pharmacists . Opens in a new window.
Research | 13 January 2020
Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas
Nature Medicine 26 , 110–117

Rights & permissionsfor article Integration of epidemiologic, pharmacologic, genetic and gut microbiome data in a drug–metabolite atlas . Opens in a new window.
Research | 25 February 2019
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
- Phuwanat Sakornsakolpat
- , Dmitry Prokopenko
- , Maxime Lamontagne
- , Nicola F. Reeve
- , Anna L. Guyatt
- , Victoria E. Jackson
- , Nick Shrine
- , Dandi Qiao
- , Traci M. Bartz
- , Deog Kyeom Kim
- , Mi Kyeong Lee
- , Jeanne C. Latourelle
- , Xingnan Li
- , Jarrett D. Morrow
- , Ma’en Obeidat
- , Annah B. Wyss
- , Per Bakke
- , R. Graham Barr
- , Terri H. Beaty
- , Steven A. Belinsky
- , Guy G. Brusselle
- , James D. Crapo
- , Kim de Jong
- , Dawn L. DeMeo
- , Tasha E. Fingerlin
- , Sina A. Gharib
- , Amund Gulsvik
- , Ian P. Hall
- , John E. Hokanson
- , Woo Jin Kim
- , David A. Lomas
- , Stephanie J. London
- , Deborah A. Meyers
- , George T. O’Connor
- , Stephen I. Rennard
- , David A. Schwartz
- , Pawel Sliwinski
- , David Sparrow
- , David P. Strachan
- , Ruth Tal-Singer
- , Yohannes Tesfaigzi
- , Jørgen Vestbo
- , Judith M. Vonk
- , Jae-Joon Yim
- , Xiaobo Zhou
- , Yohan Bossé
- , Ani Manichaikul
- , Lies Lahousse
- , Edwin K. Silverman
- , H. Marike Boezen
- , Louise V. Wain
- , Martin D. Tobin
- , Brian D. Hobbs
- , Michael H. Cho
- , Nick Shrine
- , Anna L. Guyatt
- , Chiara Batini
- , Jing Hua Zhao
- , Matthias Wielscher
- , Stefan Weiss
- , Katherine A. Kentistou
- , James P. Cook
- , Jennie Hui
- , Stefan Karrasch
- , Medea Imboden
- , Sarah E. Harris
- , Jonathan Marten
- , Stefan Enroth
- , Shona M. Kerr
- , Ida Surakka
- , Veronique Vitart
- , Terho Lehtimäki
- , Ralf Ewert
- , Christian Gieger
- , Georg Homuth
- , Peter K. Joshi
- , Claudia Langenberg
- , Lars Lind
- , Jian’an Luan
- , Anubha Mahajan
- , Alison Murray
- , David J. Porteous
- , Rajesh Rawal
- , Blair H. Smith
- , Paul R. H. J. Timmers
- , Olli T. Raitakari
- , Mika Kähönen
- , Ozren Polasek
- , Ulf Gyllensten
- , Igor Rudan
- , Ian J. Deary
- , Nicole M. Probst-Hensch
- , Holger Schulz
- , Alan L. James
- , James F. Wilson
- , Beate Stubbe
- , Eleftheria Zeggini
- , Marjo-Riitta Jarvelin
- , Nick Wareham
- , Caroline Hayward
- , Andrew P. Morris
- , David P. Strachan
- , Ian P. Hall
- , Martin D. Tobin
- , Louise V. Wain
- , Alvar Agusti
- , Wayne Anderson
- , Nawar Bakerly
- , Per Bakke
- , Robert Bals
- , Kathleen C. Barnes
- , R. Graham Barr
- , Terri H. Beaty
- , Eugene R. Bleecker
- , H. Marike Boezen
- , Yohan Bossé
- , Russell Bowler
- , Christopher Brightling
- , Marleen de Bruijne
- , Peter J. Castaldi
- , Bartolome Celli
- , Michael H. Cho
- , Harvey O. Coxson
- , James D. Crapo
- , Ron Crystal
- , Pim de Jong
- , Asger Dirksen
- , Jennifer Dy
- , Marilyn Foreman
- , Judith Garcia-Aymerich
- , Pierre Gevenois
- , Soumitra Ghosh
- , Hester Gietema
- , Amund Gulsvik
- , Ian P. Hall
- , Nadia Hansel
- , Craig P. Hersh
- , Brian D. Hobbs
- , Eric Hoffman
- , Noor Kalsheker
- , Hans-Ulrich Kauczor
- , Woo Jin Kim
- , Deog Kyeom Kim
- , Tarja Laitinen
- , Diether Lambrechts
- , Sang-Do Lee
- , Augusto A. Litonjua
- , David A. Lomas
- , Stephanie J. London
- , Daan W. Loth
- , Sharon M. Lutz
- , David Lynch
- , William MacNee
- , Merry-Lynn McDonald
- , Deborah A. Meyers
