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Amendments and Corrections | 19 July 2016 | Open
Correction: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
- Boon-Seng Soh
- , Shi-Yan Ng
- , Hao Wu
- , Kristina Buac
- , Joo-Hye C. Park
- , Xiaojun Lian
- , Jiejia Xu
- , Kylie S Foo
- , Ulrika Felldin
- , Xiaobing He
- , Massimo Nichane
- , Henry Yang
- , Lie Bu
- , Ronald A Li
- , Bing Lim
- & Kenneth R Chien
Nature Communications 7 , 1–1

Rights & permissionsfor article Correction: Corrigendum: Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells . Opens in a new window.
News and Views | 19 June 2013
Heartbroken embryos heal
- Kenneth R. Chien
Nature 498 , 439–440

Rights & permissionsfor article Heartbroken embryos heal . Opens in a new window.
Research Highlights | 20 August 2013
The Years of the Monkey
- Xiaojun Lian
- & Kenneth R Chien
Cell Research 23 , 1161–1162

Rights & permissionsfor article The Years of the Monkey . Opens in a new window.
Amendments and Corrections | 2 January 2015
Erratum: Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells
- Makoto Sahara
- , Emil M Hansson
- , Oliver Wernet
- , Kathy O Lui
- , Daniela Später
- & Kenneth R Chien
Cell Research 25 , 148–148

Rights & permissionsfor article Erratum: Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells . Opens in a new window.
Books and Arts | 1 May 2010
Regenerating physician-scientists
- Kenneth R Chien
Nature Medicine 16 , 511–511

Rights & permissionsfor article Regenerating physician-scientists . Opens in a new window.
Research Highlights | 3 July 2012
In vivo reprogramming for heart disease
Cell Research 22 , 1521–1523

Rights & permissionsfor article <i>In vivo</i> reprogramming for heart disease . Opens in a new window.
News and Views | 1 January 2003
Cre-constructing the heart
- Pilar Ruiz-Lozano
- & Kenneth R. Chien
Nature Genetics 33 , 8–9

Rights & permissionsfor article Cre-constructing the heart . Opens in a new window.
News and Views | 1 May 2003
Calcium and heart failure: the cycle game
Nature Medicine 9 , 508–509

Rights & permissionsfor article Calcium and heart failure: the cycle game . Opens in a new window.
News and Views | 1 September 2004
Unravelling Ras signals in cardiovascular disease
- Kenneth R. Chien
- & Masahiko Hoshijima
Nature Cell Biology 6 , 807–808

Rights & permissionsfor article Unravelling Ras signals in cardiovascular disease . Opens in a new window.
News and Views | 1 March 2011
Shortcuts to making cardiomyocytes
Nature Cell Biology 13 , 191–193

Rights & permissionsfor article Shortcuts to making cardiomyocytes . Opens in a new window.
News and Views | 21 March 2004
Lost in translation
- Kenneth R. Chien
Nature 428 , 607–608

Rights & permissionsfor article Lost in translation . Opens in a new window.
News and Views | 7 March 2013
Cardiac regenerative medicine 2.0
- Boon-Seng Soh
- , Hao Wu
- & Kenneth R Chien
Nature Biotechnology 31 , 209–211

Rights & permissionsfor article Cardiac regenerative medicine 2.0 . Opens in a new window.
1 September 2000
Reply to ‘Re-evaluating sarcoplasmic reticulum function in heart failure’
- Kenneth R. Chien
Nature Medicine 6 , 942–943

Rights & permissionsfor article Reply to ‘Re-evaluating sarcoplasmic reticulum function in heart failure’ . Opens in a new window.
News and Views | 1 October 1999
Inflammatory pathways and cardiac repair: the affliction of infarction
- Kirk U. Knowlton
- & Kenneth R. Chien
Nature Medicine 5 , 1122–1123

