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Research | 14 February 2020 | Open
Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis
- Yun Liao
- , Junjie Zhao
- , Katarzyna Bulek
- , Fangqiang Tang
- , Xing Chen
- , Gang Cai
- , Shang Jia
- , Paul L. Fox
- , Emina Huang
- , Theresa T. Pizarro
- , Matthew F. Kalady
- , Mark W. Jackson
- , Shideng Bao
- , Ganes C. Sen
- , George R. Stark
- , Christopher J. Chang
- & Xiaoxia Li
Nature Communications 11 , 1–15

Rights & permissionsfor article Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis . Opens in a new window.
Research | 21 March 2018
IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling
- Tomasz Herjan
- , Lingzi Hong
- , Jodi Bubenik
- , Katarzyna Bulek
- , Wen Qian
- , Caini Liu
- , Xiao Li
- , Xing Chen
- , Hui Yang
- , Suidong Ouyang
- , Hao Zhou
- , Junjie Zhao
- , Kommireddy Vasu
- , Eric Cockman
- , Mark Aronica
- , Kewal Asosingh
- , Donny D. Licatalosi
- , Jun Qin
- , Paul L. Fox
- , Thomas A. Hamilton
- , Donna Driscoll
- & Xiaoxia Li
Nature Immunology 19 , 354–365

Rights & permissionsfor article IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling . Opens in a new window.
Research | 31 May 2017 | Open
IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression
- Chenhui Wang
- , Cun-Jin Zhang
- , Bradley N. Martin
- , Katarzyna Bulek
- , Zizhen Kang
- , Junjie Zhao
- , Guanglin Bian
- , Julie A. Carman
- , Ji Gao
- , Ashok Dongre
- , Haibo Xue
- , Stephen D. Miller
- , Youcun Qian
- , Dolores Hambardzumyan
- , Tom Hamilton
- , Richard M. Ransohoff
- & Xiaoxia Li
Nature Communications 8 , 1–16

Rights & permissionsfor article IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression . Opens in a new window.
Research | 30 September 2014
IKKα negatively regulates ASC-dependent inflammasome activation
- Bradley N. Martin
- , Chenhui Wang
- , Jami Willette-Brown
- , Tomasz Herjan
- , Muhammet F. Gulen
- , Hao Zhou
- , Katarzyna Bulek
- , Luigi Franchi
- , Takashi Sato
- , Emad S. Alnemri
- , Goutham Narla
- , Xiao-Ping Zhong
- , James Thomas
- , Dennis Klinman
- , Katherine A. Fitzgerald
- , Michael Karin
- , Gabriel Nuñez
- , George Dubyak
- , Yinling Hu
- & Xiaoxia Li
Nature Communications 5 , 1–14

Rights & permissionsfor article IKKα negatively regulates ASC-dependent inflammasome activation . Opens in a new window.
Research | 7 August 2011
The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation
- Katarzyna Bulek
- , Caini Liu
- , Shadi Swaidani
- , Liwen Wang
- , Richard C Page
- , Muhammet F Gulen
- , Tomasz Herjan
- , Amina Abbadi
- , Wen Qian
- , Dongxu Sun
- , Mark Lauer
- , Vincent Hascall
- , Saurav Misra
- , Mark R Chance
- , Mark Aronica
- , Thomas Hamilton
- & Xiaoxia Li
Nature Immunology 12 , 844–852

Rights & permissionsfor article The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation . Opens in a new window.
Research | 2 December 2012
The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90
- Chenhui Wang
- , Ling Wu
- , Katarzyna Bulek
- , Bradley N Martin
- , Jarod A Zepp
- , Zizhen Kang
- , Caini Liu
- , Tomasz Herjan
- , Saurav Misra
- , Julie A Carman
- , Ji Gao
- , Ashok Dongre
- , Shujie Han
- , Kevin D Bunting
- , Jennifer S Ko
- , Hui Xiao
- , Vijay K Kuchroo
- , Wenjun Ouyang
- & Xiaoxia Li
Nature Immunology 14 , 72–81

Rights & permissionsfor article The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90 . Opens in a new window.
Research | 7 August 2011
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)
- Dongxu Sun
- , Michael Novotny
- , Katarzyna Bulek
- , Caini Liu
- , Xiaoxia Li
- & Thomas Hamilton
Nature Immunology 12 , 853–860

Rights & permissionsfor article Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF) . Opens in a new window.

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Inflammation mobilizes copper metabolism to promote colon tumorigenesis via an IL-17-STEAP4-XIAP axis

IL-17-receptor-associated adaptor Act1 directly stabilizes mRNAs to mediate IL-17 inflammatory signaling

IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression

IKKα negatively regulates ASC-dependent inflammasome activation

The inducible kinase IKKi is required for IL-17-dependent signaling associated with neutrophilia and pulmonary inflammation

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF)

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