- , John D. Newell
- , Borge G. Nordestgaard
- , George T. O’Connor
- , Ma’en Obeidat
- , Yeon-Mok Oh
- , Peter D. Paré
- , Massimo Pistolesi
- , Dirkje S. Postma
- , Milo Puhan
- , Elizabeth Regan
- , Stephen S. Rich
- , Joon Beom Seo
- , Andrea Short
- , Edwin K. Silverman
- , David Sparrow
- , Berend Stoel
- , David P. Strachan
- , Nicola Sverzellati
- , Ruth Tal-Singer
- , Gerben ter Riet
- , Yohannes Tesfaigzi
- , Martin D. Tobin
- , Edwin J. R. Van Beek
- , Bram van Ginneken
- , Jørgen Vestbo
- , Claus F. Vogelmeier
- , Louise V. Wain
- , Adam Wanner
- , George Washko
- , Els Wauters
- , Emiel F. M. Wouters
- , Robert P. Young
- & Loems Zeigler-Heitbrock
Nature Genetics 51 , 494–505

Rights & permissionsfor article Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations . Opens in a new window.
Research | 8 February 2018 | Open
Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics
European Journal of Human Genetics 26 , 709–722

Rights & permissionsfor article Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics . Opens in a new window.
Research | 30 July 2018 | Open
Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function
- Annah B. Wyss
- , Tamar Sofer
- , Mi Kyeong Lee
- , Natalie Terzikhan
- , Jennifer N. Nguyen
- , Lies Lahousse
- , Jeanne C. Latourelle
- , Albert Vernon Smith
- , Traci M. Bartz
- , Mary F. Feitosa
- , Wei Gao
- , Tarunveer S. Ahluwalia
- , Wenbo Tang
- , Christopher Oldmeadow
- , Qing Duan
- , Kim de Jong
- , Mary K. Wojczynski
- , Xin-Qun Wang
- , Raymond Noordam
- , Fernando Pires Hartwig
- , Victoria E. Jackson
- , Tianyuan Wang
- , Ma’en Obeidat
- , Brian D. Hobbs
- , Tianxiao Huan
- , Hongsheng Gui
- , Margaret M. Parker
- , Donglei Hu
- , Lauren S. Mogil
- , Gleb Kichaev
- , Jianping Jin
- , Mariaelisa Graff
- , Tamara B. Harris
- , Ravi Kalhan
- , Susan R. Heckbert
- , Lavinia Paternoster
- , Kristin M. Burkart
- , Yongmei Liu
- , Elizabeth G. Holliday
- , James G. Wilson
- , Judith M. Vonk
- , Jason L. Sanders
- , R. Graham Barr
- , Renée de Mutsert
- , Ana Maria Baptista Menezes
- , Hieab H. H. Adams
- , Maarten van den Berge
- , Roby Joehanes
- , Albert M. Levin
- , Jennifer Liberto
- , Lenore J. Launer
- , Alanna C. Morrison
- , Colleen M. Sitlani
- , Juan C. Celedón
- , Stephen B. Kritchevsky
- , Rodney J. Scott
- , Kaare Christensen
- , Jerome I. Rotter
- , Tobias N. Bonten
- , Fernando César Wehrmeister
- , Yohan Bossé
- , Shujie Xiao
- , Sam Oh
- , Nora Franceschini
- , Jennifer A. Brody
- , Robert C. Kaplan
- , Kurt Lohman
- , Mark McEvoy
- , Michael A. Province
- , Frits R. Rosendaal
- , Kent D. Taylor
- , David C. Nickle
- , L. Keoki Williams
- , Esteban G. Burchard
- , Heather E. Wheeler
- , Don D. Sin
- , Vilmundur Gudnason
- , Kari E. North
- , Myriam Fornage
- , Bruce M. Psaty
- , Richard H. Myers
- , George O’Connor
- , Torben Hansen
- , Cathy C. Laurie
- , Patricia A. Cassano
- , Joohon Sung
- , Woo Jin Kim
- , John R. Attia
- , Leslie Lange
- , H. Marike Boezen
- , Bharat Thyagarajan
- , Stephen S. Rich
- , Dennis O. Mook-Kanamori
- , Bernardo Lessa Horta
- , André G. Uitterlinden
- , Hae Kyung Im
- , Michael H. Cho
- , Guy G. Brusselle
- , Sina A. Gharib
- , Josée Dupuis
- , Ani Manichaikul
- & Stephanie J. London
Nature Communications 9 , 1–15

Rights & permissionsfor article Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function . Opens in a new window.