Rights & permissionsfor article Inflammatory pathways and cardiac repair: the affliction of infarction . Opens in a new window.
News and Views | 1 August 1995
Heart and lung disease in engineered mice
Nature Medicine 1 , 749–751

Rights & permissionsfor article Heart and lung disease in engineered mice . Opens in a new window.
News and Views | 23 May 2007
MicroRNAs and the tell-tale heart
- Kenneth R. Chien
Nature 447 , 389–390

Rights & permissionsfor article MicroRNAs and the tell-tale heart . Opens in a new window.
9 February 2010
Targeted conditional gene knockout in human embryonic stem cells
- Lei Bu
- , Xiaolin Gao
- , Xin Jiang
- , Kenneth R Chien
- & Zhong Wang
Cell Research 20 , 379–382

Rights & permissionsfor article Targeted conditional gene knockout in human embryonic stem cells . Opens in a new window.
Research | 17 February 2008
Marked differences in differentiation propensity among human embryonic stem cell lines
- Kenji Osafune
- , Leslie Caron
- , Malgorzata Borowiak
- , Rita J Martinez
- , Claire S Fitz-Gerald
- , Yasunori Sato
- , Chad A Cowan
- , Kenneth R Chien
- & Douglas A Melton
Nature Biotechnology 26 , 313–315

Rights & permissionsfor article Marked differences in differentiation propensity among human embryonic stem cell lines . Opens in a new window.
Reviews | 18 February 2019
Regenerating the field of cardiovascular cell therapy
Nature Biotechnology 37 , 232–237

Rights & permissionsfor article Regenerating the field of cardiovascular cell therapy . Opens in a new window.
14 May 2008
Regenerative medicine and human models of human disease
- Kenneth R. Chien
Nature 453 , 302–305

Rights & permissionsfor article Regenerative medicine and human models of human disease . Opens in a new window.
Research | 20 June 2004
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
- Hiroyuki Mori
- , Reiko Hanada
- , Toshikatsu Hanada
- , Daisuke Aki
- , Ryuichi Mashima
- , Hitomi Nishinakamura
- , Takehiro Torisu
- , Kenneth R Chien
- , Hideo Yasukawa
- & Akihiko Yoshimura
Nature Medicine 10 , 739–743

Rights & permissionsfor article Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity . Opens in a new window.
Research | 1 November 2001
Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα_q/Gα₁₁ in cardiomyocytes
- Nina Wettschureck
- , Hartmut Rütten
- , Alexandra Zywietz
- , Doris Gehring
- , Tom M. Wilkie
- , Ju Chen
- , Kenneth R. Chien
- & Stefan Offermanns
Nature Medicine 7 , 1236–1240

Rights & permissionsfor article Absence of pressure overload induced myocardial hypertrophy after conditional inactivation of Gα<sub>q</sub>/Gα<sub>11</sub> in cardiomyocytes . Opens in a new window.
Research | 22 July 2002
Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery
- Masahiko Hoshijima
- , Yasuhiro Ikeda
- , Yoshitaka Iwanaga
- , Susumu Minamisawa
- , Moto-o Date
- , Yusu Gu
- , Mitsuo Iwatate
- , Manxiang Li
- , Lili Wang
- , James M. Wilson
- , Yibin Wang
- , John Ross Jr
- & Kenneth R. Chien
Nature Medicine 8 , 864–871

Rights & permissionsfor article Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via <i>in vivo</i> cardiac rAAV gene delivery . Opens in a new window.
Reviews | 14 September 2000
Genomic circuits and the integrative biology of cardiac diseases
- Kenneth R. Chien
Nature 407 , 227–232

Rights & permissionsfor article Genomic circuits and the integrative biology of cardiac diseases . Opens in a new window.
Research | 1 May 2002
ErbB2 is essential in the prevention of dilated cardiomyopathy
- Steven A. Crone
- , You-Yang Zhao
- , Lian Fan
- , Yusu Gu
- , Susumu Minamisawa
- , Yang Liu
- , Kirk L. Peterson
- , Ju Chen
- , Ronald Kahn
- , Gianluigi Condorelli
- , John Ross Jr
- , Kenneth R. Chien
- & Kuo-Fen Lee
Nature Medicine 8 , 459–465