Research | 22 December 2017
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
- Florence Demenais
- , Patricia Margaritte-Jeannin
- , Kathleen C. Barnes
- , William O. C. Cookson
- , Janine Altmüller
- , Wei Ang
- , R. Graham Barr
- , Terri H. Beaty
- , Allan B. Becker
- , John Beilby
- , Hans Bisgaard
- , Unnur Steina Bjornsdottir
- , Eugene Bleecker
- , Klaus Bønnelykke
- , Dorret I. Boomsma
- , Emmanuelle Bouzigon
- , Christopher E. Brightling
- , Myriam Brossard
- , Guy G. Brusselle
- , Esteban Burchard
- , Kristin M. Burkart
- , Andrew Bush
- , Moira Chan-Yeung
- , Kian Fan Chung
- , Alexessander Couto Alves
- , John A. Curtin
- , Adnan Custovic
- , Denise Daley
- , Johan C. de Jongste
- , Blanca E. Del-Rio-Navarro
- , Kathleen M. Donohue
- , Liesbeth Duijts
- , Celeste Eng
- , Johan G. Eriksson
- , Martin Farrall
- , Yuliya Fedorova
- , Bjarke Feenstra
- , Manuel A. Ferreira
- , Maxim B. Freidin
- , Zofia Gajdos
- , Jim Gauderman
- , Ulrike Gehring
- , Frank Geller
- , Jon Genuneit
- , Sina A. Gharib
- , Frank Gilliland
- , Raquel Granell
- , Penelope E. Graves
- , Daniel F. Gudbjartsson
- , Tari Haahtela
- , Susan R. Heckbert
- , Dick Heederik
- , Joachim Heinrich
- , Markku Heliövaara
- , John Henderson
- , Blanca E. Himes
- , Hiroshi Hirose
- , Joel N. Hirschhorn
- , Albert Hofman
- , Patrick Holt
- , Jouke Hottenga
- , Thomas J. Hudson
- , Jennie Hui
- , Medea Imboden
- , Vladimir Ivanov
- , Vincent W. V. Jaddoe
- , Alan James
- , Christer Janson
- , Marjo-Riitta Jarvelin
- , Deborah Jarvis
- , Graham Jones
- , Ingileif Jonsdottir
- , Pekka Jousilahti
- , Michael Kabesch
- , Mika Kähönen
- , David B. Kantor
- , Alexandra S. Karunas
- , Elza Khusnutdinova
- , Gerard H. Koppelman
- , Anita L. Kozyrskyj
- , Eskil Kreiner
- , Michiaki Kubo
- , Rajesh Kumar
- , Ashish Kumar
- , Mikko Kuokkanen
- , Lies Lahousse
- , Tarja Laitinen
- , Catherine Laprise
- , Mark Lathrop
- , Susanne Lau
- , Young-Ae Lee
- , Terho Lehtimäki
- , Sébastien Letort
- , Albert M. Levin
- , Guo Li
- , Liming Liang
- , Laura R. Loehr
- , Stephanie J. London
- , Daan W. Loth
- , Ani Manichaikul
- , Ingo Marenholz
- , Fernando J. Martinez
- , Melanie C. Matheson
- , Rasika A. Mathias
- , Kenji Matsumoto
- , Hamdi Mbarek
- , Wendy L. McArdle
- , Mads Melbye
- , Erik Melén
- , Deborah Meyers
- , Sven Michel
- , Hamida Mohamdi
- , Arthur W. Musk
- , Rachel A. Myers
- , Maartje A. E. Nieuwenhuis
- , Emiko Noguchi
- , George T. O’Connor
- , Ludmila M. Ogorodova
- , Cameron D. Palmer
- , Aarno Palotie
- , Julie E. Park
- , Craig E. Pennell
- , Göran Pershagen
- , Alexey Polonikov
- , Dirkje S. Postma
- , Nicole Probst-Hensch
- , Valery P. Puzyrev
- , Benjamin A. Raby
- , Olli T. Raitakari
- , Adaikalavan Ramasamy
- , Stephen S. Rich