Rights & permissionsfor article ErbB2 is essential in the prevention of dilated cardiomyopathy . Opens in a new window.
Research | 10 February 2005
Postnatal isl1⁺ cardioblasts enter fully differentiated cardiomyocyte lineages
- Karl-Ludwig Laugwitz
- , Alessandra Moretti
- , Jason Lam
- , Peter Gruber
- , Yinhong Chen
- , Sarah Woodard
- , Li-Zhu Lin
- , Chen-Leng Cai
- , Min Min Lu
- , Michael Reth
- , Oleksandr Platoshyn
- , Jason X.-J. Yuan
- , Sylvia Evans
- & Kenneth R. Chien
Nature 433 , 647–653

Rights & permissionsfor article Postnatal isl1<sup>+</sup> cardioblasts enter fully differentiated cardiomyocyte lineages . Opens in a new window.
Research | 18 May 2003
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
- Hideo Yasukawa
- , Masanobu Ohishi
- , Hiroyuki Mori
- , Masaaki Murakami
- , Takatoshi Chinen
- , Daisuke Aki
- , Toshikatsu Hanada
- , Kiyoshi Takeda
- , Shizuo Akira
- , Masahiko Hoshijima
- , Toshio Hirano
- , Kenneth R Chien
- & Akihiko Yoshimura
Nature Immunology 4 , 551–556

Rights & permissionsfor article IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages . Opens in a new window.
Research | 1 May 2001
Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy
- Mohammad Pashmforoush
- , Pascal Pomiès
- , Kirk L. Peterson
- , Steve Kubalak
- , John Ross Jr
- , Andreas Hefti
- , Ueli Aebi
- , Mary C. Beckerle
- & Kenneth R. Chien
Nature Medicine 7 , 591–597

Rights & permissionsfor article Adult mice deficient in actinin–associated LIM-domain protein reveal a developmental pathway for right ventricular cardiomyopathy . Opens in a new window.
Research | 22 June 2008
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
- Bin Zhou
- , Qing Ma
- , Satish Rajagopal
- , Sean M. Wu
- , Ibrahim Domian
- , José Rivera-Feliciano
- , Dawei Jiang
- , Alexander von Gise
- , Sadakatsu Ikeda
- , Kenneth R. Chien
- & William T. Pu
Nature 454 , 109–113

Rights & permissionsfor article Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart . Opens in a new window.
Research | 15 November 2006
Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization
Nature 445 , 177–182

Rights & permissionsfor article Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization . Opens in a new window.
22 June 2009
Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation
- Morihiko Takeda
- , Laura E Briggs
- , Hiroko Wakimoto
- , Melissa H Marks
- , Sonisha A Warren
- , Jonathan T Lu
- , Ellen O Weinberg
- , Keith D Robertson
- , Kenneth R Chien
- & Hideko Kasahara
Laboratory Investigation 89 , 983–993

Rights & permissionsfor article Slow progressive conduction and contraction defects in loss of Nkx2-5 mice after cardiomyocyte terminal differentiation . Opens in a new window.
Research | 2 July 2009
Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages
- Lei Bu
- , Xin Jiang
- , Silvia Martin-Puig
- , Leslie Caron
- , Shenjun Zhu
- , Ying Shao
- , Drucilla J. Roberts
- , Paul L. Huang
- , Ibrahim J. Domian
- & Kenneth R. Chien
Nature 460 , 113–117