- , Colin F. Robertson
- , Isabelle Romieu
- , Muhammad T. Salam
- , Veikko Salomaa
- , Vivi Schlünssen
- , Robert Scott
- , Polina A. Selivanova
- , Torben Sigsgaard
- , Angela Simpson
- , Valérie Siroux
- , Lewis J. Smith
- , Maria Solodilova
- , Marie Standl
- , Kari Stefansson
- , David P. Strachan
- , Bruno H. Stricker
- , Atsushi Takahashi
- , Philip J. Thompson
- , Gudmar Thorleifsson
- , Unnur Thorsteinsdottir
- , Carla M. T. Tiesler
- , Dara G. Torgerson
- , Tatsuhiko Tsunoda
- , André G. Uitterlinden
- , Ralf J. P. van der Valk
- , Amaury Vaysse
- , Sailaja Vedantam
- , Andrea von Berg
- , Erika von Mutius
- , Judith M. Vonk
- , Johannes Waage
- , Nick J. Wareham
- , Scott T. Weiss
- , Wendy B. White
- , Magnus Wickman
- , Elisabeth Widén
- , Gonneke Willemsen
- , L. Keoki Williams
- , Inge M. Wouters
- , James J. Yang
- , Jing Hua Zhao
- , Miriam F. Moffatt
- , Carole Ober
- & Dan L. Nicolae
Nature Genetics 50 , 42–53

Rights & permissionsfor article Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks . Opens in a new window.
Research | 6 February 2017
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis
- Brian D Hobbs
- , Kim de Jong
- , Maxime Lamontagne
- , Yohan Bossé
- , Nick Shrine
- , María Soler Artigas
- , Louise V Wain
- , Ian P Hall
- , Victoria E Jackson
- , Annah B Wyss
- , Stephanie J London
- , Kari E North
- , Nora Franceschini
- , David P Strachan
- , Terri H Beaty
- , John E Hokanson
- , James D Crapo
- , Peter J Castaldi
- , Robert P Chase
- , Traci M Bartz
- , Susan R Heckbert
- , Bruce M Psaty
- , Sina A Gharib
- , Pieter Zanen
- , Jan W Lammers
- , Matthijs Oudkerk
- , H J Groen
- , Nicholas Locantore
- , Ruth Tal-Singer
- , Stephen I Rennard
- , Jørgen Vestbo
- , Wim Timens
- , Peter D Paré
- , Jeanne C Latourelle
- , Josée Dupuis
- , George T O'Connor
- , Jemma B Wilk
- , Woo Jin Kim
- , Mi Kyeong Lee
- , Yeon-Mok Oh
- , Judith M Vonk
- , Harry J de Koning
- , Shuguang Leng
- , Steven A Belinsky
- , Yohannes Tesfaigzi
- , Ani Manichaikul
- , Xin-Qun Wang
- , Stephen S Rich
- , R Graham Barr
- , David Sparrow
- , Augusto A Litonjua
- , Per Bakke
- , Amund Gulsvik
- , Lies Lahousse
- , Guy G Brusselle
- , Bruno H Stricker
- , André G Uitterlinden
- , Elizabeth J Ampleford
- , Eugene R Bleecker
- , Prescott G Woodruff
- , Deborah A Meyers
- , Dandi Qiao
- , David A Lomas
- , Jae-Joon Yim
- , Deog Kyeom Kim
- , Iwona Hawrylkiewicz
- , Pawel Sliwinski
- , Megan Hardin
- , Tasha E Fingerlin
- , David A Schwartz
- , Dirkje S Postma
- , William MacNee
- , Martin D Tobin
- , Edwin K Silverman
- , H Marike Boezen
- & Michael H Cho
Nature Genetics 49 , 426–432

Rights & permissionsfor article Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis . Opens in a new window.
Research | 15 June 2014
Genome-wide association analysis identifies six new loci associated with forced vital capacity
- Daan W Loth
- , María Soler Artigas
- , Sina A Gharib
- , Louise V Wain
- , Nora Franceschini
- , Beate Koch
- , Tess D Pottinger
- , Albert Vernon Smith
- , Qing Duan
- , Chris Oldmeadow
- , Mi Kyeong Lee
- , David P Strachan
- , Alan L James
- , Jennifer E Huffman
- , Veronique Vitart
- , Adaikalavan Ramasamy
- , Nicholas J Wareham
- , Jaakko Kaprio
- , Xin-Qun Wang
- , Holly Trochet
- , Mika Kähönen
- , Claudia Flexeder
- , Eva Albrecht
- , Lorna M Lopez
- , Kim de Jong
- , Bharat Thyagarajan
- , Alexessander Couto Alves
- , Stefan Enroth
- , Ernst Omenaas
- , Peter K Joshi
- , Tove Fall
- , Ana Viñuela
- , Lenore J Launer
- , Laura R Loehr
- , Myriam Fornage
- , Guo Li
- , Jemma B Wilk
- , Wenbo Tang
- , Ani Manichaikul
- , Lies Lahousse
- , Tamara B Harris
- , Kari E North
- , Alicja R Rudnicka
- , Jennie Hui
- , Xiangjun Gu
- , Thomas Lumley
- , Alan F Wright
- , Nicholas D Hastie
- , Susan Campbell
- , Rajesh Kumar
- , Isabelle Pin
- , Robert A Scott
- , Kirsi H Pietiläinen
- , Ida Surakka
- , Yongmei Liu
- , Elizabeth G Holliday
- , Holger Schulz
- , Joachim Heinrich
- , Gail Davies
- , Judith M Vonk
- , Mary Wojczynski
- , Anneli Pouta
- , Åsa Johansson
- , Sarah H Wild
- , Erik Ingelsson
- , Fernando Rivadeneira
- , Henry Völzke
- , Pirro G Hysi
- , Gudny Eiriksdottir
- , Alanna C Morrison
- , Jerome I Rotter
- , Wei Gao
- , Dirkje S Postma
- , Wendy B White
- , Stephen S Rich
- , Albert Hofman
- , Thor Aspelund
- , David Couper
- , Lewis J Smith
- , Bruce M Psaty
- , Kurt Lohman
- , Esteban G Burchard
- , André G Uitterlinden
- , Melissa Garcia
- , Bonnie R Joubert
- , Wendy L McArdle
- , A Bill Musk
- , Nadia Hansel
- , Susan R Heckbert
- , Lina Zgaga
- , Joyce B J van Meurs
- , Pau Navarro
- , Igor Rudan
- , Yeon-Mok Oh
- , Susan Redline
- , Deborah L Jarvis
- , Jing Hua Zhao
- , Taina Rantanen
- , George T O'Connor
- , Samuli Ripatti
- , Rodney J Scott
- , Stefan Karrasch
- , Harald Grallert
- , Nathan C Gaddis
- , John M Starr
- , Cisca Wijmenga
- , Ryan L Minster
- , David J Lederer
- , Juha Pekkanen
- , Ulf Gyllensten
- , Harry Campbell
- , Andrew P Morris
- , Sven Gläser
- , Christopher J Hammond
- , Kristin M Burkart
- , John Beilby
- , Stephen B Kritchevsky
- , Vilmundur Gudnason
- , Dana B Hancock
- , O Dale Williams
- , Ozren Polasek
- , Tatijana Zemunik
- , Ivana Kolcic
- , Marcy F Petrini
- , Matthias Wjst
- , Woo Jin Kim
- , David J Porteous
- , Generation Scotland
- , Blair H Smith
- , Anne Viljanen
- , Markku Heliövaara
- , John R Attia
- , Ian Sayers
- , Regina Hampel
- , Christian Gieger
- , Ian J Deary
- , H Marike Boezen
- , Anne Newman
- , Marjo-Riitta Jarvelin
- , James F Wilson
- , Lars Lind
- , Bruno H Stricker
- , Alexander Teumer
- , Timothy D Spector
- , Erik Melén
- , Marjolein J Peters
- , Leslie A Lange
- , R Graham Barr
- , Ken R Bracke
- , Fien M Verhamme
- , Joohon Sung
- , Pieter S Hiemstra
- , Patricia A Cassano
- , Akshay Sood
- , Caroline Hayward
- , Josée Dupuis
- , Ian P Hall
- , Guy G Brusselle
- , Martin D Tobin
- & Stephanie J London
Nature Genetics 46 , 669–677

Rights & permissionsfor article Genome-wide association analysis identifies six new loci associated with forced vital capacity . Opens in a new window.

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