Rights & permissionsfor article Human ISL1 heart progenitors generate diverse multipotent cardiovascular cell lineages . Opens in a new window.
Research | 10 January 2002
Fibulin-5/DANCE is essential for elastogenesis in vivo
- Tomoyuki Nakamura
- , Pilar Ruiz Lozano
- , Yasuhiro Ikeda
- , Yoshitaka Iwanaga
- , Aleksander Hinek
- , Susumu Minamisawa
- , Ching-Feng Cheng
- , Kazuhiro Kobuke
- , Nancy Dalton
- , Yoshikazu Takada
- , Kei Tashiro
- , John Ross Jr
- , Tasuku Honjo
- & Kenneth R. Chien
Nature 415 , 171–175

Rights & permissionsfor article Fibulin-5/DANCE is essential for elastogenesis <i>in vivo</i> . Opens in a new window.
Research | 20 February 2019 | Open
Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes
- Li-Ming Gan
- , Maria Lagerström-Fermér
- , Leif G. Carlsson
- , Cecilia Arfvidsson
- , Ann-Charlotte Egnell
- , Anna Rudvik
- , Magnus Kjaer
- , Anna Collén
- , James D. Thompson
- , John Joyal
- , Ligia Chialda
- , Thomas Koernicke
- , Rainard Fuhr
- , Kenneth R. Chien
- & Regina Fritsche-Danielson
Nature Communications 10 , 1–9

Rights & permissionsfor article Intradermal delivery of modified mRNA encoding VEGF-A in patients with type 2 diabetes . Opens in a new window.
Research | 30 November 2018 | Open
Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing
- Naidi Sun
- , Bo Ning
- , Kenny M. Hansson
- , Anthony C. Bruce
- , Scott A. Seaman
- , Chenchu Zhang
- , Michaela Rikard
- , Christopher A. DeRosa
- , Cassandra L. Fraser
- , Maria Wågberg
- , Regina Fritsche-Danielson
- , Johannes Wikström
- , Kenneth R. Chien
- , Anna Lundahl
- , Mikko Hölttä
- , Leif G. Carlsson
- , Shayn M. Peirce
- & Song Hu
Scientific Reports 8 , 1–11

Rights & permissionsfor article Modified VEGF-A mRNA induces sustained multifaceted microvascular response and accelerates diabetic wound healing . Opens in a new window.
Research | 8 March 2016 | Open
Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells
- Boon-Seng Soh
- , Shi-Yan Ng
- , Hao Wu
- , Kristina Buac
- , Joo-Hye C. Park
- , Xiaojun Lian
- , Jiejia Xu
- , Kylie S. Foo
- , Ulrika Felldin
- , Xiaobing He
- , Massimo Nichane
- , Henry Yang
- , Lei Bu
- , Ronald A. Li
- , Bing Lim
- & Kenneth R. Chien
Nature Communications 7 , 1–11

Rights & permissionsfor article Endothelin-1 supports clonal derivation and expansion of cardiovascular progenitors derived from human embryonic stem cells . Opens in a new window.
Research | 10 September 2013 | Open
Driving vascular endothelial cell fate of human multipotent Isl1⁺ heart progenitors with VEGF modified mRNA
- Kathy O Lui
- , Lior Zangi
- , Eduardo A Silva
- , Lei Bu
- , Makoto Sahara
- , Ronald A Li
- , David J Mooney
- & Kenneth R Chien
Cell Research 23 , 1172–1186

Rights & permissionsfor article Driving vascular endothelial cell fate of human multipotent Isl1<sup>+</sup> heart progenitors with VEGF modified mRNA . Opens in a new window.
Research | 8 September 2013
Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction
- Lior Zangi
- , Kathy O Lui
- , Alexander von Gise
- , Qing Ma
- , Wataru Ebina
- , Leon M Ptaszek
- , Daniela Später
- , Huansheng Xu
- , Mohammadsharif Tabebordbar
- , Rostic Gorbatov
- , Brena Sena
- , Matthias Nahrendorf
- , David M Briscoe
- , Ronald A Li
- , Amy J Wagers
- , Derrick J Rossi
- , William T Pu
- & Kenneth R Chien
Nature Biotechnology 31 , 898–907

Rights & permissionsfor article Modified mRNA directs the fate of heart progenitor cells and induces vascular regeneration after myocardial infarction . Opens in a new window.
Research | 9 May 2014 | Open
Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells
- Makoto Sahara
- , Emil M Hansson
- , Oliver Wernet
- , Kathy O Lui
- , Daniela Später
- & Kenneth R Chien
Cell Research 24 , 820–841

Rights & permissionsfor article Manipulation of a VEGF-Notch signaling circuit drives formation of functional vascular endothelial progenitors from human pluripotent stem cells . Opens in a new window.
Research | 11 May 2014
Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies
- Gang Wang
- , Megan L McCain
- , Luhan Yang
- , Aibin He
- , Francesco Silvio Pasqualini
- , Ashutosh Agarwal
- , Hongyan Yuan
- , Dawei Jiang
- , Donghui Zhang
- , Lior Zangi
- , Judith Geva
- , Amy E Roberts
- , Qing Ma
- , Jian Ding
- , Jinghai Chen
- , Da-Zhi Wang
- , Kai Li
- , Jiwu Wang
- , Ronald J A Wanders
- , Wim Kulik
- , Frédéric M Vaz
- , Michael A Laflamme
- , Charles E Murry
- , Kenneth R Chien
- , Richard I Kelley
- , George M Church
- , Kevin Kit Parker
- & William T Pu
Nature Medicine 20 , 616–623

Rights & permissionsfor article Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies . Opens in a new window.
Research | 25 August 2013
A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells
- Daniela Später
- , Monika K. Abramczuk
- , Kristina Buac
- , Lior Zangi
- , Maxine W. Stachel
- , Jonathan Clarke
- , Makoto Sahara
- , Andreas Ludwig
- & Kenneth R. Chien
Nature Cell Biology 15 , 1098–1106

Rights & permissionsfor article A HCN4+ cardiomyogenic progenitor derived from the first heart field and human pluripotent stem cells . Opens in a new window.
Research | 4 November 2014 | Open
N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment
- Boon-Seng Soh
- , Kristina Buac
- , Huansheng Xu
- , Edward Li
- , Shi-Yan Ng
- , Hao Wu
- , Jolanta Chmielowiec
- , Xin Jiang
- , Lei Bu
- , Ronald A Li
- , Chad Cowan
- & Kenneth R Chien
Cell Research 24 , 1420–1432

Rights & permissionsfor article N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment . Opens in a new window.
Research | 1 December 2014
Tolerance induction to human stem cell transplants with extension to their differentiated progeny
- Kathy O. Lui
- , Duncan Howie
- , Shu-Wing Ng
- , Shubai Liu
- , Kenneth R. Chien
- & Herman Waldmann
Nature Communications 5 , 1–13

Rights & permissionsfor article Tolerance induction to human stem cell transplants with extension to their differentiated progeny . Opens in a new window.
Research | 8 November 2011
Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature
- Huansheng Xu
- , B Alexander Yi
- , Hao Wu
- , Christoph Bock
- , Hongcang Gu
- , Kathy O Lui
- , Joo-Hye C Park
- , Ying Shao
- , Alyssa K Riley
- , Ibrahim J Domian
- , Erding Hu
- , Robert Willette
- , John Lepore
- , Alexander Meissner
- , Zhong Wang
- & Kenneth R Chien
Cell Research 22 , 142–154

Rights & permissionsfor article Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature . Opens in a new window.
Research | 30 May 2010
Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511
- Sergey Rodin
- , Anna Domogatskaya
- , Susanne Ström
- , Emil M Hansson
- , Kenneth R Chien
- , José Inzunza
- , Outi Hovatta
- & Karl Tryggvason
Nature Biotechnology 28 , 611–615

Rights & permissionsfor article Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511 . Opens in a new window.

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